PubMed:23632240 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/23632240","sourcedb":"PubMed","sourceid":"23632240","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23632240","text":"Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma.\nBACKGROUND: Numerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T\u003eC (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.\nPATIENTS AND METHODS: We enrolled 157 HCC patients and 201 cancer-free control subjects from the Korean population. MicroRNA polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.\nRESULTS: We found that the miR-34b/c TC+CC frequency was significantly higher in HCC patients than in controls (adjusted odds ratio [AOR]: 1.580; 95% confidence interval [CI]: 1.029-2.426). The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301). The SNPs miR-34b/c T\u003eC and TP53 Arg72Pro(G\u003eC) had no influence on survival of HCC patients.\nCONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T\u003eC, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean 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