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PubMed:23999440 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-83 Sentence denotes HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.
TextSentencer_T2 84-360 Sentence denotes Hypoxia occurs frequently in human cancers and induces adaptive changes in cell metabolism that include a switch from oxidative phosphorylation to glycolysis, increased glycogen synthesis, and a switch from glucose to glutamine as the major substrate for fatty acid synthesis.
TextSentencer_T3 361-524 Sentence denotes This broad metabolic reprogramming is coordinated at the transcriptional level by HIF-1, which functions as a master regulator to balance oxygen supply and demand.
TextSentencer_T4 525-771 Sentence denotes HIF-1 is also activated in cancer cells by tumor suppressor (e.g., VHL) loss of function and oncogene gain of function (leading to PI3K/AKT/mTOR activity) and mediates metabolic alterations that drive cancer progression and resistance to therapy.
TextSentencer_T5 772-915 Sentence denotes Inhibitors of HIF-1 or metabolic enzymes may impair the metabolic flexibility of cancer cells and make them more sensitive to anticancer drugs.
T1 0-83 Sentence denotes HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.
T2 84-360 Sentence denotes Hypoxia occurs frequently in human cancers and induces adaptive changes in cell metabolism that include a switch from oxidative phosphorylation to glycolysis, increased glycogen synthesis, and a switch from glucose to glutamine as the major substrate for fatty acid synthesis.
T3 361-524 Sentence denotes This broad metabolic reprogramming is coordinated at the transcriptional level by HIF-1, which functions as a master regulator to balance oxygen supply and demand.
T4 525-771 Sentence denotes HIF-1 is also activated in cancer cells by tumor suppressor (e.g., VHL) loss of function and oncogene gain of function (leading to PI3K/AKT/mTOR activity) and mediates metabolic alterations that drive cancer progression and resistance to therapy.
T5 772-915 Sentence denotes Inhibitors of HIF-1 or metabolic enzymes may impair the metabolic flexibility of cancer cells and make them more sensitive to anticancer drugs.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 661-664 gene:207 denotes AKT
T1 726-744 disease:C0178874 denotes cancer progression
T2 656-660 gene:5291 denotes PI3K
T3 726-744 disease:C0178874 denotes cancer progression
T4 656-660 gene:5290 denotes PI3K
T5 726-744 disease:C0178874 denotes cancer progression
T6 656-660 gene:5293 denotes PI3K
T7 726-744 disease:C0178874 denotes cancer progression
T8 525-530 gene:3091 denotes HIF-1
T9 552-558 disease:C0006826 denotes cancer
T10 525-530 gene:3091 denotes HIF-1
T11 552-558 disease:C1306459 denotes cancer
T12 525-530 gene:29072 denotes HIF-1
T13 552-558 disease:C0006826 denotes cancer
T14 525-530 gene:29072 denotes HIF-1
T15 552-558 disease:C1306459 denotes cancer
T16 656-660 gene:5294 denotes PI3K
T17 726-744 disease:C0178874 denotes cancer progression
T18 525-530 gene:29072 denotes HIF-1
T19 726-744 disease:C0178874 denotes cancer progression
T20 592-595 gene:7428 denotes VHL
T21 726-744 disease:C0178874 denotes cancer progression
T22 525-530 gene:3091 denotes HIF-1
T23 726-744 disease:C0178874 denotes cancer progression
T24 786-791 gene:29072 denotes HIF-1
T25 853-859 disease:C1306459 denotes cancer
T26 786-791 gene:29072 denotes HIF-1
T27 853-859 disease:C0006826 denotes cancer
T28 786-791 gene:3091 denotes HIF-1
T29 853-859 disease:C1306459 denotes cancer
T30 786-791 gene:3091 denotes HIF-1
T31 853-859 disease:C0006826 denotes cancer
R1 T0 T1 associated_with AKT,cancer progression
R2 T2 T3 associated_with PI3K,cancer progression
R3 T4 T5 associated_with PI3K,cancer progression
R4 T6 T7 associated_with PI3K,cancer progression
R5 T8 T9 associated_with HIF-1,cancer
R6 T10 T11 associated_with HIF-1,cancer
R7 T12 T13 associated_with HIF-1,cancer
R8 T14 T15 associated_with HIF-1,cancer
R9 T16 T17 associated_with PI3K,cancer progression
R10 T18 T19 associated_with HIF-1,cancer progression
R11 T20 T21 associated_with VHL,cancer progression
R12 T22 T23 associated_with HIF-1,cancer progression
R13 T24 T25 associated_with HIF-1,cancer
R14 T26 T27 associated_with HIF-1,cancer
R15 T28 T29 associated_with HIF-1,cancer
R16 T30 T31 associated_with HIF-1,cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 119-126 HP_0002664 denotes cancers
T2 552-558 HP_0002664 denotes cancer
T3 568-573 HP_0002664 denotes tumor
T4 726-732 HP_0002664 denotes cancer
T5 853-859 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23999440-3#0#5#gene3091 525-530 gene3091 denotes HIF-1
23999440-3#0#5#gene29072 525-530 gene29072 denotes HIF-1
23999440-3#131#135#gene5290 656-660 gene5290 denotes PI3K
23999440-3#131#135#gene5291 656-660 gene5291 denotes PI3K
23999440-3#131#135#gene5293 656-660 gene5293 denotes PI3K
23999440-3#131#135#gene5294 656-660 gene5294 denotes PI3K
23999440-3#67#70#gene7428 592-595 gene7428 denotes VHL
23999440-3#136#139#gene207 661-664 gene207 denotes AKT
23999440-3#201#219#diseaseC0178874 726-744 diseaseC0178874 denotes cancer progression
0#5#gene3091201#219#diseaseC0178874 23999440-3#0#5#gene3091 23999440-3#201#219#diseaseC0178874 associated_with HIF-1,cancer progression
0#5#gene29072201#219#diseaseC0178874 23999440-3#0#5#gene29072 23999440-3#201#219#diseaseC0178874 associated_with HIF-1,cancer progression
131#135#gene5290201#219#diseaseC0178874 23999440-3#131#135#gene5290 23999440-3#201#219#diseaseC0178874 associated_with PI3K,cancer progression
131#135#gene5291201#219#diseaseC0178874 23999440-3#131#135#gene5291 23999440-3#201#219#diseaseC0178874 associated_with PI3K,cancer progression
131#135#gene5293201#219#diseaseC0178874 23999440-3#131#135#gene5293 23999440-3#201#219#diseaseC0178874 associated_with PI3K,cancer progression
131#135#gene5294201#219#diseaseC0178874 23999440-3#131#135#gene5294 23999440-3#201#219#diseaseC0178874 associated_with PI3K,cancer progression
67#70#gene7428201#219#diseaseC0178874 23999440-3#67#70#gene7428 23999440-3#201#219#diseaseC0178874 associated_with VHL,cancer progression
136#139#gene207201#219#diseaseC0178874 23999440-3#136#139#gene207 23999440-3#201#219#diseaseC0178874 associated_with AKT,cancer progression

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2921 525-530 gene:3091 denotes HIF-1
T2922 726-744 disease:C0178874 denotes cancer progression
T2923 656-660 gene:5290 denotes PI3K
R1 T2921 T2922 associated_with HIF-1,cancer progression
R2 T2921 T2922 associated_with HIF-1,cancer progression
R3 T2923 T2922 associated_with PI3K,cancer progression
R4 T2923 T2922 associated_with PI3K,cancer progression
R5 T2923 T2922 associated_with PI3K,cancer progression
R6 T2923 T2922 associated_with PI3K,cancer progression