PubMed:23208007 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23208007","sourcedb":"PubMed","sourceid":"23208007","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23208007","text":"Polysialic acid enhances the migration and invasion of human cytotrophoblasts.\nPolysialic acid (polySia) is a large, cell-surface linear homopolymer composed of α2,8-linked sialic acid residues. Most extensively studied in the nervous system, this unique glycan modulates development by enhancing cell migration and regulating differentiation. PolySia also functions in developing and adult immune systems and is a signature of many cancers. In this study, we demonstrated that human placental trophoblasts, an epithelial lineage, also display this glycan. Cytotrophoblasts and syncytiotrophoblasts expressed polySia in the first trimester and downregulated it during the course of pregnancy. PolySia promoted cytotrophoblast migration in an explant model of chorionic villous growth. Removal of this glycan also reduced cytotrophoblast penetration of basement membranes in an in vitro model of invasion. Finally, we showed that polySia was overexpressed in biopsies from patients with gestational trophoblastic diseases, including benign molar pregnancies and malignant choriocarcinomas. These results demonstrated, for the first time, functional roles for polySia during normal human placental development and implicated these unusual oligosaccharides in the unrestrained invasion of trophoblast tumors.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23208007_1_0","span":{"begin":79,"end":94},"obj":"expanded"},{"id":"SS2_23208007_1_0","span":{"begin":96,"end":103},"obj":"abbr"}],"relations":[{"id":"AE1_23208007_1_0","pred":"abbreviatedTo","subj":"SS1_23208007_1_0","obj":"SS2_23208007_1_0"}],"attributes":[{"subj":"SS1_23208007_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_23208007_1_0","pred":"source","obj":"Allie"}]},{"project":"CHEMDNER-training-test","denotations":[{"id":"T1","span":{"begin":173,"end":184},"obj":"TRIVIAL"}],"attributes":[{"subj":"T1","pred":"source","obj":"CHEMDNER-training-test"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":484,"end":493},"obj":"http://purl.obolibrary.org/obo/UBERON_0001987"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":1186,"end":1195},"obj":"http://purl.obolibrary.org/obo/UBERON_0001987"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":227,"end":241},"obj":"http://purl.obolibrary.org/obo/UBERON_0001016"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":759,"end":768},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":61,"end":77},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":557,"end":573},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":710,"end":725},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":821,"end":836},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"PD-UBERON-AE-B_T9","span":{"begin":200,"end":211},"obj":"http://purl.obolibrary.org/obo/UBERON_2000106"},{"id":"PD-UBERON-AE-B_T10","span":{"begin":391,"end":405},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"PD-UBERON-AE-B_T11","span":{"begin":494,"end":506},"obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"PD-UBERON-AE-B_T12","span":{"begin":998,"end":1011},"obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"PD-UBERON-AE-B_T13","span":{"begin":1286,"end":1297},"obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"PD-UBERON-AE-B_T14","span":{"begin":578,"end":598},"obj":"http://purl.obolibrary.org/obo/UBERON_0000371"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T8","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T9","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T10","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T11","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T12","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T13","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T14","pred":"source","obj":"performance-test"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":433,"end":440},"obj":"HP_0002664"},{"id":"T2","span":{"begin":1071,"end":1087},"obj":"HP_0100768"},{"id":"T3","span":{"begin":1298,"end":1304},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":227,"end":234},"obj":"http://purl.bioontology.org/ontology/ICD10/R45.0"}],"attributes":[{"subj":"T1","pred":"source","obj":"ICD10"}]},{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":61,"end":77},"obj":"FMAID:200947"},{"id":"_T2","span":{"begin":61,"end":77},"obj":"FMAID:83039"},{"id":"_T3","span":{"begin":61,"end":77},"obj":"FMAID:197301"},{"id":"_T4","span":{"begin":117,"end":129},"obj":"FMAID:212684"},{"id":"_T5","span":{"begin":117,"end":129},"obj":"FMAID:200942"},{"id":"_T6","span":{"begin":122,"end":129},"obj":"FMAID:50594"},{"id":"_T7","span":{"begin":122,"end":129},"obj":"FMAID:146300"},{"id":"_T8","span":{"begin":227,"end":241},"obj":"FMAID:7157"},{"id":"_T9","span":{"begin":227,"end":241},"obj":"FMAID:93586"},{"id":"_T10","span":{"begin":391,"end":405},"obj":"FMAID:9825"},{"id":"_T11","span":{"begin":391,"end":405},"obj":"FMAID:97740"},{"id":"_T12","span":{"begin":494,"end":506},"obj":"FMAID:197289"},{"id":"_T13","span":{"begin":494,"end":506},"obj":"FMAID:83029"},{"id":"_T14","span":{"begin":557,"end":573},"obj":"FMAID:83039"},{"id":"_T15","span":{"begin":557,"end":573},"obj":"FMAID:197301"},{"id":"_T16","span":{"begin":557,"end":573},"obj":"FMAID:200947"},{"id":"_T17","span":{"begin":578,"end":598},"obj":"FMAID:83040"},{"id":"_T18","span":{"begin":578,"end":598},"obj":"FMAID:83043"},{"id":"_T19","span":{"begin":578,"end":598},"obj":"FMAID:197308"},{"id":"_T20","span":{"begin":578,"end":598},"obj":"FMAID:197302"},{"id":"_T21","span":{"begin":578,"end":598},"obj":"FMAID:197303"},{"id":"_T22","span":{"begin":578,"end":598},"obj":"FMAID:201968"},{"id":"_T23","span":{"begin":710,"end":725},"obj":"FMAID:200947"},{"id":"_T24","span":{"begin":710,"end":725},"obj":"FMAID:83039"},{"id":"_T25","span":{"begin":710,"end":725},"obj":"FMAID:197301"},{"id":"_T26","span":{"begin":759,"end":768},"obj":"FMAID:80224"},{"id":"_T27","span":{"begin":759,"end":768},"obj":"FMAID:188332"},{"id":"_T28","span":{"begin":821,"end":836},"obj":"FMAID:197301"},{"id":"_T29","span":{"begin":821,"end":836},"obj":"FMAID:83039"},{"id":"_T30","span":{"begin":821,"end":836},"obj":"FMAID:200947"},{"id":"_T31","span":{"begin":852,"end":870},"obj":"FMAID:167247"},{"id":"_T32","span":{"begin":852,"end":870},"obj":"FMAID:63872"},{"id":"_T33","span":{"begin":861,"end":870},"obj":"FMAID:30322"},{"id":"_T34","span":{"begin":861,"end":870},"obj":"FMAID:93573"},{"id":"_T35","span":{"begin":861,"end":870},"obj":"FMAID:7145"},{"id":"_T36","span":{"begin":861,"end":870},"obj":"FMAID:167608"},{"id":"_T37","span":{"begin":998,"end":1011},"obj":"FMAID:83029"},{"id":"_T38","span":{"begin":998,"end":1011},"obj":"FMAID:197289"},{"id":"_T39","span":{"begin":1237,"end":1253},"obj":"FMAID:82742"},{"id":"_T40","span":{"begin":1237,"end":1253},"obj":"FMAID:196731"},{"id":"_T41","span":{"begin":1286,"end":1297},"obj":"FMAID:83029"},{"id":"_T42","span":{"begin":1286,"end":1297},"obj":"FMAID:197289"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"attributes":[{"subj":"_T1","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T2","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T3","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T4","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T5","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T6","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T7","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T8","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T9","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T10","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T11","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T12","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T13","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T14","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T15","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T16","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T17","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T18","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T19","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T20","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T21","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T22","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T23","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T24","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T25","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T26","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T27","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T28","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T29","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T30","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T31","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T32","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T33","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T34","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T35","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T36","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T37","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T38","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T39","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T40","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T41","pred":"source","obj":"GlycoBiology-FMA"},{"subj":"_T42","pred":"source","obj":"GlycoBiology-FMA"}]},{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":227,"end":241},"obj":"http://purl.obolibrary.org/obo/MAT_0000026"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-MAT"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":428,"end":432},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/9973"},{"id":"T2","span":{"begin":433,"end":440},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6754"},{"id":"T3","span":{"begin":759,"end":768},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/387016"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":79,"end":194},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":195,"end":343},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":344,"end":441},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":442,"end":556},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":557,"end":692},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":693,"end":784},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":785,"end":904},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":905,"end":1088},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1089,"end":1305},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T2","span":{"begin":79,"end":194},"obj":"Sentence"},{"id":"T3","span":{"begin":195,"end":343},"obj":"Sentence"},{"id":"T4","span":{"begin":344,"end":441},"obj":"Sentence"},{"id":"T5","span":{"begin":442,"end":556},"obj":"Sentence"},{"id":"T6","span":{"begin":557,"end":692},"obj":"Sentence"},{"id":"T7","span":{"begin":693,"end":784},"obj":"Sentence"},{"id":"T8","span":{"begin":785,"end":904},"obj":"Sentence"},{"id":"T9","span":{"begin":905,"end":1088},"obj":"Sentence"},{"id":"T10","span":{"begin":1089,"end":1305},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T2","span":{"begin":79,"end":194},"obj":"Sentence"},{"id":"T3","span":{"begin":195,"end":343},"obj":"Sentence"},{"id":"T4","span":{"begin":344,"end":441},"obj":"Sentence"},{"id":"T5","span":{"begin":442,"end":556},"obj":"Sentence"},{"id":"T6","span":{"begin":557,"end":692},"obj":"Sentence"},{"id":"T7","span":{"begin":693,"end":784},"obj":"Sentence"},{"id":"T8","span":{"begin":785,"end":904},"obj":"Sentence"},{"id":"T9","span":{"begin":905,"end":1088},"obj":"Sentence"},{"id":"T10","span":{"begin":1089,"end":1305},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":272,"end":283},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T2","span":{"begin":370,"end":380},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T3","span":{"begin":297,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0016477"},{"id":"T4","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0010762"},{"id":"T5","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0030335"},{"id":"T6","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0030336"},{"id":"T7","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_1903684"},{"id":"T8","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_2000274"},{"id":"T9","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0002685"},{"id":"T10","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0071675"},{"id":"T11","span":{"begin":297,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_1903975"},{"id":"T12","span":{"begin":316,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T13","span":{"begin":484,"end":493},"obj":"http://purl.obolibrary.org/obo/GO_0001890"},{"id":"T14","span":{"begin":1186,"end":1195},"obj":"http://purl.obolibrary.org/obo/GO_0001890"},{"id":"T15","span":{"begin":777,"end":783},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T16","span":{"begin":986,"end":997},"obj":"http://purl.obolibrary.org/obo/GO_0007565"},{"id":"T17","span":{"begin":1186,"end":1207},"obj":"http://purl.obolibrary.org/obo/GO_0001890"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"},{"subj":"T5","pred":"source","obj":"GO-BP"},{"subj":"T6","pred":"source","obj":"GO-BP"},{"subj":"T7","pred":"source","obj":"GO-BP"},{"subj":"T8","pred":"source","obj":"GO-BP"},{"subj":"T9","pred":"source","obj":"GO-BP"},{"subj":"T10","pred":"source","obj":"GO-BP"},{"subj":"T11","pred":"source","obj":"GO-BP"},{"subj":"T12","pred":"source","obj":"GO-BP"},{"subj":"T13","pred":"source","obj":"GO-BP"},{"subj":"T14","pred":"source","obj":"GO-BP"},{"subj":"T15","pred":"source","obj":"GO-BP"},{"subj":"T16","pred":"source","obj":"GO-BP"},{"subj":"T17","pred":"source","obj":"GO-BP"}]},{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":117,"end":121},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":297,"end":301},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":117,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T4","span":{"begin":852,"end":870},"obj":"http://purl.obolibrary.org/obo/GO_0005604"},{"id":"T5","span":{"begin":861,"end":870},"obj":"http://purl.obolibrary.org/obo/GO_0016020"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-CC"},{"subj":"T2","pred":"source","obj":"GO-CC"},{"subj":"T3","pred":"source","obj":"GO-CC"},{"subj":"T4","pred":"source","obj":"GO-CC"},{"subj":"T5","pred":"source","obj":"GO-CC"}]},{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":61,"end":77},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"T2","span":{"begin":710,"end":725},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"T3","span":{"begin":821,"end":836},"obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"T4","span":{"begin":200,"end":211},"obj":"http://purl.obolibrary.org/obo/UBERON_2000106"},{"id":"T5","span":{"begin":227,"end":241},"obj":"http://purl.obolibrary.org/obo/UBERON_0001016"},{"id":"T6","span":{"begin":391,"end":405},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T7","span":{"begin":494,"end":506},"obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"T8","span":{"begin":998,"end":1011},"obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"T9","span":{"begin":1286,"end":1297},"obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"T10","span":{"begin":578,"end":598},"obj":"http://purl.obolibrary.org/obo/UBERON_0000371"},{"id":"T11","span":{"begin":759,"end":768},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"}],"attributes":[{"subj":"T1","pred":"source","obj":"UBERON-AE"},{"subj":"T2","pred":"source","obj":"UBERON-AE"},{"subj":"T3","pred":"source","obj":"UBERON-AE"},{"subj":"T4","pred":"source","obj":"UBERON-AE"},{"subj":"T5","pred":"source","obj":"UBERON-AE"},{"subj":"T6","pred":"source","obj":"UBERON-AE"},{"subj":"T7","pred":"source","obj":"UBERON-AE"},{"subj":"T8","pred":"source","obj":"UBERON-AE"},{"subj":"T9","pred":"source","obj":"UBERON-AE"},{"subj":"T10","pred":"source","obj":"UBERON-AE"},{"subj":"T11","pred":"source","obj":"UBERON-AE"}]},{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":55,"end":60},"obj":"http://edamontology.org/topic_2815"},{"id":"T2","span":{"begin":212,"end":219},"obj":"http://edamontology.org/topic_3678"},{"id":"T3","span":{"begin":433,"end":440},"obj":"http://edamontology.org/topic_2640"},{"id":"T4","span":{"begin":450,"end":455},"obj":"http://edamontology.org/topic_3678"},{"id":"T5","span":{"begin":478,"end":483},"obj":"http://edamontology.org/topic_2815"},{"id":"T6","span":{"begin":701,"end":709},"obj":"http://edamontology.org/topic_1312"},{"id":"T7","span":{"begin":701,"end":709},"obj":"http://edamontology.org/topic_0111"},{"id":"T8","span":{"begin":701,"end":709},"obj":"http://edamontology.org/topic_0749"},{"id":"T9","span":{"begin":1012,"end":1020},"obj":"http://edamontology.org/topic_0634"},{"id":"T10","span":{"begin":1180,"end":1185},"obj":"http://edamontology.org/topic_2815"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-topics"},{"subj":"T2","pred":"source","obj":"EDAM-topics"},{"subj":"T3","pred":"source","obj":"EDAM-topics"},{"subj":"T4","pred":"source","obj":"EDAM-topics"},{"subj":"T5","pred":"source","obj":"EDAM-topics"},{"subj":"T6","pred":"source","obj":"EDAM-topics"},{"subj":"T7","pred":"source","obj":"EDAM-topics"},{"subj":"T8","pred":"source","obj":"EDAM-topics"},{"subj":"T9","pred":"source","obj":"EDAM-topics"},{"subj":"T10","pred":"source","obj":"EDAM-topics"}]},{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":185,"end":193},"obj":"http://edamontology.org/data_1756"},{"id":"T2","span":{"begin":357,"end":366},"obj":"http://edamontology.org/operation_0004"},{"id":"T3","span":{"begin":460,"end":472},"obj":"http://edamontology.org/operation_2246"},{"id":"T4","span":{"begin":1103,"end":1115},"obj":"http://edamontology.org/operation_2246"},{"id":"T5","span":{"begin":1173,"end":1179},"obj":"http://edamontology.org/operation_3435"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-DFO"},{"subj":"T2","pred":"source","obj":"EDAM-DFO"},{"subj":"T3","pred":"source","obj":"EDAM-DFO"},{"subj":"T4","pred":"source","obj":"EDAM-DFO"},{"subj":"T5","pred":"source","obj":"EDAM-DFO"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":55,"end":60},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":478,"end":483},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1180,"end":1185},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"id":"A3","pred":"db_id","subj":"T3","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":986,"end":1020},"obj":"Disease"},{"id":"T4","span":{"begin":1039,"end":1056},"obj":"Disease"},{"id":"T6","span":{"begin":1071,"end":1087},"obj":"Disease"},{"id":"T7","span":{"begin":1286,"end":1304},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0009273"},{"id":"A2","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0016784"},{"id":"A3","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0018944"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0006248"},{"id":"A5","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0018944"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005207"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0002872"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T6","pred":"source","obj":"mondo_disease"},{"subj":"T7","pred":"source","obj":"mondo_disease"}]},{"project":"Glycan-Motif","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T2","span":{"begin":79,"end":94},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T3","span":{"begin":96,"end":103},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T4","span":{"begin":173,"end":184},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T5","span":{"begin":609,"end":616},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T6","span":{"begin":929,"end":936},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T7","span":{"begin":1158,"end":1165},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycan-Motif"},{"subj":"T2","pred":"source","obj":"Glycan-Motif"},{"subj":"T3","pred":"source","obj":"Glycan-Motif"},{"subj":"T4","pred":"source","obj":"Glycan-Motif"},{"subj":"T5","pred":"source","obj":"Glycan-Motif"},{"subj":"T6","pred":"source","obj":"Glycan-Motif"},{"subj":"T7","pred":"source","obj":"Glycan-Motif"}]},{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T2","span":{"begin":79,"end":94},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"},{"id":"T3","span":{"begin":173,"end":184},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":227,"end":241},"obj":"http://purl.obolibrary.org/obo/MAT_0000026"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":79,"end":94},"obj":"Glycan_Motif"},{"id":"T3","span":{"begin":96,"end":103},"obj":"Glycan_Motif"},{"id":"T4","span":{"begin":173,"end":184},"obj":"Glycan_Motif"},{"id":"T5","span":{"begin":609,"end":616},"obj":"Glycan_Motif"},{"id":"T6","span":{"begin":929,"end":936},"obj":"Glycan_Motif"},{"id":"T7","span":{"begin":1158,"end":1165},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO"},{"id":"A3","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO"},{"id":"A4","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A5","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO"},{"id":"A6","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO"},{"id":"A7","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO"},{"subj":"T1","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T5","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T6","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T7","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":227,"end":241},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000026"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T3","span":{"begin":391,"end":405},"obj":"Body_part"},{"id":"T4","span":{"begin":494,"end":506},"obj":"Body_part"},{"id":"T5","span":{"begin":557,"end":573},"obj":"Body_part"},{"id":"T6","span":{"begin":578,"end":598},"obj":"Body_part"},{"id":"T7","span":{"begin":710,"end":725},"obj":"Body_part"},{"id":"T8","span":{"begin":759,"end":776},"obj":"Body_part"},{"id":"T9","span":{"begin":821,"end":836},"obj":"Body_part"},{"id":"T10","span":{"begin":852,"end":870},"obj":"Body_part"},{"id":"T12","span":{"begin":998,"end":1011},"obj":"Body_part"},{"id":"T13","span":{"begin":1039,"end":1044},"obj":"Body_part"},{"id":"T14","span":{"begin":1286,"end":1297},"obj":"Body_part"},{"id":"T1","span":{"begin":61,"end":77},"obj":"Body_part"},{"id":"T2","span":{"begin":227,"end":241},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001016"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000371"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0007106"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000319"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/GO_0005604"},{"id":"A11","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0005769"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0003655"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000088"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T8","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T9","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T10","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T12","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T13","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T14","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":1071,"end":1087},"obj":"Phenotype"},{"id":"T2","span":{"begin":1286,"end":1304},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0100768"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0031502"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93ece8","default":true},{"id":"CHEMDNER-training-test","color":"#ecce93"},{"id":"performance-test","color":"#b493ec"},{"id":"PubmedHPO","color":"#93ec9a"},{"id":"ICD10","color":"#ec93a5"},{"id":"GlycoBiology-FMA","color":"#93bfec"},{"id":"GlycoBiology-MAT","color":"#d9ec93"},{"id":"GlycoBiology-NCBITAXON","color":"#e593ec"},{"id":"sentences","color":"#93eccb"},{"id":"GO-BP","color":"#ecb193"},{"id":"GO-CC","color":"#9793ec"},{"id":"UBERON-AE","color":"#a9ec93"},{"id":"EDAM-topics","color":"#ec93c3"},{"id":"EDAM-DFO","color":"#93ddec"},{"id":"NCBITAXON","color":"#ece193"},{"id":"mondo_disease","color":"#c793ec"},{"id":"Glycan-Motif","color":"#93ecad"},{"id":"GlyCosmos6-Glycan-Motif-Structure","color":"#ec9393"},{"id":"Glycosmos6-MAT","color":"#93adec"},{"id":"GlyCosmos6-Glycan-Motif-Image","color":"#c7ec93"},{"id":"Anatomy-MAT","color":"#ec93e1"},{"id":"Anatomy-UBERON","color":"#93ecdd"},{"id":"HP-phenotype","color":"#ecc393"}]}]}}