PubMed:2352258
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-153 | Sentence | denotes | Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma. |
| TextSentencer_T2 | 154-363 | Sentence | denotes | Analysis of the age incidence curves for unilateral and bilateral retinoblastoma led Knudson to propose that hereditary tumours may arise by a single event and sporadic tumours by a two stage mutation process. |
| TextSentencer_T3 | 364-474 | Sentence | denotes | It has been suggested recently that sporadic renal cell carcinoma may arise from a two stage mutation process. |
| TextSentencer_T4 | 475-782 | Sentence | denotes | We analysed the age incidence curves for symptomatic renal cell carcinoma (n = 26) and cerebellar haemangioblastoma (n = 68) in 109 patients with von Hippel-Lindau (VHL) disease, and compared them to 104 patients with sporadic renal cell carcinoma and 43 patients with sporadic cerebellar haemangioblastoma. |
| TextSentencer_T5 | 783-1066 | Sentence | denotes | The age incidence curves for renal cell carcinoma and cerebellar haemangioblastoma in VHL disease were compatible with a single mutation model, whereas the age incidence curves for sporadic renal cell carcinoma and cerebellar haemangioblastoma suggested a two stage mutation process. |
| TextSentencer_T6 | 1067-1161 | Sentence | denotes | These data are compatible with the VHL gene functioning as a recessive tumour suppressor gene. |
| TextSentencer_T7 | 1162-1306 | Sentence | denotes | Sporadic cerebellar haemangioblastoma and some renal cell carcinoma may arise from somatic mutations inactivating both alleles at the VHL locus. |
| T1 | 0-153 | Sentence | denotes | Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma. |
| T2 | 154-363 | Sentence | denotes | Analysis of the age incidence curves for unilateral and bilateral retinoblastoma led Knudson to propose that hereditary tumours may arise by a single event and sporadic tumours by a two stage mutation process. |
| T3 | 364-474 | Sentence | denotes | It has been suggested recently that sporadic renal cell carcinoma may arise from a two stage mutation process. |
| T4 | 475-782 | Sentence | denotes | We analysed the age incidence curves for symptomatic renal cell carcinoma (n = 26) and cerebellar haemangioblastoma (n = 68) in 109 patients with von Hippel-Lindau (VHL) disease, and compared them to 104 patients with sporadic renal cell carcinoma and 43 patients with sporadic cerebellar haemangioblastoma. |
| T5 | 783-1066 | Sentence | denotes | The age incidence curves for renal cell carcinoma and cerebellar haemangioblastoma in VHL disease were compatible with a single mutation model, whereas the age incidence curves for sporadic renal cell carcinoma and cerebellar haemangioblastoma suggested a two stage mutation process. |
| T6 | 1067-1161 | Sentence | denotes | These data are compatible with the VHL gene functioning as a recessive tumour suppressor gene. |
| T7 | 1162-1306 | Sentence | denotes | Sporadic cerebellar haemangioblastoma and some renal cell carcinoma may arise from somatic mutations inactivating both alleles at the VHL locus. |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 220-234 | HP_0009919 | denotes | retinoblastoma |
| T2 | 274-281 | HP_0002664 | denotes | tumours |
| T3 | 323-330 | HP_0002664 | denotes | tumours |
| T4 | 409-429 | HP_0005584 | denotes | renal cell carcinoma |
| T5 | 528-548 | HP_0005584 | denotes | renal cell carcinoma |
| T6 | 573-590 | HP_0010797 | denotes | haemangioblastoma |
| T7 | 702-722 | HP_0005584 | denotes | renal cell carcinoma |
| T8 | 764-781 | HP_0010797 | denotes | haemangioblastoma |
| T9 | 812-832 | HP_0005584 | denotes | renal cell carcinoma |
| T10 | 848-865 | HP_0010797 | denotes | haemangioblastoma |
| T11 | 973-993 | HP_0005584 | denotes | renal cell carcinoma |
| T12 | 1009-1026 | HP_0010797 | denotes | haemangioblastoma |
| T13 | 1138-1144 | HP_0002664 | denotes | tumour |
| T14 | 1182-1199 | HP_0010797 | denotes | haemangioblastoma |
| T15 | 1209-1229 | HP_0005584 | denotes | renal cell carcinoma |
| T16 | 1245-1262 | HP_0001428 | denotes | somatic mutations |
PubCasesHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| AB1 | 220-234 | HP:0009919 | denotes | retinoblastoma |
| TI1 | 132-152 | HP:0005584 | denotes | renal cell carcinoma |
| AB2 | 409-429 | HP:0005584 | denotes | renal cell carcinoma |
| AB3 | 528-548 | HP:0005584 | denotes | renal cell carcinoma |
| AB4 | 702-722 | HP:0005584 | denotes | renal cell carcinoma |
| AB5 | 812-832 | HP:0005584 | denotes | renal cell carcinoma |
| AB6 | 973-993 | HP:0005584 | denotes | renal cell carcinoma |
| AB7 | 1209-1229 | HP:0005584 | denotes | renal cell carcinoma |
PubCasesORDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TI1 | 56-81 | ORDO:892 | denotes | von Hippel-Lindau disease |
| AB1 | 640-643 | ORDO:892 | denotes | VHL |
| AB2 | 869-872 | ORDO:892 | denotes | VHL |
| AB3 | 1102-1105 | ORDO:892 | denotes | VHL |
| AB4 | 1296-1299 | ORDO:892 | denotes | VHL |
NCBIDiseaseCorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-81 | SpecificDisease:D006623 | denotes | von Hippel-Lindau disease |
| T2 | 90-127 | SpecificDisease:D018325 | denotes | sporadic cerebellar haemangioblastoma |
| T3 | 132-152 | SpecificDisease:D002292 | denotes | renal cell carcinoma |
| T4 | 195-234 | CompositeMention:D012175 | denotes | unilateral and bilateral retinoblastoma |
| T5 | 263-281 | DiseaseClass:D009386 | denotes | hereditary tumours |
| T6 | 314-330 | DiseaseClass:D009369 | denotes | sporadic tumours |
| T7 | 400-429 | SpecificDisease:D002292 | denotes | sporadic renal cell carcinoma |
| T8 | 528-548 | SpecificDisease:D002292 | denotes | renal cell carcinoma |
| T9 | 562-590 | SpecificDisease:D018325 | denotes | cerebellar haemangioblastoma |
| T10 | 621-652 | SpecificDisease:D006623 | denotes | von Hippel-Lindau (VHL) disease |
| T11 | 693-722 | SpecificDisease:D002292 | denotes | sporadic renal cell carcinoma |
| T12 | 744-781 | SpecificDisease:D018325 | denotes | sporadic cerebellar haemangioblastoma |
| T13 | 812-832 | SpecificDisease:D002292 | denotes | renal cell carcinoma |
| T14 | 837-865 | SpecificDisease:D018325 | denotes | cerebellar haemangioblastoma |
| T15 | 869-880 | SpecificDisease:D006623 | denotes | VHL disease |
| T16 | 964-993 | SpecificDisease:D002292 | denotes | sporadic renal cell carcinoma |
| T17 | 998-1026 | SpecificDisease:D018325 | denotes | cerebellar haemangioblastoma |
| T18 | 1102-1105 | Modifier:D006623 | denotes | VHL |
| T19 | 1138-1144 | Modifier:D009369 | denotes | tumour |
| T20 | 1162-1199 | SpecificDisease:D018325 | denotes | Sporadic cerebellar haemangioblastoma |
| T21 | 1209-1229 | SpecificDisease:D002292 | denotes | renal cell carcinoma |
| T22 | 1296-1299 | Modifier:D006623 | denotes | VHL |
NCBI-Disease-Train
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T254 | 56-81 | SpecificDisease | denotes | von Hippel-Lindau disease | D006623 |
| T255 | 90-127 | SpecificDisease | denotes | sporadic cerebellar haemangioblastoma | D018325 |
| T256 | 132-152 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T257 | 195-234 | CompositeMention | denotes | unilateral and bilateral retinoblastoma | D012175 |
| T258 | 263-281 | DiseaseClass | denotes | hereditary tumours | D009386 |
| T259 | 314-330 | DiseaseClass | denotes | sporadic tumours | D009369 |
| T260 | 400-429 | SpecificDisease | denotes | sporadic renal cell carcinoma | D002292 |
| T261 | 528-548 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T262 | 562-590 | SpecificDisease | denotes | cerebellar haemangioblastoma | D018325 |
| T263 | 621-652 | SpecificDisease | denotes | von Hippel-Lindau (VHL) disease | D006623 |
| T264 | 693-722 | SpecificDisease | denotes | sporadic renal cell carcinoma | D002292 |
| T265 | 744-781 | SpecificDisease | denotes | sporadic cerebellar haemangioblastoma | D018325 |
| T266 | 812-832 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T267 | 837-865 | SpecificDisease | denotes | cerebellar haemangioblastoma | D018325 |
| T268 | 869-880 | SpecificDisease | denotes | VHL disease | D006623 |
| T269 | 964-993 | SpecificDisease | denotes | sporadic renal cell carcinoma | D002292 |
| T270 | 998-1026 | SpecificDisease | denotes | cerebellar haemangioblastoma | D018325 |
| T271 | 1102-1105 | Modifier | denotes | VHL | D006623 |
| T272 | 1138-1144 | Modifier | denotes | tumour | D009369 |
| T273 | 1162-1199 | SpecificDisease | denotes | Sporadic cerebellar haemangioblastoma | D018325 |
| T274 | 1209-1229 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T275 | 1296-1299 | Modifier | denotes | VHL | D006623 |
NCBI-Disease-Corpus-All
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T254 | 56-81 | SpecificDisease | denotes | von Hippel-Lindau disease | D006623 |
| T255 | 90-127 | SpecificDisease | denotes | sporadic cerebellar haemangioblastoma | D018325 |
| T256 | 132-152 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T257 | 195-234 | CompositeMention | denotes | unilateral and bilateral retinoblastoma | D012175 |
| T258 | 263-281 | DiseaseClass | denotes | hereditary tumours | D009386 |
| T259 | 314-330 | DiseaseClass | denotes | sporadic tumours | D009369 |
| T260 | 400-429 | SpecificDisease | denotes | sporadic renal cell carcinoma | D002292 |
| T261 | 528-548 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T262 | 562-590 | SpecificDisease | denotes | cerebellar haemangioblastoma | D018325 |
| T263 | 621-652 | SpecificDisease | denotes | von Hippel-Lindau (VHL) disease | D006623 |
| T264 | 693-722 | SpecificDisease | denotes | sporadic renal cell carcinoma | D002292 |
| T265 | 744-781 | SpecificDisease | denotes | sporadic cerebellar haemangioblastoma | D018325 |
| T266 | 812-832 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T267 | 837-865 | SpecificDisease | denotes | cerebellar haemangioblastoma | D018325 |
| T268 | 869-880 | SpecificDisease | denotes | VHL disease | D006623 |
| T269 | 964-993 | SpecificDisease | denotes | sporadic renal cell carcinoma | D002292 |
| T270 | 998-1026 | SpecificDisease | denotes | cerebellar haemangioblastoma | D018325 |
| T271 | 1102-1105 | Modifier | denotes | VHL | D006623 |
| T272 | 1138-1144 | Modifier | denotes | tumour | D009369 |
| T273 | 1162-1199 | SpecificDisease | denotes | Sporadic cerebellar haemangioblastoma | D018325 |
| T274 | 1209-1229 | SpecificDisease | denotes | renal cell carcinoma | D002292 |
| T275 | 1296-1299 | Modifier | denotes | VHL | D006623 |
NCBI-Disease-Corpus-2stage-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-81 | SpecificDisease | denotes | von Hippel-Lindau disease |
| T2 | 99-127 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T3 | 132-152 | SpecificDisease | denotes | renal cell carcinoma |
| T4 | 220-234 | SpecificDisease | denotes | retinoblastoma |
| T5 | 409-429 | SpecificDisease | denotes | renal cell carcinoma |
| T6 | 528-548 | SpecificDisease | denotes | renal cell carcinoma |
| T7 | 562-590 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T8 | 621-652 | SpecificDisease | denotes | von Hippel-Lindau (VHL) disease |
| T9 | 702-722 | SpecificDisease | denotes | renal cell carcinoma |
| T10 | 753-781 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T11 | 812-832 | SpecificDisease | denotes | renal cell carcinoma |
| T12 | 837-865 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T13 | 869-880 | SpecificDisease | denotes | VHL disease |
| T14 | 973-993 | SpecificDisease | denotes | renal cell carcinoma |
| T15 | 998-1026 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T16 | 1102-1105 | Modifier | denotes | VHL |
| T17 | 1171-1199 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T18 | 1209-1229 | SpecificDisease | denotes | renal cell carcinoma |
| T19 | 1296-1299 | Modifier | denotes | VHL |
NCBI-Disease-Corpus-rezarta-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-81 | SpecificDisease | denotes | von Hippel-Lindau disease |
| T2 | 99-127 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T3 | 132-152 | SpecificDisease | denotes | renal cell carcinoma |
| T4 | 220-234 | SpecificDisease | denotes | retinoblastoma |
| T5 | 409-429 | SpecificDisease | denotes | renal cell carcinoma |
| T6 | 528-548 | SpecificDisease | denotes | renal cell carcinoma |
| T7 | 562-590 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T8 | 621-652 | SpecificDisease | denotes | von Hippel-Lindau (VHL) disease |
| T9 | 702-722 | SpecificDisease | denotes | renal cell carcinoma |
| T10 | 753-781 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T11 | 812-832 | SpecificDisease | denotes | renal cell carcinoma |
| T12 | 837-865 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T13 | 869-872 | Modifier | denotes | VHL |
| T14 | 973-993 | SpecificDisease | denotes | renal cell carcinoma |
| T15 | 998-1026 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T16 | 1102-1105 | Modifier | denotes | VHL |
| T17 | 1171-1199 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T18 | 1209-1229 | SpecificDisease | denotes | renal cell carcinoma |
| T19 | 1296-1299 | Modifier | denotes | VHL |
NCBI-Disease-Corpus-4oGuideline-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-81 | SpecificDisease | denotes | von Hippel-Lindau disease |
| T2 | 90-152 | CompositeMention | denotes | sporadic cerebellar haemangioblastoma and renal cell carcinoma |
| T3 | 220-234 | SpecificDisease | denotes | retinoblastoma |
| T4 | 400-429 | SpecificDisease | denotes | sporadic renal cell carcinoma |
| T5 | 528-548 | SpecificDisease | denotes | renal cell carcinoma |
| T6 | 562-590 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T7 | 621-652 | SpecificDisease | denotes | von Hippel-Lindau (VHL) disease |
| T8 | 693-722 | SpecificDisease | denotes | sporadic renal cell carcinoma |
| T9 | 744-781 | SpecificDisease | denotes | sporadic cerebellar haemangioblastoma |
| T10 | 812-832 | SpecificDisease | denotes | renal cell carcinoma |
| T11 | 837-865 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T12 | 869-880 | SpecificDisease | denotes | VHL disease |
| T13 | 964-993 | SpecificDisease | denotes | sporadic renal cell carcinoma |
| T14 | 998-1026 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T15 | 1162-1229 | CompositeMention | denotes | Sporadic cerebellar haemangioblastoma and some renal cell carcinoma |
NCBI-Disease-Corpus-Simple-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-81 | SpecificDisease | denotes | von Hippel-Lindau disease |
| T2 | 90-152 | CompositeMention | denotes | sporadic cerebellar haemangioblastoma and renal cell carcinoma |
| T3 | 195-219 | Modifier | denotes | unilateral and bilateral |
| T4 | 220-234 | SpecificDisease | denotes | retinoblastoma |
| T5 | 400-429 | SpecificDisease | denotes | sporadic renal cell carcinoma |
| T6 | 528-548 | SpecificDisease | denotes | renal cell carcinoma |
| T7 | 562-590 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T8 | 621-652 | SpecificDisease | denotes | von Hippel-Lindau (VHL) disease |
| T9 | 693-722 | SpecificDisease | denotes | sporadic renal cell carcinoma |
| T10 | 744-781 | SpecificDisease | denotes | sporadic cerebellar haemangioblastoma |
| T11 | 812-832 | SpecificDisease | denotes | renal cell carcinoma |
| T12 | 837-865 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T13 | 869-880 | SpecificDisease | denotes | VHL disease |
| T14 | 964-993 | SpecificDisease | denotes | sporadic renal cell carcinoma |
| T15 | 998-1026 | SpecificDisease | denotes | cerebellar haemangioblastoma |
| T16 | 1162-1229 | CompositeMention | denotes | Sporadic cerebellar haemangioblastoma and some renal cell carcinoma |