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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 214-218 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T2 588-592 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
TextSentencer_T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
TextSentencer_T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
TextSentencer_T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
TextSentencer_T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
TextSentencer_T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
TextSentencer_T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
TextSentencer_T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
TextSentencer_T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.
T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.
T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 89-104 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 106-108 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T3 836-838 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 18-23 gene:55959 denotes Sulf2
T1 27-56 disease:C3812887 denotes idiopathic pulmonary fibrosis
T2 18-23 gene:55959 denotes Sulf2
T3 27-56 disease:C1800706 denotes idiopathic pulmonary fibrosis
T4 131-136 gene:23213 denotes Sulf1
T5 402-420 disease:C0034069 denotes pulmonary fibrosis
T6 143-172 gene:7040 denotes transforming growth factor-β1
T7 402-420 disease:C0034069 denotes pulmonary fibrosis
T8 375-380 gene:55959 denotes Sulf2
T9 402-420 disease:C0034069 denotes pulmonary fibrosis
T10 330-335 gene:23213 denotes Sulf1
T11 402-420 disease:C0034069 denotes pulmonary fibrosis
T12 297-303 gene:7040 denotes TGF-β1
T13 402-420 disease:C0034069 denotes pulmonary fibrosis
T14 281-287 gene:7040 denotes TGF-β1
T15 402-420 disease:C0034069 denotes pulmonary fibrosis
T16 483-489 gene:7040 denotes TGF-β1
T17 522-540 disease:C0034069 denotes pulmonary fibrosis
T18 463-468 gene:55959 denotes Sulf2
T19 522-540 disease:C0034069 denotes pulmonary fibrosis
T20 556-561 gene:55959 denotes Sulf2
T21 626-655 disease:C3812887 denotes idiopathic pulmonary fibrosis
T22 667-672 gene:55959 denotes Sulf2
T23 657-660 disease:C3812887 denotes IPF
T24 556-561 gene:55959 denotes Sulf2
T25 657-660 disease:C1800706 denotes IPF
T26 556-561 gene:55959 denotes Sulf2
T27 626-655 disease:C1800706 denotes idiopathic pulmonary fibrosis
T28 556-561 gene:55959 denotes Sulf2
T29 657-660 disease:C3812887 denotes IPF
T30 667-672 gene:55959 denotes Sulf2
T31 626-655 disease:C3812887 denotes idiopathic pulmonary fibrosis
T32 667-672 gene:55959 denotes Sulf2
T33 626-655 disease:C1800706 denotes idiopathic pulmonary fibrosis
T34 667-672 gene:55959 denotes Sulf2
T35 657-660 disease:C1800706 denotes IPF
T36 1481-1486 gene:55959 denotes Sulf2
T37 1507-1510 disease:C3812887 denotes IPF
T38 1481-1486 gene:55959 denotes Sulf2
T39 1507-1510 disease:C1800706 denotes IPF
R1 T0 T1 associated_with Sulf2,idiopathic pulmonary fibrosis
R2 T2 T3 associated_with Sulf2,idiopathic pulmonary fibrosis
R3 T4 T5 associated_with Sulf1,pulmonary fibrosis
R4 T6 T7 associated_with transforming growth factor-β1,pulmonary fibrosis
R5 T8 T9 associated_with Sulf2,pulmonary fibrosis
R6 T10 T11 associated_with Sulf1,pulmonary fibrosis
R7 T12 T13 associated_with TGF-β1,pulmonary fibrosis
R8 T14 T15 associated_with TGF-β1,pulmonary fibrosis
R9 T16 T17 associated_with TGF-β1,pulmonary fibrosis
R10 T18 T19 associated_with Sulf2,pulmonary fibrosis
R11 T20 T21 associated_with Sulf2,idiopathic pulmonary fibrosis
R12 T22 T23 associated_with Sulf2,IPF
R13 T24 T25 associated_with Sulf2,IPF
R14 T26 T27 associated_with Sulf2,idiopathic pulmonary fibrosis
R15 T28 T29 associated_with Sulf2,IPF
R16 T30 T31 associated_with Sulf2,idiopathic pulmonary fibrosis
R17 T32 T33 associated_with Sulf2,idiopathic pulmonary fibrosis
R18 T34 T35 associated_with Sulf2,IPF
R19 T36 T37 associated_with Sulf2,IPF
R20 T38 T39 associated_with Sulf2,IPF

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 38-47 FMAID:66326 denotes pulmonary
_T2 38-47 FMAID:171535 denotes pulmonary
_T3 89-96 FMAID:165191 denotes heparan
_T4 89-96 FMAID:67110 denotes heparan
_T5 89-104 FMAID:63023 denotes heparan sulfate
_T6 89-104 FMAID:167405 denotes heparan sulfate
_T7 193-197 FMAID:198663 denotes gene
_T8 214-218 FMAID:7195 denotes lung
_T9 214-218 FMAID:169341 denotes lung
_T10 214-218 FMAID:93670 denotes lung
_T11 219-230 FMAID:162340 denotes fibroblasts
_T12 219-230 FMAID:63877 denotes fibroblasts
_T13 402-411 FMAID:66326 denotes pulmonary
_T14 402-411 FMAID:171535 denotes pulmonary
_T15 522-531 FMAID:66326 denotes pulmonary
_T16 522-531 FMAID:171535 denotes pulmonary
_T17 588-592 FMAID:7195 denotes lung
_T18 588-592 FMAID:169341 denotes lung
_T19 588-592 FMAID:93670 denotes lung
_T20 637-646 FMAID:66326 denotes pulmonary
_T21 637-646 FMAID:171535 denotes pulmonary
_T22 673-680 FMAID:165447 denotes protein
_T23 673-680 FMAID:67257 denotes protein
_T24 728-761 FMAID:167082 denotes type II alveolar epithelial cells
_T25 728-761 FMAID:62501 denotes type II alveolar epithelial cells
_T26 728-761 FMAID:62500 denotes type II alveolar epithelial cells
_T27 728-761 FMAID:167081 denotes type II alveolar epithelial cells
_T28 728-761 FMAID:166735 denotes type II alveolar epithelial cells
_T29 728-761 FMAID:166736 denotes type II alveolar epithelial cells
_T30 736-744 FMAID:264783 denotes alveolar
_T31 736-744 FMAID:242016 denotes alveolar
_T32 736-761 FMAID:62499 denotes alveolar epithelial cells
_T33 736-761 FMAID:166730 denotes alveolar epithelial cells
_T34 745-761 FMAID:67559 denotes epithelial cells
_T35 745-761 FMAID:83514 denotes epithelial cells
_T36 745-761 FMAID:165731 denotes epithelial cells
_T37 745-761 FMAID:169653 denotes epithelial cells
_T38 745-761 FMAID:66768 denotes epithelial cells
_T39 745-761 FMAID:197786 denotes epithelial cells
_T40 745-761 FMAID:69074 denotes epithelial cells
_T41 745-761 FMAID:164922 denotes epithelial cells
_T42 745-761 FMAID:69075 denotes epithelial cells
_T43 745-761 FMAID:169652 denotes epithelial cells
_T44 745-761 FMAID:165528 denotes epithelial cells
_T45 745-761 FMAID:67799 denotes epithelial cells
_T46 756-761 FMAID:169002 denotes cells
_T47 756-761 FMAID:68646 denotes cells
_T48 863-868 FMAID:169002 denotes cells
_T49 863-868 FMAID:68646 denotes cells
_T50 885-890 FMAID:169002 denotes cells
_T51 885-890 FMAID:68646 denotes cells
_T52 908-935 FMAID:62501 denotes type II alveolar epithelium
_T53 908-935 FMAID:167082 denotes type II alveolar epithelium
_T54 908-935 FMAID:167081 denotes type II alveolar epithelium
_T55 908-935 FMAID:62500 denotes type II alveolar epithelium
_T56 913-935 FMAID:162383 denotes II alveolar epithelium
_T57 913-935 FMAID:63915 denotes II alveolar epithelium
_T58 916-924 FMAID:242016 denotes alveolar
_T59 916-924 FMAID:264783 denotes alveolar
_T60 916-935 FMAID:62499 denotes alveolar epithelium
_T61 916-935 FMAID:210218 denotes alveolar epithelium
_T62 916-935 FMAID:166730 denotes alveolar epithelium
_T63 925-935 FMAID:69065 denotes epithelium
_T64 925-935 FMAID:169642 denotes epithelium
_T65 925-935 FMAID:169643 denotes epithelium
_T66 925-935 FMAID:256071 denotes epithelium
_T67 925-935 FMAID:69064 denotes epithelium
_T68 1106-1110 FMAID:198663 denotes gene
_T69 1146-1151 FMAID:169002 denotes cells
_T70 1146-1151 FMAID:68646 denotes cells
_T71 1146-1160 FMAID:226227 denotes cells compared
_T72 1178-1183 FMAID:169002 denotes cells
_T73 1178-1183 FMAID:68646 denotes cells
_T74 1256-1269 FMAID:198168 denotes type II cells
_T75 1264-1269 FMAID:68646 denotes cells
_T76 1264-1269 FMAID:169002 denotes cells
_T77 1381-1385 FMAID:198663 denotes gene
_T78 1447-1459 FMAID:166093 denotes type type II

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 18-23 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T2 375-380 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T3 463-468 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T4 556-561 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T5 667-672 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T6 813-818 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T7 975-980 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T8 1125-1130 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T9 1206-1211 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T10 1289-1294 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T11 1400-1405 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2
T12 1481-1486 http://www.uniprot.org/uniprot/Q9D8E2 denotes Sulf2

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 38-47 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary
T2 367-374 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T3 402-411 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary
T4 522-531 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary
T5 637-646 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary
T6 756-761 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 863-868 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 885-890 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 1146-1151 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 1178-1183 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T11 1264-1269 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 97-104 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T2 156-162 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3 268-277 http://purl.obolibrary.org/obo/GO_0065007 denotes regulator
T4 1534-1544 http://purl.obolibrary.org/obo/GO_0065007 denotes regulating
T5 507-518 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T6 698-707 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T7 736-744 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T8 916-924 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T9 949-965 http://purl.obolibrary.org/obo/GO_0016246 denotes interference RNA
T10 1106-1121 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T11 1381-1396 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T12 1552-1561 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

GO-CC

Id Subject Object Predicate Lexical cue
T1 756-761 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 863-868 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 885-890 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 1146-1151 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 1178-1183 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1264-1269 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 214-218 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T2 588-592 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T3 925-935 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 208-213 http://edamontology.org/topic_2815 denotes human
T2 430-435 http://edamontology.org/topic_3678 denotes study
T3 593-600 http://edamontology.org/topic_3277 denotes samples
T4 606-611 http://edamontology.org/topic_2815 denotes human
T5 673-680 http://edamontology.org/topic_0078 denotes protein
T6 943-965 http://edamontology.org/topic_0659 denotes small interference RNA
T7 1099-1105 http://edamontology.org/topic_0154 denotes target
T8 1106-1121 http://edamontology.org/topic_0203 denotes gene expression
T9 1188-1193 http://edamontology.org/topic_3678 denotes study
T10 1374-1380 http://edamontology.org/topic_0154 denotes target
T11 1381-1396 http://edamontology.org/topic_0203 denotes gene expression

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 201-207 http://edamontology.org/operation_3435 denotes normal
T2 235-244 http://edamontology.org/operation_0004 denotes functions
T3 673-680 http://edamontology.org/data_1467 denotes protein
T4 673-680 http://edamontology.org/format_1208 denotes protein
T5 1106-1124 http://edamontology.org/data_2967 denotes gene expression in
T6 1215-1221 http://edamontology.org/operation_3435 denotes normal
T7 1381-1399 http://edamontology.org/data_2967 denotes gene expression in

Allie

Id Subject Object Predicate Lexical cue
SS1_23418199_1_0 89-104 expanded denotes heparan sulfate
SS2_23418199_1_0 106-108 abbr denotes HS
SS1_23418199_1_1 143-172 expanded denotes transforming growth factor-β1
SS2_23418199_1_1 174-180 abbr denotes TGF-β1
SS1_23418199_3_0 626-655 expanded denotes idiopathic pulmonary fibrosis
SS2_23418199_3_0 657-660 abbr denotes IPF
SS1_23418199_3_1 736-761 expanded denotes alveolar epithelial cells
SS2_23418199_3_1 763-767 abbr denotes AECs
AE1_23418199_1_0 SS1_23418199_1_0 SS2_23418199_1_0 abbreviatedTo heparan sulfate,HS
AE1_23418199_1_1 SS1_23418199_1_1 SS2_23418199_1_1 abbreviatedTo transforming growth factor-β1,TGF-β1
AE1_23418199_3_0 SS1_23418199_3_0 SS2_23418199_3_0 abbreviatedTo idiopathic pulmonary fibrosis,IPF
AE1_23418199_3_1 SS1_23418199_3_1 SS2_23418199_3_1 abbreviatedTo alveolar epithelial cells,AECs

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 402-420 HP_0002206 denotes pulmonary fibrosis
T2 522-540 HP_0002206 denotes pulmonary fibrosis
T3 637-655 HP_0002206 denotes pulmonary fibrosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23418199-0#18#23#gene55959 330-380 gene55959 denotes Sulf1 as well as that of the closely related Sulf2
23418199-0#27#56#diseaseC0085786 389-655 diseaseC0085786 denotes ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis
23418199-0#27#56#diseaseC1800706 389-655 diseaseC1800706 denotes ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis
23418199-1#73#78#gene23213 131-136 gene23213 denotes Sulf1
23418199-1#272#277#gene23213 330-335 gene23213 denotes Sulf1
23418199-1#344#362#diseaseC0034069 402-420 diseaseC0034069 denotes pulmonary fibrosis
23418199-2#41#46#gene55959 463-468 gene55959 denotes Sulf2
23418199-2#61#67#gene7040 483-489 gene7040 denotes TGF-β1
23418199-2#100#118#diseaseC0034069 522-540 diseaseC0034069 denotes pulmonary fibrosis
18#23#gene5595927#56#diseaseC0085786 23418199-0#18#23#gene55959 23418199-0#27#56#diseaseC0085786 associated_with Sulf1 as well as that of the closely related Sulf2,"ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis"
18#23#gene5595927#56#diseaseC1800706 23418199-0#18#23#gene55959 23418199-0#27#56#diseaseC1800706 associated_with Sulf1 as well as that of the closely related Sulf2,"ine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis"
73#78#gene23213344#362#diseaseC0034069 23418199-1#73#78#gene23213 23418199-1#344#362#diseaseC0034069 associated_with Sulf1,pulmonary fibrosis
272#277#gene23213344#362#diseaseC0034069 23418199-1#272#277#gene23213 23418199-1#344#362#diseaseC0034069 associated_with Sulf1,pulmonary fibrosis
41#46#gene55959100#118#diseaseC0034069 23418199-2#41#46#gene55959 23418199-2#100#118#diseaseC0034069 associated_with Sulf2,pulmonary fibrosis
61#67#gene7040100#118#diseaseC0034069 23418199-2#61#67#gene7040 23418199-2#100#118#diseaseC0034069 associated_with TGF-β1,pulmonary fibrosis

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 214-218 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T2 588-592 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 89-104 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 214-218 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 588-592 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 925-935 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 214-218 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T2 588-592 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 27-56 Disease denotes idiopathic pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0008345
T2 402-420 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T3 522-540 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T4 626-655 Disease denotes idiopathic pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0008345
T5 657-660 Disease denotes IPF http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345
T7 715-727 Disease denotes hyperplastic http://purl.obolibrary.org/obo/MONDO_0005043
T8 870-884 Disease denotes adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004970
T9 1507-1510 Disease denotes IPF http://purl.obolibrary.org/obo/MONDO_0002429|http://purl.obolibrary.org/obo/MONDO_0008345

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 38-56 Phenotype denotes pulmonary fibrosis HP:0002206
T2 402-420 Phenotype denotes pulmonary fibrosis HP:0002206
T3 522-540 Phenotype denotes pulmonary fibrosis HP:0002206
T4 637-655 Phenotype denotes pulmonary fibrosis HP:0002206

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-57 Sentence denotes Overexpression of Sulf2 in idiopathic pulmonary fibrosis.
T2 58-421 Sentence denotes Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.
T3 422-541 Sentence denotes In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis.
T4 542-769 Sentence denotes We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs).
T5 770-936 Sentence denotes In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium.
T6 937-1184 Sentence denotes Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad activation, but eventually reduced TGF-β1 target gene expression in Sulf2 knockdown A549 cells compared with the control cells.
T7 1185-1309 Sentence denotes To study the role of Sulf2 in normal type II AECs, we isolated primary type II cells from wild-type and Sulf2 knockout mice.
T8 1310-1465 Sentence denotes We observed enhanced Smad activation as well as enhanced TGF-β1 target gene expression in Sulf2 knockout type II AECs compared with wild-type type II AECs.
T9 1466-1578 Sentence denotes In conclusion, Sulf2 is overexpressed in IPF and may play a role in regulating TGF-β1 signaling in type II AECs.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 27-56 Disease denotes idiopathic pulmonary fibrosis MONDO:0800029
T2 402-420 Disease denotes pulmonary fibrosis MONDO:0002771
T3 522-540 Disease denotes pulmonary fibrosis MONDO:0002771
T4 626-655 Disease denotes idiopathic pulmonary fibrosis MONDO:0800029
T5 657-660 Disease denotes IPF MONDO:0800029
T6 715-727 Disease denotes hyperplastic MONDO:0005043
T7 870-884 Disease denotes adenocarcinoma MONDO:0004970
T8 1507-1510 Disease denotes IPF MONDO:0800029

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 208-213 Organism denotes human 9606
T2 606-611 Organism denotes human 9606
T3 612-620 Organism denotes patients 9606
T4 1304-1308 Organism denotes mice 10088

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 89-104 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 106-108 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T3 836-838 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 214-218 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 219-230 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T3 588-592 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 728-761 Body_part denotes type II alveolar epithelial cells http://purl.obolibrary.org/obo/CL_0002063
T5 763-767 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T6 916-935 Body_part denotes alveolar epithelium http://purl.obolibrary.org/obo/UBERON_0004821
T7 1230-1234 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T8 1423-1427 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T9 1460-1464 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T10 1573-1577 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 214-218 Body_part denotes lung FMA:7195
T2 219-230 Body_part denotes fibroblasts FMA:63877
T3 588-592 Body_part denotes lung FMA:7195
T4 728-761 Body_part denotes type II alveolar epithelial cells FMA:62501
T5 763-767 Body_part denotes AECs FMA:62499
T6 916-924 Body_part denotes alveolar FMA:264783
T7 925-935 Body_part denotes epithelium FMA:9639
T8 1230-1234 Body_part denotes AECs FMA:62499
T9 1423-1427 Body_part denotes AECs FMA:62499
T10 1460-1464 Body_part denotes AECs FMA:62499
T11 1573-1577 Body_part denotes AECs FMA:62499

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 214-218 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T2 588-592 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 208-213 OrganismTaxon denotes human 9606
T2 606-611 OrganismTaxon denotes human 9606
T3 1304-1308 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 214-218 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 219-230 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T3 588-592 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 728-761 Body_part denotes type II alveolar epithelial cells http://purl.obolibrary.org/obo/CL_0002063
T5 763-767 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T6 916-935 Body_part denotes alveolar epithelium http://purl.obolibrary.org/obo/UBERON_0004821
T7 1230-1234 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T8 1423-1427 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T9 1460-1464 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322
T10 1573-1577 Body_part denotes AECs http://purl.obolibrary.org/obo/CL_0000322

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 38-56 Phenotype denotes pulmonary fibrosis HP:0002206
T2 402-420 Phenotype denotes pulmonary fibrosis HP:0002206
T3 522-540 Phenotype denotes pulmonary fibrosis HP:0002206
T4 637-655 Phenotype denotes pulmonary fibrosis HP:0002206

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 219-230 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T2 728-761 Cell denotes type II alveolar epithelial cells http://purl.obolibrary.org/obo/CL:0002063
T3 763-767 Cell denotes AECs http://purl.obolibrary.org/obo/CL:0000322
T4 1230-1234 Cell denotes AECs http://purl.obolibrary.org/obo/CL:0000322
T5 1423-1427 Cell denotes AECs http://purl.obolibrary.org/obo/CL:0000322
T6 1460-1464 Cell denotes AECs http://purl.obolibrary.org/obo/CL:0000322
T7 1573-1577 Cell denotes AECs http://purl.obolibrary.org/obo/CL:0000322