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PubMed:22228096 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
22228096_0 555-561 ProteinMutation denotes R1441C rs33939927
22228096_1 565-571 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T5 84-87 UBERON:0003105 denotes DLP
T8 84-88 PR:Q33DR3 denotes DLP1
T9 84-88 PR:000012522 denotes DLP1
T10 84-88 PR:Q8LF21 denotes DLP1
T11 84-88 PR:Q86YH6 denotes DLP1
T12 84-88 PR:O00429 denotes DLP1
T13 84-88 PR:Q5U2R1 denotes DLP1
T14 84-88 PR:O35303 denotes DLP1
T15 84-88 PR:O13851 denotes DLP1
T16 84-88 P97314 denotes DLP1
T17 84-88 PR:Q63164 denotes DLP1
T18 84-88 PR:000006602 denotes DLP1
T19 84-88 P82172 denotes DLP1
T20 84-88 PR:000005959 denotes DLP1
T21 84-88 PR:P97314 denotes DLP1
T23 94-101 6308 denotes leucine
T24 94-101 SO:0001437 denotes leucine
T22 94-101 CHEBI:15603 denotes leucine
T25 94-101 D007930 denotes leucine
T26 94-101 CHEBI:25017 denotes leucine
T27 94-101 D007930 denotes leucine
T28 107-113 SO:0001068 denotes repeat
T29 124-129 PR:Q5S006 denotes LRRK2
T30 124-129 PR:000003033 denotes LRRK2
T31 124-129 PR:Q5S007 denotes LRRK2
T32 170-188 C566739 denotes autosomal-dominant
T35 189-206 D010300 denotes Parkinson disease
T36 189-206 D010300 denotes Parkinson disease
T39 274-286 GO:0009405 denotes pathogenesis
T40 315-324 SO:0000817 denotes wild-type
T41 330-335 PR:Q5S006 denotes LRRK2
T42 330-335 PR:000003033 denotes LRRK2
T43 330-335 PR:Q5S007 denotes LRRK2
T46 417-424 D034281 denotes dynamin
T50 417-443 Q8LF21 denotes dynamin-like protein (DLP1
T55 430-437 SO:0000104 denotes protein
T51 430-437 GO:0003675 denotes protein
T52 430-437 CHEBI:36080 denotes protein
T53 430-437 CHEBI:11122 denotes protein
T57 439-442 UBERON:0003105 denotes DLP
T99 459-467 PR:P42697 denotes DRP1), a
T104 476-483 SO:0000104 denotes protein
T103 476-483 PR:000000001 denotes protein
T100 476-483 GO:0003675 denotes protein
T101 476-483 CHEBI:36080 denotes protein
T102 476-483 CHEBI:11122 denotes protein
T105 581-588 CVCL_0019 denotes SH-SY5Y
T107 653-658 PR:Q5S006 denotes LRRK2
T108 653-658 PR:000003033 denotes LRRK2
T109 653-658 PR:Q5S007 denotes LRRK2
T111 675-678 UBERON:0003105 denotes DLP
T114 675-679 PR:Q33DR3 denotes DLP1
T115 675-679 PR:000012522 denotes DLP1
T116 675-679 PR:Q8LF21 denotes DLP1
T117 675-679 PR:Q86YH6 denotes DLP1
T118 675-679 PR:O00429 denotes DLP1
T119 675-679 PR:Q5U2R1 denotes DLP1
T120 675-679 PR:O35303 denotes DLP1
T121 675-679 PR:O13851 denotes DLP1
T122 675-679 P97314 denotes DLP1
T123 675-679 PR:Q63164 denotes DLP1
T124 675-679 PR:000006602 denotes DLP1
T125 675-679 P82172 denotes DLP1
T126 675-679 PR:000005959 denotes DLP1
T127 675-679 PR:P97314 denotes DLP1
T128 685-690 PR:Q5S006 denotes LRRK2
T129 685-690 PR:000003033 denotes LRRK2
T130 685-690 PR:Q5S007 denotes LRRK2
T132 691-694 UBERON:0003105 denotes DLP
T135 691-695 PR:Q33DR3 denotes DLP1
T136 691-695 PR:000012522 denotes DLP1
T137 691-695 PR:Q8LF21 denotes DLP1
T138 691-695 PR:Q86YH6 denotes DLP1
T139 691-695 PR:O00429 denotes DLP1
T140 691-695 PR:Q5U2R1 denotes DLP1
T141 691-695 PR:O35303 denotes DLP1
T142 691-695 PR:O13851 denotes DLP1
T143 691-695 P97314 denotes DLP1
T144 691-695 PR:Q63164 denotes DLP1
T145 691-695 PR:000006602 denotes DLP1
T146 691-695 P82172 denotes DLP1
T147 691-695 PR:000005959 denotes DLP1
T148 691-695 PR:P97314 denotes DLP1
T150 797-800 UBERON:0003105 denotes DLP
T153 797-801 PR:Q33DR3 denotes DLP1
T154 797-801 PR:000012522 denotes DLP1
T155 797-801 PR:Q8LF21 denotes DLP1
T156 797-801 PR:Q86YH6 denotes DLP1
T157 797-801 PR:O00429 denotes DLP1
T158 797-801 PR:Q5U2R1 denotes DLP1
T159 797-801 PR:O35303 denotes DLP1
T160 797-801 PR:O13851 denotes DLP1
T161 797-801 P97314 denotes DLP1
T162 797-801 PR:Q63164 denotes DLP1
T163 797-801 PR:000006602 denotes DLP1
T164 797-801 P82172 denotes DLP1
T165 797-801 PR:000005959 denotes DLP1
T166 797-801 PR:P97314 denotes DLP1
T167 827-844 SO:0002052 denotes dominant-negative
T169 845-848 UBERON:0003105 denotes DLP
T172 845-849 PR:Q33DR3 denotes DLP1
T173 845-849 PR:000012522 denotes DLP1
T174 845-849 PR:Q8LF21 denotes DLP1
T175 845-849 PR:Q86YH6 denotes DLP1
T176 845-849 PR:O00429 denotes DLP1
T177 845-849 PR:Q5U2R1 denotes DLP1
T178 845-849 PR:O35303 denotes DLP1
T179 845-849 PR:O13851 denotes DLP1
T180 845-849 P97314 denotes DLP1
T181 845-849 PR:Q63164 denotes DLP1
T182 845-849 PR:000006602 denotes DLP1
T183 845-849 P82172 denotes DLP1
T184 845-849 PR:000005959 denotes DLP1
T185 845-849 PR:P97314 denotes DLP1
T186 850-853 PR:000009477 denotes K38
T188 850-853 O76015 denotes K38
T187 850-853 CVCL_W141 denotes K38
T189 851-854 1037951 denotes 38A
T191 861-865 PR:Q80U63 denotes Mfn2
T192 861-865 PR:O95140 denotes Mfn2
T193 861-865 PR:Q8R500 denotes Mfn2
T194 861-865 PR:000010370 denotes Mfn2
T195 874-879 PR:Q5S006 denotes LRRK2
T196 874-879 PR:000003033 denotes LRRK2
T197 874-879 PR:Q5S007 denotes LRRK2
T198 1068-1071 D006160 denotes GTP
T199 1068-1071 CHEBI:37565 denotes GTP
T200 1068-1071 D006160 denotes GTP
T201 1068-1071 CHEBI:15996 denotes GTP
T202 1068-1079 GO:0005525 denotes GTP-binding
T203 1072-1079 SO:0100018 denotes binding
T204 1072-1079 SO:0001091 denotes binding
T206 1097-1102 PR:Q5S006 denotes LRRK2
T207 1097-1102 PR:000003033 denotes LRRK2
T208 1097-1102 PR:Q5S007 denotes LRRK2
T210 1174-1177 UBERON:0003105 denotes DLP
T213 1174-1178 PR:Q33DR3 denotes DLP1
T214 1174-1178 PR:000012522 denotes DLP1
T215 1174-1178 PR:Q8LF21 denotes DLP1
T216 1174-1178 PR:Q86YH6 denotes DLP1
T217 1174-1178 PR:O00429 denotes DLP1
T218 1174-1178 PR:Q5U2R1 denotes DLP1
T219 1174-1178 PR:O35303 denotes DLP1
T220 1174-1178 PR:O13851 denotes DLP1
T221 1174-1178 P97314 denotes DLP1
T222 1174-1178 PR:Q63164 denotes DLP1
T223 1174-1178 PR:000006602 denotes DLP1
T224 1174-1178 P82172 denotes DLP1
T225 1174-1178 PR:000005959 denotes DLP1
T226 1174-1178 PR:P97314 denotes DLP1
T228 1218-1221 UBERON:0003105 denotes DLP
T231 1218-1222 PR:Q33DR3 denotes DLP1
T232 1218-1222 PR:000012522 denotes DLP1
T233 1218-1222 PR:Q8LF21 denotes DLP1
T234 1218-1222 PR:Q86YH6 denotes DLP1
T235 1218-1222 PR:O00429 denotes DLP1
T236 1218-1222 PR:Q5U2R1 denotes DLP1
T237 1218-1222 PR:O35303 denotes DLP1
T238 1218-1222 PR:O13851 denotes DLP1
T239 1218-1222 P97314 denotes DLP1
T240 1218-1222 PR:Q63164 denotes DLP1
T241 1218-1222 PR:000006602 denotes DLP1
T242 1218-1222 P82172 denotes DLP1
T243 1218-1222 PR:000005959 denotes DLP1
T244 1218-1222 PR:P97314 denotes DLP1
T245 1248-1253 PR:Q5S006 denotes LRRK2
T246 1248-1253 PR:000003033 denotes LRRK2
T247 1248-1253 PR:Q5S007 denotes LRRK2
T249 1315-1318 UBERON:0003105 denotes DLP
T252 1315-1319 PR:Q33DR3 denotes DLP1
T253 1315-1319 PR:000012522 denotes DLP1
T254 1315-1319 PR:Q8LF21 denotes DLP1
T255 1315-1319 PR:Q86YH6 denotes DLP1
T256 1315-1319 PR:O00429 denotes DLP1
T257 1315-1319 PR:Q5U2R1 denotes DLP1
T258 1315-1319 PR:O35303 denotes DLP1
T259 1315-1319 PR:O13851 denotes DLP1
T260 1315-1319 P97314 denotes DLP1
T261 1315-1319 PR:Q63164 denotes DLP1
T262 1315-1319 PR:000006602 denotes DLP1
T263 1315-1319 P82172 denotes DLP1
T264 1315-1319 PR:000005959 denotes DLP1
T265 1315-1319 PR:P97314 denotes DLP1
T267 1356-1359 UBERON:0003105 denotes DLP
T270 1356-1360 PR:Q33DR3 denotes DLP1
T271 1356-1360 PR:000012522 denotes DLP1
T272 1356-1360 PR:Q8LF21 denotes DLP1
T273 1356-1360 PR:Q86YH6 denotes DLP1
T274 1356-1360 PR:O00429 denotes DLP1
T275 1356-1360 PR:Q5U2R1 denotes DLP1
T276 1356-1360 PR:O35303 denotes DLP1
T277 1356-1360 PR:O13851 denotes DLP1
T278 1356-1360 P97314 denotes DLP1
T279 1356-1360 PR:Q63164 denotes DLP1
T280 1356-1360 PR:000006602 denotes DLP1
T281 1356-1360 P82172 denotes DLP1
T282 1356-1360 PR:000005959 denotes DLP1
T283 1356-1360 PR:P97314 denotes DLP1
T284 1366-1371 PR:Q5S006 denotes LRRK2
T285 1366-1371 PR:000003033 denotes LRRK2
T286 1366-1371 PR:Q5S007 denotes LRRK2
T287 1372-1387 GO:0016301 denotes kinase activity

DisGeNET

Id Subject Object Predicate Lexical cue
T0 94-122 gene:120892 denotes leucine-rich repeat kinase 2
T1 170-206 disease:C3489791 denotes autosomal-dominant Parkinson disease
T2 94-122 gene:120892 denotes leucine-rich repeat kinase 2
T3 208-210 disease:C3489791 denotes PD
T4 124-129 gene:120892 denotes LRRK2
T5 170-206 disease:C3489791 denotes autosomal-dominant Parkinson disease
T6 124-129 gene:120892 denotes LRRK2
T7 208-210 disease:C3489791 denotes PD
R1 T0 T1 associated_with leucine-rich repeat kinase 2,autosomal-dominant Parkinson disease
R2 T2 T3 associated_with leucine-rich repeat kinase 2,PD
R3 T4 T5 associated_with LRRK2,autosomal-dominant Parkinson disease
R4 T6 T7 associated_with LRRK2,PD

Allie

Id Subject Object Predicate Lexical cue
SS1_22228096_1_0 94-122 expanded denotes leucine-rich repeat kinase 2
SS2_22228096_1_0 124-129 abbr denotes LRRK2
SS1_22228096_1_1 189-206 expanded denotes Parkinson disease
SS2_22228096_1_1 208-210 abbr denotes PD
SS1_22228096_3_0 315-324 expanded denotes wild-type
SS2_22228096_3_0 326-328 abbr denotes WT
AE1_22228096_1_0 SS1_22228096_1_0 SS2_22228096_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_22228096_1_1 SS1_22228096_1_1 SS2_22228096_1_1 abbreviatedTo Parkinson disease,PD
AE1_22228096_3_0 SS1_22228096_3_0 SS2_22228096_3_0 abbreviatedTo wild-type,WT

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-89 DRI_Background denotes LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
T2 90-212 DRI_Approach denotes The leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of autosomal-dominant Parkinson disease (PD).
T3 213-293 DRI_Challenge denotes Mitochondrial dysfunction represents a critical event in the pathogenesis of PD.
T4 294-633 DRI_Outcome denotes We demonstrated that wild-type (WT) LRRK2 expression caused mitochondrial fragmentation along with increased mitochondrial dynamin-like protein (DLP1, also known as DRP1), a fission protein, which was further exacerbated by expression of PD-associated mutants (R1441C or G2019S) in both SH-SY5Y and differentiated primary cortical neurons.
T5 634-809 DRI_Outcome denotes We also found that LRRK2 interacted with DLP1, and LRRK2-DLP1 interaction was enhanced by PD-associated mutations that probably results in increased mitochondrial DLP1 levels.
T6 810-826 DRI_Background denotes Co-expression of
T7 827-854 Token_Label.OUTSIDE denotes dominant-negative DLP1 K38A
T8 855-965 DRI_Background denotes or WT Mfn2 blocked LRRK2-induced mitochondrial fragmentation, mitochondrial dysfunction and neuronal toxicity.
T9 966-1096 DRI_Background denotes Importantly, mitochondrial fragmentation and dysfunction were not observed in cells expressing either GTP-binding deficient mutant
T10 1097-1109 Token_Label.OUTSIDE denotes LRRK2 K1347A
T11 1110-1229 DRI_Background denotes or kinase-dead mutant D1994A which has minimal interaction with DLP1 and did not increase the mitochondrial DLP1 level.
T12 1230-1426 DRI_Challenge denotes We concluded that LRRK2 regulates mitochondrial dynamics by increasing mitochondrial DLP1 through its direct interaction with DLP1, and LRRK2 kinase activity plays a critical role in this process.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 90-212 DRI_Approach denotes The leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of autosomal-dominant Parkinson disease (PD).
T2 213-293 DRI_Challenge denotes Mitochondrial dysfunction represents a critical event in the pathogenesis of PD.
T3 294-633 DRI_Outcome denotes We demonstrated that wild-type (WT) LRRK2 expression caused mitochondrial fragmentation along with increased mitochondrial dynamin-like protein (DLP1, also known as DRP1), a fission protein, which was further exacerbated by expression of PD-associated mutants (R1441C or G2019S) in both SH-SY5Y and differentiated primary cortical neurons.
T4 634-809 DRI_Outcome denotes We also found that LRRK2 interacted with DLP1, and LRRK2-DLP1 interaction was enhanced by PD-associated mutations that probably results in increased mitochondrial DLP1 levels.
T5 810-826 DRI_Background denotes Co-expression of
T6 855-965 DRI_Background denotes or WT Mfn2 blocked LRRK2-induced mitochondrial fragmentation, mitochondrial dysfunction and neuronal toxicity.
T7 966-1096 DRI_Background denotes Importantly, mitochondrial fragmentation and dysfunction were not observed in cells expressing either GTP-binding deficient mutant
T8 1110-1229 DRI_Background denotes or kinase-dead mutant D1994A which has minimal interaction with DLP1 and did not increase the mitochondrial DLP1 level.
T9 1230-1426 DRI_Challenge denotes We concluded that LRRK2 regulates mitochondrial dynamics by increasing mitochondrial DLP1 through its direct interaction with DLP1, and LRRK2 kinase activity plays a critical role in this process.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 170-188 HP_0000006 denotes autosomal-dominant
T2 189-198 HP_0001300 denotes Parkinson
T3 213-238 HP_0003287 denotes Mitochondrial dysfunction
T4 213-226 HP_0001427 denotes Mitochondrial
T5 354-367 HP_0001427 denotes mitochondrial
T6 403-416 HP_0001427 denotes mitochondrial
T7 783-796 HP_0001427 denotes mitochondrial
T8 888-901 HP_0001427 denotes mitochondrial
T9 917-942 HP_0003287 denotes mitochondrial dysfunction
T10 917-930 HP_0001427 denotes mitochondrial
T11 979-1022 HP_0003287 denotes mitochondrial fragmentation and dysfunction
T12 979-992 HP_0001427 denotes mitochondrial
T13 1120-1124 HP_0000365 denotes dead
T14 1204-1217 HP_0001427 denotes mitochondrial
T15 1264-1277 HP_0001427 denotes mitochondrial
T16 1301-1314 HP_0001427 denotes mitochondrial

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
22228096-3#261#267#geners33939927 555-561 geners33939927 denotes R1441C
22228096-3#271#277#geners34637584 565-571 geners34637584 denotes G2019S
22228096-3#238#240#diseaseC3489791 532-534 diseaseC3489791 denotes PD
261#267#geners33939927238#240#diseaseC3489791 22228096-3#261#267#geners33939927 22228096-3#238#240#diseaseC3489791 associated_with R1441C,PD
271#277#geners34637584238#240#diseaseC3489791 22228096-3#271#277#geners34637584 22228096-3#238#240#diseaseC3489791 associated_with G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22228096-3#165#169#gene1400 459-463 gene1400 denotes DRP1
22228096-3#165#169#gene23604 459-463 gene23604 denotes DRP1
22228096-3#165#169#gene8562 459-463 gene8562 denotes DRP1
22228096-3#165#169#gene7402 459-463 gene7402 denotes DRP1
22228096-3#36#41#gene120892 330-335 gene120892 denotes LRRK2
22228096-3#238#240#diseaseC3489791 532-534 diseaseC3489791 denotes PD
22228096-3#238#240#diseaseC3489791 532-534 diseaseC3489791 denotes PD
22228096-4#57#61#gene10059 691-695 gene10059 denotes DLP1
22228096-4#57#61#gene57107 691-695 gene57107 denotes DLP1
22228096-4#163#167#gene10059 797-801 gene10059 denotes DLP1
22228096-4#163#167#gene57107 797-801 gene57107 denotes DLP1
22228096-4#90#92#diseaseC3489791 724-726 diseaseC3489791 denotes PD
22228096-6#208#212#gene10059 1174-1178 gene10059 denotes DLP1
22228096-6#208#212#gene57107 1174-1178 gene57107 denotes DLP1
22228096-6#252#256#gene10059 1218-1222 gene10059 denotes DLP1
22228096-6#252#256#gene57107 1218-1222 gene57107 denotes DLP1
22228096-6#102#105#gene92170 1068-1071 gene92170 denotes GTP
22228096-6#45#56#diseaseC3887505 1011-1022 diseaseC3887505 denotes dysfunction
22228096-6#45#56#diseaseC3887505 1011-1022 diseaseC3887505 denotes dysfunction
165#169#gene1400238#240#diseaseC3489791 22228096-3#165#169#gene1400 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene1400238#240#diseaseC3489791 22228096-3#165#169#gene1400 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene23604238#240#diseaseC3489791 22228096-3#165#169#gene23604 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene23604238#240#diseaseC3489791 22228096-3#165#169#gene23604 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene8562238#240#diseaseC3489791 22228096-3#165#169#gene8562 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene8562238#240#diseaseC3489791 22228096-3#165#169#gene8562 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene7402238#240#diseaseC3489791 22228096-3#165#169#gene7402 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
165#169#gene7402238#240#diseaseC3489791 22228096-3#165#169#gene7402 22228096-3#238#240#diseaseC3489791 associated_with DRP1,PD
36#41#gene120892238#240#diseaseC3489791 22228096-3#36#41#gene120892 22228096-3#238#240#diseaseC3489791 associated_with LRRK2,PD
36#41#gene120892238#240#diseaseC3489791 22228096-3#36#41#gene120892 22228096-3#238#240#diseaseC3489791 associated_with LRRK2,PD
57#61#gene1005990#92#diseaseC3489791 22228096-4#57#61#gene10059 22228096-4#90#92#diseaseC3489791 associated_with DLP1,PD
57#61#gene5710790#92#diseaseC3489791 22228096-4#57#61#gene57107 22228096-4#90#92#diseaseC3489791 associated_with DLP1,PD
163#167#gene1005990#92#diseaseC3489791 22228096-4#163#167#gene10059 22228096-4#90#92#diseaseC3489791 associated_with DLP1,PD
163#167#gene5710790#92#diseaseC3489791 22228096-4#163#167#gene57107 22228096-4#90#92#diseaseC3489791 associated_with DLP1,PD
208#212#gene1005945#56#diseaseC3887505 22228096-6#208#212#gene10059 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
208#212#gene1005945#56#diseaseC3887505 22228096-6#208#212#gene10059 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
208#212#gene5710745#56#diseaseC3887505 22228096-6#208#212#gene57107 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
208#212#gene5710745#56#diseaseC3887505 22228096-6#208#212#gene57107 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
252#256#gene1005945#56#diseaseC3887505 22228096-6#252#256#gene10059 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
252#256#gene1005945#56#diseaseC3887505 22228096-6#252#256#gene10059 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
252#256#gene5710745#56#diseaseC3887505 22228096-6#252#256#gene57107 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
252#256#gene5710745#56#diseaseC3887505 22228096-6#252#256#gene57107 22228096-6#45#56#diseaseC3887505 associated_with DLP1,dysfunction
102#105#gene9217045#56#diseaseC3887505 22228096-6#102#105#gene92170 22228096-6#45#56#diseaseC3887505 associated_with GTP,dysfunction
102#105#gene9217045#56#diseaseC3887505 22228096-6#102#105#gene92170 22228096-6#45#56#diseaseC3887505 associated_with GTP,dysfunction