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test-210614

Id Subject Object Predicate Lexical cue proteinmutation
22615783_0 992-998 ProteinMutation denotes G2019S rs34637584
22615783_1 845-851 ProteinMutation denotes G2019S rs34637584
22615783_2 644-650 ProteinMutation denotes G2019S rs34637584
22615783_3 528-534 ProteinMutation denotes G2019S rs34637584
22615783_4 281-287 ProteinMutation denotes G2019S rs34637584
22615783_5 98-104 ProteinMutation denotes G2019S rs34637584

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
22615783_0 992-998 ProteinMutation denotes G2019S rs34637584
22615783_1 845-851 ProteinMutation denotes G2019S rs34637584
22615783_2 644-650 ProteinMutation denotes G2019S rs34637584
22615783_3 528-534 ProteinMutation denotes G2019S rs34637584
22615783_4 281-287 ProteinMutation denotes G2019S rs34637584
22615783_5 98-104 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 5-10 PR:Q5S006 denotes LRRK2
T2 5-10 PR:000003033 denotes LRRK2
T3 5-10 PR:Q5S007 denotes LRRK2
T4 56-61 CHEBI:30216 denotes alpha
T5 56-77 D000080874 denotes alpha-synucleinopathy
T6 56-77 D000080874 denotes alpha-synucleinopathy
T9 81-86 10090 denotes mouse
T10 81-86 D051379 denotes mouse
T11 87-92 UBERON:6110636 denotes brain
T12 87-92 UBERON:0000955 denotes brain
T13 105-113 SO:0000109 denotes mutation
T14 133-140 GO:0003675 denotes protein
T18 133-140 SO:0000104 denotes protein
T17 133-140 PR:000000001 denotes protein
T15 133-140 CHEBI:36080 denotes protein
T16 133-140 CHEBI:11122 denotes protein
T20 141-148 6308 denotes leucine
T21 141-148 SO:0001437 denotes leucine
T19 141-148 CHEBI:15603 denotes leucine
T22 141-148 D007930 denotes leucine
T23 141-148 CHEBI:25017 denotes leucine
T24 141-148 D007930 denotes leucine
T25 154-160 SO:0001068 denotes repeat
T26 171-176 PR:Q5S006 denotes LRRK2
T27 171-176 PR:000003033 denotes LRRK2
T28 171-176 PR:Q5S007 denotes LRRK2
T33 237-256 D010300 denotes Parkinson's disease
T34 237-256 D010300 denotes Parkinson's disease
T37 275-280 PR:Q5S006 denotes LRRK2
T38 275-280 PR:000003033 denotes LRRK2
T39 275-280 PR:Q5S007 denotes LRRK2
T40 289-297 CHEBI:78059 denotes carriers
T41 353-360 D004194 denotes disease
T42 353-360 D004194 denotes disease
T43 366-375 UBERON:0002298 denotes brainstem
T44 407-422 D000080874 denotes synucleinopathy
T45 407-422 D000080874 denotes synucleinopathy
T46 475-478 PR:P16525 denotes Tau
T47 475-478 PR:000024142 denotes Tau
T48 475-478 PR:P10636 denotes Tau
T49 475-478 PR:000010173 denotes Tau
T50 475-478 PR:P19332 denotes Tau
T52 475-478 PR:P10637 denotes Tau
T51 475-478 CHEBI:36355 denotes Tau
T53 522-527 PR:Q5S006 denotes LRRK2
T54 522-527 PR:000003033 denotes LRRK2
T55 522-527 PR:Q5S007 denotes LRRK2
T56 536-550 D050505 denotes mutant protein
T60 543-550 PR:000000001 denotes protein
T57 543-550 GO:0003675 denotes protein
T61 543-550 SO:0000104 denotes protein
T62 584-592 CHEBI:78059 denotes carriers
T63 627-632 PR:Q5S006 denotes LRRK2
T64 627-632 PR:000003033 denotes LRRK2
T65 627-632 PR:Q5S007 denotes LRRK2
T66 683-687 PR:000005054 denotes mice
T68 683-687 O89094 denotes mice
T67 683-687 D051379 denotes mice
T69 683-687 10095 denotes mice
T70 701-706 PR:Q5S006 denotes LRRK2
T71 701-706 PR:000003033 denotes LRRK2
T72 701-706 PR:Q5S007 denotes LRRK2
T76 737-744 PR:000000001 denotes protein
T73 737-744 GO:0003675 denotes protein
T77 737-744 SO:0000104 denotes protein
T74 737-744 CHEBI:36080 denotes protein
T75 737-744 CHEBI:11122 denotes protein
T78 823-835 GO:0009405 denotes pathogenesis
T79 839-844 PR:Q5S006 denotes LRRK2
T80 839-844 PR:000003033 denotes LRRK2
T81 839-844 PR:Q5S007 denotes LRRK2
T83 878-887 P37379 denotes synuclein
T82 878-887 D051843 denotes synuclein
T89 889-892 SO:0001449 denotes aSN
T84 889-892 CHEBI:50347 denotes aSN
T85 889-892 CHEBI:50348 denotes aSN
T86 889-892 CHEBI:32654 denotes aSN
T87 889-892 CHEBI:17196 denotes aSN
T88 889-892 CHEBI:22653 denotes aSN
T90 944-948 PR:000005054 denotes mice
T92 944-948 O89094 denotes mice
T91 944-948 D051379 denotes mice
T93 944-948 10095 denotes mice
T94 1006-1011 PR:Q5S006 denotes LRRK2
T95 1006-1011 PR:000003033 denotes LRRK2
T96 1006-1011 PR:Q5S007 denotes LRRK2
T97 1015-1024 UBERON:0002298 denotes brainstem
T98 1068-1073 PR:Q5S006 denotes LRRK2
T99 1068-1073 PR:000003033 denotes LRRK2
T100 1068-1073 PR:Q5S007 denotes LRRK2
T106 1099-1102 SO:0001449 denotes aSN
T101 1099-1102 CHEBI:50347 denotes aSN
T102 1099-1102 CHEBI:50348 denotes aSN
T103 1099-1102 CHEBI:32654 denotes aSN
T104 1099-1102 CHEBI:17196 denotes aSN
T105 1099-1102 CHEBI:22653 denotes aSN
T107 1107-1110 PR:P16525 denotes Tau
T108 1107-1110 PR:000024142 denotes Tau
T109 1107-1110 PR:P10636 denotes Tau
T110 1107-1110 PR:000010173 denotes Tau
T111 1107-1110 PR:P19332 denotes Tau
T113 1107-1110 PR:P10637 denotes Tau
T112 1107-1110 CHEBI:36355 denotes Tau
T114 1173-1188 D000080874 denotes synucleinopathy
T115 1173-1188 D000080874 denotes synucleinopathy
T116 1192-1196 PR:000005054 denotes mice
T118 1192-1196 O89094 denotes mice
T117 1192-1196 D051379 denotes mice
T119 1192-1196 10095 denotes mice
T120 1230-1235 PR:Q5S006 denotes LRRK2
T121 1230-1235 PR:000003033 denotes LRRK2
T122 1230-1235 PR:Q5S007 denotes LRRK2
T128 1240-1243 SO:0001449 denotes aSN
T123 1240-1243 CHEBI:50347 denotes aSN
T124 1240-1243 CHEBI:50348 denotes aSN
T125 1240-1243 CHEBI:32654 denotes aSN
T126 1240-1243 CHEBI:17196 denotes aSN
T127 1240-1243 CHEBI:22653 denotes aSN
T129 1247-1252 UBERON:6110636 denotes brain
T130 1247-1252 UBERON:0000955 denotes brain
T131 1298-1303 PR:Q5S006 denotes LRRK2
T132 1298-1303 PR:000003033 denotes LRRK2
T133 1298-1303 PR:Q5S007 denotes LRRK2
T139 1364-1367 SO:0001449 denotes aSN
T134 1364-1367 CHEBI:50347 denotes aSN
T135 1364-1367 CHEBI:50348 denotes aSN
T136 1364-1367 CHEBI:32654 denotes aSN
T137 1364-1367 CHEBI:17196 denotes aSN
T138 1364-1367 CHEBI:22653 denotes aSN
T140 1368-1377 SO:0000902 denotes transgene
T141 1386-1393 D004194 denotes disease
T142 1386-1393 D004194 denotes disease
T143 1427-1432 PR:Q5S006 denotes LRRK2
T144 1427-1432 PR:000003033 denotes LRRK2
T145 1427-1432 PR:Q5S007 denotes LRRK2
T146 1512-1527 D000080874 denotes synucleinopathy
T147 1512-1527 D000080874 denotes synucleinopathy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 237-246 HP_0001300 denotes Parkinson
T2 671-675 HP_0000365 denotes dead

Allie

Id Subject Object Predicate Lexical cue
SS1_22615783_1_0 141-169 expanded denotes leucine-rich repeat kinase 2
SS2_22615783_1_0 171-176 abbr denotes LRRK2
SS1_22615783_1_1 237-256 expanded denotes Parkinson's disease
SS2_22615783_1_1 258-260 abbr denotes PD
SS1_22615783_5_0 876-887 expanded denotes α-synuclein
SS2_22615783_5_0 889-892 abbr denotes aSN
AE1_22615783_1_0 SS1_22615783_1_0 SS2_22615783_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_22615783_1_1 SS1_22615783_1_1 SS2_22615783_1_1 abbreviatedTo Parkinson's disease,PD
AE1_22615783_5_0 SS1_22615783_5_0 SS2_22615783_5_0 abbreviatedTo α-synuclein,aSN

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-93 DRI_Challenge denotes High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
T2 94-262 DRI_Challenge denotes The G2019S mutation in the multidomain protein leucine-rich repeat kinase 2 (LRRK2) is one of the most frequently identified genetic causes of Parkinson's disease (PD).
T3 263-455 DRI_Challenge denotes Clinically, LRRK2(G2019S) carriers with PD and idiopathic PD patients have a very similar disease with brainstem and cortical Lewy pathology (α-synucleinopathy) as histopathological hallmarks.
T4 456-489 DRI_Background denotes Some patients have Tau pathology.
T5 490-643 DRI_Background denotes Enhanced kinase function of the LRRK2(G2019S) mutant protein is a prime suspect mechanism for carriers to develop PD but observations in LRRK2 knock-out,
T6 644-659 Token_Label.OUTSIDE denotes G2019S knock-in
T7 660-775 DRI_Background denotes and kinase-dead mutant mice suggest that LRRK2 steady-state abundance of the protein also plays a determining role.
T8 776-918 DRI_Background denotes One critical question concerning the molecular pathogenesis in LRRK2(G2019S) PD patients is whether α-synuclein (aSN) has a contributory role.
T9 919-1046 DRI_Outcome denotes To this end we generated mice with high expression of either wildtype or G2019S mutant LRRK2 in brainstem and cortical neurons.
T10 1047-1261 DRI_Unspecified denotes High levels of these LRRK2 variants left endogenous aSN and Tau levels unaltered and did not exacerbate or otherwise modify α-synucleinopathy in mice that co-expressed high levels of LRRK2 and aSN in brain neurons.
T11 1262-1394 DRI_Outcome denotes On the contrary, in some lines high LRRK2 levels improved motor skills in the presence and absence of aSN-transgene-induced disease.
T12 1395-1528 DRI_Challenge denotes Therefore, in many neurons high LRRK2 levels are well tolerated and not sufficient to drive or exacerbate neuronal α-synucleinopathy.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 94-262 DRI_Approach denotes The G2019S mutation in the multidomain protein leucine-rich repeat kinase 2 (LRRK2) is one of the most frequently identified genetic causes of Parkinson's disease (PD).
T2 263-455 DRI_Challenge denotes Clinically, LRRK2(G2019S) carriers with PD and idiopathic PD patients have a very similar disease with brainstem and cortical Lewy pathology (α-synucleinopathy) as histopathological hallmarks.
T3 456-489 DRI_Background denotes Some patients have Tau pathology.
T4 490-643 DRI_Background denotes Enhanced kinase function of the LRRK2(G2019S) mutant protein is a prime suspect mechanism for carriers to develop PD but observations in LRRK2 knock-out,
T5 660-775 DRI_Background denotes and kinase-dead mutant mice suggest that LRRK2 steady-state abundance of the protein also plays a determining role.
T6 776-918 DRI_Background denotes One critical question concerning the molecular pathogenesis in LRRK2(G2019S) PD patients is whether α-synuclein (aSN) has a contributory role.
T7 919-1046 DRI_Outcome denotes To this end we generated mice with high expression of either wildtype or G2019S mutant LRRK2 in brainstem and cortical neurons.
T8 1262-1394 DRI_Outcome denotes On the contrary, in some lines high LRRK2 levels improved motor skills in the presence and absence of aSN-transgene-induced disease.
T9 1395-1528 DRI_Challenge denotes Therefore, in many neurons high LRRK2 levels are well tolerated and not sufficient to drive or exacerbate neuronal α-synucleinopathy.