PubMed:21812773 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":2442,"end":2492},"obj":"HP_0002076"},{"id":"T2","span":{"begin":2606,"end":2615},"obj":"HP_0000618"}],"text":"Migraine with binocular blindness: a clinic-based study.\nOBJECTIVE: To describe the syndrome of migraine with binocular blindness.\nBACKGROUND: Rarely do migraine patients complain of losing vision in both eyes during an attack of headache. There are no large clinic-based studies looking at the prevalence of binocular blindness in migraine sufferers and no information about patient demographics, neuroimaging, and laboratory testing.\nMETHODS: Over a 14-month time period, 383 new patients with a diagnosis of migraine were seen at the Geisinger Headache Center. All patients were asked if they ever experienced an episode of complete bilateral blindness along with their headaches. Those with a positive history had coagulopathy testing as well as brain magnetic resonance imaging and magnetic resonance angiography of the intracranial circulation.\nRESULTS: A total of 6 patients or only 1.6% of the new migraine patients had episodes of binocular blindness with their headaches. All were female and each had a history of migraine for at least 3 years. Five patients had a diagnosis of migraine without aura, while one had a diagnosis of basilar-type migraine. In all patients the blindness episodes occurred in isolation during a migraine headache. In all but one patient the blindness was instantaneous and not a slow evolution. In 2 patients the blindness episode only occurred 1 time; in 3 patients episodes occurred more than once but were rare, while 1 patient had blindness with 50% of her headaches. In regard to duration, in 2 patients blindness lasted only several seconds, 2 patients between 2 and 10 minutes, 1 patient 30 minutes and 1 patient 60-120 minutes. Neuroimaging was normal in all. Three patients had a history of smoking and 3 never smoked. Coagulopathy testing was abnormal in all patients. Two patients were homozygous for methylenetetrahydrofolate reductase (MTHFR) 677TT polymorphism, but both had normal homocysteine levels; 3 patients were heterozygous for MTHFR 677CT polymorphism and 1 had elevated homocysteine levels and 1 patient had a positive lupus anticoagulant (had the most frequent episodes of blindness).\nCONCLUSION: Binocular blindness with migraine headache is a very rare occurrence at least in a headache specialty clinic population. It is a female-predominant event and occurs mostly in migraine patients who do not have a history of aura. Blindness episodes can be very brief or prolonged and many do not fit the typical duration of a migraine aura. They are typically infrequent events and may occur only 1 time without recurrence. Migraine with binocular blindness may reflect an underlying clotting disorder. A possible etiology outside of a coagulopathy-related event is retinal spreading depression."}

{"project":"Allie","denotations":[{"id":"SS1_21812773_21_0","span":{"begin":1850,"end":1885},"obj":"expanded"},{"id":"SS2_21812773_21_0","span":{"begin":1887,"end":1892},"obj":"abbr"}],"relations":[{"id":"AE1_21812773_21_0","pred":"abbreviatedTo","subj":"SS1_21812773_21_0","obj":"SS2_21812773_21_0"}],"text":"Migraine with binocular blindness: a clinic-based study.\nOBJECTIVE: To describe the syndrome of migraine with binocular blindness.\nBACKGROUND: Rarely do migraine patients complain of losing vision in both eyes during an attack of headache. There are no large clinic-based studies looking at the prevalence of binocular blindness in migraine sufferers and no information about patient demographics, neuroimaging, and laboratory testing.\nMETHODS: Over a 14-month time period, 383 new patients with a diagnosis of migraine were seen at the Geisinger Headache Center. All patients were asked if they ever experienced an episode of complete bilateral blindness along with their headaches. Those with a positive history had coagulopathy testing as well as brain magnetic resonance imaging and magnetic resonance angiography of the intracranial circulation.\nRESULTS: A total of 6 patients or only 1.6% of the new migraine patients had episodes of binocular blindness with their headaches. All were female and each had a history of migraine for at least 3 years. Five patients had a diagnosis of migraine without aura, while one had a diagnosis of basilar-type migraine. In all patients the blindness episodes occurred in isolation during a migraine headache. In all but one patient the blindness was instantaneous and not a slow evolution. In 2 patients the blindness episode only occurred 1 time; in 3 patients episodes occurred more than once but were rare, while 1 patient had blindness with 50% of her headaches. In regard to duration, in 2 patients blindness lasted only several seconds, 2 patients between 2 and 10 minutes, 1 patient 30 minutes and 1 patient 60-120 minutes. Neuroimaging was normal in all. Three patients had a history of smoking and 3 never smoked. Coagulopathy testing was abnormal in all patients. Two patients were homozygous for methylenetetrahydrofolate reductase (MTHFR) 677TT polymorphism, but both had normal homocysteine levels; 3 patients were heterozygous for MTHFR 677CT polymorphism and 1 had elevated homocysteine levels and 1 patient had a positive lupus anticoagulant (had the most frequent episodes of blindness).\nCONCLUSION: Binocular blindness with migraine headache is a very rare occurrence at least in a headache specialty clinic population. It is a female-predominant event and occurs mostly in migraine patients who do not have a history of aura. Blindness episodes can be very brief or prolonged and many do not fit the typical duration of a migraine aura. They are typically infrequent events and may occur only 1 time without recurrence. Migraine with binocular blindness may reflect an underlying clotting disorder. A possible etiology outside of a coagulopathy-related event is retinal spreading depression."}

{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":0,"end":8},"obj":"HP:0002076"},{"id":"TI2","span":{"begin":24,"end":33},"obj":"HP:0000618"},{"id":"AB1","span":{"begin":96,"end":104},"obj":"HP:0002076"},{"id":"AB2","span":{"begin":120,"end":129},"obj":"HP:0000618"},{"id":"AB3","span":{"begin":153,"end":161},"obj":"HP:0002076"},{"id":"AB4","span":{"begin":230,"end":238},"obj":"HP:0002315"},{"id":"AB5","span":{"begin":319,"end":328},"obj":"HP:0000618"},{"id":"AB6","span":{"begin":332,"end":340},"obj":"HP:0002076"},{"id":"AB7","span":{"begin":511,"end":519},"obj":"HP:0002076"},{"id":"AB8","span":{"begin":547,"end":555},"obj":"HP:0002315"},{"id":"AB9","span":{"begin":646,"end":655},"obj":"HP:0000618"},{"id":"AB10","span":{"begin":673,"end":682},"obj":"HP:0002315"},{"id":"AB11","span":{"begin":906,"end":914},"obj":"HP:0002076"},{"id":"AB12","span":{"begin":950,"end":959},"obj":"HP:0000618"},{"id":"AB13","span":{"begin":971,"end":980},"obj":"HP:0002315"},{"id":"AB14","span":{"begin":1024,"end":1032},"obj":"HP:0002076"},{"id":"AB15","span":{"begin":1088,"end":1109},"obj":"HP:0002083"},{"id":"AB16","span":{"begin":1153,"end":1161},"obj":"HP:0002076"},{"id":"AB17","span":{"begin":1183,"end":1192},"obj":"HP:0000618"},{"id":"AB18","span":{"begin":1233,"end":1241},"obj":"HP:0002076"},{"id":"AB19","span":{"begin":1242,"end":1250},"obj":"HP:0002315"},{"id":"AB20","span":{"begin":1279,"end":1288},"obj":"HP:0000618"},{"id":"AB21","span":{"begin":1351,"end":1360},"obj":"HP:0000618"},{"id":"AB22","span":{"begin":1473,"end":1482},"obj":"HP:0000618"},{"id":"AB23","span":{"begin":1499,"end":1508},"obj":"HP:0002315"},{"id":"AB24","span":{"begin":1547,"end":1556},"obj":"HP:0000618"},{"id":"AB25","span":{"begin":2081,"end":2100},"obj":"HP:0025343"},{"id":"AB26","span":{"begin":2136,"end":2145},"obj":"HP:0000618"},{"id":"AB27","span":{"begin":2170,"end":2179},"obj":"HP:0000618"},{"id":"AB28","span":{"begin":2185,"end":2193},"obj":"HP:0002076"},{"id":"AB29","span":{"begin":2194,"end":2202},"obj":"HP:0002315"},{"id":"AB30","span":{"begin":2243,"end":2251},"obj":"HP:0002315"},{"id":"AB31","span":{"begin":2335,"end":2343},"obj":"HP:0002076"},{"id":"AB32","span":{"begin":2388,"end":2397},"obj":"HP:0000618"},{"id":"AB33","span":{"begin":2484,"end":2492},"obj":"HP:0002076"},{"id":"AB34","span":{"begin":2582,"end":2590},"obj":"HP:0002076"},{"id":"AB35","span":{"begin":2606,"end":2615},"obj":"HP:0000618"},{"id":"AB36","span":{"begin":2742,"end":2752},"obj":"HP:0000716"}],"text":"Migraine with binocular blindness: a clinic-based study.\nOBJECTIVE: To describe the syndrome of migraine with binocular blindness.\nBACKGROUND: Rarely do migraine patients complain of losing vision in both eyes during an attack of headache. There are no large clinic-based studies looking at the prevalence of binocular blindness in migraine sufferers and no information about patient demographics, neuroimaging, and laboratory testing.\nMETHODS: Over a 14-month time period, 383 new patients with a diagnosis of migraine were seen at the Geisinger Headache Center. All patients were asked if they ever experienced an episode of complete bilateral blindness along with their headaches. Those with a positive history had coagulopathy testing as well as brain magnetic resonance imaging and magnetic resonance angiography of the intracranial circulation.\nRESULTS: A total of 6 patients or only 1.6% of the new migraine patients had episodes of binocular blindness with their headaches. All were female and each had a history of migraine for at least 3 years. Five patients had a diagnosis of migraine without aura, while one had a diagnosis of basilar-type migraine. In all patients the blindness episodes occurred in isolation during a migraine headache. In all but one patient the blindness was instantaneous and not a slow evolution. In 2 patients the blindness episode only occurred 1 time; in 3 patients episodes occurred more than once but were rare, while 1 patient had blindness with 50% of her headaches. In regard to duration, in 2 patients blindness lasted only several seconds, 2 patients between 2 and 10 minutes, 1 patient 30 minutes and 1 patient 60-120 minutes. Neuroimaging was normal in all. Three patients had a history of smoking and 3 never smoked. Coagulopathy testing was abnormal in all patients. Two patients were homozygous for methylenetetrahydrofolate reductase (MTHFR) 677TT polymorphism, but both had normal homocysteine levels; 3 patients were heterozygous for MTHFR 677CT polymorphism and 1 had elevated homocysteine levels and 1 patient had a positive lupus anticoagulant (had the most frequent episodes of blindness).\nCONCLUSION: Binocular blindness with migraine headache is a very rare occurrence at least in a headache specialty clinic population. It is a female-predominant event and occurs mostly in migraine patients who do not have a history of aura. Blindness episodes can be very brief or prolonged and many do not fit the typical duration of a migraine aura. They are typically infrequent events and may occur only 1 time without recurrence. Migraine with binocular blindness may reflect an underlying clotting disorder. A possible etiology outside of a coagulopathy-related event is retinal spreading depression."}