> top > docs > PubMed:23306612 > annotations

PubMed:23306612 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-105 Sentence denotes Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer.
TextSentencer_T2 106-298 Sentence denotes The forkhead box M1 (FOXM1) transcription factor regulates the expression of genes essential for cell proliferation and transformation and is implicated in tumorigenesis and tumor progression.
TextSentencer_T3 299-418 Sentence denotes FOXM1 has been considered as a potential target for the prevention and/or therapeutic intervention in human carcinomas.
TextSentencer_T4 419-662 Sentence denotes In this study, we observed a strong expression of FOXM1 in clinical tissue specimens and cell lines of human breast cancer and a correlation between FOXM1 levels and the proliferation ability in the tested MCF-7, MDA-MB-231 and ZR-75-30 cells.
TextSentencer_T5 663-941 Sentence denotes By using an adenovirus vector (named AdFOXM1shRNA) that expresses a short hairpin RNA (shRNA) to downregulate FOXM1 expression specifically, we found that the knockdown of FOXM1 expression diminished the proliferation and anchorage-independent growth of the breast cancer cells.
TextSentencer_T6 942-1077 Sentence denotes The FOXM1 silencing in ZR-75-30 cells dramatically prevented the tumorigenicity of the AdFOXM1shRNA-treated cells in vitro and in vivo.
TextSentencer_T7 1078-1318 Sentence denotes Furthermore, the efficacy of AdFOXM1shRNA for tumor gene therapy was assessed with the breast cancer xenograft mouse model and the tumor growth was significantly suppressed when inoculated mice were injected with AdFOXM1shRNA in the tumors.
TextSentencer_T8 1319-1508 Sentence denotes Together, our results suggest that FOXM1 is a potential therapeutic target for breast cancer and AdFOXM1shRNA may be an additional gene therapeutic intervention for breast cancer treatment.
T1 0-105 Sentence denotes Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer.
T2 106-298 Sentence denotes The forkhead box M1 (FOXM1) transcription factor regulates the expression of genes essential for cell proliferation and transformation and is implicated in tumorigenesis and tumor progression.
T3 299-418 Sentence denotes FOXM1 has been considered as a potential target for the prevention and/or therapeutic intervention in human carcinomas.
T4 419-662 Sentence denotes In this study, we observed a strong expression of FOXM1 in clinical tissue specimens and cell lines of human breast cancer and a correlation between FOXM1 levels and the proliferation ability in the tested MCF-7, MDA-MB-231 and ZR-75-30 cells.
T5 663-941 Sentence denotes By using an adenovirus vector (named AdFOXM1shRNA) that expresses a short hairpin RNA (shRNA) to downregulate FOXM1 expression specifically, we found that the knockdown of FOXM1 expression diminished the proliferation and anchorage-independent growth of the breast cancer cells.
T6 942-1077 Sentence denotes The FOXM1 silencing in ZR-75-30 cells dramatically prevented the tumorigenicity of the AdFOXM1shRNA-treated cells in vitro and in vivo.
T7 1078-1318 Sentence denotes Furthermore, the efficacy of AdFOXM1shRNA for tumor gene therapy was assessed with the breast cancer xenograft mouse model and the tumor growth was significantly suppressed when inoculated mice were injected with AdFOXM1shRNA in the tumors.
T8 1319-1508 Sentence denotes Together, our results suggest that FOXM1 is a potential therapeutic target for breast cancer and AdFOXM1shRNA may be an additional gene therapeutic intervention for breast cancer treatment.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 14-19 gene:2305 denotes FOXM1
T1 91-104 disease:C0006142 denotes breast cancer
T2 14-19 gene:2305 denotes FOXM1
T3 91-104 disease:C0678222 denotes breast cancer
T4 110-125 gene:2305 denotes forkhead box M1
T5 262-275 disease:C0596263 denotes tumorigenesis
T6 110-125 gene:2305 denotes forkhead box M1
T7 280-297 disease:C0178874 denotes tumor progression
T8 127-132 gene:2305 denotes FOXM1
T9 262-275 disease:C0596263 denotes tumorigenesis
T10 127-132 gene:2305 denotes FOXM1
T11 280-297 disease:C0178874 denotes tumor progression
T12 299-304 gene:2305 denotes FOXM1
T13 407-417 disease:C0007097 denotes carcinomas
T14 568-573 gene:2305 denotes FOXM1
T15 528-541 disease:C0678222 denotes breast cancer
T16 469-474 gene:2305 denotes FOXM1
T17 528-541 disease:C0006142 denotes breast cancer
T18 568-573 gene:2305 denotes FOXM1
T19 528-541 disease:C0006142 denotes breast cancer
T20 469-474 gene:2305 denotes FOXM1
T21 528-541 disease:C0678222 denotes breast cancer
T22 835-840 gene:2305 denotes FOXM1
T23 921-934 disease:C0006142 denotes breast cancer
T24 835-840 gene:2305 denotes FOXM1
T25 921-934 disease:C0678222 denotes breast cancer
T26 1354-1359 gene:2305 denotes FOXM1
T27 1398-1411 disease:C0678222 denotes breast cancer
T28 1354-1359 gene:2305 denotes FOXM1
T29 1398-1411 disease:C0006142 denotes breast cancer
T30 1354-1359 gene:2305 denotes FOXM1
T31 1484-1497 disease:C0006142 denotes breast cancer
T32 1354-1359 gene:2305 denotes FOXM1
T33 1484-1497 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with FOXM1,breast cancer
R2 T2 T3 associated_with FOXM1,breast cancer
R3 T4 T5 associated_with forkhead box M1,tumorigenesis
R4 T6 T7 associated_with forkhead box M1,tumor progression
R5 T8 T9 associated_with FOXM1,tumorigenesis
R6 T10 T11 associated_with FOXM1,tumor progression
R7 T12 T13 associated_with FOXM1,carcinomas
R8 T14 T15 associated_with FOXM1,breast cancer
R9 T16 T17 associated_with FOXM1,breast cancer
R10 T18 T19 associated_with FOXM1,breast cancer
R11 T20 T21 associated_with FOXM1,breast cancer
R12 T22 T23 associated_with FOXM1,breast cancer
R13 T24 T25 associated_with FOXM1,breast cancer
R14 T26 T27 associated_with FOXM1,breast cancer
R15 T28 T29 associated_with FOXM1,breast cancer
R16 T30 T31 associated_with FOXM1,breast cancer
R17 T32 T33 associated_with FOXM1,breast cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_23306612_1_0 110-125 expanded denotes forkhead box M1
SS2_23306612_1_0 127-132 abbr denotes FOXM1
SS1_23306612_4_0 731-748 expanded denotes short hairpin RNA
SS2_23306612_4_0 750-755 abbr denotes shRNA
AE1_23306612_1_0 SS1_23306612_1_0 SS2_23306612_1_0 abbreviatedTo forkhead box M1,FOXM1
AE1_23306612_4_0 SS1_23306612_4_0 SS2_23306612_4_0 abbreviatedTo short hairpin RNA,shRNA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 280-285 HP_0002664 denotes tumor
T2 528-541 HP_0003002 denotes breast cancer
T3 528-541 HP_0100013 denotes breast cancer
T4 535-541 HP_0002664 denotes cancer
T5 921-934 HP_0003002 denotes breast cancer
T6 921-934 HP_0100013 denotes breast cancer
T7 928-934 HP_0002664 denotes cancer
T8 1124-1129 HP_0002664 denotes tumor
T9 1165-1178 HP_0003002 denotes breast cancer
T10 1165-1178 HP_0100013 denotes breast cancer
T11 1172-1178 HP_0002664 denotes cancer
T12 1209-1214 HP_0002664 denotes tumor
T13 1311-1317 HP_0002664 denotes tumors
T14 1398-1411 HP_0003002 denotes breast cancer
T15 1398-1411 HP_0100013 denotes breast cancer
T16 1405-1411 HP_0002664 denotes cancer
T17 1484-1497 HP_0003002 denotes breast cancer
T18 1484-1497 HP_0100013 denotes breast cancer
T19 1491-1497 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23306612-0#14#19#gene2305 14-19 gene2305 denotes FOXM1
23306612-0#91#104#diseaseC0006142 91-104 diseaseC0006142 denotes breast cancer
23306612-0#91#104#diseaseC0678222 91-104 diseaseC0678222 denotes breast cancer
23306612-1#4#19#gene2305 110-125 gene2305 denotes forkhead box M1
23306612-1#21#26#gene2305 127-132 gene2305 denotes FOXM1
23306612-1#156#169#diseaseC0596263 262-275 diseaseC0596263 denotes tumorigenesis
23306612-1#174#191#diseaseC0178874 280-297 diseaseC0178874 denotes tumor progression
23306612-1#156#169#diseaseC0596263 262-275 diseaseC0596263 denotes tumorigenesis
23306612-1#174#191#diseaseC0178874 280-297 diseaseC0178874 denotes tumor progression
14#19#gene230591#104#diseaseC0006142 23306612-0#14#19#gene2305 23306612-0#91#104#diseaseC0006142 associated_with FOXM1,breast cancer
14#19#gene230591#104#diseaseC0678222 23306612-0#14#19#gene2305 23306612-0#91#104#diseaseC0678222 associated_with FOXM1,breast cancer
4#19#gene2305156#169#diseaseC0596263 23306612-1#4#19#gene2305 23306612-1#156#169#diseaseC0596263 associated_with forkhead box M1,tumorigenesis
4#19#gene2305174#191#diseaseC0178874 23306612-1#4#19#gene2305 23306612-1#174#191#diseaseC0178874 associated_with forkhead box M1,tumor progression
4#19#gene2305156#169#diseaseC0596263 23306612-1#4#19#gene2305 23306612-1#156#169#diseaseC0596263 associated_with forkhead box M1,tumorigenesis
4#19#gene2305174#191#diseaseC0178874 23306612-1#4#19#gene2305 23306612-1#174#191#diseaseC0178874 associated_with forkhead box M1,tumor progression
21#26#gene2305156#169#diseaseC0596263 23306612-1#21#26#gene2305 23306612-1#156#169#diseaseC0596263 associated_with FOXM1,tumorigenesis
21#26#gene2305174#191#diseaseC0178874 23306612-1#21#26#gene2305 23306612-1#174#191#diseaseC0178874 associated_with FOXM1,tumor progression
21#26#gene2305156#169#diseaseC0596263 23306612-1#21#26#gene2305 23306612-1#156#169#diseaseC0596263 associated_with FOXM1,tumorigenesis
21#26#gene2305174#191#diseaseC0178874 23306612-1#21#26#gene2305 23306612-1#174#191#diseaseC0178874 associated_with FOXM1,tumor progression

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2794 14-19 gene:2305 denotes FOXM1
T2795 91-104 disease:C0006142 denotes breast cancer
R1 T2794 T2795 associated_with FOXM1,breast cancer
R2 T2794 T2795 associated_with FOXM1,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 91-97 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 528-534 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 921-927 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 1165-1171 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1398-1404 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1484-1490 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 487-493 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 487-493 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 91-97 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 528-534 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 921-927 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1165-1171 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1398-1404 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1484-1490 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast