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PubMed:24332979 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-142 Sentence denotes Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma.
TextSentencer_T2 143-289 Sentence denotes In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression.
TextSentencer_T3 290-473 Sentence denotes In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses.
TextSentencer_T4 474-688 Sentence denotes However, it presents a redox motif (CXXU), where U is a selenocysteine, and may also function as redox regulator because its decreased or increased expression regulated by dietary selenium alters redox homeostasis.
TextSentencer_T5 689-795 Sentence denotes No data are reported in literature about its involvement in cancer but only in neurodegenerative diseases.
TextSentencer_T6 796-918 Sentence denotes In this paper we evaluated the SelM expression in two hepatoma cell lines, HepG2 and Huh7, compared to normal hepatocytes.
TextSentencer_T7 919-1079 Sentence denotes The results suggested its involvement in hepatocellular carcinoma (HCC) as well as its possible use to follow the progression of this cancer as putative marker.
TextSentencer_T8 1080-1167 Sentence denotes The aim of this study has been to analyze the structure-function relationships of SelM.
TextSentencer_T9 1168-1305 Sentence denotes Hence, firstly we studied the evolutionary history of this protein by phylogenetic analysis and GC content of genes from various species.
TextSentencer_T10 1306-1440 Sentence denotes So, we modeled the three-dimensional structure of the human SelM evaluating its energetic stability by molecular dynamics simulations.
TextSentencer_T11 1441-1555 Sentence denotes Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design.
T1 0-142 Sentence denotes Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma.
T2 143-289 Sentence denotes In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression.
T3 290-473 Sentence denotes In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses.
T4 474-688 Sentence denotes However, it presents a redox motif (CXXU), where U is a selenocysteine, and may also function as redox regulator because its decreased or increased expression regulated by dietary selenium alters redox homeostasis.
T5 689-795 Sentence denotes No data are reported in literature about its involvement in cancer but only in neurodegenerative diseases.
T6 796-918 Sentence denotes In this paper we evaluated the SelM expression in two hepatoma cell lines, HepG2 and Huh7, compared to normal hepatocytes.
T7 919-1079 Sentence denotes The results suggested its involvement in hepatocellular carcinoma (HCC) as well as its possible use to follow the progression of this cancer as putative marker.
T8 1080-1167 Sentence denotes The aim of this study has been to analyze the structure-function relationships of SelM.
T9 1168-1305 Sentence denotes Hence, firstly we studied the evolutionary history of this protein by phylogenetic analysis and GC content of genes from various species.
T10 1306-1440 Sentence denotes So, we modeled the three-dimensional structure of the human SelM evaluating its energetic stability by molecular dynamics simulations.
T11 1441-1555 Sentence denotes Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 87-91 gene:140606 denotes SelM
T1 117-141 disease:C2239176 denotes hepatocellular carcinoma
T2 70-85 gene:140606 denotes selenoprotein M
T3 117-141 disease:C2239176 denotes hepatocellular carcinoma
T4 827-831 gene:140606 denotes SelM
T5 850-858 disease:C2239176 denotes hepatoma
T6 827-831 gene:140606 denotes SelM
T7 850-858 disease:C0023903 denotes hepatoma
R1 T0 T1 associated_with SelM,hepatocellular carcinoma
R2 T2 T3 associated_with selenoprotein M,hepatocellular carcinoma
R3 T4 T5 associated_with SelM,hepatoma
R4 T6 T7 associated_with SelM,hepatoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 749-755 HP_0002664 denotes cancer
T2 960-984 HP_0001402 denotes hepatocellular carcinoma
T3 1053-1059 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_24332979_0_0 70-85 expanded denotes selenoprotein M
SS2_24332979_0_0 87-91 abbr denotes SelM
SS1_24332979_2_0 305-320 expanded denotes selenoprotein M
SS2_24332979_2_0 322-326 abbr denotes SelM
SS1_24332979_6_0 960-984 expanded denotes hepatocellular carcinoma
SS2_24332979_6_0 986-989 abbr denotes HCC
AE1_24332979_0_0 SS1_24332979_0_0 SS2_24332979_0_0 abbreviatedTo selenoprotein M,SelM
AE1_24332979_2_0 SS1_24332979_2_0 SS2_24332979_2_0 abbreviatedTo selenoprotein M,SelM
AE1_24332979_6_0 SS1_24332979_6_0 SS2_24332979_6_0 abbreviatedTo hepatocellular carcinoma,HCC

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24332979-0#70#85#gene140606 70-85 gene140606 denotes selenoprotein M
24332979-0#87#91#gene140606 87-91 gene140606 denotes SelM
24332979-0#117#141#diseaseC2239176 117-141 diseaseC2239176 denotes hepatocellular carcinoma
24332979-5#31#35#gene140606 827-831 gene140606 denotes SelM
24332979-5#54#62#diseaseC0023903 850-858 diseaseC0023903 denotes hepatoma
70#85#gene140606117#141#diseaseC2239176 24332979-0#70#85#gene140606 24332979-0#117#141#diseaseC2239176 associated_with selenoprotein M,hepatocellular carcinoma
87#91#gene140606117#141#diseaseC2239176 24332979-0#87#91#gene140606 24332979-0#117#141#diseaseC2239176 associated_with SelM,hepatocellular carcinoma
31#35#gene14060654#62#diseaseC0023903 24332979-5#31#35#gene140606 24332979-5#54#62#diseaseC0023903 associated_with SelM,hepatoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1515 827-831 gene:140606 denotes SelM
T1516 850-858 disease:C0023903 denotes hepatoma
R1 T1515 T1516 associated_with SelM,hepatoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 242-255 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune-system

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 242-255 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune-system

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 117-141 Phenotype denotes hepatocellular carcinoma HP:0001402
T2 749-755 Phenotype denotes cancer HP:0002664
T3 768-794 Phenotype denotes neurodegenerative diseases HP:0002180
T4 960-984 Phenotype denotes hepatocellular carcinoma HP:0001402
T5 986-989 Phenotype denotes HCC HP:0001402
T6 1053-1059 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 117-141 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T2 749-755 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 768-794 Disease denotes neurodegenerative diseases http://purl.obolibrary.org/obo/MONDO_0005559
T4 850-858 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256
T5 960-984 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T6 986-989 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T7 1053-1059 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 64-69 OrganismTaxon denotes human 9606
T2 1360-1365 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 242-255 Body_part denotes immune-system http://purl.obolibrary.org/obo/UBERON_0002405
T2 906-917 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 906-917 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182