PubMed:23632240
Annnotations
DisGeNET
{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":155,"end":161},"obj":"gene:407040"},{"id":"T1","span":{"begin":254,"end":278},"obj":"disease:C2239176"},{"id":"T2","span":{"begin":195,"end":198},"obj":"gene:7157"},{"id":"T3","span":{"begin":212,"end":226},"obj":"disease:C0596263"},{"id":"T4","span":{"begin":155,"end":161},"obj":"gene:407040"},{"id":"T5","span":{"begin":212,"end":226},"obj":"disease:C0596263"},{"id":"T6","span":{"begin":403,"end":407},"obj":"gene:7157"},{"id":"T7","span":{"begin":450,"end":453},"obj":"disease:C2239176"},{"id":"T8","span":{"begin":403,"end":407},"obj":"gene:7157"},{"id":"T9","span":{"begin":493,"end":496},"obj":"disease:C2239176"},{"id":"T10","span":{"begin":938,"end":959},"obj":"gene:7157"},{"id":"T11","span":{"begin":1016,"end":1019},"obj":"disease:C2239176"},{"id":"T12","span":{"begin":1085,"end":1089},"obj":"gene:7157"},{"id":"T13","span":{"begin":1136,"end":1139},"obj":"disease:C2239176"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma.\nBACKGROUND: Numerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T\u003eC (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.\nPATIENTS AND METHODS: We enrolled 157 HCC patients and 201 cancer-free control subjects from the Korean population. MicroRNA polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.\nRESULTS: We found that the miR-34b/c TC+CC frequency was significantly higher in HCC patients than in controls (adjusted odds ratio [AOR]: 1.580; 95% confidence interval [CI]: 1.029-2.426). The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301). The SNPs miR-34b/c T\u003eC and TP53 Arg72Pro(G\u003eC) had no influence on survival of HCC patients.\nCONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T\u003eC, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population."}
PubmedHPO
{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":235,"end":242},"obj":"HP_0002664"},{"id":"T2","span":{"begin":254,"end":278},"obj":"HP_0001402"}],"text":"Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma.\nBACKGROUND: Numerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T\u003eC (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.\nPATIENTS AND METHODS: We enrolled 157 HCC patients and 201 cancer-free control subjects from the Korean population. MicroRNA polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.\nRESULTS: We found that the miR-34b/c TC+CC frequency was significantly higher in HCC patients than in controls (adjusted odds ratio [AOR]: 1.580; 95% confidence interval [CI]: 1.029-2.426). The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301). The SNPs miR-34b/c T\u003eC and TP53 Arg72Pro(G\u003eC) had no influence on survival of HCC patients.\nCONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T\u003eC, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population."}
Allie
{"project":"Allie","denotations":[{"id":"SS1_23632240_2_0","span":{"begin":254,"end":278},"obj":"expanded"},{"id":"SS2_23632240_2_0","span":{"begin":280,"end":283},"obj":"abbr"},{"id":"SS1_23632240_6_0","span":{"begin":662,"end":728},"obj":"expanded"},{"id":"SS2_23632240_6_0","span":{"begin":730,"end":738},"obj":"abbr"},{"id":"SS1_23632240_8_0","span":{"begin":860,"end":879},"obj":"expanded"},{"id":"SS2_23632240_8_0","span":{"begin":881,"end":884},"obj":"abbr"},{"id":"SS1_23632240_8_1","span":{"begin":898,"end":917},"obj":"expanded"},{"id":"SS2_23632240_8_1","span":{"begin":919,"end":921},"obj":"abbr"},{"id":"SS1_23632240_9_0","span":{"begin":964,"end":1019},"obj":"expanded"},{"id":"SS2_23632240_9_0","span":{"begin":1021,"end":1024},"obj":"abbr"}],"relations":[{"id":"AE1_23632240_2_0","pred":"abbreviatedTo","subj":"SS1_23632240_2_0","obj":"SS2_23632240_2_0"},{"id":"AE1_23632240_6_0","pred":"abbreviatedTo","subj":"SS1_23632240_6_0","obj":"SS2_23632240_6_0"},{"id":"AE1_23632240_8_0","pred":"abbreviatedTo","subj":"SS1_23632240_8_0","obj":"SS2_23632240_8_0"},{"id":"AE1_23632240_8_1","pred":"abbreviatedTo","subj":"SS1_23632240_8_1","obj":"SS2_23632240_8_1"},{"id":"AE1_23632240_9_0","pred":"abbreviatedTo","subj":"SS1_23632240_9_0","obj":"SS2_23632240_9_0"}],"text":"Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma.\nBACKGROUND: Numerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T\u003eC (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.\nPATIENTS AND METHODS: We enrolled 157 HCC patients and 201 cancer-free control subjects from the Korean population. MicroRNA polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.\nRESULTS: We found that the miR-34b/c TC+CC frequency was significantly higher in HCC patients than in controls (adjusted odds ratio [AOR]: 1.580; 95% confidence interval [CI]: 1.029-2.426). The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301). The SNPs miR-34b/c T\u003eC and TP53 Arg72Pro(G\u003eC) had no influence on survival of HCC patients.\nCONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T\u003eC, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population."}
DisGeNET5_gene_disease
{"project":"DisGeNET5_gene_disease","denotations":[{"id":"23632240-8#86#90#gene7157","span":{"begin":1249,"end":1253},"obj":"gene7157"},{"id":"23632240-8#133#136#diseaseC2239176","span":{"begin":1296,"end":1299},"obj":"diseaseC2239176"}],"relations":[{"id":"86#90#gene7157133#136#diseaseC2239176","pred":"associated_with","subj":"23632240-8#86#90#gene7157","obj":"23632240-8#133#136#diseaseC2239176"}],"text":"Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma.\nBACKGROUND: Numerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T\u003eC (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.\nPATIENTS AND METHODS: We enrolled 157 HCC patients and 201 cancer-free control subjects from the Korean population. MicroRNA polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.\nRESULTS: We found that the miR-34b/c TC+CC frequency was significantly higher in HCC patients than in controls (adjusted odds ratio [AOR]: 1.580; 95% confidence interval [CI]: 1.029-2.426). The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301). The SNPs miR-34b/c T\u003eC and TP53 Arg72Pro(G\u003eC) had no influence on survival of HCC patients.\nCONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T\u003eC, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population."}