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PubMed:23012375 JSONTXT

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LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
3 0-9 ChemicalEntity denotes Vitamin D MESH:D014807
4 122-130 DiseaseOrPhenotypicFeature denotes diabetic MESH:D003920
5 131-139 OrganismTaxon denotes patients Tax:9606
32 141-163 DiseaseOrPhenotypicFeature denotes Cardiovascular disease MESH:D002318
33 211-219 OrganismTaxon denotes patients Tax:9606
34 225-249 DiseaseOrPhenotypicFeature denotes type 2 diabetes mellitus MESH:D003924
35 327-342 DiseaseOrPhenotypicFeature denotes atherosclerosis MESH:D050197
36 352-360 OrganismTaxon denotes patients Tax:9606
37 365-373 OrganismTaxon denotes patients Tax:9606
38 403-423 ChemicalEntity denotes 25-hydroxy vitamin D MESH:C104450
39 527-549 DiseaseOrPhenotypicFeature denotes cardiovascular disease MESH:D002318
40 564-572 DiseaseOrPhenotypicFeature denotes diabetic MESH:D003920
41 573-581 OrganismTaxon denotes patients Tax:9606
42 648-657 ChemicalEntity denotes vitamin D MESH:D014807
43 728-737 ChemicalEntity denotes vitamin D MESH:D014807
44 764-772 OrganismTaxon denotes patients Tax:9606
45 790-797 ChemicalEntity denotes 25(OH)D
46 940-949 ChemicalEntity denotes Vitamin D MESH:D014807
47 961-969 OrganismTaxon denotes patients Tax:9606
48 1165-1171 GeneOrGeneProduct denotes PSGL-1 Gene:6404
49 1173-1186 GeneOrGeneProduct denotes β(1)-integrin Gene:3688
50 1220-1228 OrganismTaxon denotes patients Tax:9606
51 1266-1275 ChemicalEntity denotes vitamin D MESH:D014807
52 1452-1461 ChemicalEntity denotes vitamin D MESH:D014807
53 1597-1615 GeneOrGeneProduct denotes vitamin D receptor Gene:7421
54 1636-1644 DiseaseOrPhenotypicFeature denotes diabetic MESH:D003920
55 1645-1653 OrganismTaxon denotes patients Tax:9606
56 1928-1937 ChemicalEntity denotes vitamin D MESH:D014807
57 1956-1965 ChemicalEntity denotes vitamin D MESH:D014807

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 115-130 DiseaseOrPhenotypicFeature denotes type 2 diabetic D003924
T2 141-163 DiseaseOrPhenotypicFeature denotes Cardiovascular disease D002318
T3 225-249 DiseaseOrPhenotypicFeature denotes type 2 diabetes mellitus D003924
T4 251-255 DiseaseOrPhenotypicFeature denotes T2DM DISEASE
T5 327-342 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T6 379-383 DiseaseOrPhenotypicFeature denotes T2DM DISEASE
T7 527-549 DiseaseOrPhenotypicFeature denotes cardiovascular disease D002318
T8 564-572 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T9 648-667 DiseaseOrPhenotypicFeature denotes vitamin D-deficient D014808
T10 778-782 DiseaseOrPhenotypicFeature denotes T2DM DISEASE
T11 1266-1285 DiseaseOrPhenotypicFeature denotes vitamin D-deficient D014808
T12 1452-1471 DiseaseOrPhenotypicFeature denotes vitamin D-deficient D014808
T13 1636-1644 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T14 1928-1948 DiseaseOrPhenotypicFeature denotes vitamin D deficiency D014808

LitCoin-PubTator-for-Tuning-SeqVar

Id Subject Object Predicate Lexical cue
T1 1581-1596 SequenceVariant denotes deletion of the

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 115-130 DiseaseOrPhenotypicFeature denotes type 2 diabetic D003924
T2 141-163 DiseaseOrPhenotypicFeature denotes Cardiovascular disease D002318
T3 225-249 DiseaseOrPhenotypicFeature denotes type 2 diabetes mellitus D003924
T4 251-255 DiseaseOrPhenotypicFeature denotes T2DM DISEASE
T5 327-342 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T6 379-383 DiseaseOrPhenotypicFeature denotes T2DM DISEASE
T7 527-549 DiseaseOrPhenotypicFeature denotes cardiovascular disease D002318
T8 564-572 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T9 648-667 DiseaseOrPhenotypicFeature denotes vitamin D-deficient D014808
T10 778-782 DiseaseOrPhenotypicFeature denotes T2DM DISEASE
T11 1266-1285 DiseaseOrPhenotypicFeature denotes vitamin D-deficient D014808
T12 1452-1471 DiseaseOrPhenotypicFeature denotes vitamin D-deficient D014808
T13 1636-1644 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T14 1928-1948 DiseaseOrPhenotypicFeature denotes vitamin D deficiency D014808

sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients.
T2 141-361 Sentence denotes Cardiovascular disease is the leading cause of morbidity/mortality in patients with type 2 diabetes mellitus (T2DM), but there is a lack of knowledge about the mechanism(s) of increased atherosclerosis in these patients.
T3 362-602 Sentence denotes In patients with T2DM, the prevalence of 25-hydroxy vitamin D (25(OH)D) deficiency is almost twice that for nondiabetics and doubles the relative risk of developing cardiovascular disease compared with diabetic patients with normal 25(OH)D.
T4 603-783 Sentence denotes We tested the hypothesis that monocytes from vitamin D-deficient subjects will have a proatherogenic phenotype compared with vitamin D-sufficient subjects in 43 patients with T2DM.
T5 784-939 Sentence denotes Serum 25(OH)D level inversely correlated with monocyte adhesion to endothelial cells even after adjustment for demographic and comorbidity characteristics.
T6 940-1262 Sentence denotes Vitamin D-sufficient patients (≥30 ng/ml 25(OH)D) had lower monocyte endoplasmic reticulum (ER) stress, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of monocyte adhesion molecules PSGL-1, β(1)-integrin, and β(2)-integrin compared with patients with 25(OH)D levels of <30 ng/ml.
T7 1263-1415 Sentence denotes In vitamin D-deficient macrophages, activation of ER stress increased adhesion and adhesion molecule expression and induced an M2-predominant phenotype.
T8 1416-1568 Sentence denotes Moreover, adding 1,25(OH)(2)D(3) to vitamin D-deficient macrophages shifted their phenotype toward an M1-predominant phenotype with suppressed adhesion.
T9 1569-1740 Sentence denotes Conversely, deletion of the vitamin D receptor in macrophages from diabetic patients activated ER stress, accelerated adhesion, and increased adhesion molecule expression.
T10 1741-1949 Sentence denotes The absence of ER stress protein CCAAT enhancer-binding protein homologous protein suppressed monocyte adhesion, adhesion molecule expression, and the M2-predominant phenotype induced by vitamin D deficiency.
T11 1950-2060 Sentence denotes Thus, vitamin D is a natural ER stress reliever that induced an antiatherogenic monocyte/macrophage phenotype.

Allie

Id Subject Object Predicate Lexical cue
SS1_23012375_1_0 225-249 expanded denotes type 2 diabetes mellitus
SS2_23012375_1_0 251-255 abbr denotes T2DM
SS1_23012375_5_0 1009-1030 expanded denotes endoplasmic reticulum
SS2_23012375_5_0 1032-1034 abbr denotes ER
AE1_23012375_1_0 SS1_23012375_1_0 SS2_23012375_1_0 abbreviatedTo type 2 diabetes mellitus,T2DM
AE1_23012375_5_0 SS1_23012375_5_0 SS2_23012375_5_0 abbreviatedTo endoplasmic reticulum,ER

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 232-249 HP_0000819 denotes diabetes mellitus
T2 327-342 HP_0002621 denotes atherosclerosis
T3 648-667 HP_0100512 denotes vitamin D-deficient
T4 1266-1285 HP_0100512 denotes vitamin D-deficient
T5 1452-1471 HP_0100512 denotes vitamin D-deficient
T6 1928-1948 HP_0100512 denotes vitamin D deficiency

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 115-130 Disease denotes type 2 diabetic http://purl.obolibrary.org/obo/MONDO_0005148
T2 141-163 Disease denotes Cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T3 225-249 Disease denotes type 2 diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005148
T4 327-342 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T5 527-549 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 115-130 Phenotype denotes type 2 diabetic HP:0005978
T2 141-163 Phenotype denotes Cardiovascular disease HP:0001626
T3 232-249 Phenotype denotes diabetes mellitus HP:0000819
T4 327-342 Phenotype denotes atherosclerosis HP:0002621
T5 527-549 Phenotype denotes cardiovascular disease HP:0001626
T6 648-667 Phenotype denotes vitamin D-deficient HP:0100512
T7 1266-1285 Phenotype denotes vitamin D-deficient HP:0100512
T8 1452-1471 Phenotype denotes vitamin D-deficient HP:0100512
T9 1928-1948 Phenotype denotes vitamin D deficiency HP:0100512

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 37-46 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 82-90 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 91-101 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T5 633-642 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T7 830-838 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T9 851-868 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T10 1000-1008 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T12 1021-1030 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T13 1073-1083 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T14 1084-1092 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T17 1137-1145 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T19 1286-1297 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T20 1472-1483 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T21 1619-1630 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T22 1835-1843 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T24 2030-2038 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T26 2039-2049 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 82-90 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 91-101 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 633-642 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T7 830-838 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T9 851-868 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T10 1000-1008 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T12 1070-1083 Cell denotes M2 macrophage http://purl.obolibrary.org/obo/CL:0000890
T13 1073-1083 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T15 1137-1145 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T17 1286-1297 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T19 1472-1483 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T21 1619-1630 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T23 1835-1843 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T25 2030-2038 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T27 2039-2049 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394