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PubMed:21833774 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 139-351 DRI_Background denotes HMC05 is a formulation derived from eight medicinal herbs, and prevents neointima formation by inhibition of the mitogen-activated protein kinase (MAPK) pathway with induction of heat shock protein 27 expression.
T2 352-423 DRI_Challenge denotes In this study, we investigated the influence of HMC05 regulation on the
T3 460-593 DRI_Challenge denotes kinase (ERK) 1/2 signaling cascade in the inhibition of the migration and proliferation of human aortic smooth muscle cells (HASMCs).
T4 956-1166 DRI_Background denotes HMC05 prevented TNF-α receptor 1-mediated phosphorylation of signal transduction molecules involved in MAPK signaling cascades such as MEK1/2, ERK1/2, Elk-1 transcription factor and p90 kDa ribosomal S6 kinase.
T5 1167-1429 DRI_Background denotes The expression of matrix metalloproteinase, a modulator of vascular smooth muscle cell proliferation and migration, was inhibited by HMCO5 treatment, as was TNF-α-induced mRNA expression of intracellular adhesion molecule 1 and vascular cell adhesion molecule 1.
T6 1430-1531 DRI_Approach denotes HMC05 disruption of the MEK/ERK/Elk-1 and p90RSK pathways prevents HASMC migration and proliferation.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 653-658 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21833774_1_0 252-284 expanded denotes mitogen-activated protein kinase
SS2_21833774_1_0 286-290 abbr denotes MAPK
SS1_21833774_2_0 429-466 expanded denotes extracellular signal-regulated kinase
SS2_21833774_2_0 468-471 abbr denotes ERK
SS1_21833774_2_1 551-583 expanded denotes human aortic smooth muscle cells
SS2_21833774_2_1 585-591 abbr denotes HASMCs
AE1_21833774_1_0 SS1_21833774_1_0 SS2_21833774_1_0 abbreviatedTo mitogen-activated protein kinase,MAPK
AE1_21833774_2_0 SS1_21833774_2_0 SS2_21833774_2_0 abbreviatedTo extracellular signal-regulated kinase,ERK
AE1_21833774_2_1 SS1_21833774_2_1 SS2_21833774_2_1 abbreviatedTo human aortic smooth muscle cells,HASMCs