PubMed:22615783 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22615783","sourcedb":"PubMed","sourceid":"22615783","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22615783","text":"High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.\nThe G2019S mutation in the multidomain protein leucine-rich repeat kinase 2 (LRRK2) is one of the most frequently identified genetic causes of Parkinson's disease (PD). Clinically, LRRK2(G2019S) carriers with PD and idiopathic PD patients have a very similar disease with brainstem and cortical Lewy pathology (α-synucleinopathy) as histopathological hallmarks. Some patients have Tau pathology. Enhanced kinase function of the LRRK2(G2019S) mutant protein is a prime suspect mechanism for carriers to develop PD but observations in LRRK2 knock-out, G2019S knock-in and kinase-dead mutant mice suggest that LRRK2 steady-state abundance of the protein also plays a determining role. One critical question concerning the molecular pathogenesis in LRRK2(G2019S) PD patients is whether α-synuclein (aSN) has a contributory role. To this end we generated mice with high expression of either wildtype or G2019S mutant LRRK2 in brainstem and cortical neurons. High levels of these LRRK2 variants left endogenous aSN and Tau levels unaltered and did not exacerbate or otherwise modify α-synucleinopathy in mice that co-expressed high levels of LRRK2 and aSN in brain neurons. On the contrary, in some lines high LRRK2 levels improved motor skills in the presence and absence of aSN-transgene-induced disease. Therefore, in many neurons high LRRK2 levels are well tolerated and not sufficient to drive or exacerbate neuronal α-synucleinopathy.","tracks":[{"project":"test-210614","denotations":[{"id":"22615783_0","span":{"begin":992,"end":998},"obj":"ProteinMutation"},{"id":"22615783_1","span":{"begin":845,"end":851},"obj":"ProteinMutation"},{"id":"22615783_2","span":{"begin":644,"end":650},"obj":"ProteinMutation"},{"id":"22615783_3","span":{"begin":528,"end":534},"obj":"ProteinMutation"},{"id":"22615783_4","span":{"begin":281,"end":287},"obj":"ProteinMutation"},{"id":"22615783_5","span":{"begin":98,"end":104},"obj":"ProteinMutation"}],"attributes":[{"id":"22615783_0_ProteinMutation","pred":"proteinmutation","subj":"22615783_0","obj":"rs34637584"},{"id":"22615783_1_ProteinMutation","pred":"proteinmutation","subj":"22615783_1","obj":"rs34637584"},{"id":"22615783_2_ProteinMutation","pred":"proteinmutation","subj":"22615783_2","obj":"rs34637584"},{"id":"22615783_3_ProteinMutation","pred":"proteinmutation","subj":"22615783_3","obj":"rs34637584"},{"id":"22615783_4_ProteinMutation","pred":"proteinmutation","subj":"22615783_4","obj":"rs34637584"},{"id":"22615783_5_ProteinMutation","pred":"proteinmutation","subj":"22615783_5","obj":"rs34637584"},{"subj":"22615783_0","pred":"source","obj":"test-210614"},{"subj":"22615783_1","pred":"source","obj":"test-210614"},{"subj":"22615783_2","pred":"source","obj":"test-210614"},{"subj":"22615783_3","pred":"source","obj":"test-210614"},{"subj":"22615783_4","pred":"source","obj":"test-210614"},{"subj":"22615783_5","pred":"source","obj":"test-210614"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"22615783_0","span":{"begin":992,"end":998},"obj":"ProteinMutation"},{"id":"22615783_1","span":{"begin":845,"end":851},"obj":"ProteinMutation"},{"id":"22615783_2","span":{"begin":644,"end":650},"obj":"ProteinMutation"},{"id":"22615783_3","span":{"begin":528,"end":534},"obj":"ProteinMutation"},{"id":"22615783_4","span":{"begin":281,"end":287},"obj":"ProteinMutation"},{"id":"22615783_5","span":{"begin":98,"end":104},"obj":"ProteinMutation"}],"attributes":[{"id":"22615783_0_ProteinMutation","pred":"proteinmutation","subj":"22615783_0","obj":"rs34637584"},{"id":"22615783_1_ProteinMutation","pred":"proteinmutation","subj":"22615783_1","obj":"rs34637584"},{"id":"22615783_2_ProteinMutation","pred":"proteinmutation","subj":"22615783_2","obj":"rs34637584"},{"id":"22615783_3_ProteinMutation","pred":"proteinmutation","subj":"22615783_3","obj":"rs34637584"},{"id":"22615783_4_ProteinMutation","pred":"proteinmutation","subj":"22615783_4","obj":"rs34637584"},{"id":"22615783_5_ProteinMutation","pred":"proteinmutation","subj":"22615783_5","obj":"rs34637584"},{"subj":"22615783_0","pred":"source","obj":"PubTator4TogoVar"},{"subj":"22615783_1","pred":"source","obj":"PubTator4TogoVar"},{"subj":"22615783_2","pred":"source","obj":"PubTator4TogoVar"},{"subj":"22615783_3","pred":"source","obj":"PubTator4TogoVar"},{"subj":"22615783_4","pred":"source","obj":"PubTator4TogoVar"},{"subj":"22615783_5","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":5,"end":10},"obj":"PR:Q5S006"},{"id":"T2","span":{"begin":5,"end":10},"obj":"PR:000003033"},{"id":"T3","span":{"begin":5,"end":10},"obj":"PR:Q5S007"},{"id":"T4","span":{"begin":56,"end":61},"obj":"CHEBI:30216"},{"id":"T5","span":{"begin":56,"end":77},"obj":"D000080874"},{"id":"T6","span":{"begin":56,"end":77},"obj":"D000080874"},{"id":"T9","span":{"begin":81,"end":86},"obj":"10090"},{"id":"T10","span":{"begin":81,"end":86},"obj":"D051379"},{"id":"T11","span":{"begin":87,"end":92},"obj":"UBERON:6110636"},{"id":"T12","span":{"begin":87,"end":92},"obj":"UBERON:0000955"},{"id":"T13","span":{"begin":105,"end":113},"obj":"SO:0000109"},{"id":"T14","span":{"begin":133,"end":140},"obj":"GO:0003675"},{"id":"T18","span":{"begin":133,"end":140},"obj":"SO:0000104"},{"id":"T17","span":{"begin":133,"end":140},"obj":"PR:000000001"},{"id":"T15","span":{"begin":133,"end":140},"obj":"CHEBI:36080"},{"id":"T16","span":{"begin":133,"end":140},"obj":"CHEBI:11122"},{"id":"T20","span":{"begin":141,"end":148},"obj":"6308"},{"id":"T21","span":{"begin":141,"end":148},"obj":"SO:0001437"},{"id":"T19","span":{"begin":141,"end":148},"obj":"CHEBI:15603"},{"id":"T22","span":{"begin":141,"end":148},"obj":"D007930"},{"id":"T23","span":{"begin":141,"end":148},"obj":"CHEBI:25017"},{"id":"T24","span":{"begin":141,"end":148},"obj":"D007930"},{"id":"T25","span":{"begin":154,"end":160},"obj":"SO:0001068"},{"id":"T26","span":{"begin":171,"end":176},"obj":"PR:Q5S006"},{"id":"T27","span":{"begin":171,"end":176},"obj":"PR:000003033"},{"id":"T28","span":{"begin":171,"end":176},"obj":"PR:Q5S007"},{"id":"T33","span":{"begin":237,"end":256},"obj":"D010300"},{"id":"T34","span":{"begin":237,"end":256},"obj":"D010300"},{"id":"T37","span":{"begin":275,"end":280},"obj":"PR:Q5S006"},{"id":"T38","span":{"begin":275,"end":280},"obj":"PR:000003033"},{"id":"T39","span":{"begin":275,"end":280},"obj":"PR:Q5S007"},{"id":"T40","span":{"begin":289,"end":297},"obj":"CHEBI:78059"},{"id":"T41","span":{"begin":353,"end":360},"obj":"D004194"},{"id":"T42","span":{"begin":353,"end":360},"obj":"D004194"},{"id":"T43","span":{"begin":366,"end":375},"obj":"UBERON:0002298"},{"id":"T44","span":{"begin":407,"end":422},"obj":"D000080874"},{"id":"T45","span":{"begin":407,"end":422},"obj":"D000080874"},{"id":"T46","span":{"begin":475,"end":478},"obj":"PR:P16525"},{"id":"T47","span":{"begin":475,"end":478},"obj":"PR:000024142"},{"id":"T48","span":{"begin":475,"end":478},"obj":"PR:P10636"},{"id":"T49","span":{"begin":475,"end":478},"obj":"PR:000010173"},{"id":"T50","span":{"begin":475,"end":478},"obj":"PR:P19332"},{"id":"T52","span":{"begin":475,"end":478},"obj":"PR:P10637"},{"id":"T51","span":{"begin":475,"end":478},"obj":"CHEBI:36355"},{"id":"T53","span":{"begin":522,"end":527},"obj":"PR:Q5S006"},{"id":"T54","span":{"begin":522,"end":527},"obj":"PR:000003033"},{"id":"T55","span":{"begin":522,"end":527},"obj":"PR:Q5S007"},{"id":"T56","span":{"begin":536,"end":550},"obj":"D050505"},{"id":"T60","span":{"begin":543,"end":550},"obj":"PR:000000001"},{"id":"T57","span":{"begin":543,"end":550},"obj":"GO:0003675"},{"id":"T61","span":{"begin":543,"end":550},"obj":"SO:0000104"},{"id":"T62","span":{"begin":584,"end":592},"obj":"CHEBI:78059"},{"id":"T63","span":{"begin":627,"end":632},"obj":"PR:Q5S006"},{"id":"T64","span":{"begin":627,"end":632},"obj":"PR:000003033"},{"id":"T65","span":{"begin":627,"end":632},"obj":"PR:Q5S007"},{"id":"T66","span":{"begin":683,"end":687},"obj":"PR:000005054"},{"id":"T68","span":{"begin":683,"end":687},"obj":"O89094"},{"id":"T67","span":{"begin":683,"end":687},"obj":"D051379"},{"id":"T69","span":{"begin":683,"end":687},"obj":"10095"},{"id":"T70","span":{"begin":701,"end":706},"obj":"PR:Q5S006"},{"id":"T71","span":{"begin":701,"end":706},"obj":"PR:000003033"},{"id":"T72","span":{"begin":701,"end":706},"obj":"PR:Q5S007"},{"id":"T76","span":{"begin":737,"end":744},"obj":"PR:000000001"},{"id":"T73","span":{"begin":737,"end":744},"obj":"GO:0003675"},{"id":"T77","span":{"begin":737,"end":744},"obj":"SO:0000104"},{"id":"T74","span":{"begin":737,"end":744},"obj":"CHEBI:36080"},{"id":"T75","span":{"begin":737,"end":744},"obj":"CHEBI:11122"},{"id":"T78","span":{"begin":823,"end":835},"obj":"GO:0009405"},{"id":"T79","span":{"begin":839,"end":844},"obj":"PR:Q5S006"},{"id":"T80","span":{"begin":839,"end":844},"obj":"PR:000003033"},{"id":"T81","span":{"begin":839,"end":844},"obj":"PR:Q5S007"},{"id":"T83","span":{"begin":878,"end":887},"obj":"P37379"},{"id":"T82","span":{"begin":878,"end":887},"obj":"D051843"},{"id":"T89","span":{"begin":889,"end":892},"obj":"SO:0001449"},{"id":"T84","span":{"begin":889,"end":892},"obj":"CHEBI:50347"},{"id":"T85","span":{"begin":889,"end":892},"obj":"CHEBI:50348"},{"id":"T86","span":{"begin":889,"end":892},"obj":"CHEBI:32654"},{"id":"T87","span":{"begin":889,"end":892},"obj":"CHEBI:17196"},{"id":"T88","span":{"begin":889,"end":892},"obj":"CHEBI:22653"},{"id":"T90","span":{"begin":944,"end":948},"obj":"PR:000005054"},{"id":"T92","span":{"begin":944,"end":948},"obj":"O89094"},{"id":"T91","span":{"begin":944,"end":948},"obj":"D051379"},{"id":"T93","span":{"begin":944,"end":948},"obj":"10095"},{"id":"T94","span":{"begin":1006,"end":1011},"obj":"PR:Q5S006"},{"id":"T95","span":{"begin":1006,"end":1011},"obj":"PR:000003033"},{"id":"T96","span":{"begin":1006,"end":1011},"obj":"PR:Q5S007"},{"id":"T97","span":{"begin":1015,"end":1024},"obj":"UBERON:0002298"},{"id":"T98","span":{"begin":1068,"end":1073},"obj":"PR:Q5S006"},{"id":"T99","span":{"begin":1068,"end":1073},"obj":"PR:000003033"},{"id":"T100","span":{"begin":1068,"end":1073},"obj":"PR:Q5S007"},{"id":"T106","span":{"begin":1099,"end":1102},"obj":"SO:0001449"},{"id":"T101","span":{"begin":1099,"end":1102},"obj":"CHEBI:50347"},{"id":"T102","span":{"begin":1099,"end":1102},"obj":"CHEBI:50348"},{"id":"T103","span":{"begin":1099,"end":1102},"obj":"CHEBI:32654"},{"id":"T104","span":{"begin":1099,"end":1102},"obj":"CHEBI:17196"},{"id":"T105","span":{"begin":1099,"end":1102},"obj":"CHEBI:22653"},{"id":"T107","span":{"begin":1107,"end":1110},"obj":"PR:P16525"},{"id":"T108","span":{"begin":1107,"end":1110},"obj":"PR:000024142"},{"id":"T109","span":{"begin":1107,"end":1110},"obj":"PR:P10636"},{"id":"T110","span":{"begin":1107,"end":1110},"obj":"PR:000010173"},{"id":"T111","span":{"begin":1107,"end":1110},"obj":"PR:P19332"},{"id":"T113","span":{"begin":1107,"end":1110},"obj":"PR:P10637"},{"id":"T112","span":{"begin":1107,"end":1110},"obj":"CHEBI:36355"},{"id":"T114","span":{"begin":1173,"end":1188},"obj":"D000080874"},{"id":"T115","span":{"begin":1173,"end":1188},"obj":"D000080874"},{"id":"T116","span":{"begin":1192,"end":1196},"obj":"PR:000005054"},{"id":"T118","span":{"begin":1192,"end":1196},"obj":"O89094"},{"id":"T117","span":{"begin":1192,"end":1196},"obj":"D051379"},{"id":"T119","span":{"begin":1192,"end":1196},"obj":"10095"},{"id":"T120","span":{"begin":1230,"end":1235},"obj":"PR:Q5S006"},{"id":"T121","span":{"begin":1230,"end":1235},"obj":"PR:000003033"},{"id":"T122","span":{"begin":1230,"end":1235},"obj":"PR:Q5S007"},{"id":"T128","span":{"begin":1240,"end":1243},"obj":"SO:0001449"},{"id":"T123","span":{"begin":1240,"end":1243},"obj":"CHEBI:50347"},{"id":"T124","span":{"begin":1240,"end":1243},"obj":"CHEBI:50348"},{"id":"T125","span":{"begin":1240,"end":1243},"obj":"CHEBI:32654"},{"id":"T126","span":{"begin":1240,"end":1243},"obj":"CHEBI:17196"},{"id":"T127","span":{"begin":1240,"end":1243},"obj":"CHEBI:22653"},{"id":"T129","span":{"begin":1247,"end":1252},"obj":"UBERON:6110636"},{"id":"T130","span":{"begin":1247,"end":1252},"obj":"UBERON:0000955"},{"id":"T131","span":{"begin":1298,"end":1303},"obj":"PR:Q5S006"},{"id":"T132","span":{"begin":1298,"end":1303},"obj":"PR:000003033"},{"id":"T133","span":{"begin":1298,"end":1303},"obj":"PR:Q5S007"},{"id":"T139","span":{"begin":1364,"end":1367},"obj":"SO:0001449"},{"id":"T134","span":{"begin":1364,"end":1367},"obj":"CHEBI:50347"},{"id":"T135","span":{"begin":1364,"end":1367},"obj":"CHEBI:50348"},{"id":"T136","span":{"begin":1364,"end":1367},"obj":"CHEBI:32654"},{"id":"T137","span":{"begin":1364,"end":1367},"obj":"CHEBI:17196"},{"id":"T138","span":{"begin":1364,"end":1367},"obj":"CHEBI:22653"},{"id":"T140","span":{"begin":1368,"end":1377},"obj":"SO:0000902"},{"id":"T141","span":{"begin":1386,"end":1393},"obj":"D004194"},{"id":"T142","span":{"begin":1386,"end":1393},"obj":"D004194"},{"id":"T143","span":{"begin":1427,"end":1432},"obj":"PR:Q5S006"},{"id":"T144","span":{"begin":1427,"end":1432},"obj":"PR:000003033"},{"id":"T145","span":{"begin":1427,"end":1432},"obj":"PR:Q5S007"},{"id":"T146","span":{"begin":1512,"end":1527},"obj":"D000080874"},{"id":"T147","span":{"begin":1512,"end":1527},"obj":"D000080874"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":237,"end":246},"obj":"HP_0001300"},{"id":"T2","span":{"begin":671,"end":675},"obj":"HP_0000365"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_22615783_1_0","span":{"begin":141,"end":169},"obj":"expanded"},{"id":"SS2_22615783_1_0","span":{"begin":171,"end":176},"obj":"abbr"},{"id":"SS1_22615783_1_1","span":{"begin":237,"end":256},"obj":"expanded"},{"id":"SS2_22615783_1_1","span":{"begin":258,"end":260},"obj":"abbr"},{"id":"SS1_22615783_5_0","span":{"begin":876,"end":887},"obj":"expanded"},{"id":"SS2_22615783_5_0","span":{"begin":889,"end":892},"obj":"abbr"}],"relations":[{"id":"AE1_22615783_1_0","pred":"abbreviatedTo","subj":"SS1_22615783_1_0","obj":"SS2_22615783_1_0"},{"id":"AE1_22615783_1_1","pred":"abbreviatedTo","subj":"SS1_22615783_1_1","obj":"SS2_22615783_1_1"},{"id":"AE1_22615783_5_0","pred":"abbreviatedTo","subj":"SS1_22615783_5_0","obj":"SS2_22615783_5_0"}],"attributes":[{"subj":"SS1_22615783_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_22615783_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_22615783_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_22615783_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_22615783_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_22615783_5_0","pred":"source","obj":"Allie"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":93},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":94,"end":262},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":263,"end":455},"obj":"DRI_Challenge"},{"id":"T4","span":{"begin":456,"end":489},"obj":"DRI_Background"},{"id":"T5","span":{"begin":490,"end":643},"obj":"DRI_Background"},{"id":"T6","span":{"begin":644,"end":659},"obj":"Token_Label.OUTSIDE"},{"id":"T7","span":{"begin":660,"end":775},"obj":"DRI_Background"},{"id":"T8","span":{"begin":776,"end":918},"obj":"DRI_Background"},{"id":"T9","span":{"begin":919,"end":1046},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1047,"end":1261},"obj":"DRI_Unspecified"},{"id":"T11","span":{"begin":1262,"end":1394},"obj":"DRI_Outcome"},{"id":"T12","span":{"begin":1395,"end":1528},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":94,"end":262},"obj":"DRI_Approach"},{"id":"T2","span":{"begin":263,"end":455},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":456,"end":489},"obj":"DRI_Background"},{"id":"T4","span":{"begin":490,"end":643},"obj":"DRI_Background"},{"id":"T5","span":{"begin":660,"end":775},"obj":"DRI_Background"},{"id":"T6","span":{"begin":776,"end":918},"obj":"DRI_Background"},{"id":"T7","span":{"begin":919,"end":1046},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":1262,"end":1394},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":1395,"end":1528},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"test-210614","color":"#cb93ec","default":true},{"id":"PubTator4TogoVar","color":"#93ecb0"},{"id":"c_corpus","color":"#ec9693"},{"id":"PubmedHPO","color":"#93a9ec"},{"id":"Allie","color":"#c3ec93"},{"id":"UseCases_ArguminSci_Discourse","color":"#ec93dd"},{"id":"PubMed_ArguminSci","color":"#93ece1"}]}]}}