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PubMed:22736029 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
22736029_0 0-6 ProteinMutation denotes G2019S rs34637584
22736029_1 1609-1615 ProteinMutation denotes G2019S rs34637584
22736029_2 1344-1350 ProteinMutation denotes G2019S rs34637584
22736029_3 705-711 ProteinMutation denotes G2019S rs34637584
22736029_4 601-607 ProteinMutation denotes G2019S rs34637584
22736029_5 395-401 ProteinMutation denotes G2019S rs34637584
22736029_6 105-111 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 5-14 CHEBI:15603 denotes S leucine
T3 7-14 6308 denotes leucine
T4 7-14 SO:0001437 denotes leucine
T8 20-26 SO:0001068 denotes repeat
T13 54-61 SO:0000104 denotes protein
T12 54-61 PR:000000001 denotes protein
T10 54-61 CHEBI:36080 denotes protein
T11 54-61 CHEBI:11122 denotes protein
T9 54-61 GO:0003675 denotes protein
T14 71-99 GO:0051882 denotes mitochondrial depolarization
T15 110-119 CHEBI:15603 denotes S leucine
T17 112-119 6308 denotes leucine
T18 112-119 SO:0001437 denotes leucine
T22 125-131 SO:0001068 denotes repeat
T23 142-147 PR:Q5S006 denotes LRRK2
T24 142-147 PR:000003033 denotes LRRK2
T25 142-147 PR:Q5S007 denotes LRRK2
T26 149-157 SO:0000109 denotes mutation
T31 194-213 D010300 denotes Parkinson's disease
T32 194-213 D010300 denotes Parkinson's disease
T35 343-355 GO:0009405 denotes pathogenesis
T36 385-391 PR:Q54JW9 denotes impact
T37 385-391 PR:Q642J4 denotes impact
T38 409-414 PR:Q5S006 denotes LRRK2
T39 409-414 PR:000003033 denotes LRRK2
T40 409-414 PR:Q5S007 denotes LRRK2
T41 458-463 PR:Q5S006 denotes LRRK2
T42 458-463 PR:000003033 denotes LRRK2
T43 458-463 PR:Q5S007 denotes LRRK2
T44 458-471 D000071158 denotes LRRK2 protein
T49 464-471 SO:0000104 denotes protein
T48 464-471 PR:000000001 denotes protein
T45 464-471 GO:0003675 denotes protein
T50 572-577 10090 denotes mouse
T51 572-577 D051379 denotes mouse
T52 578-583 UBERON:6110636 denotes brain
T53 578-583 UBERON:0000955 denotes brain
T54 608-613 PR:Q5S006 denotes LRRK2
T55 608-613 PR:000003033 denotes LRRK2
T56 608-613 PR:Q5S007 denotes LRRK2
T57 614-622 SO:0000109 denotes mutation
T58 641-646 PR:Q5S006 denotes LRRK2
T59 641-646 PR:000003033 denotes LRRK2
T60 641-646 PR:Q5S007 denotes LRRK2
T61 712-717 PR:Q5S006 denotes LRRK2
T62 712-717 PR:000003033 denotes LRRK2
T63 712-717 PR:Q5S007 denotes LRRK2
T64 718-726 SO:0000109 denotes mutation
T65 735-745 CL:0000057 denotes fibroblast
T66 750-763 D009447 denotes neuroblastoma
T67 750-763 D009447 denotes neuroblastoma
T68 852-874 GO:0031966 denotes mitochondrial membrane
T69 866-874 UBERON:0000094 denotes membrane
T71 866-874 UBERON:0000158 denotes membrane
T73 899-905 7806 denotes oxygen
T72 899-905 CHEBI:25805 denotes oxygen
T74 934-944 D009840 denotes oligomycin
T75 934-944 CHEBI:25675 denotes oligomycin
T76 934-944 D009840 denotes oligomycin
T78 1007-1010 318 denotes ATP
T77 1007-1010 D000255 denotes ATP
T79 1007-1010 CHEBI:30616 denotes ATP
T80 1007-1010 D000255 denotes ATP
T81 1007-1010 CHEBI:15422 denotes ATP
T82 1098-1123 GO:0006119 denotes oxidative phosphorylation
T87 1183-1190 PR:000000001 denotes protein
T85 1183-1190 CHEBI:36080 denotes protein
T86 1183-1190 CHEBI:11122 denotes protein
T88 1183-1190 SO:0000104 denotes protein
T84 1183-1190 GO:0003675 denotes protein
T93 1192-1198 PR:Q11119 denotes UCP) 2
T94 1192-1198 Q5R5A8 denotes UCP) 2
T95 1192-1198 PR:P70406 denotes UCP) 2
T96 1192-1198 PR:Q9ZWG1 denotes UCP) 2
T97 1192-1198 Q3SZI5 denotes UCP) 2
T98 1192-1198 P56500 denotes UCP) 2
T99 1192-1198 Q9N2J1 denotes UCP) 2
T100 1192-1198 O97562 denotes UCP) 2
T101 1192-1198 P55851 denotes UCP) 2
T102 1192-1198 Q9W725 denotes UCP) 2
T103 1192-1198 PR:000017036 denotes UCP) 2
T104 1192-1198 P70406 denotes UCP) 2
T105 1192-1198 PR:Q9W720 denotes UCP) 2
T106 1192-1198 Q9W720 denotes UCP) 2
T107 1192-1198 PR:P56500 denotes UCP) 2
T108 1192-1198 PR:P55851 denotes UCP) 2
T110 1232-1254 GO:0031966 denotes mitochondrial membrane
T111 1246-1254 UBERON:0000094 denotes membrane
T113 1246-1254 UBERON:0000158 denotes membrane
T114 1272-1275 PR:P12242 denotes UCP
T115 1272-1275 PR:000017035 denotes UCP
T116 1272-1275 PR:P04633 denotes UCP
T117 1272-1275 PR:P25874 denotes UCP
T118 1272-1285 CHEBI:145437 denotes UCP inhibitor
T120 1286-1293 CHEBI:5298 denotes genipin
T121 1286-1293 C007834 denotes genipin
T122 1286-1293 C007834 denotes genipin
T123 1286-1293 C007834 denotes genipin
T124 1351-1356 PR:Q5S006 denotes LRRK2
T125 1351-1356 PR:000003033 denotes LRRK2
T126 1351-1356 PR:Q5S007 denotes LRRK2
T131 1394-1398 PR:000015023 denotes UCP4
T132 1394-1398 PR:O95847 denotes UCP4
T133 1394-1398 PR:Q9SB52 denotes UCP4
T134 1394-1398 O95847 denotes UCP4
T137 1399-1403 SO:0000234 denotes mRNA
T135 1399-1403 D012333 denotes mRNA
T136 1399-1403 CHEBI:33699 denotes mRNA
T138 1407-1417 GO:0065007 denotes regulation
T139 1423-1428 PR:Q5S006 denotes LRRK2
T140 1423-1428 PR:000003033 denotes LRRK2
T141 1423-1428 PR:Q5S007 denotes LRRK2
T142 1466-1471 PR:Q5S006 denotes LRRK2
T143 1466-1471 PR:000003033 denotes LRRK2
T144 1466-1471 PR:Q5S007 denotes LRRK2
T145 1510-1513 PR:P12242 denotes UCP
T146 1510-1513 PR:000017035 denotes UCP
T147 1510-1513 PR:P04633 denotes UCP
T148 1510-1513 PR:P25874 denotes UCP
T149 1616-1621 PR:Q5S006 denotes LRRK2
T150 1616-1621 PR:000003033 denotes LRRK2
T151 1616-1621 PR:Q5S007 denotes LRRK2
T152 1691-1696 PR:Q5S006 denotes LRRK2
T153 1691-1696 PR:000003033 denotes LRRK2
T154 1691-1696 PR:Q5S007 denotes LRRK2

DisGeNET

Id Subject Object Predicate Lexical cue
T0 712-717 gene:120892 denotes LRRK2
T1 750-763 disease:C0027819 denotes neuroblastoma
T2 712-717 gene:120892 denotes LRRK2
T3 750-763 disease:C0700095 denotes neuroblastoma
R1 T0 T1 associated_with LRRK2,neuroblastoma
R2 T2 T3 associated_with LRRK2,neuroblastoma

Allie

Id Subject Object Predicate Lexical cue
SS1_22736029_1_0 112-140 expanded denotes leucine rich repeat kinase 2
SS2_22736029_1_0 142-147 abbr denotes LRRK2
SS1_22736029_1_1 194-213 expanded denotes Parkinson's disease
SS2_22736029_1_1 215-217 abbr denotes PD
SS1_22736029_8_0 1172-1190 expanded denotes uncoupling protein
SS2_22736029_8_0 1192-1195 abbr denotes UCP
AE1_22736029_1_0 SS1_22736029_1_0 SS2_22736029_1_0 abbreviatedTo leucine rich repeat kinase 2,LRRK2
AE1_22736029_1_1 SS1_22736029_1_1 SS2_22736029_1_1 abbreviatedTo Parkinson's disease,PD
AE1_22736029_8_0 SS1_22736029_8_0 SS2_22736029_8_0 abbreviatedTo uncoupling protein,UCP

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-100 DRI_Approach denotes G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.
T2 101-287 DRI_Challenge denotes The G2019S leucine rich repeat kinase 2 (LRRK2) mutation is the most common genetic cause of Parkinson's disease (PD), clinically and pathologically indistinguishable from idiopathic PD.
T3 288-457 DRI_Background denotes Mitochondrial abnormalities are a common feature in PD pathogenesis and we have investigated the impact of G2019S mutant LRRK2 expression on mitochondrial bioenergetics.
T4 458-584 DRI_Background denotes LRRK2 protein expression was detected in fibroblasts and lymphoblasts at levels higher than those observed in the mouse brain.
T5 585-600 DRI_Background denotes The presence of
T6 601-613 Token_Label.OUTSIDE denotes G2019S LRRK2
T7 614-673 DRI_Background denotes mutation did not influence LRRK2 expression in fibroblasts.
T8 674-704 DRI_Outcome denotes However, the expression of the
T9 705-717 Token_Label.OUTSIDE denotes G2019S LRRK2
T10 718-815 DRI_Outcome denotes mutation in both fibroblast and neuroblastoma cells was associated with mitochondrial uncoupling.
T11 816-966 DRI_Background denotes This was characterized by decreased mitochondrial membrane potential and increased oxygen utilization under basal and oligomycin-inhibited conditions.
T12 967-1064 DRI_Approach denotes This resulted in a decrease in cellular ATP levels consistent with compromised cellular function.
T13 1065-1216 DRI_Background denotes This uncoupling of mitochondrial oxidative phosphorylation was associated with a cell-specific increase in uncoupling protein (UCP) 2 and 4 expression.
T14 1217-1339 DRI_Background denotes Restoration of mitochondrial membrane potential by the UCP inhibitor genipin confirmed the role of UCPs in this mechanism.
T15 1340-1343 DRI_Background denotes The
T16 1344-1364 Token_Label.OUTSIDE denotes G2019S LRRK2-induced
T17 1365-1422 DRI_Background denotes mitochondrial uncoupling and UCP4 mRNA up-regulation were
T18 1423-1445 Token_Label.OUTSIDE denotes LRRK2 kinase-dependent
T19 1445-1525 DRI_Background denotes , whereas endogenous LRRK2 levels were required for constitutive UCP expression.
T20 1526-1608 DRI_Challenge denotes We propose that normal mitochondrial function was deregulated by the expression of
T21 1609-1621 Token_Label.OUTSIDE denotes G2019S LRRK2
T22 1622-1782 DRI_Challenge denotes in a kinase-dependent mechanism that is a modification of the normal LRRK2 function, and this leads to the vulnerability of selected neuronal populations in PD.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 101-287 DRI_Challenge denotes The G2019S leucine rich repeat kinase 2 (LRRK2) mutation is the most common genetic cause of Parkinson's disease (PD), clinically and pathologically indistinguishable from idiopathic PD.
T2 288-457 DRI_Background denotes Mitochondrial abnormalities are a common feature in PD pathogenesis and we have investigated the impact of G2019S mutant LRRK2 expression on mitochondrial bioenergetics.
T3 458-584 DRI_Background denotes LRRK2 protein expression was detected in fibroblasts and lymphoblasts at levels higher than those observed in the mouse brain.
T4 585-600 DRI_Background denotes The presence of
T5 614-673 DRI_Background denotes mutation did not influence LRRK2 expression in fibroblasts.
T6 674-704 DRI_Outcome denotes However, the expression of the
T7 718-815 DRI_Outcome denotes mutation in both fibroblast and neuroblastoma cells was associated with mitochondrial uncoupling.
T8 816-966 DRI_Background denotes This was characterized by decreased mitochondrial membrane potential and increased oxygen utilization under basal and oligomycin-inhibited conditions.
T9 967-1064 DRI_Approach denotes This resulted in a decrease in cellular ATP levels consistent with compromised cellular function.
T10 1065-1216 DRI_Background denotes This uncoupling of mitochondrial oxidative phosphorylation was associated with a cell-specific increase in uncoupling protein (UCP) 2 and 4 expression.
T11 1217-1339 DRI_Background denotes Restoration of mitochondrial membrane potential by the UCP inhibitor genipin confirmed the role of UCPs in this mechanism.
T12 1340-1343 DRI_Background denotes The
T13 1365-1422 DRI_Background denotes mitochondrial uncoupling and UCP4 mRNA up-regulation were
T14 1445-1525 DRI_Background denotes , whereas endogenous LRRK2 levels were required for constitutive UCP expression.
T15 1526-1608 DRI_Challenge denotes We propose that normal mitochondrial function was deregulated by the expression of
T16 1622-1782 DRI_Challenge denotes in a kinase-dependent mechanism that is a modification of the normal LRRK2 function, and this leads to the vulnerability of selected neuronal populations in PD.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 194-203 HP_0001300 denotes Parkinson
T2 288-301 HP_0001427 denotes Mitochondrial
T3 429-442 HP_0001427 denotes mitochondrial
T4 750-763 HP_0003006 denotes neuroblastoma
T5 790-803 HP_0001427 denotes mitochondrial
T6 852-865 HP_0001427 denotes mitochondrial
T7 1084-1097 HP_0001427 denotes mitochondrial
T8 1232-1245 HP_0001427 denotes mitochondrial
T9 1365-1378 HP_0001427 denotes mitochondrial
T10 1549-1562 HP_0001427 denotes mitochondrial

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
22736029-11#83#89#geners34637584 1609-1615 geners34637584 denotes G2019S
22736029-11#253#255#diseaseC0030567 1779-1781 diseaseC0030567 denotes PD
22736029-2#107#113#geners34637584 395-401 geners34637584 denotes G2019S
22736029-2#0#27#diseaseC4020732 288-315 diseaseC4020732 denotes Mitochondrial abnormalities
22736029-5#31#37#geners34637584 705-711 geners34637584 denotes G2019S
22736029-5#76#89#diseaseC0027819 750-763 diseaseC0027819 denotes neuroblastoma
22736029-5#76#89#diseaseC0700095 750-763 diseaseC0700095 denotes neuroblastoma
83#89#geners34637584253#255#diseaseC0030567 22736029-11#83#89#geners34637584 22736029-11#253#255#diseaseC0030567 associated_with G2019S,PD
107#113#geners346375840#27#diseaseC4020732 22736029-2#107#113#geners34637584 22736029-2#0#27#diseaseC4020732 associated_with G2019S,Mitochondrial abnormalities
31#37#geners3463758476#89#diseaseC0027819 22736029-5#31#37#geners34637584 22736029-5#76#89#diseaseC0027819 associated_with G2019S,neuroblastoma
31#37#geners3463758476#89#diseaseC0700095 22736029-5#31#37#geners34637584 22736029-5#76#89#diseaseC0700095 associated_with G2019S,neuroblastoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22736029-11#90#95#gene120892 1616-1621 gene120892 denotes LRRK2
22736029-11#165#170#gene120892 1691-1696 gene120892 denotes LRRK2
22736029-11#253#255#diseaseC0030567 1779-1781 diseaseC0030567 denotes PD
22736029-2#121#126#gene120892 409-414 gene120892 denotes LRRK2
22736029-2#0#27#diseaseC4020732 288-315 diseaseC4020732 denotes Mitochondrial abnormalities
22736029-5#38#43#gene120892 712-717 gene120892 denotes LRRK2
22736029-5#76#89#diseaseC0027819 750-763 diseaseC0027819 denotes neuroblastoma
22736029-5#76#89#diseaseC0700095 750-763 diseaseC0700095 denotes neuroblastoma
90#95#gene120892253#255#diseaseC0030567 22736029-11#90#95#gene120892 22736029-11#253#255#diseaseC0030567 associated_with LRRK2,PD
165#170#gene120892253#255#diseaseC0030567 22736029-11#165#170#gene120892 22736029-11#253#255#diseaseC0030567 associated_with LRRK2,PD
121#126#gene1208920#27#diseaseC4020732 22736029-2#121#126#gene120892 22736029-2#0#27#diseaseC4020732 associated_with LRRK2,Mitochondrial abnormalities
38#43#gene12089276#89#diseaseC0027819 22736029-5#38#43#gene120892 22736029-5#76#89#diseaseC0027819 associated_with LRRK2,neuroblastoma
38#43#gene12089276#89#diseaseC0700095 22736029-5#38#43#gene120892 22736029-5#76#89#diseaseC0700095 associated_with LRRK2,neuroblastoma