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PubMed:23307905 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 188-203 https://glytoucan.org/Structures/Glycans/G00065MO denotes polysialic acid
T2 205-212 https://glytoucan.org/Structures/Glycans/G00065MO denotes polySia
T3 805-812 https://glytoucan.org/Structures/Glycans/G00065MO denotes polySia

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 188-203 Glycan_Motif denotes polysialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO
T2 205-212 Glycan_Motif denotes polySia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO
T3 805-812 Glycan_Motif denotes polySia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality.
TextSentencer_T2 103-255 Sentence denotes The enteropathogenic Escherichia coli K92 synthesizes a unique capsule consisting of polysialic acid (polySia) with alternating α2,8- and α2,9-linkages.
TextSentencer_T3 256-450 Sentence denotes The fact that a single enzyme is responsible for the synthesis of these alternating regioisomeric linkages raises questions as to how this controlled bifunctionality is achieved mechanistically.
TextSentencer_T4 451-725 Sentence denotes Aiming to identify the sequence elements responsible for dual regiospecificity, we have utilized a high-throughput polysialyltransferase (polyST) activity screen to explore the relevant sequence space between this enzyme and its close monofunctional homolog from E. coli K1.
TextSentencer_T5 726-855 Sentence denotes The linkage specificity of selected mutants was subsequently confirmed using a polySia permethylation linkage analysis technique.
TextSentencer_T6 856-984 Sentence denotes We have identified a single amino acid exchange at residue 52 that toggles these enzymes between mono and dual regiospecificity.
TextSentencer_T7 985-1098 Sentence denotes The results have implications for the mechanism by which the E. coli K92 polyST achieves bifunctional elongation.
T1 0-102 Sentence denotes A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality.
T2 103-255 Sentence denotes The enteropathogenic Escherichia coli K92 synthesizes a unique capsule consisting of polysialic acid (polySia) with alternating α2,8- and α2,9-linkages.
T3 256-450 Sentence denotes The fact that a single enzyme is responsible for the synthesis of these alternating regioisomeric linkages raises questions as to how this controlled bifunctionality is achieved mechanistically.
T4 451-725 Sentence denotes Aiming to identify the sequence elements responsible for dual regiospecificity, we have utilized a high-throughput polysialyltransferase (polyST) activity screen to explore the relevant sequence space between this enzyme and its close monofunctional homolog from E. coli K1.
T5 726-855 Sentence denotes The linkage specificity of selected mutants was subsequently confirmed using a polySia permethylation linkage analysis technique.
T6 856-984 Sentence denotes We have identified a single amino acid exchange at residue 52 that toggles these enzymes between mono and dual regiospecificity.
T7 985-1098 Sentence denotes The results have implications for the mechanism by which the E. coli K92 polyST achieves bifunctional elongation.
T1 0-102 Sentence denotes A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality.
T2 103-255 Sentence denotes The enteropathogenic Escherichia coli K92 synthesizes a unique capsule consisting of polysialic acid (polySia) with alternating α2,8- and α2,9-linkages.
T3 256-450 Sentence denotes The fact that a single enzyme is responsible for the synthesis of these alternating regioisomeric linkages raises questions as to how this controlled bifunctionality is achieved mechanistically.
T4 451-725 Sentence denotes Aiming to identify the sequence elements responsible for dual regiospecificity, we have utilized a high-throughput polysialyltransferase (polyST) activity screen to explore the relevant sequence space between this enzyme and its close monofunctional homolog from E. coli K1.
T5 726-855 Sentence denotes The linkage specificity of selected mutants was subsequently confirmed using a polySia permethylation linkage analysis technique.
T6 856-984 Sentence denotes We have identified a single amino acid exchange at residue 52 that toggles these enzymes between mono and dual regiospecificity.
T7 985-1098 Sentence denotes The results have implications for the mechanism by which the E. coli K92 polyST achieves bifunctional elongation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 188-203 https://glytoucan.org/Structures/Glycans/G00065MO denotes polysialic acid

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC002,LEC056,LEC062,LEC069,LEC081,LEC111,LEC133,LEC171,LEC177,LEC187,LEC211,LEC242,LEC252,LEC258,LEC259,LEC260,LEC262,LEC369,LEC377,LEC422,LEC442,LEC448,LEC450,LEC451,LEC454,LEC472,LEC492,LEC620 denotes Escherichia coli
_T2 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC636 denotes Escherichia coli
_T3 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC157,LEC407 denotes Escherichia coli
_T4 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC054,LEC058,LEC073,LEC082,LEC091,LEC103,LEC109,LEC110,LEC123,LEC158,LEC179,LEC198,LEC205,LEC222,LEC223,LEC224,LEC225,LEC232,LEC298,LEC357,LEC378,LEC383,LEC388,LEC389,LEC397,LEC401,LEC410,LEC452 denotes Escherichia coli
_T5 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC754 denotes Escherichia coli
_T6 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC244,LEC256,LEC354 denotes Escherichia coli
_T7 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC243,LEC640 denotes Escherichia coli
_T8 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC487 denotes Escherichia coli
_T9 28-44 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC295,LEC417 denotes Escherichia coli
_T10 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC295,LEC417 denotes Escherichia coli
_T11 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC243,LEC640 denotes Escherichia coli
_T12 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC636 denotes Escherichia coli
_T13 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC002,LEC056,LEC062,LEC069,LEC081,LEC111,LEC133,LEC171,LEC177,LEC187,LEC211,LEC242,LEC252,LEC258,LEC259,LEC260,LEC262,LEC369,LEC377,LEC422,LEC442,LEC448,LEC450,LEC451,LEC454,LEC472,LEC492,LEC620 denotes Escherichia coli
_T14 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC754 denotes Escherichia coli
_T15 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC054,LEC058,LEC073,LEC082,LEC091,LEC103,LEC109,LEC110,LEC123,LEC158,LEC179,LEC198,LEC205,LEC222,LEC223,LEC224,LEC225,LEC232,LEC298,LEC357,LEC378,LEC383,LEC388,LEC389,LEC397,LEC401,LEC410,LEC452 denotes Escherichia coli
_T16 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC157,LEC407 denotes Escherichia coli
_T17 124-140 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC244,LEC256,LEC354 denotes Escherichia coli
_T18 124-144 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC720 denotes Escherichia coli K92
_T19 124-144 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC487 denotes Escherichia coli K92

ICD10

Id Subject Object Predicate Lexical cue
T1 107-140 http://purl.bioontology.org/ontology/ICD10/A04.0 denotes enteropathogenic Escherichia coli

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 9-19 FMAID:82739 denotes amino acid
_T2 9-19 FMAID:196728 denotes amino acid
_T3 166-173 FMAID:85272 denotes capsule
_T4 166-173 FMAID:199625 denotes capsule
_T5 884-894 FMAID:82739 denotes amino acid
_T6 884-894 FMAID:196728 denotes amino acid

uniprot-human

Id Subject Object Predicate Lexical cue
T1 722-724 http://www.uniprot.org/uniprot/P04264 denotes K1

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 722-724 http://www.uniprot.org/uniprot/P04104 denotes K1

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 28-39 http://purl.bioontology.org/ontology/NCBITAXON/561 denotes Escherichia
T2 124-135 http://purl.bioontology.org/ontology/NCBITAXON/561 denotes Escherichia
T3 1023-1032 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 309-318 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2 895-903 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 166-173 http://purl.obolibrary.org/obo/UBERON_0003893 denotes capsule

Allie

Id Subject Object Predicate Lexical cue
SS1_23307905_1_0 188-203 expanded denotes polysialic acid
SS2_23307905_1_0 205-212 abbr denotes polySia
SS1_23307905_3_0 566-587 expanded denotes polysialyltransferase
SS2_23307905_3_0 589-595 abbr denotes polyST
AE1_23307905_1_0 SS1_23307905_1_0 SS2_23307905_1_0 abbreviatedTo polysialic acid,polySia
AE1_23307905_3_0 SS1_23307905_3_0 SS2_23307905_3_0 abbreviatedTo polysialyltransferase,polyST

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 915-917 http://www.glycoepitope.jp/epitopes/AN0785 denotes 52

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 166-173 http://purl.obolibrary.org/obo/UBERON_0003893 denotes capsule

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 28-44 OrganismTaxon denotes Escherichia coli 562
T2 124-140 OrganismTaxon denotes Escherichia coli 562
T3 714-721 OrganismTaxon denotes E. coli 562
T4 1046-1053 OrganismTaxon denotes E. coli 562

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 646-651 Body_part denotes space http://purl.obolibrary.org/obo/UBERON_0000464