PubMed:2352258
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2352258","sourcedb":"PubMed","sourceid":"2352258","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2352258","text":"Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma.\nAnalysis of the age incidence curves for unilateral and bilateral retinoblastoma led Knudson to propose that hereditary tumours may arise by a single event and sporadic tumours by a two stage mutation process. It has been suggested recently that sporadic renal cell carcinoma may arise from a two stage mutation process. We analysed the age incidence curves for symptomatic renal cell carcinoma (n = 26) and cerebellar haemangioblastoma (n = 68) in 109 patients with von Hippel-Lindau (VHL) disease, and compared them to 104 patients with sporadic renal cell carcinoma and 43 patients with sporadic cerebellar haemangioblastoma. The age incidence curves for renal cell carcinoma and cerebellar haemangioblastoma in VHL disease were compatible with a single mutation model, whereas the age incidence curves for sporadic renal cell carcinoma and cerebellar haemangioblastoma suggested a two stage mutation process. These data are compatible with the VHL gene functioning as a recessive tumour suppressor gene. Sporadic cerebellar haemangioblastoma and some renal cell carcinoma may arise from somatic mutations inactivating both alleles at the VHL locus.","tracks":[{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":56,"end":81},"obj":"SpecificDisease:D006623"},{"id":"T2","span":{"begin":90,"end":127},"obj":"SpecificDisease:D018325"},{"id":"T3","span":{"begin":132,"end":152},"obj":"SpecificDisease:D002292"},{"id":"T4","span":{"begin":195,"end":234},"obj":"CompositeMention:D012175"},{"id":"T5","span":{"begin":263,"end":281},"obj":"DiseaseClass:D009386"},{"id":"T6","span":{"begin":314,"end":330},"obj":"DiseaseClass:D009369"},{"id":"T7","span":{"begin":400,"end":429},"obj":"SpecificDisease:D002292"},{"id":"T8","span":{"begin":528,"end":548},"obj":"SpecificDisease:D002292"},{"id":"T9","span":{"begin":562,"end":590},"obj":"SpecificDisease:D018325"},{"id":"T10","span":{"begin":621,"end":652},"obj":"SpecificDisease:D006623"},{"id":"T11","span":{"begin":693,"end":722},"obj":"SpecificDisease:D002292"},{"id":"T12","span":{"begin":744,"end":781},"obj":"SpecificDisease:D018325"},{"id":"T13","span":{"begin":812,"end":832},"obj":"SpecificDisease:D002292"},{"id":"T14","span":{"begin":837,"end":865},"obj":"SpecificDisease:D018325"},{"id":"T15","span":{"begin":869,"end":880},"obj":"SpecificDisease:D006623"},{"id":"T16","span":{"begin":964,"end":993},"obj":"SpecificDisease:D002292"},{"id":"T17","span":{"begin":998,"end":1026},"obj":"SpecificDisease:D018325"},{"id":"T18","span":{"begin":1102,"end":1105},"obj":"Modifier:D006623"},{"id":"T19","span":{"begin":1138,"end":1144},"obj":"Modifier:D009369"},{"id":"T20","span":{"begin":1162,"end":1199},"obj":"SpecificDisease:D018325"},{"id":"T21","span":{"begin":1209,"end":1229},"obj":"SpecificDisease:D002292"},{"id":"T22","span":{"begin":1296,"end":1299},"obj":"Modifier:D006623"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T2","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T3","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T4","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T5","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T6","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T7","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T8","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T9","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T10","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T11","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T12","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T13","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T14","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T15","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T16","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T17","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T18","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T19","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T20","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T21","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T22","pred":"source","obj":"NCBIDiseaseCorpus"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":220,"end":234},"obj":"HP_0009919"},{"id":"T2","span":{"begin":274,"end":281},"obj":"HP_0002664"},{"id":"T3","span":{"begin":323,"end":330},"obj":"HP_0002664"},{"id":"T4","span":{"begin":409,"end":429},"obj":"HP_0005584"},{"id":"T5","span":{"begin":528,"end":548},"obj":"HP_0005584"},{"id":"T6","span":{"begin":573,"end":590},"obj":"HP_0010797"},{"id":"T7","span":{"begin":702,"end":722},"obj":"HP_0005584"},{"id":"T8","span":{"begin":764,"end":781},"obj":"HP_0010797"},{"id":"T9","span":{"begin":812,"end":832},"obj":"HP_0005584"},{"id":"T10","span":{"begin":848,"end":865},"obj":"HP_0010797"},{"id":"T11","span":{"begin":973,"end":993},"obj":"HP_0005584"},{"id":"T12","span":{"begin":1009,"end":1026},"obj":"HP_0010797"},{"id":"T13","span":{"begin":1138,"end":1144},"obj":"HP_0002664"},{"id":"T14","span":{"begin":1182,"end":1199},"obj":"HP_0010797"},{"id":"T15","span":{"begin":1209,"end":1229},"obj":"HP_0005584"},{"id":"T16","span":{"begin":1245,"end":1262},"obj":"HP_0001428"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"},{"subj":"T12","pred":"source","obj":"PubmedHPO"},{"subj":"T13","pred":"source","obj":"PubmedHPO"},{"subj":"T14","pred":"source","obj":"PubmedHPO"},{"subj":"T15","pred":"source","obj":"PubmedHPO"},{"subj":"T16","pred":"source","obj":"PubmedHPO"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":153},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":154,"end":363},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":364,"end":474},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":475,"end":782},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":783,"end":1066},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":1067,"end":1161},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1162,"end":1306},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":153},"obj":"Sentence"},{"id":"T2","span":{"begin":154,"end":363},"obj":"Sentence"},{"id":"T3","span":{"begin":364,"end":474},"obj":"Sentence"},{"id":"T4","span":{"begin":475,"end":782},"obj":"Sentence"},{"id":"T5","span":{"begin":783,"end":1066},"obj":"Sentence"},{"id":"T6","span":{"begin":1067,"end":1161},"obj":"Sentence"},{"id":"T7","span":{"begin":1162,"end":1306},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"}]},{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":220,"end":234},"obj":"HP:0009919"},{"id":"TI1","span":{"begin":132,"end":152},"obj":"HP:0005584"},{"id":"AB2","span":{"begin":409,"end":429},"obj":"HP:0005584"},{"id":"AB3","span":{"begin":528,"end":548},"obj":"HP:0005584"},{"id":"AB4","span":{"begin":702,"end":722},"obj":"HP:0005584"},{"id":"AB5","span":{"begin":812,"end":832},"obj":"HP:0005584"},{"id":"AB6","span":{"begin":973,"end":993},"obj":"HP:0005584"},{"id":"AB7","span":{"begin":1209,"end":1229},"obj":"HP:0005584"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"TI1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"},{"subj":"AB3","pred":"source","obj":"PubCasesHPO"},{"subj":"AB4","pred":"source","obj":"PubCasesHPO"},{"subj":"AB5","pred":"source","obj":"PubCasesHPO"},{"subj":"AB6","pred":"source","obj":"PubCasesHPO"},{"subj":"AB7","pred":"source","obj":"PubCasesHPO"}]},{"project":"PubCasesORDO","denotations":[{"id":"TI1","span":{"begin":56,"end":81},"obj":"ORDO:892"},{"id":"AB1","span":{"begin":640,"end":643},"obj":"ORDO:892"},{"id":"AB2","span":{"begin":869,"end":872},"obj":"ORDO:892"},{"id":"AB3","span":{"begin":1102,"end":1105},"obj":"ORDO:892"},{"id":"AB4","span":{"begin":1296,"end":1299},"obj":"ORDO:892"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB2","pred":"source","obj":"PubCasesORDO"},{"subj":"AB3","pred":"source","obj":"PubCasesORDO"},{"subj":"AB4","pred":"source","obj":"PubCasesORDO"}]},{"project":"NCBI-Disease-Train","denotations":[{"id":"T254","span":{"begin":56,"end":81},"obj":"SpecificDisease"},{"id":"T255","span":{"begin":90,"end":127},"obj":"SpecificDisease"},{"id":"T256","span":{"begin":132,"end":152},"obj":"SpecificDisease"},{"id":"T257","span":{"begin":195,"end":234},"obj":"CompositeMention"},{"id":"T258","span":{"begin":263,"end":281},"obj":"DiseaseClass"},{"id":"T259","span":{"begin":314,"end":330},"obj":"DiseaseClass"},{"id":"T260","span":{"begin":400,"end":429},"obj":"SpecificDisease"},{"id":"T261","span":{"begin":528,"end":548},"obj":"SpecificDisease"},{"id":"T262","span":{"begin":562,"end":590},"obj":"SpecificDisease"},{"id":"T263","span":{"begin":621,"end":652},"obj":"SpecificDisease"},{"id":"T264","span":{"begin":693,"end":722},"obj":"SpecificDisease"},{"id":"T265","span":{"begin":744,"end":781},"obj":"SpecificDisease"},{"id":"T266","span":{"begin":812,"end":832},"obj":"SpecificDisease"},{"id":"T267","span":{"begin":837,"end":865},"obj":"SpecificDisease"},{"id":"T268","span":{"begin":869,"end":880},"obj":"SpecificDisease"},{"id":"T269","span":{"begin":964,"end":993},"obj":"SpecificDisease"},{"id":"T270","span":{"begin":998,"end":1026},"obj":"SpecificDisease"},{"id":"T271","span":{"begin":1102,"end":1105},"obj":"Modifier"},{"id":"T272","span":{"begin":1138,"end":1144},"obj":"Modifier"},{"id":"T273","span":{"begin":1162,"end":1199},"obj":"SpecificDisease"},{"id":"T274","span":{"begin":1209,"end":1229},"obj":"SpecificDisease"},{"id":"T275","span":{"begin":1296,"end":1299},"obj":"Modifier"}],"attributes":[{"id":"A254","pred":"database_id","subj":"T254","obj":"D006623"},{"id":"A255","pred":"database_id","subj":"T255","obj":"D018325"},{"id":"A256","pred":"database_id","subj":"T256","obj":"D002292"},{"id":"A257","pred":"database_id","subj":"T257","obj":"D012175"},{"id":"A258","pred":"database_id","subj":"T258","obj":"D009386"},{"id":"A259","pred":"database_id","subj":"T259","obj":"D009369"},{"id":"A260","pred":"database_id","subj":"T260","obj":"D002292"},{"id":"A261","pred":"database_id","subj":"T261","obj":"D002292"},{"id":"A262","pred":"database_id","subj":"T262","obj":"D018325"},{"id":"A263","pred":"database_id","subj":"T263","obj":"D006623"},{"id":"A264","pred":"database_id","subj":"T264","obj":"D002292"},{"id":"A265","pred":"database_id","subj":"T265","obj":"D018325"},{"id":"A266","pred":"database_id","subj":"T266","obj":"D002292"},{"id":"A267","pred":"database_id","subj":"T267","obj":"D018325"},{"id":"A268","pred":"database_id","subj":"T268","obj":"D006623"},{"id":"A269","pred":"database_id","subj":"T269","obj":"D002292"},{"id":"A270","pred":"database_id","subj":"T270","obj":"D018325"},{"id":"A271","pred":"database_id","subj":"T271","obj":"D006623"},{"id":"A272","pred":"database_id","subj":"T272","obj":"D009369"},{"id":"A273","pred":"database_id","subj":"T273","obj":"D018325"},{"id":"A274","pred":"database_id","subj":"T274","obj":"D002292"},{"id":"A275","pred":"database_id","subj":"T275","obj":"D006623"},{"subj":"T254","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T255","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T256","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T257","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T258","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T259","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T260","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T261","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T262","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T263","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T264","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T265","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T266","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T267","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T268","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T269","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T270","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T271","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T272","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T273","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T274","pred":"source","obj":"NCBI-Disease-Train"},{"subj":"T275","pred":"source","obj":"NCBI-Disease-Train"}]},{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T254","span":{"begin":56,"end":81},"obj":"SpecificDisease"},{"id":"T255","span":{"begin":90,"end":127},"obj":"SpecificDisease"},{"id":"T256","span":{"begin":132,"end":152},"obj":"SpecificDisease"},{"id":"T257","span":{"begin":195,"end":234},"obj":"CompositeMention"},{"id":"T258","span":{"begin":263,"end":281},"obj":"DiseaseClass"},{"id":"T259","span":{"begin":314,"end":330},"obj":"DiseaseClass"},{"id":"T260","span":{"begin":400,"end":429},"obj":"SpecificDisease"},{"id":"T261","span":{"begin":528,"end":548},"obj":"SpecificDisease"},{"id":"T262","span":{"begin":562,"end":590},"obj":"SpecificDisease"},{"id":"T263","span":{"begin":621,"end":652},"obj":"SpecificDisease"},{"id":"T264","span":{"begin":693,"end":722},"obj":"SpecificDisease"},{"id":"T265","span":{"begin":744,"end":781},"obj":"SpecificDisease"},{"id":"T266","span":{"begin":812,"end":832},"obj":"SpecificDisease"},{"id":"T267","span":{"begin":837,"end":865},"obj":"SpecificDisease"},{"id":"T268","span":{"begin":869,"end":880},"obj":"SpecificDisease"},{"id":"T269","span":{"begin":964,"end":993},"obj":"SpecificDisease"},{"id":"T270","span":{"begin":998,"end":1026},"obj":"SpecificDisease"},{"id":"T271","span":{"begin":1102,"end":1105},"obj":"Modifier"},{"id":"T272","span":{"begin":1138,"end":1144},"obj":"Modifier"},{"id":"T273","span":{"begin":1162,"end":1199},"obj":"SpecificDisease"},{"id":"T274","span":{"begin":1209,"end":1229},"obj":"SpecificDisease"},{"id":"T275","span":{"begin":1296,"end":1299},"obj":"Modifier"}],"attributes":[{"id":"A254","pred":"database_id","subj":"T254","obj":"D006623"},{"id":"A255","pred":"database_id","subj":"T255","obj":"D018325"},{"id":"A256","pred":"database_id","subj":"T256","obj":"D002292"},{"id":"A257","pred":"database_id","subj":"T257","obj":"D012175"},{"id":"A258","pred":"database_id","subj":"T258","obj":"D009386"},{"id":"A259","pred":"database_id","subj":"T259","obj":"D009369"},{"id":"A260","pred":"database_id","subj":"T260","obj":"D002292"},{"id":"A261","pred":"database_id","subj":"T261","obj":"D002292"},{"id":"A262","pred":"database_id","subj":"T262","obj":"D018325"},{"id":"A263","pred":"database_id","subj":"T263","obj":"D006623"},{"id":"A264","pred":"database_id","subj":"T264","obj":"D002292"},{"id":"A265","pred":"database_id","subj":"T265","obj":"D018325"},{"id":"A266","pred":"database_id","subj":"T266","obj":"D002292"},{"id":"A267","pred":"database_id","subj":"T267","obj":"D018325"},{"id":"A268","pred":"database_id","subj":"T268","obj":"D006623"},{"id":"A269","pred":"database_id","subj":"T269","obj":"D002292"},{"id":"A270","pred":"database_id","subj":"T270","obj":"D018325"},{"id":"A271","pred":"database_id","subj":"T271","obj":"D006623"},{"id":"A272","pred":"database_id","subj":"T272","obj":"D009369"},{"id":"A273","pred":"database_id","subj":"T273","obj":"D018325"},{"id":"A274","pred":"database_id","subj":"T274","obj":"D002292"},{"id":"A275","pred":"database_id","subj":"T275","obj":"D006623"},{"subj":"T254","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T255","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T256","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T257","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T258","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T259","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T260","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T261","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T262","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T263","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T264","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T265","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T266","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T267","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T268","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T269","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T270","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T271","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T272","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T273","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T274","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T275","pred":"source","obj":"NCBI-Disease-Corpus-All"}]},{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":56,"end":81},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":99,"end":127},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":132,"end":152},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":220,"end":234},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":409,"end":429},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":528,"end":548},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":562,"end":590},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":621,"end":652},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":702,"end":722},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":753,"end":781},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":812,"end":832},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":837,"end":865},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":869,"end":880},"obj":"SpecificDisease"},{"id":"T14","span":{"begin":973,"end":993},"obj":"SpecificDisease"},{"id":"T15","span":{"begin":998,"end":1026},"obj":"SpecificDisease"},{"id":"T16","span":{"begin":1102,"end":1105},"obj":"Modifier"},{"id":"T17","span":{"begin":1171,"end":1199},"obj":"SpecificDisease"},{"id":"T18","span":{"begin":1209,"end":1229},"obj":"SpecificDisease"},{"id":"T19","span":{"begin":1296,"end":1299},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T11","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T12","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T13","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T14","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T15","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T16","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T17","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T18","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T19","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"}]},{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":56,"end":81},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":99,"end":127},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":132,"end":152},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":220,"end":234},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":409,"end":429},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":528,"end":548},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":562,"end":590},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":621,"end":652},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":702,"end":722},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":753,"end":781},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":812,"end":832},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":837,"end":865},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":869,"end":872},"obj":"Modifier"},{"id":"T14","span":{"begin":973,"end":993},"obj":"SpecificDisease"},{"id":"T15","span":{"begin":998,"end":1026},"obj":"SpecificDisease"},{"id":"T16","span":{"begin":1102,"end":1105},"obj":"Modifier"},{"id":"T17","span":{"begin":1171,"end":1199},"obj":"SpecificDisease"},{"id":"T18","span":{"begin":1209,"end":1229},"obj":"SpecificDisease"},{"id":"T19","span":{"begin":1296,"end":1299},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T11","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T12","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T13","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T14","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T15","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T16","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T17","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T18","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T19","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"}]},{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":56,"end":81},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":90,"end":152},"obj":"CompositeMention"},{"id":"T3","span":{"begin":220,"end":234},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":429},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":528,"end":548},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":562,"end":590},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":621,"end":652},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":693,"end":722},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":744,"end":781},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":812,"end":832},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":837,"end":865},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":869,"end":880},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":964,"end":993},"obj":"SpecificDisease"},{"id":"T14","span":{"begin":998,"end":1026},"obj":"SpecificDisease"},{"id":"T15","span":{"begin":1162,"end":1229},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T11","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T12","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T13","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T14","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T15","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"}]},{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":56,"end":81},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":90,"end":152},"obj":"CompositeMention"},{"id":"T3","span":{"begin":195,"end":219},"obj":"Modifier"},{"id":"T4","span":{"begin":220,"end":234},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":400,"end":429},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":528,"end":548},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":562,"end":590},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":621,"end":652},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":693,"end":722},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":744,"end":781},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":812,"end":832},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":837,"end":865},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":869,"end":880},"obj":"SpecificDisease"},{"id":"T14","span":{"begin":964,"end":993},"obj":"SpecificDisease"},{"id":"T15","span":{"begin":998,"end":1026},"obj":"SpecificDisease"},{"id":"T16","span":{"begin":1162,"end":1229},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T11","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T12","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T13","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T14","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T15","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T16","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NCBIDiseaseCorpus","color":"#a4ec93","default":true},{"id":"PubmedHPO","color":"#ec93be"},{"id":"sentences","color":"#93d8ec"},{"id":"PubCasesHPO","color":"#ece693"},{"id":"PubCasesORDO","color":"#cb93ec"},{"id":"NCBI-Disease-Train","color":"#93ecb1"},{"id":"NCBI-Disease-Corpus-All","color":"#ec9793"},{"id":"NCBI-Disease-Corpus-2stage-All","color":"#93a8ec"},{"id":"NCBI-Disease-Corpus-rezarta-All","color":"#c2ec93"},{"id":"NCBI-Disease-Corpus-4oGuideline-All","color":"#ec93dc"},{"id":"NCBI-Disease-Corpus-Simple-All","color":"#93ece2"}]}]}}