PubMed:23952588 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23952588","sourcedb":"PubMed","sourceid":"23952588","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23952588","text":"Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease.\nUNLABELLED: Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD.\nMETHODS: This is a cross-sectional study involving 95 patients with PD on uninterrupted levodopa therapy for at least 6 months. The instrument used was the UPDRS questionnaires. The predictors of dyskinesia were determined using multivariate logistic regression analysis.\nRESULTS: The mean age was 65.6 ± 8.5 years. The mean onset age was 58.5 ± 9.8 years. The median disease duration was 6 (7) years. Dyskinesia was present in 44% (n = 42) with median levodopa therapy of 3 years. There were 64.3% Chinese, 31% Malays, and 3.7% Indians and other ethnic groups. Eighty-one percent of patients with dyskinesia had clinical fluctuations. Patients with dyskinesia had lower onset age ( p \u003c 0.001), longer duration of levodopa therapy ( p \u003c 0.001), longer disease duration ( p \u003c 0.001), higher total daily levodopa dose ( p \u003c 0.001), and higher total UPDRS scores ( p = 0.005) than patients without dyskinesia. The three significant predictors of dyskinesia were duration of levodopa therapy, onset age, and total daily levodopa dose.\nCONCLUSIONS: The prevalence of levodopa-induced dyskinesia in our patients was 44%. The most significant predictors were duration of levodopa therapy, total daily levodopa dose, and onset 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