PubMed:23083294 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23083294","sourcedb":"PubMed","sourceid":"23083294","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23083294","text":"Association of HLA locus variant in Parkinson's disease.\nA variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.62, 0.96, p = 0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23083294_1_0","span":{"begin":86,"end":115},"obj":"expanded"},{"id":"SS2_23083294_1_0","span":{"begin":117,"end":121},"obj":"abbr"},{"id":"SS1_23083294_1_1","span":{"begin":146,"end":169},"obj":"expanded"},{"id":"SS2_23083294_1_1","span":{"begin":171,"end":174},"obj":"abbr"},{"id":"SS1_23083294_1_2","span":{"begin":246,"end":265},"obj":"expanded"},{"id":"SS2_23083294_1_2","span":{"begin":267,"end":269},"obj":"abbr"},{"id":"SS1_23083294_5_0","span":{"begin":744,"end":754},"obj":"expanded"},{"id":"SS2_23083294_5_0","span":{"begin":756,"end":758},"obj":"abbr"},{"id":"SS1_23083294_5_1","span":{"begin":772,"end":791},"obj":"expanded"},{"id":"SS2_23083294_5_1","span":{"begin":793,"end":795},"obj":"abbr"}],"relations":[{"id":"AE1_23083294_1_0","pred":"abbreviatedTo","subj":"SS1_23083294_1_0","obj":"SS2_23083294_1_0"},{"id":"AE1_23083294_1_1","pred":"abbreviatedTo","subj":"SS1_23083294_1_1","obj":"SS2_23083294_1_1"},{"id":"AE1_23083294_1_2","pred":"abbreviatedTo","subj":"SS1_23083294_1_2","obj":"SS2_23083294_1_2"},{"id":"AE1_23083294_5_0","pred":"abbreviatedTo","subj":"SS1_23083294_5_0","obj":"SS2_23083294_5_0"},{"id":"AE1_23083294_5_1","pred":"abbreviatedTo","subj":"SS1_23083294_5_1","obj":"SS2_23083294_5_1"}],"attributes":[{"subj":"SS1_23083294_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_23083294_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_23083294_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_23083294_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_23083294_1_2","pred":"source","obj":"Allie"},{"subj":"SS2_23083294_1_2","pred":"source","obj":"Allie"},{"subj":"SS1_23083294_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_23083294_5_0","pred":"source","obj":"Allie"},{"subj":"SS1_23083294_5_1","pred":"source","obj":"Allie"},{"subj":"SS2_23083294_5_1","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":246,"end":255},"obj":"HP_0001300"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"23083294-1#11#20#geners3129882","span":{"begin":68,"end":77},"obj":"geners3129882"},{"id":"23083294-1#189#208#diseaseC0030567","span":{"begin":246,"end":265},"obj":"diseaseC0030567"},{"id":"23083294-1#210#212#diseaseC0030567","span":{"begin":267,"end":269},"obj":"diseaseC0030567"}],"relations":[{"id":"11#20#geners3129882189#208#diseaseC0030567","pred":"associated_with","subj":"23083294-1#11#20#geners3129882","obj":"23083294-1#189#208#diseaseC0030567"},{"id":"11#20#geners3129882210#212#diseaseC0030567","pred":"associated_with","subj":"23083294-1#11#20#geners3129882","obj":"23083294-1#210#212#diseaseC0030567"}],"attributes":[{"subj":"23083294-1#11#20#geners3129882","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"23083294-1#189#208#diseaseC0030567","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"23083294-1#210#212#diseaseC0030567","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":56},"obj":"Sentence"},{"id":"T2","span":{"begin":57,"end":295},"obj":"Sentence"},{"id":"T3","span":{"begin":296,"end":330},"obj":"Sentence"},{"id":"T4","span":{"begin":331,"end":494},"obj":"Sentence"},{"id":"T5","span":{"begin":495,"end":588},"obj":"Sentence"},{"id":"T6","span":{"begin":589,"end":822},"obj":"Sentence"},{"id":"T7","span":{"begin":823,"end":1009},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":56},"obj":"Sentence"},{"id":"T2","span":{"begin":57,"end":295},"obj":"Sentence"},{"id":"T3","span":{"begin":296,"end":330},"obj":"Sentence"},{"id":"T4","span":{"begin":331,"end":494},"obj":"Sentence"},{"id":"T5","span":{"begin":495,"end":588},"obj":"Sentence"},{"id":"T6","span":{"begin":589,"end":822},"obj":"Sentence"},{"id":"T7","span":{"begin":823,"end":1009},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"17","span":{"begin":68,"end":77},"obj":"SNP"},{"id":"22","span":{"begin":360,"end":369},"obj":"SNP"},{"id":"24","span":{"begin":499,"end":508},"obj":"SNP"}],"attributes":[{"id":"A17","pred":"resolved_to","subj":"17","obj":"tmVar:rs3129882;VariantGroup:0;CorrespondingGene:3122;RS#:3129882;CorrespondingSpecies:9606"},{"i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