PubMed:22547651 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22547651","sourcedb":"PubMed","sourceid":"22547651","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22547651","text":"Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.\nHuman skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood. In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs). CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation. Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs. These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity. These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity. Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_22547651_2_0","span":{"begin":326,"end":340},"obj":"expanded"},{"id":"SS2_22547651_2_0","span":{"begin":342,"end":344},"obj":"abbr"},{"id":"SS1_22547651_4_0","span":{"begin":693,"end":705},"obj":"expanded"},{"id":"SS2_22547651_4_0","span":{"begin":707,"end":712},"obj":"abbr"}],"relations":[{"id":"AE1_22547651_2_0","pred":"abbreviatedTo","subj":"SS1_22547651_2_0","obj":"SS2_22547651_2_0"},{"id":"AE1_22547651_4_0","pred":"abbreviatedTo","subj":"SS1_22547651_4_0","obj":"SS2_22547651_4_0"}],"attributes":[{"subj":"SS1_22547651_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_22547651_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_22547651_4_0","pred":"source","obj":"Allie"},{"subj":"SS2_22547651_4_0","pred":"source","obj":"Allie"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":812,"end":817},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":207,"end":213},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":310,"end":316},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":771,"end":777},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":353,"end":359},"obj":"http://purl.obolibrary.org/obo/UBERON_0002067"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":506,"end":511},"obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":506,"end":516},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"performance-test"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":674,"end":691},"obj":"HP_0011123"},{"id":"T2","span":{"begin":974,"end":979},"obj":"HP_0002664"},{"id":"T3","span":{"begin":1141,"end":1146},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":484,"end":489},"obj":"gene:7056"},{"id":"T1","span":{"begin":674,"end":691},"obj":"disease:C0011603"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":131,"end":262},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":263,"end":483},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":484,"end":692},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":693,"end":822},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":823,"end":993},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":994,"end":1160},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1161,"end":1282},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"T2","span":{"begin":131,"end":262},"obj":"Sentence"},{"id":"T3","span":{"begin":263,"end":483},"obj":"Sentence"},{"id":"T4","span":{"begin":484,"end":692},"obj":"Sentence"},{"id":"T5","span":{"begin":693,"end":822},"obj":"Sentence"},{"id":"T6","span":{"begin":823,"end":993},"obj":"Sentence"},{"id":"T7","span":{"begin":994,"end":1160},"obj":"Sentence"},{"id":"T8","span":{"begin":1161,"end":1282},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":207,"end":213},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":310,"end":316},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":771,"end":777},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":353,"end":359},"obj":"http://purl.obolibrary.org/obo/UBERON_0002067"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":506,"end":511},"obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":506,"end":516},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":812,"end":817},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T1877","span":{"begin":9,"end":14},"obj":"gene:7056"},{"id":"T1878","span":{"begin":112,"end":129},"obj":"disease:C0011603"},{"id":"T1879","span":{"begin":16,"end":21},"obj":"gene:7056"},{"id":"T1880","span":{"begin":62,"end":67},"obj":"gene:3586"},{"id":"T1881","span":{"begin":493,"end":496},"obj":"gene:1644"},{"id":"T1882","span":{"begin":674,"end":691},"obj":"disease:C0011603"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T1877","obj":"T1878"},{"id":"R2","pred":"associated_with","subj":"T1877","obj":"T1878"},{"id":"R3","pred":"associated_with","subj":"T1879","obj":"T1878"},{"id":"R4","pred":"associated_with","subj":"T1879","obj":"T1878"},{"id":"R5","pred":"associated_with","subj":"T1880","obj":"T1878"},{"id":"R6","pred":"associated_with","subj":"T1880","obj":"T1878"},{"id":"R7","pred":"associated_with","subj":"T1881","obj":"T1882"},{"id":"R8","pred":"associated_with","subj":"T1881","obj":"T1882"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T1877","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1878","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1879","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1880","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1881","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T1882","pred":"source","obj":"DisGeNet-2017-sample"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"22547651-0#9#14#gene7056","span":{"begin":9,"end":14},"obj":"gene7056"},{"id":"22547651-0#16#21#gene7056","span":{"begin":16,"end":21},"obj":"gene7056"},{"id":"22547651-0#62#67#gene3586","span":{"begin":62,"end":67},"obj":"gene3586"},{"id":"22547651-0#112#129#diseaseC0011603","span":{"begin":112,"end":129},"obj":"diseaseC0011603"},{"id":"22547651-0#112#129#diseaseC3875321","span":{"begin":112,"end":129},"obj":"diseaseC3875321"},{"id":"22547651-0#112#129#diseaseC0011603","span":{"begin":112,"end":129},"obj":"diseaseC0011603"},{"id":"22547651-0#112#129#diseaseC3875321","span":{"begin":112,"end":129},"obj":"diseaseC3875321"},{"id":"22547651-0#112#129#diseaseC0011603","span":{"begin":112,"end":129},"obj":"diseaseC0011603"},{"id":"22547651-0#112#129#diseaseC3875321","span":{"begin":112,"end":129},"obj":"diseaseC3875321"},{"id":"22547651-3#9#12#gene1644","span":{"begin":493,"end":496},"obj":"gene1644"},{"id":"22547651-3#190#207#diseaseC0011603","span":{"begin":674,"end":691},"obj":"diseaseC0011603"},{"id":"22547651-3#190#207#diseaseC3875321","span":{"begin":674,"end":691},"obj":"diseaseC3875321"},{"id":"22547651-5#6#11#gene7056","span":{"begin":829,"end":834},"obj":"gene7056"},{"id":"22547651-5#15#18#gene1644","span":{"begin":838,"end":841},"obj":"gene1644"},{"id":"22547651-5#121#146#diseaseC0018133","span":{"begin":944,"end":969},"obj":"diseaseC0018133"}],"relations":[{"id":"9#14#gene7056112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#9#14#gene7056","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"9#14#gene7056112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#9#14#gene7056","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"9#14#gene7056112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#9#14#gene7056","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"9#14#gene7056112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#9#14#gene7056","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"9#14#gene7056112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#9#14#gene7056","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"9#14#gene7056112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#9#14#gene7056","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"16#21#gene7056112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#16#21#gene7056","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"16#21#gene7056112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#16#21#gene7056","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"16#21#gene7056112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#16#21#gene7056","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"16#21#gene7056112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#16#21#gene7056","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"16#21#gene7056112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#16#21#gene7056","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"16#21#gene7056112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#16#21#gene7056","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"62#67#gene3586112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#62#67#gene3586","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"62#67#gene3586112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#62#67#gene3586","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"62#67#gene3586112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#62#67#gene3586","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"62#67#gene3586112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#62#67#gene3586","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"62#67#gene3586112#129#diseaseC0011603","pred":"associated_with","subj":"22547651-0#62#67#gene3586","obj":"22547651-0#112#129#diseaseC0011603"},{"id":"62#67#gene3586112#129#diseaseC3875321","pred":"associated_with","subj":"22547651-0#62#67#gene3586","obj":"22547651-0#112#129#diseaseC3875321"},{"id":"9#12#gene1644190#207#diseaseC0011603","pred":"associated_with","subj":"22547651-3#9#12#gene1644","obj":"22547651-3#190#207#diseaseC0011603"},{"id":"9#12#gene1644190#207#diseaseC3875321","pred":"associated_with","subj":"22547651-3#9#12#gene1644","obj":"22547651-3#190#207#diseaseC3875321"},{"id":"6#11#gene7056121#146#diseaseC0018133","pred":"associated_with","subj":"22547651-5#6#11#gene7056","obj":"22547651-5#121#146#diseaseC0018133"},{"id":"15#18#gene1644121#146#diseaseC0018133","pred":"associated_with","subj":"22547651-5#15#18#gene1644","obj":"22547651-5#121#146#diseaseC0018133"}],"attributes":[{"subj":"22547651-0#9#14#gene7056","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#16#21#gene7056","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#62#67#gene3586","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#112#129#diseaseC0011603","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#112#129#diseaseC3875321","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#112#129#diseaseC0011603","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#112#129#diseaseC3875321","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#112#129#diseaseC0011603","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-0#112#129#diseaseC3875321","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-3#9#12#gene1644","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-3#190#207#diseaseC0011603","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-3#190#207#diseaseC3875321","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-5#6#11#gene7056","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-5#15#18#gene1644","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22547651-5#121#146#diseaseC0018133","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"T2","span":{"begin":131,"end":262},"obj":"Sentence"},{"id":"T3","span":{"begin":263,"end":483},"obj":"Sentence"},{"id":"T4","span":{"begin":484,"end":692},"obj":"Sentence"},{"id":"T5","span":{"begin":693,"end":822},"obj":"Sentence"},{"id":"T6","span":{"begin":823,"end":993},"obj":"Sentence"},{"id":"T7","span":{"begin":994,"end":1160},"obj":"Sentence"},{"id":"T8","span":{"begin":1161,"end":1282},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"T2","span":{"begin":131,"end":262},"obj":"Sentence"},{"id":"T3","span":{"begin":263,"end":483},"obj":"Sentence"},{"id":"T4","span":{"begin":484,"end":692},"obj":"Sentence"},{"id":"T5","span":{"begin":693,"end":822},"obj":"Sentence"},{"id":"T6","span":{"begin":823,"end":993},"obj":"Sentence"},{"id":"T7","span":{"begin":994,"end":1160},"obj":"Sentence"},{"id":"T8","span":{"begin":1161,"end":1282},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#d7ec93","default":true},{"id":"performance-test","color":"#e793ec"},{"id":"PubmedHPO","color":"#93eccd"},{"id":"DisGeNET","color":"#ecb393"},{"id":"sentences","color":"#9993ec"},{"id":"UBERON-AE","color":"#a6ec93"},{"id":"DisGeNet-2017-sample","color":"#ec93c1"},{"id":"DisGeNET5_gene_disease","color":"#93dbec"},{"id":"Inflammaging","color":"#ece393"}]}]}}