PubMed:23012375 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23012375","sourcedb":"PubMed","sourceid":"23012375","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23012375","text":"Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients.\nCardiovascular disease is the leading cause of morbidity/mortality in patients with type 2 diabetes mellitus (T2DM), but there is a lack of knowledge about the mechanism(s) of increased atherosclerosis in these patients. In patients with T2DM, the prevalence of 25-hydroxy vitamin D (25(OH)D) deficiency is almost twice that for nondiabetics and doubles the relative risk of developing cardiovascular disease compared with diabetic patients with normal 25(OH)D. We tested the hypothesis that monocytes from vitamin D-deficient subjects will have a proatherogenic phenotype compared with vitamin D-sufficient subjects in 43 patients with T2DM. Serum 25(OH)D level inversely correlated with monocyte adhesion to endothelial cells even after adjustment for demographic and comorbidity characteristics. Vitamin D-sufficient patients (≥30 ng/ml 25(OH)D) had lower monocyte endoplasmic reticulum (ER) stress, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of monocyte adhesion molecules PSGL-1, β(1)-integrin, and β(2)-integrin compared with patients with 25(OH)D levels of \u003c30 ng/ml. In vitamin D-deficient macrophages, activation of ER stress increased adhesion and adhesion molecule expression and induced an M2-predominant phenotype. Moreover, adding 1,25(OH)(2)D(3) to vitamin D-deficient macrophages shifted their phenotype toward an M1-predominant phenotype with suppressed adhesion. Conversely, deletion of the vitamin D receptor in macrophages from diabetic patients activated ER stress, accelerated adhesion, and increased adhesion molecule expression. The absence of ER stress protein CCAAT enhancer-binding protein homologous protein suppressed monocyte adhesion, adhesion molecule expression, and the M2-predominant phenotype induced by vitamin D deficiency. Thus, vitamin D is a natural ER stress reliever that induced an antiatherogenic monocyte/macrophage phenotype.","tracks":[{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"3","span":{"begin":0,"end":9},"obj":"ChemicalEntity"},{"id":"4","span":{"begin":122,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5","span":{"begin":131,"end":139},"obj":"OrganismTaxon"},{"id":"32","span":{"begin":141,"end":163},"obj":"DiseaseOrPhenotypicFeature"},{"id":"33","span":{"begin":211,"end":219},"obj":"OrganismTaxon"},{"id":"34","span":{"begin":225,"end":249},"obj":"DiseaseOrPhenotypicFeature"},{"id":"35","span":{"begin":327,"end":342},"obj":"DiseaseOrPhenotypicFeature"},{"id":"36","span":{"begin":352,"end":360},"obj":"OrganismTaxon"},{"id":"37","span":{"begin":365,"end":373},"obj":"OrganismTaxon"},{"id":"38","span":{"begin":403,"end":423},"obj":"ChemicalEntity"},{"id":"39","span":{"begin":527,"end":549},"obj":"DiseaseOrPhenotypicFeature"},{"id":"40","span":{"begin":564,"end":572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"41","span":{"begin":573,"end":581},"obj":"OrganismTaxon"},{"id":"42","span":{"begin":648,"end":657},"obj":"ChemicalEntity"},{"id":"43","span":{"begin":728,"end":737},"obj":"ChemicalEntity"},{"id":"44","span":{"begin":764,"end":772},"obj":"OrganismTaxon"},{"id":"45","span":{"begin":790,"end":797},"obj":"ChemicalEntity"},{"id":"46","span":{"begin":940,"end":949},"obj":"ChemicalEntity"},{"id":"47","span":{"begin":961,"end":969},"obj":"OrganismTaxon"},{"id":"48","span":{"begin":1165,"end":1171},"obj":"GeneOrGeneProduct"},{"id":"49","span":{"begin":1173,"end":1186},"obj":"GeneOrGeneProduct"},{"id":"50","span":{"begin":1220,"end":1228},"obj":"OrganismTaxon"},{"id":"51","span":{"begin":1266,"end":1275},"obj":"ChemicalEntity"},{"id":"52","span":{"begin":1452,"end":1461},"obj":"ChemicalEntity"},{"id":"53","span":{"begin":1597,"end":1615},"obj":"GeneOrGeneProduct"},{"id":"54","span":{"begin":1636,"end":1644},"obj":"DiseaseOrPhenotypicFeature"},{"id":"55","span":{"begin":1645,"end":1653},"obj":"OrganismTaxon"},{"id":"56","span":{"begin":1928,"end":1937},"obj":"ChemicalEntity"},{"id":"57","span":{"begin":1956,"end":1965},"obj":"ChemicalEntity"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D014807"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D003920"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:9606"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D002318"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:9606"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D003924"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D050197"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Tax:9606"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"Tax:9606"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:C104450"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D002318"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:D003920"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"Tax:9606"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"MESH:D014807"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D014807"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"Tax:9606"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:D014807"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Tax:9606"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Gene:6404"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Gene:3688"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Tax:9606"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"MESH:D014807"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"MESH:D014807"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Gene:7421"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"MESH:D003920"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:9606"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"MESH:D014807"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"MESH:D014807"},{"subj":"3","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"4","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"5","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"32","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"33","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"34","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"35","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"36","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"37","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"38","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"39","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"40","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"41","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"42","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"43","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"44","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"45","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"46","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"47","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"48","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"49","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"50","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"51","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"52","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"53","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"54","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"55","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"56","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"57","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-Disease-Tuning-1","denotations":[{"id":"T1","span":{"begin":115,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":141,"end":163},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":225,"end":249},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":251,"end":255},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":327,"end":342},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":379,"end":383},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":527,"end":549},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":564,"end":572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":648,"end":667},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":778,"end":782},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1266,"end":1285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1452,"end":1471},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1636,"end":1644},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1928,"end":1948},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A14","pred":"ID:","subj":"T14","obj":"D014808"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D002318"},{"id":"A10","pred":"ID:","subj":"T10","obj":"DISEASE"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D003924"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D002318"},{"id":"A8","pred":"ID:","subj":"T8","obj":"DISEASE"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D014808"},{"id":"A13","pred":"ID:","subj":"T13","obj":"DISEASE"},{"id":"A4","pred":"ID:","subj":"T4","obj":"DISEASE"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D003924"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D014808"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D014808"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D050197"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T9","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T10","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T11","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T12","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T13","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T14","pred":"source","obj":"LitCoin-Disease-Tuning-1"}]},{"project":"LitCoin-PubTator-for-Tuning-SeqVar","denotations":[{"id":"T1","span":{"begin":1581,"end":1596},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-PubTator-for-Tuning-SeqVar"}]},{"project":"LitEisuke","denotations":[{"id":"T1","span":{"begin":115,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":141,"end":163},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":225,"end":249},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":251,"end":255},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":327,"end":342},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":379,"end":383},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":527,"end":549},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":564,"end":572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":648,"end":667},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":778,"end":782},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1266,"end":1285},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1452,"end":1471},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1636,"end":1644},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1928,"end":1948},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D003924"},{"id":"A2","pred":"#label","subj":"T2","obj":"D002318"},{"id":"A3","pred":"#label","subj":"T3","obj":"D003924"},{"id":"A4","pred":"#label","subj":"T4","obj":"DISEASE"},{"id":"A5","pred":"#label","subj":"T5","obj":"D050197"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"#label","subj":"T7","obj":"D002318"},{"id":"A8","pred":"#label","subj":"T8","obj":"DISEASE"},{"id":"A9","pred":"#label","subj":"T9","obj":"D014808"},{"id":"A10","pred":"#label","subj":"T10","obj":"DISEASE"},{"id":"A11","pred":"#label","subj":"T11","obj":"D014808"},{"id":"A12","pred":"#label","subj":"T12","obj":"D014808"},{"id":"A13","pred":"#label","subj":"T13","obj":"DISEASE"},{"id":"A14","pred":"#label","subj":"T14","obj":"D014808"},{"subj":"T1","pred":"source","obj":"LitEisuke"},{"subj":"T2","pred":"source","obj":"LitEisuke"},{"subj":"T3","pred":"source","obj":"LitEisuke"},{"subj":"T4","pred":"source","obj":"LitEisuke"},{"subj":"T5","pred":"source","obj":"LitEisuke"},{"subj":"T6","pred":"source","obj":"LitEisuke"},{"subj":"T7","pred":"source","obj":"LitEisuke"},{"subj":"T8","pred":"source","obj":"LitEisuke"},{"subj":"T9","pred":"source","obj":"LitEisuke"},{"subj":"T10","pred":"source","obj":"LitEisuke"},{"subj":"T11","pred":"source","obj":"LitEisuke"},{"subj":"T12","pred":"source","obj":"LitEisuke"},{"subj":"T13","pred":"source","obj":"LitEisuke"},{"subj":"T14","pred":"source","obj":"LitEisuke"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":140},"obj":"Sentence"},{"id":"T2","span":{"begin":141,"end":361},"obj":"Sentence"},{"id":"T3","span":{"begin":362,"end":602},"obj":"Sentence"},{"id":"T4","span":{"begin":603,"end":783},"obj":"Sentence"},{"id":"T5","span":{"begin":784,"end":939},"obj":"Sentence"},{"id":"T6","span":{"begin":940,"end":1262},"obj":"Sentence"},{"id":"T7","span":{"begin":1263,"end":1415},"obj":"Sentence"},{"id":"T8","span":{"begin":1416,"end":1568},"obj":"Sentence"},{"id":"T9","span":{"begin":1569,"end":1740},"obj":"Sentence"},{"id":"T10","span":{"begin":1741,"end":1949},"obj":"Sentence"},{"id":"T11","span":{"begin":1950,"end":2060},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"}]},{"project":"Allie","denotations":[{"id":"SS1_23012375_1_0","span":{"begin":225,"end":249},"obj":"expanded"},{"id":"SS2_23012375_1_0","span":{"begin":251,"end":255},"obj":"abbr"},{"id":"SS1_23012375_5_0","span":{"begin":1009,"end":1030},"obj":"expanded"},{"id":"SS2_23012375_5_0","span":{"begin":1032,"end":1034},"obj":"abbr"}],"relations":[{"id":"AE1_23012375_1_0","pred":"abbreviatedTo","subj":"SS1_23012375_1_0","obj":"SS2_23012375_1_0"},{"id":"AE1_23012375_5_0","pred":"abbreviatedTo","subj":"SS1_23012375_5_0","obj":"SS2_23012375_5_0"}],"attributes":[{"subj":"SS1_23012375_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_23012375_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_23012375_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_23012375_5_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":232,"end":249},"obj":"HP_0000819"},{"id":"T2","span":{"begin":327,"end":342},"obj":"HP_0002621"},{"id":"T3","span":{"begin":648,"end":667},"obj":"HP_0100512"},{"id":"T4","span":{"begin":1266,"end":1285},"obj":"HP_0100512"},{"id":"T5","span":{"begin":1452,"end":1471},"obj":"HP_0100512"},{"id":"T6","span":{"begin":1928,"end":1948},"obj":"HP_0100512"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":115,"end":130},"obj":"Disease"},{"id":"T2","span":{"begin":141,"end":163},"obj":"Disease"},{"id":"T3","span":{"begin":225,"end":249},"obj":"Disease"},{"id":"T4","span":{"begin":327,"end":342},"obj":"Disease"},{"id":"T5","span":{"begin":527,"end":549},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005148"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005148"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005311"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"}]},{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":115,"end":130},"obj":"Phenotype"},{"id":"T2","span":{"begin":141,"end":163},"obj":"Phenotype"},{"id":"T3","span":{"begin":232,"end":249},"obj":"Phenotype"},{"id":"T4","span":{"begin":327,"end":342},"obj":"Phenotype"},{"id":"T5","span":{"begin":527,"end":549},"obj":"Phenotype"},{"id":"T6","span":{"begin":648,"end":667},"obj":"Phenotype"},{"id":"T7","span":{"begin":1266,"end":1285},"obj":"Phenotype"},{"id":"T8","span":{"begin":1452,"end":1471},"obj":"Phenotype"},{"id":"T9","span":{"begin":1928,"end":1948},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0005978"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0001626"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0000819"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0002621"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"HP:0001626"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"HP:0100512"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"HP:0100512"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"HP:0100512"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"HP:0100512"},{"subj":"T1","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T2","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T3","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T4","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T5","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T6","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T7","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T8","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T9","pred":"source","obj":"GlyCosmos15-HP"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":37,"end":46},"obj":"Body_part"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Body_part"},{"id":"T4","span":{"begin":91,"end":101},"obj":"Body_part"},{"id":"T5","span":{"begin":633,"end":642},"obj":"Body_part"},{"id":"T7","span":{"begin":830,"end":838},"obj":"Body_part"},{"id":"T9","span":{"begin":851,"end":868},"obj":"Body_part"},{"id":"T10","span":{"begin":1000,"end":1008},"obj":"Body_part"},{"id":"T12","span":{"begin":1021,"end":1030},"obj":"Body_part"},{"id":"T13","span":{"begin":1073,"end":1083},"obj":"Body_part"},{"id":"T14","span":{"begin":1084,"end":1092},"obj":"Body_part"},{"id":"T17","span":{"begin":1137,"end":1145},"obj":"Body_part"},{"id":"T19","span":{"begin":1286,"end":1297},"obj":"Body_part"},{"id":"T20","span":{"begin":1472,"end":1483},"obj":"Body_part"},{"id":"T21","span":{"begin":1619,"end":1630},"obj":"Body_part"},{"id":"T22","span":{"begin":1835,"end":1843},"obj":"Body_part"},{"id":"T24","span":{"begin":2030,"end":2038},"obj":"Body_part"},{"id":"T26","span":{"begin":2039,"end":2049},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0007361"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A3","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A6","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A8","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A11","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0007361"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A15","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000094"},{"id":"A16","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A18","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A23","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A25","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T9","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T10","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T12","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T13","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T14","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T17","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T19","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T20","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T21","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T22","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T24","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T26","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"Glycosmos15-CL","denotations":[{"id":"T1","span":{"begin":82,"end":90},"obj":"Cell"},{"id":"T3","span":{"begin":91,"end":101},"obj":"Cell"},{"id":"T5","span":{"begin":633,"end":642},"obj":"Cell"},{"id":"T7","span":{"begin":830,"end":838},"obj":"Cell"},{"id":"T9","span":{"begin":851,"end":868},"obj":"Cell"},{"id":"T10","span":{"begin":1000,"end":1008},"obj":"Cell"},{"id":"T12","span":{"begin":1070,"end":1083},"obj":"Cell"},{"id":"T13","span":{"begin":1073,"end":1083},"obj":"Cell"},{"id":"T15","span":{"begin":1137,"end":1145},"obj":"Cell"},{"id":"T17","span":{"begin":1286,"end":1297},"obj":"Cell"},{"id":"T19","span":{"begin":1472,"end":1483},"obj":"Cell"},{"id":"T21","span":{"begin":1619,"end":1630},"obj":"Cell"},{"id":"T23","span":{"begin":1835,"end":1843},"obj":"Cell"},{"id":"T25","span":{"begin":2030,"end":2038},"obj":"Cell"},{"id":"T27","span":{"begin":2039,"end":2049},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A6","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A8","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000115"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A11","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A12","pred":"cl_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL:0000890"},{"id":"A13","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A14","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A15","pred":"cl_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A16","pred":"cl_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A17","pred":"cl_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A18","pred":"cl_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A19","pred":"cl_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A20","pred":"cl_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A21","pred":"cl_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A22","pred":"cl_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A23","pred":"cl_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A24","pred":"cl_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A25","pred":"cl_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A26","pred":"cl_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A27","pred":"cl_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A28","pred":"cl_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"subj":"T1","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T3","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T5","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T7","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T9","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T10","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T12","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T13","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T15","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T17","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T19","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T21","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T23","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T25","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T27","pred":"source","obj":"Glycosmos15-CL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-PubTator-for-Tuning","color":"#93ecca","default":true},{"id":"LitCoin-Disease-Tuning-1","color":"#ecb093"},{"id":"LitCoin-PubTator-for-Tuning-SeqVar","color":"#9693ec"},{"id":"LitEisuke","color":"#a9ec93"},{"id":"sentences","color":"#ec93c3"},{"id":"Allie","color":"#93ddec"},{"id":"PubmedHPO","color":"#ece093"},{"id":"mondo_disease","color":"#c693ec"},{"id":"GlyCosmos15-HP","color":"#93ecac"},{"id":"Anatomy-UBERON","color":"#ec9393"},{"id":"Glycosmos15-CL","color":"#93adec"}]}]}}