PubMed:23418199
Annnotations
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 214-218 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
T2 | 588-592 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-57 | Sentence | denotes | Overexpression of Sulf2 in idiopathic pulmonary fibrosis. |
TextSentencer_T2 | 58-421 | Sentence | denotes | Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis. |
TextSentencer_T3 | 422-541 | Sentence | denotes | In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. |
TextSentencer_T4 | 542-769 | Sentence | denotes | We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs). |
TextSentencer_T5 | 770-936 | Sentence | denotes | In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium. |
TextSentencer_T6 | 937-1184 | Sentence | denotes | Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells. |
TextSentencer_T7 | 1185-1309 | Sentence | denotes | To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice. |
TextSentencer_T8 | 1310-1465 | Sentence | denotes | We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs. |
TextSentencer_T9 | 1466-1578 | Sentence | denotes | In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs. |
T1 | 0-57 | Sentence | denotes | Overexpression of Sulf2 in idiopathic pulmonary fibrosis. |
T2 | 58-421 | Sentence | denotes | Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis. |
T3 | 422-541 | Sentence | denotes | In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. |
T4 | 542-769 | Sentence | denotes | We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs). |
T5 | 770-936 | Sentence | denotes | In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium. |
T6 | 937-1184 | Sentence | denotes | Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells. |
T7 | 1185-1309 | Sentence | denotes | To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice. |
T8 | 1310-1465 | Sentence | denotes | We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs. |
T9 | 1466-1578 | Sentence | denotes | In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs. |
T1 | 0-57 | Sentence | denotes | Overexpression of Sulf2 in idiopathic pulmonary fibrosis. |
T2 | 58-421 | Sentence | denotes | Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis. |
T3 | 422-541 | Sentence | denotes | In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. |
T4 | 542-769 | Sentence | denotes | We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs). |
T5 | 770-936 | Sentence | denotes | In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium. |
T6 | 937-1184 | Sentence | denotes | Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells. |
T7 | 1185-1309 | Sentence | denotes | To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice. |
T8 | 1310-1465 | Sentence | denotes | We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs. |
T9 | 1466-1578 | Sentence | denotes | In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs. |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 89-104 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
T2 | 106-108 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
T3 | 836-838 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 18-23 | gene:55959 | denotes | Sulf2 |
T1 | 27-56 | disease:C3812887 | denotes | idiopathic pulmonary fibrosis |
T2 | 18-23 | gene:55959 | denotes | Sulf2 |
T3 | 27-56 | disease:C1800706 | denotes | idiopathic pulmonary fibrosis |
T4 | 131-136 | gene:23213 | denotes | Sulf1 |
T5 | 402-420 | disease:C0034069 | denotes | pulmonary fibrosis |
T6 | 143-172 | gene:7040 | denotes | transforming growth factor-β1 |
T7 | 402-420 | disease:C0034069 | denotes | pulmonary fibrosis |
T8 | 375-380 | gene:55959 | denotes | Sulf2 |
T9 | 402-420 | disease:C0034069 | denotes | pulmonary fibrosis |
T10 | 330-335 | gene:23213 | denotes | Sulf1 |
T11 | 402-420 | disease:C0034069 | denotes | pulmonary fibrosis |
T12 | 297-303 | gene:7040 | denotes | TGF-β1 |
T13 | 402-420 | disease:C0034069 | denotes | pulmonary fibrosis |
T14 | 281-287 | gene:7040 | denotes | TGF-β1 |
T15 | 402-420 | disease:C0034069 | denotes | pulmonary fibrosis |
T16 | 483-489 | gene:7040 | denotes | TGF-β1 |
T17 | 522-540 | disease:C0034069 | denotes | pulmonary fibrosis |
T18 | 463-468 | gene:55959 | denotes | Sulf2 |
T19 | 522-540 | disease:C0034069 | denotes | pulmonary fibrosis |
T20 | 556-561 | gene:55959 | denotes | Sulf2 |
T21 | 626-655 | disease:C3812887 | denotes | idiopathic pulmonary fibrosis |
T22 | 667-672 | gene:55959 | denotes | Sulf2 |
T23 | 657-660 | disease:C3812887 | denotes | IPF |
T24 | 556-561 | gene:55959 | denotes | Sulf2 |
T25 | 657-660 | disease:C1800706 | denotes | IPF |
T26 | 556-561 | gene:55959 | denotes | Sulf2 |
T27 | 626-655 | disease:C1800706 | denotes | idiopathic pulmonary fibrosis |
T28 | 556-561 | gene:55959 | denotes | Sulf2 |
T29 | 657-660 | disease:C3812887 | denotes | IPF |
T30 | 667-672 | gene:55959 | denotes | Sulf2 |
T31 | 626-655 | disease:C3812887 | denotes | idiopathic pulmonary fibrosis |
T32 | 667-672 | gene:55959 | denotes | Sulf2 |
T33 | 626-655 | disease:C1800706 | denotes | idiopathic pulmonary fibrosis |
T34 | 667-672 | gene:55959 | denotes | Sulf2 |
T35 | 657-660 | disease:C1800706 | denotes | IPF |
T36 | 1481-1486 | gene:55959 | denotes | Sulf2 |
T37 | 1507-1510 | disease:C3812887 | denotes | IPF |
T38 | 1481-1486 | gene:55959 | denotes | Sulf2 |
T39 | 1507-1510 | disease:C1800706 | denotes | IPF |
R1 | T0 | T1 | associated_with | Sulf2,idiopathic pulmonary fibrosis |
R2 | T2 | T3 | associated_with | Sulf2,idiopathic pulmonary fibrosis |
R3 | T4 | T5 | associated_with | Sulf1,pulmonary fibrosis |
R4 | T6 | T7 | associated_with | transforming growth factor-β1,pulmonary fibrosis |
R5 | T8 | T9 | associated_with | Sulf2,pulmonary fibrosis |
R6 | T10 | T11 | associated_with | Sulf1,pulmonary fibrosis |
R7 | T12 | T13 | associated_with | TGF-β1,pulmonary fibrosis |
R8 | T14 | T15 | associated_with | TGF-β1,pulmonary fibrosis |
R9 | T16 | T17 | associated_with | TGF-β1,pulmonary fibrosis |
R10 | T18 | T19 | associated_with | Sulf2,pulmonary fibrosis |
R11 | T20 | T21 | associated_with | Sulf2,idiopathic pulmonary fibrosis |
R12 | T22 | T23 | associated_with | Sulf2,IPF |
R13 | T24 | T25 | associated_with | Sulf2,IPF |
R14 | T26 | T27 | associated_with | Sulf2,idiopathic pulmonary fibrosis |
R15 | T28 | T29 | associated_with | Sulf2,IPF |
R16 | T30 | T31 | associated_with | Sulf2,idiopathic pulmonary fibrosis |
R17 | T32 | T33 | associated_with | Sulf2,idiopathic pulmonary fibrosis |
R18 | T34 | T35 | associated_with | Sulf2,IPF |
R19 | T36 | T37 | associated_with | Sulf2,IPF |
R20 | T38 | T39 | associated_with | Sulf2,IPF |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 38-47 | FMAID:66326 | denotes | pulmonary |
_T2 | 38-47 | FMAID:171535 | denotes | pulmonary |
_T3 | 89-96 | FMAID:165191 | denotes | heparan |
_T4 | 89-96 | FMAID:67110 | denotes | heparan |
_T5 | 89-104 | FMAID:63023 | denotes | heparan sulfate |
_T6 | 89-104 | FMAID:167405 | denotes | heparan sulfate |
_T7 | 193-197 | FMAID:198663 | denotes | gene |
_T8 | 214-218 | FMAID:7195 | denotes | lung |
_T9 | 214-218 | FMAID:169341 | denotes | lung |
_T10 | 214-218 | FMAID:93670 | denotes | lung |
_T11 | 219-230 | FMAID:162340 | denotes | fibroblasts |
_T12 | 219-230 | FMAID:63877 | denotes | fibroblasts |
_T13 | 402-411 | FMAID:66326 | denotes | pulmonary |
_T14 | 402-411 | FMAID:171535 | denotes | pulmonary |
_T15 | 522-531 | FMAID:66326 | denotes | pulmonary |
_T16 | 522-531 | FMAID:171535 | denotes | pulmonary |
_T17 | 588-592 | FMAID:7195 | denotes | lung |
_T18 | 588-592 | FMAID:169341 | denotes | lung |
_T19 | 588-592 | FMAID:93670 | denotes | lung |
_T20 | 637-646 | FMAID:66326 | denotes | pulmonary |
_T21 | 637-646 | FMAID:171535 | denotes | pulmonary |
_T22 | 673-680 | FMAID:165447 | denotes | protein |
_T23 | 673-680 | FMAID:67257 | denotes | protein |
_T24 | 728-761 | FMAID:167082 | denotes | type II alveolar epithelial cells |
_T25 | 728-761 | FMAID:62501 | denotes | type II alveolar epithelial cells |
_T26 | 728-761 | FMAID:62500 | denotes | type II alveolar epithelial cells |
_T27 | 728-761 | FMAID:167081 | denotes | type II alveolar epithelial cells |
_T28 | 728-761 | FMAID:166735 | denotes | type II alveolar epithelial cells |
_T29 | 728-761 | FMAID:166736 | denotes | type II alveolar epithelial cells |
_T30 | 736-744 | FMAID:264783 | denotes | alveolar |
_T31 | 736-744 | FMAID:242016 | denotes | alveolar |
_T32 | 736-761 | FMAID:62499 | denotes | alveolar epithelial cells |
_T33 | 736-761 | FMAID:166730 | denotes | alveolar epithelial cells |
_T34 | 745-761 | FMAID:67559 | denotes | epithelial cells |
_T35 | 745-761 | FMAID:83514 | denotes | epithelial cells |
_T36 | 745-761 | FMAID:165731 | denotes | epithelial cells |
_T37 | 745-761 | FMAID:169653 | denotes | epithelial cells |
_T38 | 745-761 | FMAID:66768 | denotes | epithelial cells |
_T39 | 745-761 | FMAID:197786 | denotes | epithelial cells |
_T40 | 745-761 | FMAID:69074 | denotes | epithelial cells |
_T41 | 745-761 | FMAID:164922 | denotes | epithelial cells |
_T42 | 745-761 | FMAID:69075 | denotes | epithelial cells |
_T43 | 745-761 | FMAID:169652 | denotes | epithelial cells |
_T44 | 745-761 | FMAID:165528 | denotes | epithelial cells |
_T45 | 745-761 | FMAID:67799 | denotes | epithelial cells |
_T46 | 756-761 | FMAID:169002 | denotes | cells |
_T47 | 756-761 | FMAID:68646 | denotes | cells |
_T48 | 863-868 | FMAID:169002 | denotes | cells |
_T49 | 863-868 | FMAID:68646 | denotes | cells |
_T50 | 885-890 | FMAID:169002 | denotes | cells |
_T51 | 885-890 | FMAID:68646 | denotes | cells |
_T52 | 908-935 | FMAID:62501 | denotes | type II alveolar epithelium |
_T53 | 908-935 | FMAID:167082 | denotes | type II alveolar epithelium |
_T54 | 908-935 | FMAID:167081 | denotes | type II alveolar epithelium |
_T55 | 908-935 | FMAID:62500 | denotes | type II alveolar epithelium |
_T56 | 913-935 | FMAID:162383 | denotes | II alveolar epithelium |
_T57 | 913-935 | FMAID:63915 | denotes | II alveolar epithelium |
_T58 | 916-924 | FMAID:242016 | denotes | alveolar |
_T59 | 916-924 | FMAID:264783 | denotes | alveolar |
_T60 | 916-935 | FMAID:62499 | denotes | alveolar epithelium |
_T61 | 916-935 | FMAID:210218 | denotes | alveolar epithelium |
_T62 | 916-935 | FMAID:166730 | denotes | alveolar epithelium |
_T63 | 925-935 | FMAID:69065 | denotes | epithelium |
_T64 | 925-935 | FMAID:169642 | denotes | epithelium |
_T65 | 925-935 | FMAID:169643 | denotes | epithelium |
_T66 | 925-935 | FMAID:256071 | denotes | epithelium |
_T67 | 925-935 | FMAID:69064 | denotes | epithelium |
_T68 | 1106-1110 | FMAID:198663 | denotes | gene |
_T69 | 1146-1151 | FMAID:169002 | denotes | cells |
_T70 | 1146-1151 | FMAID:68646 | denotes | cells |
_T71 | 1146-1160 | FMAID:226227 | denotes | cells compared |
_T72 | 1178-1183 | FMAID:169002 | denotes | cells |
_T73 | 1178-1183 | FMAID:68646 | denotes | cells |
_T74 | 1256-1269 | FMAID:198168 | denotes | type II cells |
_T75 | 1264-1269 | FMAID:68646 | denotes | cells |
_T76 | 1264-1269 | FMAID:169002 | denotes | cells |
_T77 | 1381-1385 | FMAID:198663 | denotes | gene |
_T78 | 1447-1459 | FMAID:166093 | denotes | type type II |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 18-23 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T2 | 375-380 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T3 | 463-468 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T4 | 556-561 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T5 | 667-672 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T6 | 813-818 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T7 | 975-980 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T8 | 1125-1130 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T9 | 1206-1211 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T10 | 1289-1294 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T11 | 1400-1405 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
T12 | 1481-1486 | http://www.uniprot.org/uniprot/Q9D8E2 | denotes | Sulf2 |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-47 | http://purl.bioontology.org/ontology/NCBITAXON/136615 | denotes | pulmonary |
T2 | 367-374 | http://purl.bioontology.org/ontology/NCBITAXON/353209 | denotes | related |
T3 | 402-411 | http://purl.bioontology.org/ontology/NCBITAXON/136615 | denotes | pulmonary |
T4 | 522-531 | http://purl.bioontology.org/ontology/NCBITAXON/136615 | denotes | pulmonary |
T5 | 637-646 | http://purl.bioontology.org/ontology/NCBITAXON/136615 | denotes | pulmonary |
T6 | 756-761 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T7 | 863-868 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T8 | 885-890 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T9 | 1146-1151 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T10 | 1178-1183 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T11 | 1264-1269 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 97-104 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
T2 | 156-162 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T3 | 268-277 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulator |
T4 | 1534-1544 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulating |
T5 | 507-518 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T6 | 698-707 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localized |
T7 | 736-744 | http://purl.obolibrary.org/obo/GO_0048286 | denotes | alveolar |
T8 | 916-924 | http://purl.obolibrary.org/obo/GO_0048286 | denotes | alveolar |
T9 | 949-965 | http://purl.obolibrary.org/obo/GO_0016246 | denotes | interference RNA |
T10 | 1106-1121 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T11 | 1381-1396 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T12 | 1552-1561 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 756-761 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2 | 863-868 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T3 | 885-890 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T4 | 1146-1151 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5 | 1178-1183 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T6 | 1264-1269 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 214-218 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T2 | 588-592 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T3 | 925-935 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelium |
EDAM-topics
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 208-213 | http://edamontology.org/topic_2815 | denotes | human |
T2 | 430-435 | http://edamontology.org/topic_3678 | denotes | study |
T3 | 593-600 | http://edamontology.org/topic_3277 | denotes | samples |
T4 | 606-611 | http://edamontology.org/topic_2815 | denotes | human |
T5 | 673-680 | http://edamontology.org/topic_0078 | denotes | protein |
T6 | 943-965 | http://edamontology.org/topic_0659 | denotes | small interference RNA |
T7 | 1099-1105 | http://edamontology.org/topic_0154 | denotes | target |
T8 | 1106-1121 | http://edamontology.org/topic_0203 | denotes | gene expression |
T9 | 1188-1193 | http://edamontology.org/topic_3678 | denotes | study |
T10 | 1374-1380 | http://edamontology.org/topic_0154 | denotes | target |
T11 | 1381-1396 | http://edamontology.org/topic_0203 | denotes | gene expression |
EDAM-DFO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 201-207 | http://edamontology.org/operation_3435 | denotes | normal |
T2 | 235-244 | http://edamontology.org/operation_0004 | denotes | functions |
T3 | 673-680 | http://edamontology.org/data_1467 | denotes | protein |
T4 | 673-680 | http://edamontology.org/format_1208 | denotes | protein |
T5 | 1106-1124 | http://edamontology.org/data_2967 | denotes | gene expression in |
T6 | 1215-1221 | http://edamontology.org/operation_3435 | denotes | normal |
T7 | 1381-1399 | http://edamontology.org/data_2967 | denotes | gene expression in |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_23418199_1_0 | 89-104 | expanded | denotes | heparan sulfate |
SS2_23418199_1_0 | 106-108 | abbr | denotes | HS |
SS1_23418199_1_1 | 143-172 | expanded | denotes | transforming growth factor-β1 |
SS2_23418199_1_1 | 174-180 | abbr | denotes | TGF-β1 |
SS1_23418199_3_0 | 626-655 | expanded | denotes | idiopathic pulmonary fibrosis |
SS2_23418199_3_0 | 657-660 | abbr | denotes | IPF |
SS1_23418199_3_1 | 736-761 | expanded | denotes | alveolar epithelial cells |
SS2_23418199_3_1 | 763-767 | abbr | denotes | AECs |
AE1_23418199_1_0 | SS1_23418199_1_0 | SS2_23418199_1_0 | abbreviatedTo | heparan sulfate,HS |
AE1_23418199_1_1 | SS1_23418199_1_1 | SS2_23418199_1_1 | abbreviatedTo | transforming growth factor-β1,TGF-β1 |
AE1_23418199_3_0 | SS1_23418199_3_0 | SS2_23418199_3_0 | abbreviatedTo | idiopathic pulmonary fibrosis,IPF |
AE1_23418199_3_1 | SS1_23418199_3_1 | SS2_23418199_3_1 | abbreviatedTo | alveolar epithelial cells,AECs |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 402-420 | HP_0002206 | denotes | pulmonary fibrosis |
T2 | 522-540 | HP_0002206 | denotes | pulmonary fibrosis |
T3 | 637-655 | HP_0002206 | denotes | pulmonary fibrosis |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
23418199-0#18#23#gene55959 | 330-380 | gene55959 | denotes | Sulf1 as well as that of the closely related Sulf2 |
23418199-0#27#56#diseaseC0085786 | 389-655 | diseaseC0085786 | denotes | ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis |
23418199-0#27#56#diseaseC1800706 | 389-655 | diseaseC1800706 | denotes | ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis |
23418199-1#73#78#gene23213 | 131-136 | gene23213 | denotes | Sulf1 |
23418199-1#272#277#gene23213 | 330-335 | gene23213 | denotes | Sulf1 |
23418199-1#344#362#diseaseC0034069 | 402-420 | diseaseC0034069 | denotes | pulmonary fibrosis |
23418199-2#41#46#gene55959 | 463-468 | gene55959 | denotes | Sulf2 |
23418199-2#61#67#gene7040 | 483-489 | gene7040 | denotes | TGF-β1 |
23418199-2#100#118#diseaseC0034069 | 522-540 | diseaseC0034069 | denotes | pulmonary fibrosis |
18#23#gene5595927#56#diseaseC0085786 | 23418199-0#18#23#gene55959 | 23418199-0#27#56#diseaseC0085786 | associated_with | Sulf1 as well as that of the closely related Sulf2,"ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis" |
18#23#gene5595927#56#diseaseC1800706 | 23418199-0#18#23#gene55959 | 23418199-0#27#56#diseaseC1800706 | associated_with | Sulf1 as well as that of the closely related Sulf2,"ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis" |
73#78#gene23213344#362#diseaseC0034069 | 23418199-1#73#78#gene23213 | 23418199-1#344#362#diseaseC0034069 | associated_with | Sulf1,pulmonary fibrosis |
272#277#gene23213344#362#diseaseC0034069 | 23418199-1#272#277#gene23213 | 23418199-1#344#362#diseaseC0034069 | associated_with | Sulf1,pulmonary fibrosis |
41#46#gene55959100#118#diseaseC0034069 | 23418199-2#41#46#gene55959 | 23418199-2#100#118#diseaseC0034069 | associated_with | Sulf2,pulmonary fibrosis |
61#67#gene7040100#118#diseaseC0034069 | 23418199-2#61#67#gene7040 | 23418199-2#100#118#diseaseC0034069 | associated_with | TGF-β1,pulmonary fibrosis |
GlycoBiology-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 214-218 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
T2 | 588-592 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
GlycoBiology-Epitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-GlycoEpitope-B_T1 | 89-104 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 214-218 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
PD-UBERON-AE-B_T2 | 588-592 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
PD-UBERON-AE-B_T3 | 925-935 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelium |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 214-218 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T2 | 588-592 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 27-56 | Disease | denotes | idiopathic pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0008345 |
T2 | 402-420 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
T3 | 522-540 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
T4 | 626-655 | Disease | denotes | idiopathic pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0008345 |
T5 | 657-660 | Disease | denotes | IPF | http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345 |
T7 | 715-727 | Disease | denotes | hyperplastic | http://purl.obolibrary.org/obo/MONDO_0005043 |
T8 | 870-884 | Disease | denotes | adenocarcinoma | http://purl.obolibrary.org/obo/MONDO_0004970 |
T9 | 1507-1510 | Disease | denotes | IPF | http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 208-213 | OrganismTaxon | denotes | human | 9606 |
T2 | 606-611 | OrganismTaxon | denotes | human | 9606 |
T3 | 1304-1308 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 214-218 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T2 | 219-230 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
T3 | 588-592 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T4 | 728-761 | Body_part | denotes | type II alveolar epithelial cells | http://purl.obolibrary.org/obo/CL_0002063 |
T5 | 763-767 | Body_part | denotes | AECs | http://purl.obolibrary.org/obo/CL_0000322 |
T6 | 916-935 | Body_part | denotes | alveolar epithelium | http://purl.obolibrary.org/obo/UBERON_0004821 |
T7 | 1230-1234 | Body_part | denotes | AECs | http://purl.obolibrary.org/obo/CL_0000322 |
T8 | 1423-1427 | Body_part | denotes | AECs | http://purl.obolibrary.org/obo/CL_0000322 |
T9 | 1460-1464 | Body_part | denotes | AECs | http://purl.obolibrary.org/obo/CL_0000322 |
T10 | 1573-1577 | Body_part | denotes | AECs | http://purl.obolibrary.org/obo/CL_0000322 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 38-56 | Phenotype | denotes | pulmonary fibrosis | HP:0002206 |
T2 | 402-420 | Phenotype | denotes | pulmonary fibrosis | HP:0002206 |
T3 | 522-540 | Phenotype | denotes | pulmonary fibrosis | HP:0002206 |
T4 | 637-655 | Phenotype | denotes | pulmonary fibrosis | HP:0002206 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 219-230 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
T2 | 728-761 | Cell | denotes | type II alveolar epithelial cells | http://purl.obolibrary.org/obo/CL:0002063 |
T3 | 763-767 | Cell | denotes | AECs | http://purl.obolibrary.org/obo/CL:0000322 |
T4 | 1230-1234 | Cell | denotes | AECs | http://purl.obolibrary.org/obo/CL:0000322 |
T5 | 1423-1427 | Cell | denotes | AECs | http://purl.obolibrary.org/obo/CL:0000322 |
T6 | 1460-1464 | Cell | denotes | AECs | http://purl.obolibrary.org/obo/CL:0000322 |
T7 | 1573-1577 | Cell | denotes | AECs | http://purl.obolibrary.org/obo/CL:0000322 |