PubMed:21784840
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 478-483 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T2 | 500-511 | Body_part | denotes | blood cells | http://purl.obolibrary.org/obo/CL_0000081 |
T3 | 600-610 | Body_part | denotes | blood cell | http://purl.obolibrary.org/obo/CL_0000081 |
T4 | 1025-1030 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 51-194 | DRI_Background | denotes | Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. |
T2 | 195-301 | DRI_Background | denotes | However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear. |
T3 | 302-398 | DRI_Outcome | denotes | Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis. |
T4 | 399-619 | DRI_Background | denotes | Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers. |
T5 | 620-706 | DRI_Background | denotes | Furthermore, mll depletion prevented the differentiation of hematopoietic progenitors. |
T6 | 707-863 | DRI_Approach | denotes | In addition, we identified the N-terminal mini-peptide of Mll that acted as a dominant negative form to disrupt normal function of mll during embryogenesis. |
T7 | 864-939 | DRI_Approach | denotes | As expected, mll knockdown altered the expression of a subset of Hox genes. |
T8 | 940-1117 | DRI_Approach | denotes | However, overexpression of these down-regulated Hox genes only partially rescued the blood deficiency, suggesting that mll may target additional genes to regulate hematopoiesis. |
T9 | 1207-1376 | DRI_Outcome | denotes | Multiple assays indicate that mll inhibited gadd45αa expression and that overexpression of gadd45αa mRNA led to a phenotype similar to the one seen in the mll morphants. |
T10 | 1377-1590 | DRI_Approach | denotes | Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis. |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-50 | Sentence | denotes | Zebrafish mll gene is essential for hematopoiesis. |
T2 | 51-194 | Sentence | denotes | Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. |
T3 | 195-301 | Sentence | denotes | However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear. |
T4 | 302-398 | Sentence | denotes | Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis. |
T5 | 399-619 | Sentence | denotes | Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers. |
T6 | 620-706 | Sentence | denotes | Furthermore, mll depletion prevented the differentiation of hematopoietic progenitors. |
T7 | 707-863 | Sentence | denotes | In addition, we identified the N-terminal mini-peptide of Mll that acted as a dominant negative form to disrupt normal function of mll during embryogenesis. |
T8 | 864-939 | Sentence | denotes | As expected, mll knockdown altered the expression of a subset of Hox genes. |
T9 | 940-1117 | Sentence | denotes | However, overexpression of these down-regulated Hox genes only partially rescued the blood deficiency, suggesting that mll may target additional genes to regulate hematopoiesis. |
T10 | 1118-1206 | Sentence | denotes | In the mll morphants, microarray analysis revealed a dramatic up-regulation of gadd45αa. |
T11 | 1207-1376 | Sentence | denotes | Multiple assays indicate that mll inhibited gadd45αa expression and that overexpression of gadd45αa mRNA led to a phenotype similar to the one seen in the mll morphants. |
T12 | 1377-1590 | Sentence | denotes | Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis. |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 478-483 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T2 | 478-483 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
T3 | 500-511 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood cells |
T4 | 500-505 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
T5 | 600-605 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T6 | 600-605 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
T7 | 1025-1030 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
T8 | 1025-1030 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 506-511 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2 | 606-610 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 109-117 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 0-9 | OrganismTaxon | denotes | Zebrafish | NCBItxid:7955 |
T2 | 346-355 | OrganismTaxon | denotes | zebrafish | NCBItxid:7955 |
T3 | 1425-1434 | OrganismTaxon | denotes | zebrafish | NCBItxid:7955 |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_21784840_1_0 | 95-117 | expanded | denotes | mixed lineage leukemia |
SS2_21784840_1_0 | 119-122 | abbr | denotes | Mll |
AE1_21784840_1_0 | SS1_21784840_1_0 | SS2_21784840_1_0 | abbreviatedTo | mixed lineage leukemia,Mll |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 109-117 | HP_0001909 | denotes | leukemia |