PubMed:24486742 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":109,"end":298},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":299,"end":567},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":568,"end":713},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T2","span":{"begin":109,"end":298},"obj":"Sentence"},{"id":"T3","span":{"begin":299,"end":567},"obj":"Sentence"},{"id":"T4","span":{"begin":568,"end":713},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":67,"end":83},"obj":"gene:7031"},{"id":"T1","span":{"begin":87,"end":101},"obj":"disease:C0699791"},{"id":"T2","span":{"begin":67,"end":83},"obj":"gene:7031"},{"id":"T3","span":{"begin":87,"end":101},"obj":"disease:C0024623"},{"id":"T4","span":{"begin":425,"end":429},"obj":"gene:7031"},{"id":"T5","span":{"begin":546,"end":560},"obj":"disease:C0024623"},{"id":"T6","span":{"begin":425,"end":429},"obj":"gene:7031"},{"id":"T7","span":{"begin":546,"end":560},"obj":"disease:C0699791"},{"id":"T8","span":{"begin":596,"end":603},"obj":"gene:494335"},{"id":"T9","span":{"begin":698,"end":712},"obj":"disease:C0699791"},{"id":"T10","span":{"begin":596,"end":603},"obj":"gene:494335"},{"id":"T11","span":{"begin":698,"end":712},"obj":"disease:C0024623"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":261,"end":266},"obj":"HP_0002664"},{"id":"T2","span":{"begin":546,"end":560},"obj":"HP_0012126"},{"id":"T3","span":{"begin":554,"end":560},"obj":"HP_0002664"},{"id":"T4","span":{"begin":698,"end":712},"obj":"HP_0012126"},{"id":"T5","span":{"begin":706,"end":712},"obj":"HP_0002664"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"24486742-0#67#83#gene7031","span":{"begin":67,"end":83},"obj":"gene7031"},{"id":"24486742-0#87#101#diseaseC0024623","span":{"begin":87,"end":101},"obj":"diseaseC0024623"},{"id":"24486742-0#87#101#diseaseC0699791","span":{"begin":87,"end":101},"obj":"diseaseC0699791"},{"id":"24486742-3#28#35#gene494335","span":{"begin":596,"end":603},"obj":"gene494335"},{"id":"24486742-3#130#144#diseaseC0024623","span":{"begin":698,"end":712},"obj":"diseaseC0024623"},{"id":"24486742-3#130#144#diseaseC0699791","span":{"begin":698,"end":712},"obj":"diseaseC0699791"}],"relations":[{"id":"67#83#gene703187#101#diseaseC0024623","pred":"associated_with","subj":"24486742-0#67#83#gene7031","obj":"24486742-0#87#101#diseaseC0024623"},{"id":"67#83#gene703187#101#diseaseC0699791","pred":"associated_with","subj":"24486742-0#67#83#gene7031","obj":"24486742-0#87#101#diseaseC0699791"},{"id":"28#35#gene494335130#144#diseaseC0024623","pred":"associated_with","subj":"24486742-3#28#35#gene494335","obj":"24486742-3#130#144#diseaseC0024623"},{"id":"28#35#gene494335130#144#diseaseC0699791","pred":"associated_with","subj":"24486742-3#28#35#gene494335","obj":"24486742-3#130#144#diseaseC0699791"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T2116","span":{"begin":596,"end":603},"obj":"gene:494335"},{"id":"T2117","span":{"begin":698,"end":712},"obj":"disease:C0024623"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T2116","obj":"T2117"},{"id":"R2","pred":"associated_with","subj":"T2116","obj":"T2117"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":290,"end":297},"obj":"http://purl.obolibrary.org/obo/UBERON_0000945"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":290,"end":297},"obj":"http://purl.obolibrary.org/obo/UBERON_0000945"}],"text":"miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.\nTFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer."}