PubMed:24403068
Annnotations
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 154-172 | Cell | denotes | hematopoietic cell | http://purl.obolibrary.org/obo/CL:0000988 |
T2 | 732-742 | Cell | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL:0000182 |
T3 | 948-973 | Cell | denotes | bone marrow stromal cells | http://purl.obolibrary.org/obo/CL:0000134 |
T4 | 1139-1161 | Cell | denotes | attachment to the cell | http://purl.obolibrary.org/obo/CL:0000386 |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 108-282 | DRI_Background | denotes | Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple myeloma (MM) cells. |
T2 | 283-396 | DRI_Background | denotes | High levels of serglycin are present in the bone marrow aspirates of at least 30% of newly diagnosed MM patients. |
T3 | 397-463 | DRI_Background | denotes | However, its contribution to the pathophysiology of MM is unknown. |
T4 | 464-547 | DRI_Outcome | denotes | Here, we show that serglycin knockdown (by ∼85% compared with normal levels), using |
T5 | 564-652 | DRI_Outcome | denotes | , dramatically attenuated MM tumor growth in mice with severe combined immunodeficiency. |
T6 | 653-867 | DRI_Approach | denotes | Tumors formed from cells deficient in serglycin exhibited diminished levels of hepatocyte growth factor expression and impaired development of blood vessels, indicating that serglycin may affect tumor angiogenesis. |
T7 | 868-989 | DRI_Background | denotes | Furthermore, knockdown of serglycin significantly decreased MM cell adhesion to bone marrow stromal cells and collagen I. |
T8 | 990-1241 | DRI_Outcome | denotes | Even though serglycin proteoglycan does not have a transmembrane domain, flow cytometry showed that serglycin is present on the MM cell surface, and attachment to the cell surface is, at least in part, dependent on its chondroitin sulfate side chains. |
T9 | 1242-1500 | DRI_Approach | denotes | Co-precipitation of serglycin from conditioned medium of MM cells using a CD44-Fc chimera suggests that CD44 is the cell surface-binding partner for serglycin, which therefore may serve as a major ligand for CD44 at various stages during myeloma progression. |
T10 | 1501-1680 | DRI_Outcome | denotes | Finally, we demonstrate that serglycin mRNA expression in MM cells is up-regulated by activin, a predominant cytokine among those increased in MM patients with osteolytic lesions. |
T11 | 1681-1854 | DRI_Background | denotes | These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1209-1220 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1209-1220 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T1 | 1209-1220 | GlycoEpitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-107 | Sentence | denotes | Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization. |
T2 | 108-282 | Sentence | denotes | Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple myeloma (MM) cells. |
T3 | 283-396 | Sentence | denotes | High levels of serglycin are present in the bone marrow aspirates of at least 30% of newly diagnosed MM patients. |
T4 | 397-463 | Sentence | denotes | However, its contribution to the pathophysiology of MM is unknown. |
T5 | 464-652 | Sentence | denotes | Here, we show that serglycin knockdown (by ∼85% compared with normal levels), using lentiviral shRNA, dramatically attenuated MM tumor growth in mice with severe combined immunodeficiency. |
T6 | 653-867 | Sentence | denotes | Tumors formed from cells deficient in serglycin exhibited diminished levels of hepatocyte growth factor expression and impaired development of blood vessels, indicating that serglycin may affect tumor angiogenesis. |
T7 | 868-989 | Sentence | denotes | Furthermore, knockdown of serglycin significantly decreased MM cell adhesion to bone marrow stromal cells and collagen I. |
T8 | 990-1241 | Sentence | denotes | Even though serglycin proteoglycan does not have a transmembrane domain, flow cytometry showed that serglycin is present on the MM cell surface, and attachment to the cell surface is, at least in part, dependent on its chondroitin sulfate side chains. |
T9 | 1242-1500 | Sentence | denotes | Co-precipitation of serglycin from conditioned medium of MM cells using a CD44-Fc chimera suggests that CD44 is the cell surface-binding partner for serglycin, which therefore may serve as a major ligand for CD44 at various stages during myeloma progression. |
T10 | 1501-1680 | Sentence | denotes | Finally, we demonstrate that serglycin mRNA expression in MM cells is up-regulated by activin, a predominant cytokine among those increased in MM patients with osteolytic lesions. |
T11 | 1681-1854 | Sentence | denotes | These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 327-338 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
T2 | 327-331 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
T3 | 796-809 | http://purl.obolibrary.org/obo/MAT_0000393 | denotes | blood vessels |
T4 | 796-801 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T5 | 796-801 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
T6 | 948-959 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
T7 | 948-952 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 0-22 | gene:5552 | denotes | Serglycin proteoglycan |
T1 | 39-55 | disease:C0026764 | denotes | multiple myeloma |
T2 | 141-150 | gene:5552 | denotes | serglycin |
T3 | 254-274 | disease:C0026764 | denotes | multiple myeloma (MM |
T4 | 298-307 | gene:5552 | denotes | serglycin |
T5 | 384-386 | disease:C0026764 | denotes | MM |
T6 | 483-492 | gene:5552 | denotes | serglycin |
T7 | 590-592 | disease:C0026764 | denotes | MM |
T8 | 483-492 | gene:5552 | denotes | serglycin |
T9 | 619-651 | disease:C0085110 | denotes | severe combined immunodeficiency |
T10 | 827-836 | gene:5552 | denotes | serglycin |
T11 | 848-866 | disease:C1519670 | denotes | tumor angiogenesis |
T12 | 732-756 | gene:3082 | denotes | hepatocyte growth factor |
T13 | 848-866 | disease:C1519670 | denotes | tumor angiogenesis |
T14 | 691-700 | gene:5552 | denotes | serglycin |
T15 | 848-866 | disease:C1519670 | denotes | tumor angiogenesis |
T16 | 1090-1099 | gene:5552 | denotes | serglycin |
T17 | 1118-1120 | disease:C0026764 | denotes | MM |
T18 | 1002-1024 | gene:5552 | denotes | serglycin proteoglycan |
T19 | 1118-1120 | disease:C0026764 | denotes | MM |
T20 | 1450-1454 | gene:960 | denotes | CD44 |
T21 | 1480-1487 | disease:C0026764 | denotes | myeloma |
T22 | 1346-1350 | gene:960 | denotes | CD44 |
T23 | 1480-1487 | disease:C0026764 | denotes | myeloma |
T24 | 1391-1400 | gene:5552 | denotes | serglycin |
T25 | 1480-1487 | disease:C0026764 | denotes | myeloma |
T26 | 1262-1271 | gene:5552 | denotes | serglycin |
T27 | 1299-1301 | disease:C0026764 | denotes | MM |
T28 | 1262-1271 | gene:5552 | denotes | serglycin |
T29 | 1480-1487 | disease:C0026764 | denotes | myeloma |
T30 | 1316-1320 | gene:960 | denotes | CD44 |
T31 | 1480-1487 | disease:C0026764 | denotes | myeloma |
T32 | 1530-1539 | gene:5552 | denotes | serglycin |
T33 | 1559-1561 | disease:C0026764 | denotes | MM |
R1 | T0 | T1 | associated_with | Serglycin proteoglycan,multiple myeloma |
R2 | T2 | T3 | associated_with | serglycin,multiple myeloma (MM |
R3 | T4 | T5 | associated_with | serglycin,MM |
R4 | T6 | T7 | associated_with | serglycin,MM |
R5 | T8 | T9 | associated_with | serglycin,severe combined immunodeficiency |
R6 | T10 | T11 | associated_with | serglycin,tumor angiogenesis |
R7 | T12 | T13 | associated_with | hepatocyte growth factor,tumor angiogenesis |
R8 | T14 | T15 | associated_with | serglycin,tumor angiogenesis |
R9 | T16 | T17 | associated_with | serglycin,MM |
R10 | T18 | T19 | associated_with | serglycin proteoglycan,MM |
R11 | T20 | T21 | associated_with | CD44,myeloma |
R12 | T22 | T23 | associated_with | CD44,myeloma |
R13 | T24 | T25 | associated_with | serglycin,myeloma |
R14 | T26 | T27 | associated_with | serglycin,MM |
R15 | T28 | T29 | associated_with | serglycin,myeloma |
R16 | T30 | T31 | associated_with | CD44,myeloma |
R17 | T32 | T33 | associated_with | serglycin,MM |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 254-270 | HP_0006775 | denotes | multiple myeloma |
T2 | 339-348 | HP_0002835 | denotes | aspirates |
T3 | 593-598 | HP_0002664 | denotes | tumor |
T4 | 619-651 | HP_0004430 | denotes | severe combined immunodeficiency |
T5 | 626-651 | HP_0005387 | denotes | combined immunodeficiency |
T6 | 635-651 | HP_0002721 | denotes | immunodeficiency |
T7 | 653-659 | HP_0002664 | denotes | Tumors |
T8 | 848-853 | HP_0002664 | denotes | tumor |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_24403068_1_0 | 254-270 | expanded | denotes | multiple myeloma |
SS2_24403068_1_0 | 272-274 | abbr | denotes | MM |
AE1_24403068_1_0 | SS1_24403068_1_0 | SS2_24403068_1_0 | abbreviatedTo | multiple myeloma,MM |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
24403068-0#0#22#gene5552 | 0-22 | gene5552 | denotes | Serglycin proteoglycan |
24403068-0#39#55#diseaseC0026764 | 39-55 | diseaseC0026764 | denotes | multiple myeloma |
24403068-4#19#28#gene5552 | 483-492 | gene5552 | denotes | serglycin |
24403068-4#155#187#diseaseC0085110 | 619-651 | diseaseC0085110 | denotes | severe combined immunodeficiency |
24403068-5#38#47#gene5552 | 691-700 | gene5552 | denotes | serglycin |
24403068-5#79#103#gene3082 | 732-756 | gene3082 | denotes | hepatocyte growth factor |
24403068-5#174#183#gene5552 | 827-836 | gene5552 | denotes | serglycin |
24403068-5#195#213#diseaseC1519670 | 848-866 | diseaseC1519670 | denotes | tumor angiogenesis |
24403068-8#74#78#gene960 | 1316-1320 | gene960 | denotes | CD44 |
24403068-8#104#108#gene960 | 1346-1350 | gene960 | denotes | CD44 |
24403068-8#208#212#gene960 | 1450-1454 | gene960 | denotes | CD44 |
24403068-8#238#245#diseaseC0026764 | 1480-1487 | diseaseC0026764 | denotes | myeloma |
0#22#gene555239#55#diseaseC0026764 | 24403068-0#0#22#gene5552 | 24403068-0#39#55#diseaseC0026764 | associated_with | Serglycin proteoglycan,multiple myeloma |
19#28#gene5552155#187#diseaseC0085110 | 24403068-4#19#28#gene5552 | 24403068-4#155#187#diseaseC0085110 | associated_with | serglycin,severe combined immunodeficiency |
38#47#gene5552195#213#diseaseC1519670 | 24403068-5#38#47#gene5552 | 24403068-5#195#213#diseaseC1519670 | associated_with | serglycin,tumor angiogenesis |
79#103#gene3082195#213#diseaseC1519670 | 24403068-5#79#103#gene3082 | 24403068-5#195#213#diseaseC1519670 | associated_with | hepatocyte growth factor,tumor angiogenesis |
174#183#gene5552195#213#diseaseC1519670 | 24403068-5#174#183#gene5552 | 24403068-5#195#213#diseaseC1519670 | associated_with | serglycin,tumor angiogenesis |
74#78#gene960238#245#diseaseC0026764 | 24403068-8#74#78#gene960 | 24403068-8#238#245#diseaseC0026764 | associated_with | CD44,myeloma |
104#108#gene960238#245#diseaseC0026764 | 24403068-8#104#108#gene960 | 24403068-8#238#245#diseaseC0026764 | associated_with | CD44,myeloma |
208#212#gene960238#245#diseaseC0026764 | 24403068-8#208#212#gene960 | 24403068-8#238#245#diseaseC0026764 | associated_with | CD44,myeloma |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 39-55 | Disease | denotes | multiple myeloma | http://purl.obolibrary.org/obo/MONDO_0009693 |
T2 | 254-270 | Disease | denotes | multiple myeloma | http://purl.obolibrary.org/obo/MONDO_0009693 |
T3 | 272-274 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T4 | 384-386 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T5 | 449-451 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T6 | 590-592 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T7 | 593-598 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T8 | 619-651 | Disease | denotes | severe combined immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0015974 |
T9 | 653-659 | Disease | denotes | Tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
T10 | 848-853 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T11 | 928-930 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T12 | 1118-1120 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T13 | 1299-1301 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T14 | 1480-1487 | Disease | denotes | myeloma | http://purl.obolibrary.org/obo/MONDO_0005170|http://purl.obolibrary.org/obo/MONDO_0009693 |
T16 | 1559-1561 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T17 | 1644-1646 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T18 | 1661-1679 | Disease | denotes | osteolytic lesions | http://purl.obolibrary.org/obo/MONDO_0043731 |
T19 | 1756-1758 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T20 | 1851-1853 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1209-1220 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 1209-1220 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 39-55 | Phenotype | denotes | multiple myeloma | HP:0006775 |
T2 | 254-270 | Phenotype | denotes | multiple myeloma | HP:0006775 |
T3 | 272-274 | Phenotype | denotes | MM | HP:0006775 |
T4 | 384-386 | Phenotype | denotes | MM | HP:0006775 |
T5 | 449-451 | Phenotype | denotes | MM | HP:0006775 |
T6 | 590-592 | Phenotype | denotes | MM | HP:0006775 |
T7 | 593-598 | Phenotype | denotes | tumor | HP:0002664 |
T8 | 619-651 | Phenotype | denotes | severe combined immunodeficiency | HP:0004430 |
T9 | 848-853 | Phenotype | denotes | tumor | HP:0002664 |
T10 | 928-930 | Phenotype | denotes | MM | HP:0006775 |
T11 | 1118-1120 | Phenotype | denotes | MM | HP:0006775 |
T12 | 1299-1301 | Phenotype | denotes | MM | HP:0006775 |
T13 | 1559-1561 | Phenotype | denotes | MM | HP:0006775 |
T14 | 1644-1646 | Phenotype | denotes | MM | HP:0006775 |
T15 | 1756-1758 | Phenotype | denotes | MM | HP:0006775 |
T16 | 1851-1853 | Phenotype | denotes | MM | HP:0006775 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 39-55 | Disease | denotes | multiple myeloma | http://purl.obolibrary.org/obo/MONDO_0009693 |
T2 | 254-270 | Disease | denotes | multiple myeloma | http://purl.obolibrary.org/obo/MONDO_0009693 |
T3 | 272-274 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T4 | 384-386 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T5 | 449-451 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T6 | 590-592 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T7 | 593-598 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T8 | 619-651 | Disease | denotes | severe combined immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0015974 |
T9 | 653-659 | Disease | denotes | Tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
T10 | 848-853 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T11 | 928-930 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T12 | 1118-1120 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T13 | 1299-1301 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T14 | 1480-1487 | Disease | denotes | myeloma | http://purl.obolibrary.org/obo/MONDO_0005170|http://purl.obolibrary.org/obo/MONDO_0009693 |
T16 | 1559-1561 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T17 | 1644-1646 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T18 | 1661-1679 | Disease | denotes | osteolytic lesions | http://purl.obolibrary.org/obo/MONDO_0043731 |
T19 | 1756-1758 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
T20 | 1851-1853 | Disease | denotes | MM | http://purl.obolibrary.org/obo/MONDO_0009693 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 609-613 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 154-172 | Cell | denotes | hematopoietic cell | http://purl.obolibrary.org/obo/CL:0000988 |
T2 | 732-742 | Cell | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL:0000182 |
T3 | 948-973 | Cell | denotes | bone marrow stromal cells | http://purl.obolibrary.org/obo/CL:0000134 |
T4 | 1139-1161 | Cell | denotes | attachment to the cell | http://purl.obolibrary.org/obo/CL:0000386 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 154-172 | Body_part | denotes | hematopoietic cell | http://purl.obolibrary.org/obo/CL_0000988 |
T2 | 327-338 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
T3 | 732-742 | Body_part | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL_0000182 |
T4 | 796-809 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/UBERON_0004537 |
T5 | 948-973 | Body_part | denotes | bone marrow stromal cells | http://purl.obolibrary.org/obo/CL_0000134 |
T6 | 1041-1054 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
T7 | 1139-1161 | Body_part | denotes | attachment to the cell | http://purl.obolibrary.org/obo/CL_0000386 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 327-338 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
T2 | 796-809 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/MAT_0000393 |
T3 | 948-959 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-107 | Sentence | denotes | Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization. |
T2 | 108-282 | Sentence | denotes | Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple myeloma (MM) cells. |
T3 | 283-396 | Sentence | denotes | High levels of serglycin are present in the bone marrow aspirates of at least 30% of newly diagnosed MM patients. |
T4 | 397-463 | Sentence | denotes | However, its contribution to the pathophysiology of MM is unknown. |
T5 | 464-652 | Sentence | denotes | Here, we show that serglycin knockdown (by ∼85% compared with normal levels), using lentiviral shRNA, dramatically attenuated MM tumor growth in mice with severe combined immunodeficiency. |
T6 | 653-867 | Sentence | denotes | Tumors formed from cells deficient in serglycin exhibited diminished levels of hepatocyte growth factor expression and impaired development of blood vessels, indicating that serglycin may affect tumor angiogenesis. |
T7 | 868-989 | Sentence | denotes | Furthermore, knockdown of serglycin significantly decreased MM cell adhesion to bone marrow stromal cells and collagen I. |
T8 | 990-1241 | Sentence | denotes | Even though serglycin proteoglycan does not have a transmembrane domain, flow cytometry showed that serglycin is present on the MM cell surface, and attachment to the cell surface is, at least in part, dependent on its chondroitin sulfate side chains. |
T9 | 1242-1500 | Sentence | denotes | Co-precipitation of serglycin from conditioned medium of MM cells using a CD44-Fc chimera suggests that CD44 is the cell surface-binding partner for serglycin, which therefore may serve as a major ligand for CD44 at various stages during myeloma progression. |
T10 | 1501-1680 | Sentence | denotes | Finally, we demonstrate that serglycin mRNA expression in MM cells is up-regulated by activin, a predominant cytokine among those increased in MM patients with osteolytic lesions. |
T11 | 1681-1854 | Sentence | denotes | These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-107 | Sentence | denotes | Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization. |
T2 | 108-282 | Sentence | denotes | Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple myeloma (MM) cells. |
T3 | 283-396 | Sentence | denotes | High levels of serglycin are present in the bone marrow aspirates of at least 30% of newly diagnosed MM patients. |
T4 | 397-463 | Sentence | denotes | However, its contribution to the pathophysiology of MM is unknown. |
T5 | 464-652 | Sentence | denotes | Here, we show that serglycin knockdown (by ∼85% compared with normal levels), using lentiviral shRNA, dramatically attenuated MM tumor growth in mice with severe combined immunodeficiency. |
T6 | 653-867 | Sentence | denotes | Tumors formed from cells deficient in serglycin exhibited diminished levels of hepatocyte growth factor expression and impaired development of blood vessels, indicating that serglycin may affect tumor angiogenesis. |
T7 | 868-1241 | Sentence | denotes | Furthermore, knockdown of serglycin significantly decreased MM cell adhesion to bone marrow stromal cells and collagen I. Even though serglycin proteoglycan does not have a transmembrane domain, flow cytometry showed that serglycin is present on the MM cell surface, and attachment to the cell surface is, at least in part, dependent on its chondroitin sulfate side chains. |
T8 | 1242-1500 | Sentence | denotes | Co-precipitation of serglycin from conditioned medium of MM cells using a CD44-Fc chimera suggests that CD44 is the cell surface-binding partner for serglycin, which therefore may serve as a major ligand for CD44 at various stages during myeloma progression. |
T9 | 1501-1680 | Sentence | denotes | Finally, we demonstrate that serglycin mRNA expression in MM cells is up-regulated by activin, a predominant cytokine among those increased in MM patients with osteolytic lesions. |
T10 | 1681-1854 | Sentence | denotes | These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 1209-1220 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 1209-1220 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 609-613 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 327-338 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
T2 | 796-809 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/MAT_0000393 |
T3 | 948-959 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 154-172 | Body_part | denotes | hematopoietic cell | http://purl.obolibrary.org/obo/CL_0000988 |
T2 | 327-338 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
T3 | 732-742 | Body_part | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL_0000182 |
T4 | 796-809 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/UBERON_0004537 |
T5 | 948-973 | Body_part | denotes | bone marrow stromal cells | http://purl.obolibrary.org/obo/CL_0000134 |
T6 | 1041-1054 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
T7 | 1139-1161 | Body_part | denotes | attachment to the cell | http://purl.obolibrary.org/obo/CL_0000386 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 39-55 | Phenotype | denotes | multiple myeloma | HP:0006775 |
T2 | 254-270 | Phenotype | denotes | multiple myeloma | HP:0006775 |
T3 | 272-274 | Phenotype | denotes | MM | HP:0006775 |
T4 | 384-386 | Phenotype | denotes | MM | HP:0006775 |
T5 | 449-451 | Phenotype | denotes | MM | HP:0006775 |
T6 | 590-592 | Phenotype | denotes | MM | HP:0006775 |
T7 | 593-598 | Phenotype | denotes | tumor | HP:0002664 |
T8 | 619-651 | Phenotype | denotes | severe combined immunodeficiency | HP:0004430 |
T9 | 848-853 | Phenotype | denotes | tumor | HP:0002664 |
T10 | 928-930 | Phenotype | denotes | MM | HP:0006775 |
T11 | 1118-1120 | Phenotype | denotes | MM | HP:0006775 |
T12 | 1299-1301 | Phenotype | denotes | MM | HP:0006775 |
T13 | 1559-1561 | Phenotype | denotes | MM | HP:0006775 |
T14 | 1644-1646 | Phenotype | denotes | MM | HP:0006775 |
T15 | 1756-1758 | Phenotype | denotes | MM | HP:0006775 |
T16 | 1851-1853 | Phenotype | denotes | MM | HP:0006775 |