PubMed:21784840
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 51-194 | DRI_Background | denotes | Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. |
| T2 | 195-301 | DRI_Background | denotes | However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear. |
| T3 | 302-398 | DRI_Outcome | denotes | Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis. |
| T4 | 399-619 | DRI_Background | denotes | Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers. |
| T5 | 620-706 | DRI_Background | denotes | Furthermore, mll depletion prevented the differentiation of hematopoietic progenitors. |
| T6 | 707-863 | DRI_Approach | denotes | In addition, we identified the N-terminal mini-peptide of Mll that acted as a dominant negative form to disrupt normal function of mll during embryogenesis. |
| T7 | 864-939 | DRI_Approach | denotes | As expected, mll knockdown altered the expression of a subset of Hox genes. |
| T8 | 940-1117 | DRI_Approach | denotes | However, overexpression of these down-regulated Hox genes only partially rescued the blood deficiency, suggesting that mll may target additional genes to regulate hematopoiesis. |
| T9 | 1207-1376 | DRI_Outcome | denotes | Multiple assays indicate that mll inhibited gadd45αa expression and that overexpression of gadd45αa mRNA led to a phenotype similar to the one seen in the mll morphants. |
| T10 | 1377-1590 | DRI_Approach | denotes | Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis. |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-50 | Sentence | denotes | Zebrafish mll gene is essential for hematopoiesis. |
| T2 | 51-194 | Sentence | denotes | Studies implicate an important role for the mixed lineage leukemia (Mll) gene in hematopoiesis, mainly through maintaining Hox gene expression. |
| T3 | 195-301 | Sentence | denotes | However, the mechanisms underlying Mll-mediated hematopoiesis during embryogenesis remain largely unclear. |
| T4 | 302-398 | Sentence | denotes | Here, we investigate the role of mll during zebrafish embryogenesis, particularly hematopoiesis. |
| T5 | 399-619 | Sentence | denotes | Mll depletion caused severe defects in hematopoiesis as indicated by a lack of blood flow and mature blood cells as well as a significant reduction in expression of hematopoietic progenitor and mature blood cell markers. |
| T6 | 620-706 | Sentence | denotes | Furthermore, mll depletion prevented the differentiation of hematopoietic progenitors. |
| T7 | 707-863 | Sentence | denotes | In addition, we identified the N-terminal mini-peptide of Mll that acted as a dominant negative form to disrupt normal function of mll during embryogenesis. |
| T8 | 864-939 | Sentence | denotes | As expected, mll knockdown altered the expression of a subset of Hox genes. |
| T9 | 940-1117 | Sentence | denotes | However, overexpression of these down-regulated Hox genes only partially rescued the blood deficiency, suggesting that mll may target additional genes to regulate hematopoiesis. |
| T10 | 1118-1206 | Sentence | denotes | In the mll morphants, microarray analysis revealed a dramatic up-regulation of gadd45αa. |
| T11 | 1207-1376 | Sentence | denotes | Multiple assays indicate that mll inhibited gadd45αa expression and that overexpression of gadd45αa mRNA led to a phenotype similar to the one seen in the mll morphants. |
| T12 | 1377-1590 | Sentence | denotes | Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 478-483 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T2 | 478-483 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T3 | 500-511 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood cells |
| T4 | 500-505 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T5 | 600-605 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T6 | 600-605 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T7 | 1025-1030 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T8 | 1025-1030 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_21784840_1_0 | 95-117 | expanded | denotes | mixed lineage leukemia |
| SS2_21784840_1_0 | 119-122 | abbr | denotes | Mll |
| AE1_21784840_1_0 | SS1_21784840_1_0 | SS2_21784840_1_0 | abbreviatedTo | mixed lineage leukemia,Mll |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 109-117 | HP_0001909 | denotes | leukemia |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 109-117 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 478-483 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 500-511 | Body_part | denotes | blood cells | http://purl.obolibrary.org/obo/MAT_0000083 |
| T4 | 600-605 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T6 | 1025-1030 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 109-117 | Phenotype | denotes | leukemia | HP:0001909 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 0-9 | OrganismTaxon | denotes | Zebrafish | 7955 |
| T2 | 346-355 | OrganismTaxon | denotes | zebrafish | 7955 |
| T3 | 1425-1434 | OrganismTaxon | denotes | zebrafish | 7955 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 478-483 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T2 | 500-511 | Body_part | denotes | blood cells | http://purl.obolibrary.org/obo/CL_0000081 |
| T3 | 600-610 | Body_part | denotes | blood cell | http://purl.obolibrary.org/obo/CL_0000081 |
| T4 | 1025-1030 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 500-511 | Cell | denotes | blood cells | http://purl.obolibrary.org/obo/CL:0000081 |
| T2 | 600-610 | Cell | denotes | blood cell | http://purl.obolibrary.org/obo/CL:0000081 |