PubMed:22065579
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 367-380 | Body_part | denotes | intracellular |
T2 | 620-626 | Body_part | denotes | tissue |
T3 | 822-826 | Body_part | denotes | cell |
T4 | 827-840 | Body_part | denotes | proliferation |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-213 | Sentence | denotes | Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS). |
T2 | 214-306 | Sentence | denotes | Growth factors, insulin, oxidative stress, and cytokines activate ERK1/2 by PKCδ and MEK1/2. |
T3 | 307-503 | Sentence | denotes | Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase and intracellular scaffold/bridge/anchor, is a nuclear transporter of MEK1/2-stimulated ERK1/2 (Lerner-Marmarosh, N., Miralem, T., Gibbs, P. |
T4 | 504-522 | Sentence | denotes | E., and Maines, M. |
T5 | 523-538 | Sentence | denotes | D. (2008) Proc. |
T6 | 539-544 | Sentence | denotes | Natl. |
T7 | 545-550 | Sentence | denotes | Acad. |
T8 | 551-555 | Sentence | denotes | Sci. |
T9 | 556-562 | Sentence | denotes | U.S.A. |
T10 | 563-669 | Sentence | denotes | 105, 6870-6875). hBVR, PKCδ, and MEK1/2 overlap in their tissue expression profile and type of activators. |
T11 | 670-852 | Sentence | denotes | Presently, we report on formation of an hBVR-PKCδ-ERK2 ternary complex that is essential for ERK2 signal transduction and activation of genes linked to cell proliferation and cancer. |
T12 | 853-926 | Sentence | denotes | MEK1/2 and the protein phosphatase PP2A were also present in the complex. |
T13 | 927-1211 | Sentence | denotes | When cells were stimulated with insulin-like growth factor-1 (IGF-1), an increased interaction between hBVR and PKCδ was detected by FRET-fluorescence lifetime imaging microscopy. hBVR and ERK2 were phosphorylated by PKCδ; however, the PKC was not a substrate for either ERK2 or hBVR. |
T14 | 1212-1340 | Sentence | denotes | IGF-1 and phorbol ester increased hBVR/PKCδ binding; hBVR was required for the activation of PKCδ and its interaction with ERK2. |
T15 | 1341-1482 | Sentence | denotes | The C-terminal phenylalanine residues of PKCδ (Phe(660), Phe(663), and Phe(665)) were necessary for binding to ERK2 but not for hBVR binding. |
T16 | 1483-1611 | Sentence | denotes | Formation of the hBVR-PKCδ-ERK2 complex required the hBVR docking site for ERK, FXFP (DEF, C-box) and D(δ)-box (ILXXLXL) motifs. |
T17 | 1612-1698 | Sentence | denotes | The hBVR-based peptide KKRILHCLGLA inhibited PKC activation and PKCδ/ERK2 interaction. |
T18 | 1699-1904 | Sentence | denotes | Phorbol ester- and TNF-α-dependent activation of the ERK-regulated transcription factors Elk1 and NF-κB and expression of the iNOS gene were suppressed by hBVR siRNA; those activities were rescued by hBVR. |
T19 | 1905-2047 | Sentence | denotes | The findings reveal the direct input of hBVR in PKCδ/ERK signaling and identify hBVR-based peptide regulators of ERK-mediated gene activation. |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 121-131 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T2 | 271-279 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
T3 | 658-668 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activators |
T4 | 792-802 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T5 | 822-826 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T6 | 932-937 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T7 | 1291-1301 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T8 | 1661-1671 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T9 | 1734-1744 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T10 | 1872-1882 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
T11 | 2036-2046 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 845-851 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 32-37 | OrganismTaxon | denotes | human | NCBItxid:9606 |
T2 | 307-312 | OrganismTaxon | denotes | Human | NCBItxid:9606 |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 845-851 | HP_0002664 | denotes | cancer |
bionlp-st-pc-2013-training
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-58 | Gene_or_gene_product | denotes | biliverdin reductase |
T2 | 59-76 | Gene_or_gene_product | denotes | protein kinase Cδ |
T3 | 77-81 | Gene_or_gene_product | denotes | ERK2 |
T4 | 107-111 | Gene_or_gene_product | denotes | ERK2 |
T5 | 135-139 | Gene_or_gene_product | denotes | Elk1 |
T6 | 149-166 | Complex | denotes | nuclear factor-κB |
T7 | 182-205 | Gene_or_gene_product | denotes | nitric-oxidase synthase |
T8 | 207-211 | Gene_or_gene_product | denotes | iNOS |
T9 | 230-237 | Gene_or_gene_product | denotes | insulin |
T10 | 280-286 | Gene_or_gene_product | denotes | ERK1/2 |
T11 | 290-294 | Gene_or_gene_product | denotes | PKCδ |
T12 | 299-305 | Gene_or_gene_product | denotes | MEK1/2 |
T13 | 313-333 | Gene_or_gene_product | denotes | biliverdin reductase |
T14 | 335-339 | Gene_or_gene_product | denotes | hBVR |
T15 | 344-347 | Simple_chemical | denotes | Ser |
T16 | 348-351 | Simple_chemical | denotes | Thr |
T17 | 352-355 | Simple_chemical | denotes | Tyr |
T18 | 367-380 | Cellular_component | denotes | intracellular |
T19 | 410-417 | Cellular_component | denotes | nuclear |
T20 | 433-439 | Gene_or_gene_product | denotes | MEK1/2 |
T21 | 451-457 | Gene_or_gene_product | denotes | ERK1/2 |
T22 | 580-584 | Gene_or_gene_product | denotes | hBVR |
T23 | 586-590 | Gene_or_gene_product | denotes | PKCδ |
T24 | 596-602 | Gene_or_gene_product | denotes | MEK1/2 |
T25 | 710-724 | Complex | denotes | hBVR-PKCδ-ERK2 |
T26 | 763-767 | Gene_or_gene_product | denotes | ERK2 |
T27 | 853-859 | Gene_or_gene_product | denotes | MEK1/2 |
T28 | 888-892 | Gene_or_gene_product | denotes | PP2A |
T29 | 959-987 | Gene_or_gene_product | denotes | insulin-like growth factor-1 |
T30 | 989-994 | Gene_or_gene_product | denotes | IGF-1 |
T31 | 1030-1034 | Gene_or_gene_product | denotes | hBVR |
T32 | 1039-1043 | Gene_or_gene_product | denotes | PKCδ |
T33 | 1107-1111 | Gene_or_gene_product | denotes | hBVR |
T34 | 1116-1120 | Gene_or_gene_product | denotes | ERK2 |
T35 | 1144-1148 | Gene_or_gene_product | denotes | PKCδ |
T36 | 1163-1166 | Gene_or_gene_product | denotes | PKC |
T37 | 1198-1202 | Gene_or_gene_product | denotes | ERK2 |
T38 | 1206-1210 | Gene_or_gene_product | denotes | hBVR |
T39 | 1212-1217 | Gene_or_gene_product | denotes | IGF-1 |
T40 | 1222-1235 | Simple_chemical | denotes | phorbol ester |
T41 | 1246-1250 | Gene_or_gene_product | denotes | hBVR |
T42 | 1251-1255 | Gene_or_gene_product | denotes | PKCδ |
T43 | 1265-1269 | Gene_or_gene_product | denotes | hBVR |
T44 | 1305-1309 | Gene_or_gene_product | denotes | PKCδ |
T45 | 1335-1339 | Gene_or_gene_product | denotes | ERK2 |
T46 | 1382-1386 | Gene_or_gene_product | denotes | PKCδ |
T47 | 1388-1396 | Simple_chemical | denotes | Phe(660) |
T48 | 1398-1406 | Simple_chemical | denotes | Phe(663) |
T49 | 1412-1420 | Simple_chemical | denotes | Phe(665) |
T50 | 1452-1456 | Gene_or_gene_product | denotes | ERK2 |
T51 | 1469-1473 | Gene_or_gene_product | denotes | hBVR |
T52 | 1500-1514 | Complex | denotes | hBVR-PKCδ-ERK2 |
T53 | 1536-1540 | Gene_or_gene_product | denotes | hBVR |
T54 | 1558-1561 | Gene_or_gene_product | denotes | ERK |
T55 | 1616-1620 | Gene_or_gene_product | denotes | hBVR |
T56 | 1657-1660 | Gene_or_gene_product | denotes | PKC |
T57 | 1676-1680 | Gene_or_gene_product | denotes | PKCδ |
T58 | 1681-1685 | Gene_or_gene_product | denotes | ERK2 |
T59 | 1699-1712 | Simple_chemical | denotes | Phorbol ester |
T60 | 1718-1723 | Gene_or_gene_product | denotes | TNF-α |
T61 | 1752-1755 | Gene_or_gene_product | denotes | ERK |
T62 | 1788-1792 | Gene_or_gene_product | denotes | Elk1 |
T63 | 1797-1802 | Complex | denotes | NF-κB |
T64 | 1825-1829 | Gene_or_gene_product | denotes | iNOS |
T65 | 1854-1858 | Gene_or_gene_product | denotes | hBVR |
T66 | 1899-1903 | Gene_or_gene_product | denotes | hBVR |
T67 | 1945-1949 | Gene_or_gene_product | denotes | hBVR |
T68 | 1953-1957 | Gene_or_gene_product | denotes | PKCδ |
T69 | 1958-1961 | Gene_or_gene_product | denotes | ERK |
T70 | 1985-1989 | Gene_or_gene_product | denotes | hBVR |
T71 | 2018-2021 | Gene_or_gene_product | denotes | ERK |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_22065579_0_0 | 172-205 | expanded | denotes | inducible nitric-oxidase synthase |
SS2_22065579_0_0 | 207-211 | abbr | denotes | iNOS |
SS1_22065579_2_0 | 307-333 | expanded | denotes | Human biliverdin reductase |
SS2_22065579_2_0 | 335-339 | abbr | denotes | hBVR |
SS1_22065579_5_0 | 959-987 | expanded | denotes | insulin-like growth factor-1 |
SS2_22065579_5_0 | 989-994 | abbr | denotes | IGF-1 |
AE1_22065579_0_0 | SS1_22065579_0_0 | SS2_22065579_0_0 | abbreviatedTo | inducible nitric-oxidase synthase,iNOS |
AE1_22065579_2_0 | SS1_22065579_2_0 | SS2_22065579_2_0 | abbreviatedTo | Human biliverdin reductase,hBVR |
AE1_22065579_5_0 | SS1_22065579_5_0 | SS2_22065579_5_0 | abbreviatedTo | insulin-like growth factor-1,IGF-1 |