Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-68 |
Sentence |
denotes |
Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells. |
T2 |
69-276 |
Sentence |
denotes |
BACKGROUND: CD4- Vγ2Vδ2 T cells are depleted during human immunodeficiency virus (HIV) infection but can recover to near normal levels in patients who spontaneously control viremia in the absence of therapy. |
T3 |
277-484 |
Sentence |
denotes |
By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia. |
T4 |
485-493 |
Sentence |
denotes |
METHODS: |
T5 |
494-584 |
Sentence |
denotes |
Peripheral blood Vγ2Vδ2 T-cell levels and phenotypes were characterized by flow cytometry. |
T6 |
585-642 |
Sentence |
denotes |
Lymphoproliferation assays measured functional responses. |
T7 |
643-700 |
Sentence |
denotes |
Spectratyping characterized damage to the TCR repertoire. |
T8 |
701-709 |
Sentence |
denotes |
RESULTS: |
T9 |
710-949 |
Sentence |
denotes |
Levels, responses to antigen and the proportion of T effector memory Vγ2Vδ2 T cells in patients with persistent viremia, were intermediate between patients with natural virus suppression (NVS) and patients receiving antiretroviral therapy. |
T10 |
950-1161 |
Sentence |
denotes |
Damage to the TCR γ-2 chain repertoire and depletion of CD56+ Vγ2Vδ2 T cells were more pronounced in viremic patients, compared with antiretroviral therapy recipients and patients with natural virus suppression. |
T11 |
1162-1174 |
Sentence |
denotes |
CONCLUSIONS: |
T12 |
1175-1423 |
Sentence |
denotes |
Characteristics of Vγ2Vδ2 T cells in viremic patients reflect both active responses (increasing cell numbers, better antigen responses, and higher proportion of effector memory cells) and ongoing damage (repertoire changes and loss of CD56+ cells). |
T13 |
1424-1624 |
Sentence |
denotes |
Unlike patients who control viremia to undetectable levels, Vγ2Vδ2 T cells are diminished during persistent viremia and may eventually be lost because of progressive destruction of the TCR repertoire. |
T1 |
0-68 |
Sentence |
denotes |
Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells. |
T2 |
69-276 |
Sentence |
denotes |
BACKGROUND: CD4- Vγ2Vδ2 T cells are depleted during human immunodeficiency virus (HIV) infection but can recover to near normal levels in patients who spontaneously control viremia in the absence of therapy. |
T3 |
277-484 |
Sentence |
denotes |
By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia. |
T4 |
485-493 |
Sentence |
denotes |
METHODS: |
T5 |
494-584 |
Sentence |
denotes |
Peripheral blood Vγ2Vδ2 T-cell levels and phenotypes were characterized by flow cytometry. |
T6 |
585-642 |
Sentence |
denotes |
Lymphoproliferation assays measured functional responses. |
T7 |
643-700 |
Sentence |
denotes |
Spectratyping characterized damage to the TCR repertoire. |
T8 |
701-709 |
Sentence |
denotes |
RESULTS: |
T9 |
710-949 |
Sentence |
denotes |
Levels, responses to antigen and the proportion of T effector memory Vγ2Vδ2 T cells in patients with persistent viremia, were intermediate between patients with natural virus suppression (NVS) and patients receiving antiretroviral therapy. |
T10 |
950-1161 |
Sentence |
denotes |
Damage to the TCR γ-2 chain repertoire and depletion of CD56+ Vγ2Vδ2 T cells were more pronounced in viremic patients, compared with antiretroviral therapy recipients and patients with natural virus suppression. |
T11 |
1162-1174 |
Sentence |
denotes |
CONCLUSIONS: |
T12 |
1175-1423 |
Sentence |
denotes |
Characteristics of Vγ2Vδ2 T cells in viremic patients reflect both active responses (increasing cell numbers, better antigen responses, and higher proportion of effector memory cells) and ongoing damage (repertoire changes and loss of CD56+ cells). |
T13 |
1424-1624 |
Sentence |
denotes |
Unlike patients who control viremia to undetectable levels, Vγ2Vδ2 T cells are diminished during persistent viremia and may eventually be lost because of progressive destruction of the TCR repertoire. |