PubMed:22752006
Annnotations
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 656-664 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-95 | Sentence | denotes | Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss. |
| TextSentencer_T2 | 96-223 | Sentence | denotes | Mechanisms accounting for the protection of the fetal semi-allograft from maternal immune cells remain incompletely understood. |
| TextSentencer_T3 | 224-415 | Sentence | denotes | In previous studies, we showed that galectin-1 (Gal1), an immunoregulatory glycan-binding protein, hierarchically triggers a cascade of tolerogenic events at the mouse fetomaternal interface. |
| TextSentencer_T4 | 416-552 | Sentence | denotes | Here, we show that Gal1 confers immune privilege to human trophoblast cells through the modulation of a number of regulatory mechanisms. |
| TextSentencer_T5 | 553-704 | Sentence | denotes | Gal1 was mainly expressed in invasive extravillous trophoblast cells of human first trimester and term placenta in direct contact with maternal tissue. |
| TextSentencer_T6 | 705-1025 | Sentence | denotes | Expression of Gal1 by the human trophoblast cell line JEG-3 was primarily controlled by progesterone and pro-inflammatory cytokines and impaired T-cell responses by limiting T cell viability, suppressing the secretion of Th1-type cytokines and favoring the expansion of CD4(+)CD25(+)FoxP3(+) regulatory T (T(reg)) cells. |
| TextSentencer_T7 | 1026-1233 | Sentence | denotes | Targeted inhibition of Gal1 expression through antibody (Ab)-mediated blockade, addition of the specific disaccharide lactose or retroviral-mediated siRNA strategies prevented these immunoregulatory effects. |
| TextSentencer_T8 | 1234-1470 | Sentence | denotes | Consistent with a homeostatic role of endogenous Gal1, patients with recurrent pregnancy loss showed considerably lower levels of circulating Gal1 and had higher frequency of anti-Gal1 auto-Abs in their sera compared with fertile women. |
| TextSentencer_T9 | 1471-1641 | Sentence | denotes | Thus, endogenous Gal1 confers immune privilege to human trophoblast cells by triggering a broad tolerogenic program with potential implications in threatened pregnancies. |
| T1 | 0-95 | Sentence | denotes | Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss. |
| T2 | 96-223 | Sentence | denotes | Mechanisms accounting for the protection of the fetal semi-allograft from maternal immune cells remain incompletely understood. |
| T3 | 224-415 | Sentence | denotes | In previous studies, we showed that galectin-1 (Gal1), an immunoregulatory glycan-binding protein, hierarchically triggers a cascade of tolerogenic events at the mouse fetomaternal interface. |
| T4 | 416-552 | Sentence | denotes | Here, we show that Gal1 confers immune privilege to human trophoblast cells through the modulation of a number of regulatory mechanisms. |
| T5 | 553-704 | Sentence | denotes | Gal1 was mainly expressed in invasive extravillous trophoblast cells of human first trimester and term placenta in direct contact with maternal tissue. |
| T6 | 705-1025 | Sentence | denotes | Expression of Gal1 by the human trophoblast cell line JEG-3 was primarily controlled by progesterone and pro-inflammatory cytokines and impaired T-cell responses by limiting T cell viability, suppressing the secretion of Th1-type cytokines and favoring the expansion of CD4(+)CD25(+)FoxP3(+) regulatory T (T(reg)) cells. |
| T7 | 1026-1233 | Sentence | denotes | Targeted inhibition of Gal1 expression through antibody (Ab)-mediated blockade, addition of the specific disaccharide lactose or retroviral-mediated siRNA strategies prevented these immunoregulatory effects. |
| T8 | 1234-1470 | Sentence | denotes | Consistent with a homeostatic role of endogenous Gal1, patients with recurrent pregnancy loss showed considerably lower levels of circulating Gal1 and had higher frequency of anti-Gal1 auto-Abs in their sera compared with fertile women. |
| T9 | 1471-1641 | Sentence | denotes | Thus, endogenous Gal1 confers immune privilege to human trophoblast cells by triggering a broad tolerogenic program with potential implications in threatened pregnancies. |
| T1 | 0-95 | Sentence | denotes | Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss. |
| T2 | 96-223 | Sentence | denotes | Mechanisms accounting for the protection of the fetal semi-allograft from maternal immune cells remain incompletely understood. |
| T3 | 224-415 | Sentence | denotes | In previous studies, we showed that galectin-1 (Gal1), an immunoregulatory glycan-binding protein, hierarchically triggers a cascade of tolerogenic events at the mouse fetomaternal interface. |
| T4 | 416-552 | Sentence | denotes | Here, we show that Gal1 confers immune privilege to human trophoblast cells through the modulation of a number of regulatory mechanisms. |
| T5 | 553-704 | Sentence | denotes | Gal1 was mainly expressed in invasive extravillous trophoblast cells of human first trimester and term placenta in direct contact with maternal tissue. |
| T6 | 705-1025 | Sentence | denotes | Expression of Gal1 by the human trophoblast cell line JEG-3 was primarily controlled by progesterone and pro-inflammatory cytokines and impaired T-cell responses by limiting T cell viability, suppressing the secretion of Th1-type cytokines and favoring the expansion of CD4(+)CD25(+)FoxP3(+) regulatory T (T(reg)) cells. |
| T7 | 1026-1233 | Sentence | denotes | Targeted inhibition of Gal1 expression through antibody (Ab)-mediated blockade, addition of the specific disaccharide lactose or retroviral-mediated siRNA strategies prevented these immunoregulatory effects. |
| T8 | 1234-1470 | Sentence | denotes | Consistent with a homeostatic role of endogenous Gal1, patients with recurrent pregnancy loss showed considerably lower levels of circulating Gal1 and had higher frequency of anti-Gal1 auto-Abs in their sera compared with fertile women. |
| T9 | 1471-1641 | Sentence | denotes | Thus, endogenous Gal1 confers immune privilege to human trophoblast cells by triggering a broad tolerogenic program with potential implications in threatened pregnancies. |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 45-56 | FMAID:83029 | denotes | trophoblast |
| _T2 | 45-56 | FMAID:197289 | denotes | trophoblast |
| _T3 | 186-191 | FMAID:169002 | denotes | cells |
| _T4 | 186-191 | FMAID:68646 | denotes | cells |
| _T5 | 314-321 | FMAID:165447 | denotes | protein |
| _T6 | 314-321 | FMAID:67257 | denotes | protein |
| _T7 | 474-485 | FMAID:83029 | denotes | trophoblast |
| _T8 | 474-485 | FMAID:197289 | denotes | trophoblast |
| _T9 | 474-491 | FMAID:202194 | denotes | trophoblast cells |
| _T10 | 474-491 | FMAID:83028 | denotes | trophoblast cells |
| _T11 | 474-491 | FMAID:200947 | denotes | trophoblast cells |
| _T12 | 474-491 | FMAID:197288 | denotes | trophoblast cells |
| _T13 | 486-491 | FMAID:169002 | denotes | cells |
| _T14 | 486-491 | FMAID:68646 | denotes | cells |
| _T15 | 604-615 | FMAID:197289 | denotes | trophoblast |
| _T16 | 604-615 | FMAID:83029 | denotes | trophoblast |
| _T17 | 604-621 | FMAID:202194 | denotes | trophoblast cells |
| _T18 | 604-621 | FMAID:83028 | denotes | trophoblast cells |
| _T19 | 604-621 | FMAID:200947 | denotes | trophoblast cells |
| _T20 | 604-621 | FMAID:197288 | denotes | trophoblast cells |
| _T21 | 616-621 | FMAID:68646 | denotes | cells |
| _T22 | 616-621 | FMAID:169002 | denotes | cells |
| _T23 | 656-664 | FMAID:63934 | denotes | placenta |
| _T24 | 656-664 | FMAID:162401 | denotes | placenta |
| _T25 | 697-703 | FMAID:256050 | denotes | tissue |
| _T26 | 737-748 | FMAID:197289 | denotes | trophoblast |
| _T27 | 737-748 | FMAID:83029 | denotes | trophoblast |
| _T28 | 737-753 | FMAID:200947 | denotes | trophoblast cell |
| _T29 | 737-753 | FMAID:202194 | denotes | trophoblast cell |
| _T30 | 737-753 | FMAID:83028 | denotes | trophoblast cell |
| _T31 | 737-753 | FMAID:197288 | denotes | trophoblast cell |
| _T32 | 827-836 | FMAID:197972 | denotes | cytokines |
| _T33 | 827-836 | FMAID:84050 | denotes | cytokines |
| _T34 | 935-944 | FMAID:197972 | denotes | cytokines |
| _T35 | 935-944 | FMAID:84050 | denotes | cytokines |
| _T36 | 1019-1024 | FMAID:68646 | denotes | cells |
| _T37 | 1019-1024 | FMAID:169002 | denotes | cells |
| _T38 | 1073-1081 | FMAID:167180 | denotes | antibody |
| _T39 | 1131-1143 | FMAID:196733 | denotes | disaccharide |
| _T40 | 1131-1143 | FMAID:82744 | denotes | disaccharide |
| _T41 | 1527-1538 | FMAID:197289 | denotes | trophoblast |
| _T42 | 1527-1538 | FMAID:83029 | denotes | trophoblast |
| _T43 | 1527-1544 | FMAID:197288 | denotes | trophoblast cells |
| _T44 | 1527-1544 | FMAID:200947 | denotes | trophoblast cells |
| _T45 | 1527-1544 | FMAID:83028 | denotes | trophoblast cells |
| _T46 | 1527-1544 | FMAID:202194 | denotes | trophoblast cells |
| _T47 | 1539-1544 | FMAID:68646 | denotes | cells |
| _T48 | 1539-1544 | FMAID:169002 | denotes | cells |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-10 | http://www.uniprot.org/uniprot/P09382 | denotes | Galectin-1 |
| T2 | 260-270 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
| T3 | 975-978 | http://www.uniprot.org/uniprot/P01730 | denotes | CD4 |
| T4 | 981-985 | http://www.uniprot.org/uniprot/P01589 | denotes | CD25 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-10 | http://www.uniprot.org/uniprot/P16045 | denotes | Galectin-1 |
| T2 | 260-270 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
| T3 | 810-813 | http://www.uniprot.org/uniprot/Q08761 | denotes | pro |
| T4 | 926-929 | http://www.uniprot.org/uniprot/Q64279 | denotes | Th1 |
| T5 | 926-929 | http://www.uniprot.org/uniprot/Q922L6 | denotes | Th1 |
| T6 | 975-978 | http://www.uniprot.org/uniprot/P06332 | denotes | CD4 |
| T7 | 981-985 | http://www.uniprot.org/uniprot/P01590 | denotes | CD25 |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 96-106 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | Mechanisms |
| T2 | 186-191 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T3 | 372-378 | http://purl.bioontology.org/ontology/STY/T051 | denotes | events |
| T4 | 486-491 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T5 | 541-551 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanisms |
| T6 | 616-621 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T7 | 651-655 | http://purl.bioontology.org/ontology/NCBITAXON/62951 | denotes | term |
| T8 | 697-703 | http://purl.bioontology.org/ontology/STY/T024 | denotes | tissue |
| T9 | 1019-1024 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T10 | 1539-1544 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 913-922 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T2 | 1437-1441 | http://purl.obolibrary.org/obo/GO_0004617 | denotes | sera |
| T3 | 1456-1463 | http://purl.obolibrary.org/obo/GO_0009566 | denotes | fertile |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 306-313 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T2 | 306-313 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T3 | 306-313 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T4 | 306-313 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
| T5 | 306-321 | http://purl.obolibrary.org/obo/GO_0005515 | denotes | binding protein |
| T6 | 1073-1081 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 186-191 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T2 | 486-491 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T3 | 616-621 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T4 | 1019-1024 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T5 | 749-753 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T6 | 852-856 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T7 | 881-885 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 45-56 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| T2 | 474-485 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| T3 | 604-615 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| T4 | 737-748 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| T5 | 1527-1538 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| T6 | 591-615 | http://purl.obolibrary.org/obo/UBERON_0000426 | denotes | extravillous trophoblast |
| T7 | 656-664 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| T8 | 697-703 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22752006_2_0 | 260-270 | expanded | denotes | galectin-1 |
| SS2_22752006_2_0 | 272-276 | abbr | denotes | Gal1 |
| SS1_22752006_6_0 | 1073-1081 | expanded | denotes | antibody |
| SS2_22752006_6_0 | 1083-1085 | abbr | denotes | Ab |
| AE1_22752006_2_0 | SS1_22752006_2_0 | SS2_22752006_2_0 | abbreviatedTo | galectin-1,Gal1 |
| AE1_22752006_6_0 | SS1_22752006_6_0 | SS2_22752006_6_0 | abbreviatedTo | antibody,Ab |
GlyTouCan-IUPAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| GlycanIUPAC_T1 | 269-276 | "http://rdf.glycoinfo.org/glycan/G04340UO" | denotes | 1 (Gal1 |
| GlycanIUPAC_T2 | 269-276 | "http://rdf.glycoinfo.org/glycan/G79992SX" | denotes | 1 (Gal1 |
| GlycanIUPAC_T3 | 269-276 | "http://rdf.glycoinfo.org/glycan/G20773IW" | denotes | 1 (Gal1 |
| GlycanIUPAC_T4 | 269-276 | "http://rdf.glycoinfo.org/glycan/G61666PA" | denotes | 1 (Gal1 |
| GlycanIUPAC_T5 | 269-276 | "http://rdf.glycoinfo.org/glycan/G98350CS" | denotes | 1 (Gal1 |
| GlycanIUPAC_T6 | 269-276 | "http://rdf.glycoinfo.org/glycan/G26289JC" | denotes | 1 (Gal1 |
| GlycanIUPAC_T7 | 269-276 | "http://rdf.glycoinfo.org/glycan/G01753HF" | denotes | 1 (Gal1 |
| GlycanIUPAC_T8 | 269-276 | "http://rdf.glycoinfo.org/glycan/G25061NQ" | denotes | 1 (Gal1 |
| GlycanIUPAC_T9 | 269-276 | "http://rdf.glycoinfo.org/glycan/G91444NO" | denotes | 1 (Gal1 |
| GlycanIUPAC_T10 | 272-276 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T11 | 435-439 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T12 | 553-557 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T13 | 719-723 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T14 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T15 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T16 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T17 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T18 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G32871SU" | denotes | Gal1 |
| GlycanIUPAC_T19 | 272-276 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T20 | 435-439 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T21 | 553-557 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T22 | 719-723 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T23 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T24 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T25 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T26 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T27 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G07087RJ" | denotes | Gal1 |
| GlycanIUPAC_T28 | 272-276 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T29 | 435-439 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T30 | 553-557 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T31 | 719-723 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T32 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T33 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T34 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T35 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T36 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G40843KY" | denotes | Gal1 |
| GlycanIUPAC_T37 | 272-276 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T38 | 435-439 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T39 | 553-557 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T40 | 719-723 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T41 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T42 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T43 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T44 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T45 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G68158BT" | denotes | Gal1 |
| GlycanIUPAC_T46 | 272-276 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T47 | 435-439 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T48 | 553-557 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T49 | 719-723 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T50 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T51 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T52 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T53 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T54 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G75623HL" | denotes | Gal1 |
| GlycanIUPAC_T55 | 272-276 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T56 | 435-439 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T57 | 553-557 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T58 | 719-723 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T59 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T60 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T61 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T62 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T63 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G08908FU" | denotes | Gal1 |
| GlycanIUPAC_T64 | 272-276 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T65 | 435-439 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T66 | 553-557 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T67 | 719-723 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T68 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T69 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T70 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T71 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T72 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G38028NH" | denotes | Gal1 |
| GlycanIUPAC_T73 | 272-276 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T74 | 435-439 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T75 | 553-557 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T76 | 719-723 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T77 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T78 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T79 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T80 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T81 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G48426CT" | denotes | Gal1 |
| GlycanIUPAC_T82 | 272-276 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T83 | 435-439 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T84 | 553-557 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T85 | 719-723 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T86 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T87 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T88 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T89 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T90 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G34526ZS" | denotes | Gal1 |
| GlycanIUPAC_T91 | 272-276 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T92 | 435-439 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T93 | 553-557 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T94 | 719-723 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T95 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T96 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T97 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T98 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T99 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G25681JY" | denotes | Gal1 |
| GlycanIUPAC_T100 | 272-276 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T101 | 435-439 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T102 | 553-557 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T103 | 719-723 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T104 | 1049-1053 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T105 | 1283-1287 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T106 | 1376-1380 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T107 | 1414-1418 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
| GlycanIUPAC_T108 | 1488-1492 | "http://rdf.glycoinfo.org/glycan/G75236KD" | denotes | Gal1 |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 656-664 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| Lectin_T1 | 0-8 | https://acgg.asia/db/lfdb/LfDB0272 | denotes | Galectin |
| Lectin_T2 | 0-10 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | Galectin-1 |
| Lectin_T3 | 260-270 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
| Lectin_T4 | 0-8 | https://acgg.asia/db/lfdb/LfDB0274 | denotes | Galectin |
| Lectin_T5 | 0-10 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | Galectin-1 |
| Lectin_T6 | 260-270 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 697-703 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
| PD-UBERON-AE-B_T2 | 656-664 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | placenta |
| PD-UBERON-AE-B_T3 | 45-56 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T4 | 474-485 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T5 | 604-615 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T6 | 737-748 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T7 | 1527-1538 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T8 | 591-615 | http://purl.obolibrary.org/obo/UBERON_0000426 | denotes | extravillous trophoblast |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1144-1151 | Glycan | denotes | lactose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1144-1151 | Glycan | denotes | lactose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 179-191 | Cell | denotes | immune cells | http://purl.obolibrary.org/obo/CL:0000738 |
| T2 | 474-491 | Cell | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL:0000351 |
| T3 | 591-615 | Cell | denotes | extravillous trophoblast | http://purl.obolibrary.org/obo/CL:0008036 |
| T4 | 737-753 | Cell | denotes | trophoblast cell | http://purl.obolibrary.org/obo/CL:0000351 |
| T5 | 850-856 | Cell | denotes | T-cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T6 | 879-885 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T7 | 1011-1017 | Cell | denotes | T(reg) | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
| T9 | 1527-1544 | Cell | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL:0000351 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 45-56 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T2 | 179-191 | Body_part | denotes | immune cells | http://purl.obolibrary.org/obo/CL_0000738 |
| T3 | 474-491 | Body_part | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL_0000351 |
| T4 | 591-615 | Body_part | denotes | extravillous trophoblast | http://purl.obolibrary.org/obo/UBERON_0000426 |
| T5 | 656-664 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T6 | 697-703 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T7 | 737-753 | Body_part | denotes | trophoblast cell | http://purl.obolibrary.org/obo/CL_0000351 |
| T8 | 850-856 | Body_part | denotes | T-cell | http://purl.obolibrary.org/obo/CL_0000084 |
| T9 | 879-885 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
| T10 | 1527-1544 | Body_part | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL_0000351 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 39-44 | Organism | denotes | human | 9606 |
| T2 | 386-391 | Organism | denotes | mouse | 10088|10090 |
| T4 | 468-473 | Organism | denotes | human | 9606 |
| T5 | 625-630 | Organism | denotes | human | 9606 |
| T6 | 731-736 | Organism | denotes | human | 9606 |
| T7 | 1289-1297 | Organism | denotes | patients | 9606 |
| T8 | 1521-1526 | Organism | denotes | human | 9606 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-95 | Sentence | denotes | Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss. |
| T2 | 96-223 | Sentence | denotes | Mechanisms accounting for the protection of the fetal semi-allograft from maternal immune cells remain incompletely understood. |
| T3 | 224-415 | Sentence | denotes | In previous studies, we showed that galectin-1 (Gal1), an immunoregulatory glycan-binding protein, hierarchically triggers a cascade of tolerogenic events at the mouse fetomaternal interface. |
| T4 | 416-552 | Sentence | denotes | Here, we show that Gal1 confers immune privilege to human trophoblast cells through the modulation of a number of regulatory mechanisms. |
| T5 | 553-704 | Sentence | denotes | Gal1 was mainly expressed in invasive extravillous trophoblast cells of human first trimester and term placenta in direct contact with maternal tissue. |
| T6 | 705-1025 | Sentence | denotes | Expression of Gal1 by the human trophoblast cell line JEG-3 was primarily controlled by progesterone and pro-inflammatory cytokines and impaired T-cell responses by limiting T cell viability, suppressing the secretion of Th1-type cytokines and favoring the expansion of CD4(+)CD25(+)FoxP3(+) regulatory T (T(reg)) cells. |
| T7 | 1026-1233 | Sentence | denotes | Targeted inhibition of Gal1 expression through antibody (Ab)-mediated blockade, addition of the specific disaccharide lactose or retroviral-mediated siRNA strategies prevented these immunoregulatory effects. |
| T8 | 1234-1470 | Sentence | denotes | Consistent with a homeostatic role of endogenous Gal1, patients with recurrent pregnancy loss showed considerably lower levels of circulating Gal1 and had higher frequency of anti-Gal1 auto-Abs in their sera compared with fertile women. |
| T9 | 1471-1641 | Sentence | denotes | Thus, endogenous Gal1 confers immune privilege to human trophoblast cells by triggering a broad tolerogenic program with potential implications in threatened pregnancies. |
GlyCosmos15-Lectin-Jamboree
| Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
|---|---|---|---|---|---|
| T1 | 0-10 | Lectin | denotes | Galectin-1 | GL_001885 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 45-56 | Body_part | denotes | trophoblast | FMA:83029 |
| T2 | 474-491 | Body_part | denotes | trophoblast cells | FMA:83028 |
| T3 | 591-615 | Body_part | denotes | extravillous trophoblast | FMA:86561 |
| T4 | 656-664 | Body_part | denotes | placenta | FMA:0329329|FMA:63934 |
| T6 | 697-703 | Body_part | denotes | tissue | FMA:9637 |
| T7 | 737-753 | Body_part | denotes | trophoblast cell | FMA:83028 |
| T8 | 1527-1544 | Body_part | denotes | trophoblast cells | FMA:83028 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 656-664 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 39-44 | OrganismTaxon | denotes | human | 9606 |
| T2 | 386-391 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T4 | 468-473 | OrganismTaxon | denotes | human | 9606 |
| T5 | 625-630 | OrganismTaxon | denotes | human | 9606 |
| T6 | 731-736 | OrganismTaxon | denotes | human | 9606 |
| T7 | 1521-1526 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 45-56 | Body_part | denotes | trophoblast | http://purl.obolibrary.org/obo/UBERON_0000088 |
| T2 | 179-191 | Body_part | denotes | immune cells | http://purl.obolibrary.org/obo/CL_0000738 |
| T3 | 474-491 | Body_part | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL_0000351 |
| T4 | 591-615 | Body_part | denotes | extravillous trophoblast | http://purl.obolibrary.org/obo/UBERON_0000426 |
| T5 | 656-664 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T6 | 697-703 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T7 | 737-753 | Body_part | denotes | trophoblast cell | http://purl.obolibrary.org/obo/CL_0000351 |
| T8 | 850-856 | Body_part | denotes | T-cell | http://purl.obolibrary.org/obo/CL_0000084 |
| T9 | 879-885 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
| T10 | 1527-1544 | Body_part | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL_0000351 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 656-664 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
GlyCosmos15-Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 272-276 | GL_000469 | denotes | Gal1 |
| T2 | 435-439 | GL_000469 | denotes | Gal1 |
| T3 | 553-557 | GL_000469 | denotes | Gal1 |
| T4 | 719-723 | GL_000469 | denotes | Gal1 |
| T5 | 1049-1053 | GL_000469 | denotes | Gal1 |
| T6 | 1283-1287 | GL_000469 | denotes | Gal1 |
| T7 | 1376-1380 | GL_000469 | denotes | Gal1 |
| T8 | 1414-1418 | GL_000469 | denotes | Gal1 |
| T9 | 1488-1492 | GL_000469 | denotes | Gal1 |
Lectin_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 272-276 | GL_000469 | denotes | Gal1 |
| T2 | 435-439 | GL_000469 | denotes | Gal1 |
| T3 | 553-557 | GL_000469 | denotes | Gal1 |
| T4 | 719-723 | GL_000469 | denotes | Gal1 |
| T5 | 1049-1053 | GL_000469 | denotes | Gal1 |
| T6 | 1283-1287 | GL_000469 | denotes | Gal1 |
| T7 | 1376-1380 | GL_000469 | denotes | Gal1 |
| T8 | 1414-1418 | GL_000469 | denotes | Gal1 |
| T9 | 1488-1492 | GL_000469 | denotes | Gal1 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 179-191 | Cell | denotes | immune cells | http://purl.obolibrary.org/obo/CL:0000738 |
| T2 | 474-491 | Cell | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL:0000351 |
| T3 | 591-615 | Cell | denotes | extravillous trophoblast | http://purl.obolibrary.org/obo/CL:0008036 |
| T4 | 737-753 | Cell | denotes | trophoblast cell | http://purl.obolibrary.org/obo/CL:0000351 |
| T5 | 850-856 | Cell | denotes | T-cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T6 | 879-885 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T7 | 1011-1017 | Cell | denotes | T(reg) | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
| T9 | 1527-1544 | Cell | denotes | trophoblast cells | http://purl.obolibrary.org/obo/CL:0000351 |