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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 478-483 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 500-511 Body_part denotes blood cells http://purl.obolibrary.org/obo/CL_0000081
T3 600-610 Body_part denotes blood cell http://purl.obolibrary.org/obo/CL_0000081
T4 1025-1030 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 51-194 DRI_Background denotes Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression.
T2 195-301 DRI_Background denotes However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear.
T3 302-398 DRI_Outcome denotes Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis.
T4 399-619 DRI_Background denotes Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers.
T5 620-706 DRI_Background denotes Furthermore, mll depletion prevented the differentiation of hematopoietic progenitors.
T6 707-863 DRI_Approach denotes In addition, we identified the N-terminal mini-peptide of Mll that acted as a dominant negative form to disrupt normal function of mll during embryogenesis.
T7 864-939 DRI_Approach denotes As expected, mll knockdown altered the expression of a subset of Hox genes.
T8 940-1117 DRI_Approach denotes However, overexpression of these down-regulated Hox genes only partially rescued the blood deficiency, suggesting that mll may target additional genes to regulate hematopoiesis.
T9 1207-1376 DRI_Outcome denotes Multiple assays indicate that mll inhibited gadd45αa expression and that overexpression of gadd45αa mRNA led to a phenotype similar to the one seen in the mll morphants.
T10 1377-1590 DRI_Approach denotes Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis.

sentences

Id Subject Object Predicate Lexical cue
T1 0-50 Sentence denotes Zebrafish mll gene is essential for hematopoiesis.
T2 51-194 Sentence denotes Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression.
T3 195-301 Sentence denotes However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear.
T4 302-398 Sentence denotes Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis.
T5 399-619 Sentence denotes Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers.
T6 620-706 Sentence denotes Furthermore, mll depletion prevented the differentiation of hematopoietic progenitors.
T7 707-863 Sentence denotes In addition, we identified the N-terminal mini-peptide of Mll that acted as a dominant negative form to disrupt normal function of mll during embryogenesis.
T8 864-939 Sentence denotes As expected, mll knockdown altered the expression of a subset of Hox genes.
T9 940-1117 Sentence denotes However, overexpression of these down-regulated Hox genes only partially rescued the blood deficiency, suggesting that mll may target additional genes to regulate hematopoiesis.
T10 1118-1206 Sentence denotes In the mll morphants, microarray analysis revealed a dramatic up-regulation of gadd45αa.
T11 1207-1376 Sentence denotes Multiple assays indicate that mll inhibited gadd45αa expression and that overexpression of gadd45αa mRNA led to a phenotype similar to the one seen in the mll morphants.
T12 1377-1590 Sentence denotes Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 478-483 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 478-483 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 500-511 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood cells
T4 500-505 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T5 600-605 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T6 600-605 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T7 1025-1030 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T8 1025-1030 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 506-511 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 606-610 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 109-117 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-9 OrganismTaxon denotes Zebrafish NCBItxid:7955
T2 346-355 OrganismTaxon denotes zebrafish NCBItxid:7955
T3 1425-1434 OrganismTaxon denotes zebrafish NCBItxid:7955

Allie

Id Subject Object Predicate Lexical cue
SS1_21784840_1_0 95-117 expanded denotes mixed lineage leukemia
SS2_21784840_1_0 119-122 abbr denotes Mll
AE1_21784840_1_0 SS1_21784840_1_0 SS2_21784840_1_0 abbreviatedTo mixed lineage leukemia,Mll

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 109-117 HP_0001909 denotes leukemia