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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.
T2 131-262 Sentence denotes Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood.
T3 263-483 Sentence denotes In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs).
T4 484-692 Sentence denotes CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation.
T5 693-822 Sentence denotes Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs.
T6 823-993 Sentence denotes These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity.
T7 994-1160 Sentence denotes These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity.
T8 1161-1282 Sentence denotes Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.
T1 0-130 Sentence denotes Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.
T2 131-262 Sentence denotes Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood.
T3 263-483 Sentence denotes In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs).
T4 484-692 Sentence denotes CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation.
T5 693-822 Sentence denotes Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs.
T6 823-993 Sentence denotes These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity.
T7 994-1160 Sentence denotes These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity.
T8 1161-1282 Sentence denotes Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 484-489 gene:7056 denotes CD141
T1 674-691 disease:C0011603 denotes skin inflammation
R1 T0 T1 associated_with CD141,skin inflammation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 674-691 HP_0011123 denotes skin inflammation
T2 974-979 HP_0002664 denotes tumor
T3 1141-1146 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_22547651_2_0 326-340 expanded denotes dendritic cell
SS2_22547651_2_0 342-344 abbr denotes DC
SS1_22547651_4_0 693-705 expanded denotes Vitamin D(3)
SS2_22547651_4_0 707-712 abbr denotes VitD3
AE1_22547651_2_0 SS1_22547651_2_0 SS2_22547651_2_0 abbreviatedTo dendritic cell,DC
AE1_22547651_4_0 SS1_22547651_4_0 SS2_22547651_4_0 abbreviatedTo Vitamin D(3),VitD3

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22547651-0#9#14#gene7056 9-14 gene7056 denotes CD141
22547651-0#16#21#gene7056 16-21 gene7056 denotes BDCA3
22547651-0#62#67#gene3586 62-67 gene3586 denotes IL-10
22547651-0#112#129#diseaseC0011603 112-129 diseaseC0011603 denotes skin inflammation
22547651-0#112#129#diseaseC3875321 112-129 diseaseC3875321 denotes skin inflammation
22547651-0#112#129#diseaseC0011603 112-129 diseaseC0011603 denotes skin inflammation
22547651-0#112#129#diseaseC3875321 112-129 diseaseC3875321 denotes skin inflammation
22547651-0#112#129#diseaseC0011603 112-129 diseaseC0011603 denotes skin inflammation
22547651-0#112#129#diseaseC3875321 112-129 diseaseC3875321 denotes skin inflammation
22547651-3#9#12#gene1644 493-496 gene1644 denotes DDC
22547651-3#190#207#diseaseC0011603 674-691 diseaseC0011603 denotes skin inflammation
22547651-3#190#207#diseaseC3875321 674-691 diseaseC3875321 denotes skin inflammation
22547651-5#6#11#gene7056 829-834 gene7056 denotes CD141
22547651-5#15#18#gene1644 838-841 gene1644 denotes DDC
22547651-5#121#146#diseaseC0018133 944-969 diseaseC0018133 denotes graft versus host disease
9#14#gene7056112#129#diseaseC0011603 22547651-0#9#14#gene7056 22547651-0#112#129#diseaseC0011603 associated_with CD141,skin inflammation
9#14#gene7056112#129#diseaseC3875321 22547651-0#9#14#gene7056 22547651-0#112#129#diseaseC3875321 associated_with CD141,skin inflammation
9#14#gene7056112#129#diseaseC0011603 22547651-0#9#14#gene7056 22547651-0#112#129#diseaseC0011603 associated_with CD141,skin inflammation
9#14#gene7056112#129#diseaseC3875321 22547651-0#9#14#gene7056 22547651-0#112#129#diseaseC3875321 associated_with CD141,skin inflammation
9#14#gene7056112#129#diseaseC0011603 22547651-0#9#14#gene7056 22547651-0#112#129#diseaseC0011603 associated_with CD141,skin inflammation
9#14#gene7056112#129#diseaseC3875321 22547651-0#9#14#gene7056 22547651-0#112#129#diseaseC3875321 associated_with CD141,skin inflammation
16#21#gene7056112#129#diseaseC0011603 22547651-0#16#21#gene7056 22547651-0#112#129#diseaseC0011603 associated_with BDCA3,skin inflammation
16#21#gene7056112#129#diseaseC3875321 22547651-0#16#21#gene7056 22547651-0#112#129#diseaseC3875321 associated_with BDCA3,skin inflammation
16#21#gene7056112#129#diseaseC0011603 22547651-0#16#21#gene7056 22547651-0#112#129#diseaseC0011603 associated_with BDCA3,skin inflammation
16#21#gene7056112#129#diseaseC3875321 22547651-0#16#21#gene7056 22547651-0#112#129#diseaseC3875321 associated_with BDCA3,skin inflammation
16#21#gene7056112#129#diseaseC0011603 22547651-0#16#21#gene7056 22547651-0#112#129#diseaseC0011603 associated_with BDCA3,skin inflammation
16#21#gene7056112#129#diseaseC3875321 22547651-0#16#21#gene7056 22547651-0#112#129#diseaseC3875321 associated_with BDCA3,skin inflammation
62#67#gene3586112#129#diseaseC0011603 22547651-0#62#67#gene3586 22547651-0#112#129#diseaseC0011603 associated_with IL-10,skin inflammation
62#67#gene3586112#129#diseaseC3875321 22547651-0#62#67#gene3586 22547651-0#112#129#diseaseC3875321 associated_with IL-10,skin inflammation
62#67#gene3586112#129#diseaseC0011603 22547651-0#62#67#gene3586 22547651-0#112#129#diseaseC0011603 associated_with IL-10,skin inflammation
62#67#gene3586112#129#diseaseC3875321 22547651-0#62#67#gene3586 22547651-0#112#129#diseaseC3875321 associated_with IL-10,skin inflammation
62#67#gene3586112#129#diseaseC0011603 22547651-0#62#67#gene3586 22547651-0#112#129#diseaseC0011603 associated_with IL-10,skin inflammation
62#67#gene3586112#129#diseaseC3875321 22547651-0#62#67#gene3586 22547651-0#112#129#diseaseC3875321 associated_with IL-10,skin inflammation
9#12#gene1644190#207#diseaseC0011603 22547651-3#9#12#gene1644 22547651-3#190#207#diseaseC0011603 associated_with DDC,skin inflammation
9#12#gene1644190#207#diseaseC3875321 22547651-3#9#12#gene1644 22547651-3#190#207#diseaseC3875321 associated_with DDC,skin inflammation
6#11#gene7056121#146#diseaseC0018133 22547651-5#6#11#gene7056 22547651-5#121#146#diseaseC0018133 associated_with CD141,graft versus host disease
15#18#gene1644121#146#diseaseC0018133 22547651-5#15#18#gene1644 22547651-5#121#146#diseaseC0018133 associated_with DDC,graft versus host disease

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1877 9-14 gene:7056 denotes CD141
T1878 112-129 disease:C0011603 denotes skin inflammation
T1879 16-21 gene:7056 denotes BDCA3
T1880 62-67 gene:3586 denotes IL-10
T1881 493-496 gene:1644 denotes DDC
T1882 674-691 disease:C0011603 denotes skin inflammation
R1 T1877 T1878 associated_with CD141,skin inflammation
R2 T1877 T1878 associated_with CD141,skin inflammation
R3 T1879 T1878 associated_with BDCA3,skin inflammation
R4 T1879 T1878 associated_with BDCA3,skin inflammation
R5 T1880 T1878 associated_with IL-10,skin inflammation
R6 T1880 T1878 associated_with IL-10,skin inflammation
R7 T1881 T1882 associated_with DDC,skin inflammation
R8 T1881 T1882 associated_with DDC,skin inflammation

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.
TextSentencer_T2 131-262 Sentence denotes Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood.
TextSentencer_T3 263-483 Sentence denotes In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs).
TextSentencer_T4 484-692 Sentence denotes CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation.
TextSentencer_T5 693-822 Sentence denotes Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs.
TextSentencer_T6 823-993 Sentence denotes These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity.
TextSentencer_T7 994-1160 Sentence denotes These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity.
TextSentencer_T8 1161-1282 Sentence denotes Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.
T1 0-130 Sentence denotes Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.
T2 131-262 Sentence denotes Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood.
T3 263-483 Sentence denotes In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs).
T4 484-692 Sentence denotes CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation.
T5 693-822 Sentence denotes Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs.
T6 823-993 Sentence denotes These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity.
T7 994-1160 Sentence denotes These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity.
T8 1161-1282 Sentence denotes Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 207-213 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 310-316 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 771-777 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 353-359 http://purl.obolibrary.org/obo/UBERON_0002067 denotes dermis
PD-UBERON-AE-B_T5 506-511 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T6 506-516 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph node
PD-UBERON-AE-B_T7 812-817 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 812-817 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 207-213 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 310-316 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 771-777 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T5 353-359 http://purl.obolibrary.org/obo/UBERON_0002067 denotes dermis
PD-UBERON-AE-B_T6 506-511 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T7 506-516 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph node