PubMed:22228096 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22228096","sourcedb":"PubMed","sourceid":"22228096","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22228096","text":"LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.\nThe leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of autosomal-dominant Parkinson disease (PD). Mitochondrial dysfunction represents a critical event in the pathogenesis of PD. We demonstrated that wild-type (WT) LRRK2 expression caused mitochondrial fragmentation along with increased mitochondrial dynamin-like protein (DLP1, also known as DRP1), a fission protein, which was further exacerbated by expression of PD-associated mutants (R1441C or G2019S) in both SH-SY5Y and differentiated primary cortical neurons. We also found that LRRK2 interacted with DLP1, and LRRK2-DLP1 interaction was enhanced by PD-associated mutations that probably results in increased mitochondrial DLP1 levels. Co-expression of dominant-negative DLP1 K38A or WT Mfn2 blocked LRRK2-induced mitochondrial fragmentation, mitochondrial dysfunction and neuronal toxicity. Importantly, mitochondrial fragmentation and dysfunction were not observed in cells expressing either GTP-binding deficient mutant LRRK2 K1347A or kinase-dead mutant D1994A which has minimal interaction with DLP1 and did not increase the mitochondrial DLP1 level. We concluded that LRRK2 regulates mitochondrial dynamics by increasing mitochondrial DLP1 through its direct interaction with DLP1, and LRRK2 kinase activity plays a critical role in this process.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_22228096_1_0","span":{"begin":94,"end":122},"obj":"expanded"},{"id":"SS2_22228096_1_0","span":{"begin":124,"end":129},"obj":"abbr"},{"id":"SS1_22228096_1_1","span":{"begin":189,"end":206},"obj":"expanded"},{"id":"SS2_22228096_1_1","span":{"begin":208,"end":210},"obj":"abbr"},{"id":"SS1_22228096_3_0","span":{"begin":315,"end":324},"obj":"expanded"},{"id":"SS2_22228096_3_0","span":{"begin":326,"end":328},"obj":"abbr"}],"relations":[{"id":"AE1_22228096_1_0","pred":"abbreviatedTo","subj":"SS1_22228096_1_0","obj":"SS2_22228096_1_0"},{"id":"AE1_22228096_1_1","pred":"abbreviatedTo","subj":"SS1_22228096_1_1","obj":"SS2_22228096_1_1"},{"id":"AE1_22228096_3_0","pred":"abbreviatedTo","subj":"SS1_22228096_3_0","obj":"SS2_22228096_3_0"}],"attributes":[{"subj":"SS1_22228096_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_22228096_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_22228096_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_22228096_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_22228096_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_22228096_3_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":170,"end":188},"obj":"HP_0000006"},{"id":"T2","span":{"begin":189,"end":198},"obj":"HP_0001300"},{"id":"T3","span":{"begin":213,"end":238},"obj":"HP_0003287"},{"id":"T4","span":{"begin":213,"end":226},"obj":"HP_0001427"},{"id":"T5","span":{"begin":354,"end":367},"obj":"HP_0001427"},{"id":"T6","span":{"begin":403,"end":416},"obj":"HP_0001427"},{"id":"T7","span":{"begin":783,"end":796},"obj":"HP_0001427"},{"id":"T8","span":{"begin":888,"end":901},"obj":"HP_0001427"},{"id":"T9","span":{"begin":917,"end":942},"obj":"HP_0003287"},{"id":"T10","span":{"begin":917,"end":930},"obj":"HP_0001427"},{"id":"T11","span":{"begin":979,"end":1022},"obj":"HP_0003287"},{"id":"T12","span":{"begin":979,"end":992},"obj":"HP_0001427"},{"id":"T13","span":{"begin":1120,"end":1124},"obj":"HP_0000365"},{"id":"T14","span":{"begin":1204,"end":1217},"obj":"HP_0001427"},{"id":"T15","span":{"begin":1264,"end":1277},"obj":"HP_0001427"},{"id":"T16","span":{"begin":1301,"end":1314},"obj":"HP_0001427"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"},{"subj":"T12","pred":"source","obj":"PubmedHPO"},{"subj":"T13","pred":"source","obj":"PubmedHPO"},{"subj":"T14","pred":"source","obj":"PubmedHPO"},{"subj":"T15","pred":"source","obj":"PubmedHPO"},{"subj":"T16","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":94,"end":122},"obj":"gene:120892"},{"id":"T1","span":{"begin":170,"end":206},"obj":"disease:C3489791"},{"id":"T2","span":{"begin":94,"end":122},"obj":"gene:120892"},{"id":"T3","span":{"begin":208,"end":210},"obj":"disease:C3489791"},{"id":"T4","span":{"begin":124,"end":129},"obj":"gene:120892"},{"id":"T5","span":{"begin":170,"end":206},"obj":"disease:C3489791"},{"id":"T6","span":{"begin":124,"end":129},"obj":"gene:120892"},{"id":"T7","span":{"begin":208,"end":210},"obj":"disease:C3489791"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"22228096-3#261#267#geners33939927","span":{"begin":555,"end":561},"obj":"geners33939927"},{"id":"22228096-3#271#277#geners34637584","span":{"begin":565,"end":571},"obj":"geners34637584"},{"id":"22228096-3#238#240#diseaseC3489791","span":{"begin":532,"end":534},"obj":"diseaseC3489791"}],"relations":[{"id":"261#267#geners33939927238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#261#267#geners33939927","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"271#277#geners34637584238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#271#277#geners34637584","obj":"22228096-3#238#240#diseaseC3489791"}],"attributes":[{"subj":"22228096-3#261#267#geners33939927","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"22228096-3#271#277#geners34637584","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"22228096-3#238#240#diseaseC3489791","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"22228096-3#165#169#gene1400","span":{"begin":459,"end":463},"obj":"gene1400"},{"id":"22228096-3#165#169#gene23604","span":{"begin":459,"end":463},"obj":"gene23604"},{"id":"22228096-3#165#169#gene8562","span":{"begin":459,"end":463},"obj":"gene8562"},{"id":"22228096-3#165#169#gene7402","span":{"begin":459,"end":463},"obj":"gene7402"},{"id":"22228096-3#36#41#gene120892","span":{"begin":330,"end":335},"obj":"gene120892"},{"id":"22228096-3#238#240#diseaseC3489791","span":{"begin":532,"end":534},"obj":"diseaseC3489791"},{"id":"22228096-3#238#240#diseaseC3489791","span":{"begin":532,"end":534},"obj":"diseaseC3489791"},{"id":"22228096-4#57#61#gene10059","span":{"begin":691,"end":695},"obj":"gene10059"},{"id":"22228096-4#57#61#gene57107","span":{"begin":691,"end":695},"obj":"gene57107"},{"id":"22228096-4#163#167#gene10059","span":{"begin":797,"end":801},"obj":"gene10059"},{"id":"22228096-4#163#167#gene57107","span":{"begin":797,"end":801},"obj":"gene57107"},{"id":"22228096-4#90#92#diseaseC3489791","span":{"begin":724,"end":726},"obj":"diseaseC3489791"},{"id":"22228096-6#208#212#gene10059","span":{"begin":1174,"end":1178},"obj":"gene10059"},{"id":"22228096-6#208#212#gene57107","span":{"begin":1174,"end":1178},"obj":"gene57107"},{"id":"22228096-6#252#256#gene10059","span":{"begin":1218,"end":1222},"obj":"gene10059"},{"id":"22228096-6#252#256#gene57107","span":{"begin":1218,"end":1222},"obj":"gene57107"},{"id":"22228096-6#102#105#gene92170","span":{"begin":1068,"end":1071},"obj":"gene92170"},{"id":"22228096-6#45#56#diseaseC3887505","span":{"begin":1011,"end":1022},"obj":"diseaseC3887505"},{"id":"22228096-6#45#56#diseaseC3887505","span":{"begin":1011,"end":1022},"obj":"diseaseC3887505"}],"relations":[{"id":"165#169#gene1400238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene1400","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene1400238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene1400","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene23604238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene23604","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene23604238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene23604","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene8562238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene8562","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene8562238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene8562","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene7402238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene7402","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"165#169#gene7402238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#165#169#gene7402","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"36#41#gene120892238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#36#41#gene120892","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"36#41#gene120892238#240#diseaseC3489791","pred":"associated_with","subj":"22228096-3#36#41#gene120892","obj":"22228096-3#238#240#diseaseC3489791"},{"id":"57#61#gene1005990#92#diseaseC3489791","pred":"associated_with","subj":"22228096-4#57#61#gene10059","obj":"22228096-4#90#92#diseaseC3489791"},{"id":"57#61#gene5710790#92#diseaseC3489791","pred":"associated_with","subj":"22228096-4#57#61#gene57107","obj":"22228096-4#90#92#diseaseC3489791"},{"id":"163#167#gene1005990#92#diseaseC3489791","pred":"associated_with","subj":"22228096-4#163#167#gene10059","obj":"22228096-4#90#92#diseaseC3489791"},{"id":"163#167#gene5710790#92#diseaseC3489791","pred":"associated_with","subj":"22228096-4#163#167#gene57107","obj":"22228096-4#90#92#diseaseC3489791"},{"id":"208#212#gene1005945#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#208#212#gene10059","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"208#212#gene1005945#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#208#212#gene10059","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"208#212#gene5710745#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#208#212#gene57107","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"208#212#gene5710745#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#208#212#gene57107","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"252#256#gene1005945#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#252#256#gene10059","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"252#256#gene1005945#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#252#256#gene10059","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"252#256#gene5710745#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#252#256#gene57107","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"252#256#gene5710745#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#252#256#gene57107","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"102#105#gene9217045#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#102#105#gene92170","obj":"22228096-6#45#56#diseaseC3887505"},{"id":"102#105#gene9217045#56#diseaseC3887505","pred":"associated_with","subj":"22228096-6#102#105#gene92170","obj":"22228096-6#45#56#diseaseC3887505"}],"attributes":[{"subj":"22228096-3#165#169#gene1400","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-3#165#169#gene23604","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-3#165#169#gene8562","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-3#165#169#gene7402","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-3#36#41#gene120892","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-3#238#240#diseaseC3489791","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-3#238#240#diseaseC3489791","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-4#57#61#gene10059","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-4#57#61#gene57107","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-4#163#167#gene10059","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-4#163#167#gene57107","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-4#90#92#diseaseC3489791","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#208#212#gene10059","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#208#212#gene57107","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#252#256#gene10059","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#252#256#gene57107","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#102#105#gene92170","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#45#56#diseaseC3887505","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22228096-6#45#56#diseaseC3887505","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":89},"obj":"DRI_Background"},{"id":"T2","span":{"begin":90,"end":212},"obj":"DRI_Approach"},{"id":"T3","span":{"begin":213,"end":293},"obj":"DRI_Challenge"},{"id":"T4","span":{"begin":294,"end":633},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":634,"end":809},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":810,"end":826},"obj":"DRI_Background"},{"id":"T7","span":{"begin":827,"end":854},"obj":"Token_Label.OUTSIDE"},{"id":"T8","span":{"begin":855,"end":965},"obj":"DRI_Background"},{"id":"T9","span":{"begin":966,"end":1096},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1097,"end":1109},"obj":"Token_Label.OUTSIDE"},{"id":"T11","span":{"begin":1110,"end":1229},"obj":"DRI_Background"},{"id":"T12","span":{"begin":1230,"end":1426},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":90,"end":212},"obj":"DRI_Approach"},{"id":"T2","span":{"begin":213,"end":293},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":294,"end":633},"obj":"DRI_Outcome"},{"id":"T4","span":{"begin":634,"end":809},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":810,"end":826},"obj":"DRI_Background"},{"id":"T6","span":{"begin":855,"end":965},"obj":"DRI_Background"},{"id":"T7","span":{"begin":966,"end":1096},"obj":"DRI_Background"},{"id":"T8","span":{"begin":1110,"end":1229},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1230,"end":1426},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"PR:Q5S006"},{"id":"T2","span":{"begin":0,"end":5},"obj":"PR:000003033"},{"id":"T3","span":{"begin":0,"end":5},"obj":"PR:Q5S007"},{"id":"T5","span":{"begin":84,"end":87},"obj":"UBERON:0003105"},{"id":"T8","span":{"begin":84,"end":88},"obj":"PR:Q33DR3"},{"id":"T9","span":{"begin":84,"end":88},"obj":"PR:000012522"},{"id":"T10","span":{"begin":84,"end":88},"obj":"PR:Q8LF21"},{"id":"T11","span":{"begin":84,"end":88},"obj":"PR:Q86YH6"},{"id":"T12","span":{"begin":84,"end":88},"obj":"PR:O00429"},{"id":"T13","span":{"begin":84,"end":88},"obj":"PR:Q5U2R1"},{"id":"T14","span":{"begin":84,"end":88},"obj":"PR:O35303"},{"id":"T15","span":{"begin":84,"end":88},"obj":"PR:O13851"},{"id":"T16","span":{"begin":84,"end":88},"obj":"P97314"},{"id":"T17","span":{"begin":84,"end":88},"obj":"PR:Q63164"},{"id":"T18","span":{"begin":84,"end":88},"obj":"PR:000006602"},{"id":"T19","span":{"begin":84,"end":88},"obj":"P82172"},{"id":"T20","span":{"begin":84,"end":88},"obj":"PR:000005959"},{"id":"T21","span":{"begin":84,"end":88},"obj":"PR:P97314"},{"id":"T23","span":{"begin":94,"end":101},"obj":"6308"},{"id":"T24","span":{"begin":94,"end":101},"obj":"SO:0001437"},{"id":"T22","span":{"begin":94,"end":101},"obj":"CHEBI:15603"},{"id":"T25","span":{"begin":94,"end":101},"obj":"D007930"},{"id":"T26","span":{"begin":94,"end":101},"obj":"CHEBI:25017"},{"id":"T27","span":{"begin":94,"end":101},"obj":"D007930"},{"id":"T28","span":{"begin":107,"end":113},"obj":"SO:0001068"},{"id":"T29","span":{"begin":124,"end":129},"obj":"PR:Q5S006"},{"id":"T30","span":{"begin":124,"end":129},"obj":"PR:000003033"},{"id":"T31","span":{"begin":124,"end":129},"obj":"PR:Q5S007"},{"id":"T32","span":{"begin":170,"end":188},"obj":"C566739"},{"id":"T35","span":{"begin":189,"end":206},"obj":"D010300"},{"id":"T36","span":{"begin":189,"end":206},"obj":"D010300"},{"id":"T39","span":{"begin":274,"end":286},"obj":"GO:0009405"},{"id":"T40","span":{"begin":315,"end":324},"obj":"SO:0000817"},{"id":"T41","span":{"begin":330,"end":335},"obj":"PR:Q5S006"},{"id":"T42","span":{"begin":330,"end":335},"obj":"PR:000003033"},{"id":"T43","span":{"begin":330,"end":335},"obj":"PR:Q5S007"},{"id":"T46","span":{"begin":417,"end":424},"obj":"D034281"},{"id":"T50","span":{"begin":417,"end":443},"obj":"Q8LF21"},{"id":"T55","span":{"begin":430,"end":437},"obj":"SO:0000104"},{"id":"T51","span":{"begin":430,"end":437},"obj":"GO:0003675"},{"id":"T52","span":{"begin":430,"end":437},"obj":"CHEBI:36080"},{"id":"T53","span":{"begin":430,"end":437},"obj":"CHEBI:11122"},{"id":"T57","span":{"begin":439,"end":442},"obj":"UBERON:0003105"},{"id":"T99","span":{"begin":459,"end":467},"obj":"PR:P42697"},{"id":"T104","span":{"begin":476,"end":483},"obj":"SO:0000104"},{"id":"T103","span":{"begin":476,"end":483},"obj":"PR:000000001"},{"id":"T100","span":{"begin":476,"end":483},"obj":"GO:0003675"},{"id":"T101","span":{"begin":476,"end":483},"obj":"CHEBI:36080"},{"id":"T102","span":{"begin":476,"end":483},"obj":"CHEBI:11122"},{"id":"T105","span":{"begin":581,"end":588},"obj":"CVCL_0019"},{"id":"T107","span":{"begin":653,"end":658},"obj":"PR:Q5S006"},{"id":"T108","span":{"begin":653,"end":658},"obj":"PR:000003033"},{"id":"T109","span":{"begin":653,"end":658},"obj":"PR:Q5S007"},{"id":"T111","span":{"begin":675,"end":678},"obj":"UBERON:0003105"},{"id":"T114","span":{"begin":675,"end":679},"obj":"PR:Q33DR3"},{"id":"T115","span":{"begin":675,"end":679},"obj":"PR:000012522"},{"id":"T116","span":{"begin":675,"end":679},"obj":"PR:Q8LF21"},{"id":"T117","span":{"begin":675,"end":679},"obj":"PR:Q86YH6"},{"id":"T118","span":{"begin":675,"end":679},"obj":"PR:O00429"},{"id":"T119","span":{"begin":675,"end":679},"obj":"PR:Q5U2R1"},{"id":"T120","span":{"begin":675,"end":679},"obj":"PR:O35303"},{"id":"T121","span":{"begin":675,"end":679},"obj":"PR:O13851"},{"id":"T122","span":{"begin":675,"end":679},"obj":"P97314"},{"id":"T123","span":{"begin":675,"end":679},"obj":"PR:Q63164"},{"id":"T124","span":{"begin":675,"end":679},"obj":"PR:000006602"},{"id":"T125","span":{"begin":675,"end":679},"obj":"P82172"},{"id":"T126","span":{"begin":675,"end":679},"obj":"PR:000005959"},{"id":"T127","span":{"begin":675,"end":679},"obj":"PR:P97314"},{"id":"T128","span":{"begin":685,"end":690},"obj":"PR:Q5S006"},{"id":"T129","span":{"begin":685,"end":690},"obj":"PR:000003033"},{"id":"T130","span":{"begin":685,"end":690},"obj":"PR:Q5S007"},{"id":"T132","span":{"begin":691,"end":694},"obj":"UBERON:0003105"},{"id":"T135","span":{"begin":691,"end":695},"obj":"PR:Q33DR3"},{"id":"T136","span":{"begin":691,"end":695},"obj":"PR:000012522"},{"id":"T137","span":{"begin":691,"end":695},"obj":"PR:Q8LF21"},{"id":"T138","span":{"begin":691,"end":695},"obj":"PR:Q86YH6"},{"id":"T139","span":{"begin":691,"end":695},"obj":"PR:O00429"},{"id":"T140","span":{"begin":691,"end":695},"obj":"PR:Q5U2R1"},{"id":"T141","span":{"begin":691,"end":695},"obj":"PR:O35303"},{"id":"T142","span":{"begin":691,"end":695},"obj":"PR:O13851"},{"id":"T143","span":{"begin":691,"end":695},"obj":"P97314"},{"id":"T144","span":{"begin":691,"end":695},"obj":"PR:Q63164"},{"id":"T145","span":{"begin":691,"end":695},"obj":"PR:000006602"},{"id":"T146","span":{"begin":691,"end":695},"obj":"P82172"},{"id":"T147","span":{"begin":691,"end":695},"obj":"PR:000005959"},{"id":"T148","span":{"begin":691,"end":695},"obj":"PR:P97314"},{"id":"T150","span":{"begin":797,"end":800},"obj":"UBERON:0003105"},{"id":"T153","span":{"begin":797,"end":801},"obj":"PR:Q33DR3"},{"id":"T154","span":{"begin":797,"end":801},"obj":"PR:000012522"},{"id":"T155","span":{"begin":797,"end":801},"obj":"PR:Q8LF21"},{"id":"T156","span":{"begin":797,"end":801},"obj":"PR:Q86YH6"},{"id":"T157","span":{"begin":797,"end":801},"obj":"PR:O00429"},{"id":"T158","span":{"begin":797,"end":801},"obj":"PR:Q5U2R1"},{"id":"T159","span":{"begin":797,"end":801},"obj":"PR:O35303"},{"id":"T160","span":{"begin":797,"end":801},"obj":"PR:O13851"},{"id":"T161","span":{"begin":797,"end":801},"obj":"P97314"},{"id":"T162","span":{"begin":797,"end":801},"obj":"PR:Q63164"},{"id":"T163","span":{"begin":797,"end":801},"obj":"PR:000006602"},{"id":"T164","span":{"begin":797,"end":801},"obj":"P82172"},{"id":"T165","span":{"begin":797,"end":801},"obj":"PR:000005959"},{"id":"T166","span":{"begin":797,"end":801},"obj":"PR:P97314"},{"id":"T167","span":{"begin":827,"end":844},"obj":"SO:0002052"},{"id":"T169","span":{"begin":845,"end":848},"obj":"UBERON:0003105"},{"id":"T172","span":{"begin":845,"end":849},"obj":"PR:Q33DR3"},{"id":"T173","span":{"begin":845,"end":849},"obj":"PR:000012522"},{"id":"T174","span":{"begin":845,"end":849},"obj":"PR:Q8LF21"},{"id":"T175","span":{"begin":845,"end":849},"obj":"PR:Q86YH6"},{"id":"T176","span":{"begin":845,"end":849},"obj":"PR:O00429"},{"id":"T177","span":{"begin":845,"end":849},"obj":"PR:Q5U2R1"},{"id":"T178","span":{"begin":845,"end":849},"obj":"PR:O35303"},{"id":"T179","span":{"begin":845,"end":849},"obj":"PR:O13851"},{"id":"T180","span":{"begin":845,"end":849},"obj":"P97314"},{"id":"T181","span":{"begin":845,"end":849},"obj":"PR:Q63164"},{"id":"T182","span":{"begin":845,"end":849},"obj":"PR:000006602"},{"id":"T183","span":{"begin":845,"end":849},"obj":"P82172"},{"id":"T184","span":{"begin":845,"end":849},"obj":"PR:000005959"},{"id":"T185","span":{"begin":845,"end":849},"obj":"PR:P97314"},{"id":"T186","span":{"begin":850,"end":853},"obj":"PR:000009477"},{"id":"T188","span":{"begin":850,"end":853},"obj":"O76015"},{"id":"T187","span":{"begin":850,"end":853},"obj":"CVCL_W141"},{"id":"T189","span":{"begin":851,"end":854},"obj":"1037951"},{"id":"T191","span":{"begin":861,"end":865},"obj":"PR:Q80U63"},{"id":"T192","span":{"begin":861,"end":865},"obj":"PR:O95140"},{"id":"T193","span":{"begin":861,"end":865},"obj":"PR:Q8R500"},{"id":"T194","span":{"begin":861,"end":865},"obj":"PR:000010370"},{"id":"T195","span":{"begin":874,"end":879},"obj":"PR:Q5S006"},{"id":"T196","span":{"begin":874,"end":879},"obj":"PR:000003033"},{"id":"T197","span":{"begin":874,"end":879},"obj":"PR:Q5S007"},{"id":"T198","span":{"begin":1068,"end":1071},"obj":"D006160"},{"id":"T199","span":{"begin":1068,"end":1071},"obj":"CHEBI:37565"},{"id":"T200","span":{"begin":1068,"end":1071},"obj":"D006160"},{"id":"T201","span":{"begin":1068,"end":1071},"obj":"CHEBI:15996"},{"id":"T202","span":{"begin":1068,"end":1079},"obj":"GO:0005525"},{"id":"T203","span":{"begin":1072,"end":1079},"obj":"SO:0100018"},{"id":"T204","span":{"begin":1072,"end":1079},"obj":"SO:0001091"},{"id":"T206","span":{"begin":1097,"end":1102},"obj":"PR:Q5S006"},{"id":"T207","span":{"begin":1097,"end":1102},"obj":"PR:000003033"},{"id":"T208","span":{"begin":1097,"end":1102},"obj":"PR:Q5S007"},{"id":"T210","span":{"begin":1174,"end":1177},"obj":"UBERON:0003105"},{"id":"T213","span":{"begin":1174,"end":1178},"obj":"PR:Q33DR3"},{"id":"T214","span":{"begin":1174,"end":1178},"obj":"PR:000012522"},{"id":"T215","span":{"begin":1174,"end":1178},"obj":"PR:Q8LF21"},{"id":"T216","span":{"begin":1174,"end":1178},"obj":"PR:Q86YH6"},{"id":"T217","span":{"begin":1174,"end":1178},"obj":"PR:O00429"},{"id":"T218","span":{"begin":1174,"end":1178},"obj":"PR:Q5U2R1"},{"id":"T219","span":{"begin":1174,"end":1178},"obj":"PR:O35303"},{"id":"T220","span":{"begin":1174,"end":1178},"obj":"PR:O13851"},{"id":"T221","span":{"begin":1174,"end":1178},"obj":"P97314"},{"id":"T222","span":{"begin":1174,"end":1178},"obj":"PR:Q63164"},{"id":"T223","span":{"begin":1174,"end":1178},"obj":"PR:000006602"},{"id":"T224","span":{"begin":1174,"end":1178},"obj":"P82172"},{"id":"T225","span":{"begin":1174,"end":1178},"obj":"PR:000005959"},{"id":"T226","span":{"begin":1174,"end":1178},"obj":"PR:P97314"},{"id":"T228","span":{"begin":1218,"end":1221},"obj":"UBERON:0003105"},{"id":"T231","span":{"begin":1218,"end":1222},"obj":"PR:Q33DR3"},{"id":"T232","span":{"begin":1218,"end":1222},"obj":"PR:000012522"},{"id":"T233","span":{"begin":1218,"end":1222},"obj":"PR:Q8LF21"},{"id":"T234","span":{"begin":1218,"end":1222},"obj":"PR:Q86YH6"},{"id":"T235","span":{"begin":1218,"end":1222},"obj":"PR:O00429"},{"id":"T236","span":{"begin":1218,"end":1222},"obj":"PR:Q5U2R1"},{"id":"T237","span":{"begin":1218,"end":1222},"obj":"PR:O35303"},{"id":"T238","span":{"begin":1218,"end":1222},"obj":"PR:O13851"},{"id":"T239","span":{"begin":1218,"end":1222},"obj":"P97314"},{"id":"T240","span":{"begin":1218,"end":1222},"obj":"PR:Q63164"},{"id":"T241","span":{"begin":1218,"end":1222},"obj":"PR:000006602"},{"id":"T242","span":{"begin":1218,"end":1222},"obj":"P82172"},{"id":"T243","span":{"begin":1218,"end":1222},"obj":"PR:000005959"},{"id":"T244","span":{"begin":1218,"end":1222},"obj":"PR:P97314"},{"id":"T245","span":{"begin":1248,"end":1253},"obj":"PR:Q5S006"},{"id":"T246","span":{"begin":1248,"end":1253},"obj":"PR:000003033"},{"id":"T247","span":{"begin":1248,"end":1253},"obj":"PR:Q5S007"},{"id":"T249","span":{"begin":1315,"end":1318},"obj":"UBERON:0003105"},{"id":"T252","span":{"begin":1315,"end":1319},"obj":"PR:Q33DR3"},{"id":"T253","span":{"begin":1315,"end":1319},"obj":"PR:000012522"},{"id":"T254","span":{"begin":1315,"end":1319},"obj":"PR:Q8LF21"},{"id":"T255","span":{"begin":1315,"end":1319},"obj":"PR:Q86YH6"},{"id":"T256","span":{"begin":1315,"end":1319},"obj":"PR:O00429"},{"id":"T257","span":{"begin":1315,"end":1319},"obj":"PR:Q5U2R1"},{"id":"T258","span":{"begin":1315,"end":1319},"obj":"PR:O35303"},{"id":"T259","span":{"begin":1315,"end":1319},"obj":"PR:O13851"},{"id":"T260","span":{"begin":1315,"end":1319},"obj":"P97314"},{"id":"T261","span":{"begin":1315,"end":1319},"obj":"PR:Q63164"},{"id":"T262","span":{"begin":1315,"end":1319},"obj":"PR:000006602"},{"id":"T263","span":{"begin":1315,"end":1319},"obj":"P82172"},{"id":"T264","span":{"begin":1315,"end":1319},"obj":"PR:000005959"},{"id":"T265","span":{"begin":1315,"end":1319},"obj":"PR:P97314"},{"id":"T267","span":{"begin":1356,"end":1359},"obj":"UBERON:0003105"},{"id":"T270","span":{"begin":1356,"end":1360},"obj":"PR:Q33DR3"},{"id":"T271","span":{"begin":1356,"end":1360},"obj":"PR:000012522"},{"id":"T272","span":{"begin":1356,"end":1360},"obj":"PR:Q8LF21"},{"id":"T273","span":{"begin":1356,"end":1360},"obj":"PR:Q86YH6"},{"id":"T274","span":{"begin":1356,"end":1360},"obj":"PR:O00429"},{"id":"T275","span":{"begin":1356,"end":1360},"obj":"PR:Q5U2R1"},{"id":"T276","span":{"begin":1356,"end":1360},"obj":"PR:O35303"},{"id":"T277","span":{"begin":1356,"end":1360},"obj":"PR:O13851"},{"id":"T278","span":{"begin":1356,"end":1360},"obj":"P97314"},{"id":"T279","span":{"begin":1356,"end":1360},"obj":"PR:Q63164"},{"id":"T280","span":{"begin":1356,"end":1360},"obj":"PR:000006602"},{"id":"T281","span":{"begin":1356,"end":1360},"obj":"P82172"},{"id":"T282","span":{"begin":1356,"end":1360},"obj":"PR:000005959"},{"id":"T283","span":{"begin":1356,"end":1360},"obj":"PR:P97314"},{"id":"T284","span":{"begin":1366,"end":1371},"obj":"PR:Q5S006"},{"id":"T285","span":{"begin":1366,"end":1371},"obj":"PR:000003033"},{"id":"T286","span":{"begin":1366,"end":1371},"obj":"PR:Q5S007"},{"id":"T287","span":{"begin":1372,"end":1387},"obj":"GO:0016301"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T201","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"},{"subj":"T234","pred":"source","obj":"c_corpus"},{"subj":"T235","pred":"source","obj":"c_corpus"},{"subj":"T236","pred":"source","obj":"c_corpus"},{"subj":"T237","pred":"source","obj":"c_corpus"},{"subj":"T238","pred":"source","obj":"c_corpus"},{"subj":"T239","pred":"source","obj":"c_corpus"},{"subj":"T240","pred":"source","obj":"c_corpus"},{"subj":"T241","pred":"source","obj":"c_corpus"},{"subj":"T242","pred":"source","obj":"c_corpus"},{"subj":"T243","pred":"source","obj":"c_corpus"},{"subj":"T244","pred":"source","obj":"c_corpus"},{"subj":"T245","pred":"source","obj":"c_corpus"},{"subj":"T246","pred":"source","obj":"c_corpus"},{"subj":"T247","pred":"source","obj":"c_corpus"},{"subj":"T249","pred":"source","obj":"c_corpus"},{"subj":"T252","pred":"source","obj":"c_corpus"},{"subj":"T253","pred":"source","obj":"c_corpus"},{"subj":"T254","pred":"source","obj":"c_corpus"},{"subj":"T255","pred":"source","obj":"c_corpus"},{"subj":"T256","pred":"source","obj":"c_corpus"},{"subj":"T257","pred":"source","obj":"c_corpus"},{"subj":"T258","pred":"source","obj":"c_corpus"},{"subj":"T259","pred":"source","obj":"c_corpus"},{"subj":"T260","pred":"source","obj":"c_corpus"},{"subj":"T261","pred":"source","obj":"c_corpus"},{"subj":"T262","pred":"source","obj":"c_corpus"},{"subj":"T263","pred":"source","obj":"c_corpus"},{"subj":"T264","pred":"source","obj":"c_corpus"},{"subj":"T265","pred":"source","obj":"c_corpus"},{"subj":"T267","pred":"source","obj":"c_corpus"},{"subj":"T270","pred":"source","obj":"c_corpus"},{"subj":"T271","pred":"source","obj":"c_corpus"},{"subj":"T272","pred":"source","obj":"c_corpus"},{"subj":"T273","pred":"source","obj":"c_corpus"},{"subj":"T274","pred":"source","obj":"c_corpus"},{"subj":"T275","pred":"source","obj":"c_corpus"},{"subj":"T276","pred":"source","obj":"c_corpus"},{"subj":"T277","pred":"source","obj":"c_corpus"},{"subj":"T278","pred":"source","obj":"c_corpus"},{"subj":"T279","pred":"source","obj":"c_corpus"},{"subj":"T280","pred":"source","obj":"c_corpus"},{"subj":"T281","pred":"source","obj":"c_corpus"},{"subj":"T282","pred":"source","obj":"c_corpus"},{"subj":"T283","pred":"source","obj":"c_corpus"},{"subj":"T284","pred":"source","obj":"c_corpus"},{"subj":"T285","pred":"source","obj":"c_corpus"},{"subj":"T286","pred":"source","obj":"c_corpus"},{"subj":"T287","pred":"source","obj":"c_corpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ec9793","default":true},{"id":"PubmedHPO","color":"#93a8ec"},{"id":"DisGeNET","color":"#c2ec93"},{"id":"DisGeNET5_variant_disease","color":"#ec93dc"},{"id":"DisGeNET5_gene_disease","color":"#93ece2"},{"id":"UseCases_ArguminSci_Discourse","color":"#ecc893"},{"id":"PubMed_ArguminSci","color":"#ae93ec"},{"id":"c_corpus","color":"#93ec94"}]}]}}