PubMed:22506732 / 516-1018 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T2","span":{"begin":0,"end":502},"obj":"OBJECTIVE"}],"text":"We hypothesised that RAO-affected horses would have high levels of reactive species and that the test agents would reduce them. The objectives were as follows: 1) to determine the level of ROS and RNS in pulmonary tissues (bronchial and arterial rings) of RAO-affected and clinically healthy horses; and 2) to determine the ability of pentoxifylline, pyrrolidine-dithiocarbamate and a combined use of endothelin A and B receptor antagonists (BQ123 and BQ788, respectively) in reducing reactive species."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T5","span":{"begin":0,"end":2},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T6","span":{"begin":34,"end":40},"obj":"CVCL_9124|Undefined_cell_line_type|Cricetulus griseus"},{"id":"T7","span":{"begin":292,"end":298},"obj":"CVCL_9124|Undefined_cell_line_type|Cricetulus griseus"},{"id":"T8","span":{"begin":300,"end":305},"obj":"CVCL_B527|Embryonic_stem_cell|Homo sapiens"},{"id":"T9","span":{"begin":383,"end":384},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T10","span":{"begin":412,"end":413},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T11","span":{"begin":418,"end":419},"obj":"CVCL_6480|Finite_cell_line|Mus musculus"}],"text":"We hypothesised that RAO-affected horses would have high levels of reactive species and that the test agents would reduce them. The objectives were as follows: 1) to determine the level of ROS and RNS in pulmonary tissues (bronchial and arterial rings) of RAO-affected and clinically healthy horses; and 2) to determine the ability of pentoxifylline, pyrrolidine-dithiocarbamate and a combined use of endothelin A and B receptor antagonists (BQ123 and BQ788, respectively) in reducing reactive species."}

{"project":"GoldHamster","denotations":[{"id":"T29","span":{"begin":21,"end":24},"obj":"O75106"},{"id":"T30","span":{"begin":21,"end":24},"obj":"Q812C9"},{"id":"T31","span":{"begin":21,"end":24},"obj":"PR:000004086"},{"id":"T32","span":{"begin":189,"end":192},"obj":"PR:P08922"},{"id":"T34","span":{"begin":189,"end":192},"obj":"PR:000014165"},{"id":"T33","span":{"begin":189,"end":192},"obj":"CHEBI:26523"},{"id":"T36","span":{"begin":197,"end":200},"obj":"CHEBI:62764"},{"id":"T35","span":{"begin":197,"end":200},"obj":"C535282"},{"id":"T37","span":{"begin":256,"end":259},"obj":"O75106"},{"id":"T38","span":{"begin":256,"end":259},"obj":"Q812C9"},{"id":"T39","span":{"begin":256,"end":259},"obj":"PR:000004086"},{"id":"T44","span":{"begin":335,"end":349},"obj":"8013"},{"id":"T41","span":{"begin":335,"end":349},"obj":"CHEBI:7986"},{"id":"T42","span":{"begin":335,"end":349},"obj":"D010431"},{"id":"T43","span":{"begin":335,"end":349},"obj":"D010431"},{"id":"T48","span":{"begin":351,"end":378},"obj":"C020972"},{"id":"T49","span":{"begin":351,"end":378},"obj":"CHEBI:78782"},{"id":"T50","span":{"begin":351,"end":378},"obj":"C020972"},{"id":"T51","span":{"begin":401,"end":411},"obj":"D016232"},{"id":"T52","span":{"begin":401,"end":411},"obj":"D016232"},{"id":"T53","span":{"begin":429,"end":440},"obj":"CHEBI:48706"},{"id":"T54","span":{"begin":442,"end":447},"obj":"C072247"},{"id":"T55","span":{"begin":442,"end":447},"obj":"C072247"},{"id":"T56","span":{"begin":442,"end":447},"obj":"CHEBI:2965"},{"id":"T57","span":{"begin":452,"end":457},"obj":"C086539"},{"id":"T58","span":{"begin":452,"end":457},"obj":"C086539"}],"text":"We hypothesised that RAO-affected horses would have high levels of reactive species and that the test agents would reduce them. The objectives were as follows: 1) to determine the level of ROS and RNS in pulmonary tissues (bronchial and arterial rings) of RAO-affected and clinically healthy horses; and 2) to determine the ability of pentoxifylline, pyrrolidine-dithiocarbamate and a combined use of endothelin A and B receptor antagonists (BQ123 and BQ788, respectively) in reducing reactive species."}