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PubMed:23362253 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications.
T2 143-315 Sentence denotes CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear.
T3 316-464 Sentence denotes Here, we show that MYCN inhibits the expression of CLU by direct interaction with the non-canonical E box sequence CACGCG in the 5'-flanking region.
T4 465-620 Sentence denotes Binding of MYCN to the CLU gene induces bivalent epigenetic marks and recruitment of repressive proteins such as histone deacetylases and Polycomb members.
T5 621-747 Sentence denotes MYCN physically binds in vitro and in vivo to EZH2, a component of the Polycomb repressive complex 2, required to repress CLU.
T6 748-867 Sentence denotes Notably, EZH2 interacts with the Myc box domain 3, a segment of MYC known to be essential for its transforming effects.
T7 868-975 Sentence denotes The expression of CLU can be restored in MYCN-amplified cells by epigenetic drugs with therapeutic results.
T8 976-1086 Sentence denotes Importantly, the anticancer effects of the drugs are ablated if CLU expression is blunted by RNA interference.
T9 1087-1298 Sentence denotes Our study implies that MYC tumorigenesis can be effectively antagonized by epigenetic drugs that interfere with the recruitment of chromatin modifiers at repressive E boxes of tumor suppressor genes such as CLU.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 29-33 gene:4613 denotes MYCN
T1 87-100 disease:C0027819 denotes neuroblastoma
T2 29-33 gene:4613 denotes MYCN
T3 87-100 disease:C0700095 denotes neuroblastoma
R1 T0 T1 associated_with MYCN,neuroblastoma
R2 T2 T3 associated_with MYCN,neuroblastoma

Allie

Id Subject Object Predicate Lexical cue
SS1_23362253_0_0 47-76 expanded denotes polycomb repressive complex 2
SS2_23362253_0_0 78-82 abbr denotes PRC2
AE1_23362253_0_0 SS1_23362253_0_0 SS2_23362253_0_0 abbreviatedTo polycomb repressive complex 2,PRC2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 164-169 HP_0002664 denotes tumor
T2 1263-1268 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23362253-0#29#33#gene4613 29-33 gene4613 denotes MYCN
23362253-0#87#100#diseaseC0027819 87-100 diseaseC0027819 denotes neuroblastoma
23362253-0#87#100#diseaseC0700095 87-100 diseaseC0700095 denotes neuroblastoma
23362253-8#207#210#gene1191 1294-1297 gene1191 denotes CLU
23362253-8#27#40#diseaseC0596263 1114-1127 diseaseC0596263 denotes tumorigenesis
29#33#gene461387#100#diseaseC0027819 23362253-0#29#33#gene4613 23362253-0#87#100#diseaseC0027819 associated_with MYCN,neuroblastoma
29#33#gene461387#100#diseaseC0700095 23362253-0#29#33#gene4613 23362253-0#87#100#diseaseC0700095 associated_with MYCN,neuroblastoma
207#210#gene119127#40#diseaseC0596263 23362253-8#207#210#gene1191 23362253-8#27#40#diseaseC0596263 associated_with CLU,tumorigenesis

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 87-100 Phenotype denotes neuroblastoma HP:0003006
T2 164-169 Phenotype denotes tumor HP:0002664
T3 1263-1268 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 87-100 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T2 164-169 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 1263-1268 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 801-808 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914