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PubMed:22988877 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 44-49 PR:Q5S006 denotes LRRK2
T2 44-49 PR:000003033 denotes LRRK2
T3 44-49 PR:Q5S007 denotes LRRK2
T4 54-63 GO:0016236 denotes autophagy
T5 54-63 GO:0006914 denotes autophagy
T10 67-86 D010300 denotes Parkinson's disease
T11 67-86 D010300 denotes Parkinson's disease
T20 92-111 D010300 denotes Parkinson's disease
T21 92-111 D010300 denotes Parkinson's disease
T26 118-144 D019636 denotes neurodegenerative disorder
T27 118-144 D019636 denotes neurodegenerative disorder
T32 163-171 3628 denotes dopamine
T28 163-171 CHEBI:59905 denotes dopamine
T29 163-171 CHEBI:18243 denotes dopamine
T30 163-171 D004298 denotes dopamine
T31 163-171 D004298 denotes dopamine
T33 196-212 UBERON:0002038 denotes substantia nigra
T34 347-354 D004194 denotes disease
T35 347-354 D004194 denotes disease
T36 373-378 PR:Q5S006 denotes LRRK2
T37 373-378 PR:000003033 denotes LRRK2
T38 373-378 PR:Q5S007 denotes LRRK2
T40 380-387 6308 denotes leucine
T41 380-387 SO:0001437 denotes leucine
T39 380-387 CHEBI:15603 denotes leucine
T42 380-387 D007930 denotes leucine
T43 380-387 CHEBI:25017 denotes leucine
T44 380-387 D007930 denotes leucine
T45 393-399 SO:0001068 denotes repeat
T46 410-414 SO:0000704 denotes gene
T47 421-431 D000067562 denotes late-onset
T48 421-431 D000067562 denotes late-onset
T49 510-515 PR:Q5S006 denotes LRRK2
T50 510-515 PR:000003033 denotes LRRK2
T51 510-515 PR:Q5S007 denotes LRRK2
T52 556-565 GO:0016236 denotes autophagy
T53 556-565 GO:0006914 denotes autophagy
T54 566-576 GO:0065007 denotes regulation
T55 578-587 GO:0016236 denotes Autophagy
T56 578-587 GO:0006914 denotes Autophagy
T57 594-607 GO:0005622 denotes intracellular
T58 672-680 CHEBI:36080 denotes proteins
T59 754-759 PR:Q5S006 denotes LRRK2
T60 754-759 PR:000003033 denotes LRRK2
T61 754-759 PR:Q5S007 denotes LRRK2
T62 763-772 GO:0016236 denotes autophagy
T63 763-772 GO:0006914 denotes autophagy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 92-101 HP_0001300 denotes Parkinson

Allie

Id Subject Object Predicate Lexical cue
SS1_22988877_1_0 92-111 expanded denotes Parkinson's disease
SS2_22988877_1_0 88-90 abbr denotes PD
SS1_22988877_3_0 380-408 expanded denotes leucine-rich repeat kinase 2
SS2_22988877_3_0 373-378 abbr denotes LRRK2
AE1_22988877_1_0 SS1_22988877_1_0 SS2_22988877_1_0 abbreviatedTo Parkinson's disease,PD
AE1_22988877_3_0 SS1_22988877_3_0 SS2_22988877_3_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-87 DRI_Challenge denotes Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease.
T2 88-213 DRI_Background denotes PD (Parkinson's disease) is a neurodegenerative disorder caused by loss of dopamine-generating cells in the substantia nigra.
T3 214-355 DRI_Approach denotes The implication of genetic factors in the aetiology of PD has an essential importance in our understanding of the development of the disease.
T4 356-499 DRI_Approach denotes Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene cause late-onset PD with a clinical appearance indistinguishable from idiopathic PD.
T5 500-577 DRI_Background denotes Moreover, LRRK2 has been associated with the process of autophagy regulation.
T6 578-708 DRI_Background denotes Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles.
T7 709-862 DRI_Challenge denotes In the present paper, we discuss the role of LRRK2 in autophagy, and the importance of this relationship in the development of nigral degeneration in PD.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22988877-0#44#49#gene120892 44-49 gene120892 denotes LRRK2
22988877-0#67#86#diseaseC0030567 67-86 diseaseC0030567 denotes Parkinson's disease
44#49#gene12089267#86#diseaseC0030567 22988877-0#44#49#gene120892 22988877-0#67#86#diseaseC0030567 associated_with LRRK2,Parkinson's disease