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sentences

Id Subject Object Predicate Lexical cue
T1 0-213 Sentence denotes Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS).
T2 214-306 Sentence denotes Growth factors, insulin, oxidative stress, and cytokines activate ERK1/2 by PKCδ and MEK1/2.
T3 307-503 Sentence denotes Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase and intracellular scaffold/bridge/anchor, is a nuclear transporter of MEK1/2-stimulated ERK1/2 (Lerner-Marmarosh, N., Miralem, T., Gibbs, P.
T4 504-522 Sentence denotes E., and Maines, M.
T5 523-538 Sentence denotes D. (2008) Proc.
T6 539-544 Sentence denotes Natl.
T7 545-550 Sentence denotes Acad.
T8 551-555 Sentence denotes Sci.
T9 556-562 Sentence denotes U.S.A.
T10 563-669 Sentence denotes 105, 6870-6875). hBVR, PKCδ, and MEK1/2 overlap in their tissue expression profile and type of activators.
T11 670-852 Sentence denotes Presently, we report on formation of an hBVR-PKCδ-ERK2 ternary complex that is essential for ERK2 signal transduction and activation of genes linked to cell proliferation and cancer.
T12 853-926 Sentence denotes MEK1/2 and the protein phosphatase PP2A were also present in the complex.
T13 927-1211 Sentence denotes When cells were stimulated with insulin-like growth factor-1 (IGF-1), an increased interaction between hBVR and PKCδ was detected by FRET-fluorescence lifetime imaging microscopy. hBVR and ERK2 were phosphorylated by PKCδ; however, the PKC was not a substrate for either ERK2 or hBVR.
T14 1212-1340 Sentence denotes IGF-1 and phorbol ester increased hBVR/PKCδ binding; hBVR was required for the activation of PKCδ and its interaction with ERK2.
T15 1341-1482 Sentence denotes The C-terminal phenylalanine residues of PKCδ (Phe(660), Phe(663), and Phe(665)) were necessary for binding to ERK2 but not for hBVR binding.
T16 1483-1611 Sentence denotes Formation of the hBVR-PKCδ-ERK2 complex required the hBVR docking site for ERK, FXFP (DEF, C-box) and D(δ)-box (ILXXLXL) motifs.
T17 1612-1698 Sentence denotes The hBVR-based peptide KKRILHCLGLA inhibited PKC activation and PKCδ/ERK2 interaction.
T18 1699-1904 Sentence denotes Phorbol ester- and TNF-α-dependent activation of the ERK-regulated transcription factors Elk1 and NF-κB and expression of the iNOS gene were suppressed by hBVR siRNA; those activities were rescued by hBVR.
T19 1905-2047 Sentence denotes The findings reveal the direct input of hBVR in PKCδ/ERK signaling and identify hBVR-based peptide regulators of ERK-mediated gene activation.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 845-851 HP_0002664 denotes cancer

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 38-58 Gene_or_gene_product denotes biliverdin reductase
T2 59-76 Gene_or_gene_product denotes protein kinase Cδ
T3 77-81 Gene_or_gene_product denotes ERK2
T4 107-111 Gene_or_gene_product denotes ERK2
T5 135-139 Gene_or_gene_product denotes Elk1
T6 149-166 Complex denotes nuclear factor-κB
T7 182-205 Gene_or_gene_product denotes nitric-oxidase synthase
T8 207-211 Gene_or_gene_product denotes iNOS
T9 230-237 Gene_or_gene_product denotes insulin
T10 280-286 Gene_or_gene_product denotes ERK1/2
T11 290-294 Gene_or_gene_product denotes PKCδ
T12 299-305 Gene_or_gene_product denotes MEK1/2
T13 313-333 Gene_or_gene_product denotes biliverdin reductase
T14 335-339 Gene_or_gene_product denotes hBVR
T15 344-347 Simple_chemical denotes Ser
T16 348-351 Simple_chemical denotes Thr
T17 352-355 Simple_chemical denotes Tyr
T18 367-380 Cellular_component denotes intracellular
T19 410-417 Cellular_component denotes nuclear
T20 433-439 Gene_or_gene_product denotes MEK1/2
T21 451-457 Gene_or_gene_product denotes ERK1/2
T22 580-584 Gene_or_gene_product denotes hBVR
T23 586-590 Gene_or_gene_product denotes PKCδ
T24 596-602 Gene_or_gene_product denotes MEK1/2
T25 710-724 Complex denotes hBVR-PKCδ-ERK2
T26 763-767 Gene_or_gene_product denotes ERK2
T27 853-859 Gene_or_gene_product denotes MEK1/2
T28 888-892 Gene_or_gene_product denotes PP2A
T29 959-987 Gene_or_gene_product denotes insulin-like growth factor-1
T30 989-994 Gene_or_gene_product denotes IGF-1
T31 1030-1034 Gene_or_gene_product denotes hBVR
T32 1039-1043 Gene_or_gene_product denotes PKCδ
T33 1107-1111 Gene_or_gene_product denotes hBVR
T34 1116-1120 Gene_or_gene_product denotes ERK2
T35 1144-1148 Gene_or_gene_product denotes PKCδ
T36 1163-1166 Gene_or_gene_product denotes PKC
T37 1198-1202 Gene_or_gene_product denotes ERK2
T38 1206-1210 Gene_or_gene_product denotes hBVR
T39 1212-1217 Gene_or_gene_product denotes IGF-1
T40 1222-1235 Simple_chemical denotes phorbol ester
T41 1246-1250 Gene_or_gene_product denotes hBVR
T42 1251-1255 Gene_or_gene_product denotes PKCδ
T43 1265-1269 Gene_or_gene_product denotes hBVR
T44 1305-1309 Gene_or_gene_product denotes PKCδ
T45 1335-1339 Gene_or_gene_product denotes ERK2
T46 1382-1386 Gene_or_gene_product denotes PKCδ
T47 1388-1396 Simple_chemical denotes Phe(660)
T48 1398-1406 Simple_chemical denotes Phe(663)
T49 1412-1420 Simple_chemical denotes Phe(665)
T50 1452-1456 Gene_or_gene_product denotes ERK2
T51 1469-1473 Gene_or_gene_product denotes hBVR
T52 1500-1514 Complex denotes hBVR-PKCδ-ERK2
T53 1536-1540 Gene_or_gene_product denotes hBVR
T54 1558-1561 Gene_or_gene_product denotes ERK
T55 1616-1620 Gene_or_gene_product denotes hBVR
T56 1657-1660 Gene_or_gene_product denotes PKC
T57 1676-1680 Gene_or_gene_product denotes PKCδ
T58 1681-1685 Gene_or_gene_product denotes ERK2
T59 1699-1712 Simple_chemical denotes Phorbol ester
T60 1718-1723 Gene_or_gene_product denotes TNF-α
T61 1752-1755 Gene_or_gene_product denotes ERK
T62 1788-1792 Gene_or_gene_product denotes Elk1
T63 1797-1802 Complex denotes NF-κB
T64 1825-1829 Gene_or_gene_product denotes iNOS
T65 1854-1858 Gene_or_gene_product denotes hBVR
T66 1899-1903 Gene_or_gene_product denotes hBVR
T67 1945-1949 Gene_or_gene_product denotes hBVR
T68 1953-1957 Gene_or_gene_product denotes PKCδ
T69 1958-1961 Gene_or_gene_product denotes ERK
T70 1985-1989 Gene_or_gene_product denotes hBVR
T71 2018-2021 Gene_or_gene_product denotes ERK

Allie

Id Subject Object Predicate Lexical cue
SS1_22065579_0_0 172-205 expanded denotes inducible nitric-oxidase synthase
SS2_22065579_0_0 207-211 abbr denotes iNOS
SS1_22065579_2_0 307-333 expanded denotes Human biliverdin reductase
SS2_22065579_2_0 335-339 abbr denotes hBVR
SS1_22065579_5_0 959-987 expanded denotes insulin-like growth factor-1
SS2_22065579_5_0 989-994 abbr denotes IGF-1
AE1_22065579_0_0 SS1_22065579_0_0 SS2_22065579_0_0 abbreviatedTo inducible nitric-oxidase synthase,iNOS
AE1_22065579_2_0 SS1_22065579_2_0 SS2_22065579_2_0 abbreviatedTo Human biliverdin reductase,hBVR
AE1_22065579_5_0 SS1_22065579_5_0 SS2_22065579_5_0 abbreviatedTo insulin-like growth factor-1,IGF-1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 845-851 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 32-37 OrganismTaxon denotes human 9606
T2 307-312 OrganismTaxon denotes Human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 367-380 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T2 620-626 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 239-255 Phenotype denotes oxidative stress HP:0025464
T2 845-851 Phenotype denotes cancer HP:0002664