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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-68 Sentence denotes Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells.
T2 69-276 Sentence denotes BACKGROUND: CD4- Vγ2Vδ2 T cells are depleted during human immunodeficiency virus (HIV) infection but can recover to near normal levels in patients who spontaneously control viremia in the absence of therapy.
T3 277-484 Sentence denotes By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia.
T4 485-493 Sentence denotes METHODS:
T5 494-584 Sentence denotes Peripheral blood Vγ2Vδ2 T-cell levels and phenotypes were characterized by flow cytometry.
T6 585-642 Sentence denotes Lymphoproliferation assays measured functional responses.
T7 643-700 Sentence denotes Spectratyping characterized damage to the TCR repertoire.
T8 701-709 Sentence denotes RESULTS:
T9 710-949 Sentence denotes Levels, responses to antigen and the proportion of T effector memory Vγ2Vδ2 T cells in patients with persistent viremia, were intermediate between patients with natural virus suppression (NVS) and patients receiving antiretroviral therapy.
T10 950-1161 Sentence denotes Damage to the TCR γ-2 chain repertoire and depletion of CD56+ Vγ2Vδ2 T cells were more pronounced in viremic patients, compared with antiretroviral therapy recipients and patients with natural virus suppression.
T11 1162-1174 Sentence denotes CONCLUSIONS:
T12 1175-1423 Sentence denotes Characteristics of Vγ2Vδ2 T cells in viremic patients reflect both active responses (increasing cell numbers, better antigen responses, and higher proportion of effector memory cells) and ongoing damage (repertoire changes and loss of CD56+ cells).
T13 1424-1624 Sentence denotes Unlike patients who control viremia to undetectable levels, Vγ2Vδ2 T cells are diminished during persistent viremia and may eventually be lost because of progressive destruction of the TCR repertoire.
T1 0-68 Sentence denotes Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells.
T2 69-276 Sentence denotes BACKGROUND: CD4- Vγ2Vδ2 T cells are depleted during human immunodeficiency virus (HIV) infection but can recover to near normal levels in patients who spontaneously control viremia in the absence of therapy.
T3 277-484 Sentence denotes By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia.
T4 485-493 Sentence denotes METHODS:
T5 494-584 Sentence denotes Peripheral blood Vγ2Vδ2 T-cell levels and phenotypes were characterized by flow cytometry.
T6 585-642 Sentence denotes Lymphoproliferation assays measured functional responses.
T7 643-700 Sentence denotes Spectratyping characterized damage to the TCR repertoire.
T8 701-709 Sentence denotes RESULTS:
T9 710-949 Sentence denotes Levels, responses to antigen and the proportion of T effector memory Vγ2Vδ2 T cells in patients with persistent viremia, were intermediate between patients with natural virus suppression (NVS) and patients receiving antiretroviral therapy.
T10 950-1161 Sentence denotes Damage to the TCR γ-2 chain repertoire and depletion of CD56+ Vγ2Vδ2 T cells were more pronounced in viremic patients, compared with antiretroviral therapy recipients and patients with natural virus suppression.
T11 1162-1174 Sentence denotes CONCLUSIONS:
T12 1175-1423 Sentence denotes Characteristics of Vγ2Vδ2 T cells in viremic patients reflect both active responses (increasing cell numbers, better antigen responses, and higher proportion of effector memory cells) and ongoing damage (repertoire changes and loss of CD56+ cells).
T13 1424-1624 Sentence denotes Unlike patients who control viremia to undetectable levels, Vγ2Vδ2 T cells are diminished during persistent viremia and may eventually be lost because of progressive destruction of the TCR repertoire.

Allie

Id Subject Object Predicate Lexical cue
SS1_22454465_2_0 121-149 expanded denotes human immunodeficiency virus
SS2_22454465_2_0 151-154 abbr denotes HIV
SS1_22454465_3_0 330-345 expanded denotes T-cell receptor
SS2_22454465_3_0 347-350 abbr denotes TCR
SS1_22454465_9_0 871-896 expanded denotes natural virus suppression
SS2_22454465_9_0 898-901 abbr denotes NVS
AE1_22454465_2_0 SS1_22454465_2_0 SS2_22454465_2_0 abbreviatedTo human immunodeficiency virus,HIV
AE1_22454465_3_0 SS1_22454465_3_0 SS2_22454465_3_0 abbreviatedTo T-cell receptor,TCR
AE1_22454465_9_0 SS1_22454465_9_0 SS2_22454465_9_0 abbreviatedTo natural virus suppression,NVS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 127-143 HP_0002721 denotes immunodeficiency