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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 102-227 DRI_Outcome denotes Activation of the atrial renin-angiotensin system plays an important role in the pathophysiology of atrial fibrillation (AF).
T2 228-331 DRI_Background denotes The pulmonary vein (PV) and left atrium (LA) are important trigger and substrate for the genesis of AF.
T3 332-488 DRI_Challenge denotes We investigate the effects of a direct renin inhibitor, aliskiren, on the PV and LA arrhythmogenic activity and the underlying electromechanical mechanisms.
T4 489-683 DRI_Background denotes Conventional microelectrodes were used to record action potentials and contractility in isolated rabbit PVs and LA tissues before and after the administration of aliskiren (0.1, 1, 3 and 10 μM).
T5 684-717 DRI_Background denotes By the whole-cell patch clamp and
T6 738-919 DRI_Background denotes ratio techniques, ionic currents and intracellular calcium transient were studied in isolated single PV and LA cardiomyocyte before and after the administration of aliskiren (3 μM).
T7 920-1162 DRI_Outcome denotes Aliskiren (0.1, 1, 3 and 10 μM) reduced PV firing rate in a concentration-dependent manner (6, 10, 14 and 17%) and decreased PV diastolic tension, which could be attenuated in the presence of 100 μM L-N(G)-Nitroarginine Methyl Ester (L-NAME).
T8 1163-1272 DRI_Approach denotes Aliskiren induced PV automatic rhythm exit block causing slow and irregular PV activity with variable pauses.
T9 1273-1381 DRI_Background denotes Aliskiren increased PV and LA contractility, which could be abolished by pre-treating with 0.1 μM ryanodine.
T10 1382-1605 DRI_Background denotes Aliskiren (3 μM) decreased L-type calcium currents, but increased reverse-mode of Na( + )/Ca(2+ ) exchanger currents, intracellular calcium transients, and sarcoplasmic reticulum calcium content in PV and LA cardiomyocytes.
T11 1606-1724 DRI_Background denotes Pretreatment with renin, losartan or angiotensin II did not alter the effect of aliskiren on sarcolemmal calcium flux.
T12 1725-1875 DRI_Outcome denotes In conclusion, aliskiren reduces PV arrhythmogenic activity with a direct vasodilatory property and has a positive inotropic effect on cardiomyocytes.
T13 1876-1969 DRI_Background denotes These findings may reveal the anti-arrhythmic and anti-heart failure potentials of aliskiren.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 102-112 CVCL_C410|Hybridoma|Mus musculus denotes Activation
T2 158-160 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T3 158-160 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T4 332-334 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T5 362-363 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 431-439 CVCL_C410|Hybridoma|Mus musculus denotes activity
T7 702-707 CVCL_E012|Induced_pluripotent_stem_cell|Homo sapiens denotes patch
T8 978-979 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 1012-1017 CVCL_UM80|Cancer_cell_line|Homo sapiens denotes 6, 10
T10 1019-1021 CVCL_ZS48|Finite_cell_line|Homo sapiens denotes 14
T11 1117-1120 CVCL_F566|Transformed_cell_line|Homo sapiens denotes M L
T12 1117-1120 CVCL_W799|Cancer_cell_line|Homo sapiens denotes M L
T13 1121-1125 CVCL_6D57|Cancer_cell_line|Rattus norvegicus denotes N(G)
T14 1242-1250 CVCL_C410|Hybridoma|Mus musculus denotes activity
T15 1464-1466 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T16 1472-1474 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T17 1776-1784 CVCL_C410|Hybridoma|Mus musculus denotes activity
T18 1790-1791 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T19 1825-1828 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T20 1825-1828 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T21 1829-1830 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T22 1891-1894 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T1 40-45 P08424 denotes renin
T2 40-45 PR:000013883 denotes renin
T3 40-45 P00797 denotes renin
T4 40-45 Q6DLS0 denotes renin
T5 40-45 Q6DLW5 denotes renin
T6 40-45 Q9TSZ1 denotes renin
T7 40-45 P60016 denotes renin
T8 40-45 Q6DYE7 denotes renin
T9 40-45 P52115 denotes renin
T10 40-45 D012083 denotes renin
T11 46-55 CHEBI:35222 denotes inhibitor
T14 57-66 325646 denotes aliskiren
T12 57-66 C446481 denotes aliskiren
T13 57-66 C446481 denotes aliskiren
T15 57-66 CHEBI:601027 denotes aliskiren
T16 75-89 UBERON:0002016 denotes pulmonary vein
T18 94-100 UBERON:0003165 denotes atrium
T19 94-100 UBERON:0002081 denotes atrium
T20 127-132 P08424 denotes renin
T21 127-132 PR:000013883 denotes renin
T22 127-132 P00797 denotes renin
T23 127-132 Q6DLS0 denotes renin
T24 127-132 Q6DLW5 denotes renin
T25 127-132 Q9TSZ1 denotes renin
T26 127-132 P60016 denotes renin
T27 127-132 Q6DYE7 denotes renin
T28 127-132 P52115 denotes renin
T29 127-132 D012083 denotes renin
T30 127-151 UBERON:0018229 denotes renin-angiotensin system
T35 133-144 Q10757 denotes angiotensin
T31 133-144 CHEBI:48433 denotes angiotensin
T32 133-144 CHEBI:2719 denotes angiotensin
T33 133-144 D000809 denotes angiotensin
T34 133-144 D000809 denotes angiotensin
T36 202-221 D001281 denotes atrial fibrillation
T37 202-221 D001281 denotes atrial fibrillation
T38 232-246 UBERON:0002016 denotes pulmonary vein
T40 256-267 UBERON:0002079 denotes left atrium
T43 371-376 P08424 denotes renin
T44 371-376 PR:000013883 denotes renin
T45 371-376 P00797 denotes renin
T46 371-376 Q6DLS0 denotes renin
T47 371-376 Q6DLW5 denotes renin
T48 371-376 Q9TSZ1 denotes renin
T49 371-376 P60016 denotes renin
T50 371-376 Q6DYE7 denotes renin
T51 371-376 P52115 denotes renin
T52 371-376 D012083 denotes renin
T53 377-386 CHEBI:35222 denotes inhibitor
T56 388-397 325646 denotes aliskiren
T54 388-397 C446481 denotes aliskiren
T55 388-397 C446481 denotes aliskiren
T57 388-397 CHEBI:601027 denotes aliskiren
T59 586-592 813859 denotes rabbit
T58 586-592 D011817 denotes rabbit
T60 586-592 9986 denotes rabbit
T61 593-596 PR:000002067 denotes PVs
T62 593-596 PR:P15151 denotes PVs
T63 593-596 PR:P32507 denotes PVs
T64 593-596 PR:000002069 denotes PVs
T67 651-660 325646 denotes aliskiren
T65 651-660 C446481 denotes aliskiren
T66 651-660 C446481 denotes aliskiren
T68 651-660 CHEBI:601027 denotes aliskiren
T73 708-713 PR:Q99JL1 denotes clamp
T74 708-713 PR:Q9JJ40 denotes clamp
T75 718-722 PR:Q9ERD9 denotes indo
T76 718-722 PR:000009030 denotes indo
T77 718-722 PR:P28776 denotes indo
T78 718-722 PR:P14902 denotes indo
T79 718-724 CHEBI:52084 denotes indo-1
T80 718-724 C048960 denotes indo-1
T81 718-724 C048960 denotes indo-1
T82 775-788 GO:0005622 denotes intracellular
T83 789-796 1895 denotes calcium
T84 789-796 CHEBI:29320 denotes calcium
T85 789-796 CHEBI:22984 denotes calcium
T86 849-862 CL:0000746 denotes cardiomyocyte
T89 902-911 325646 denotes aliskiren
T87 902-911 C446481 denotes aliskiren
T88 902-911 C446481 denotes aliskiren
T90 902-911 CHEBI:601027 denotes aliskiren
T97 920-929 325646 denotes Aliskiren
T95 920-929 C446481 denotes Aliskiren
T96 920-929 C446481 denotes Aliskiren
T98 920-929 CHEBI:601027 denotes Aliskiren
T109 1121-1152 D019331 denotes N(G)-Nitroarginine Methyl Ester
T110 1121-1152 D019331 denotes N(G)-Nitroarginine Methyl Ester
T111 1121-1152 CHEBI:7549 denotes N(G)-Nitroarginine Methyl Ester
T118 1154-1160 D019331 denotes L-NAME
T119 1154-1160 D019331 denotes L-NAME
T120 1154-1160 CHEBI:7549 denotes L-NAME
T123 1163-1172 325646 denotes Aliskiren
T121 1163-1172 C446481 denotes Aliskiren
T122 1163-1172 C446481 denotes Aliskiren
T124 1163-1172 CHEBI:601027 denotes Aliskiren
T125 1194-1200 GO:0048511 denotes rhythm
T128 1273-1282 325646 denotes Aliskiren
T126 1273-1282 C446481 denotes Aliskiren
T127 1273-1282 C446481 denotes Aliskiren
T129 1273-1282 CHEBI:601027 denotes Aliskiren
T132 1346-1349 SO:0002045 denotes pre
T131 1346-1349 PR:Q8LLD0 denotes pre
T133 1346-1349 UBERON:0001782 denotes pre
T130 1346-1349 GO:0003904 denotes pre
T138 1371-1380 D012433 denotes ryanodine
T139 1371-1380 CHEBI:8925 denotes ryanodine
T140 1371-1380 D012433 denotes ryanodine
T143 1382-1391 325646 denotes Aliskiren
T141 1382-1391 C446481 denotes Aliskiren
T142 1382-1391 C446481 denotes Aliskiren
T144 1382-1391 CHEBI:601027 denotes Aliskiren
T149 1416-1423 1895 denotes calcium
T150 1416-1423 CHEBI:29320 denotes calcium
T151 1416-1423 CHEBI:22984 denotes calcium
T152 1448-1455 SO:0001031 denotes reverse
T153 1464-1489 D019831 denotes Na( + )/Ca(2+ ) exchanger
T159 1472-1476 1316581 denotes Ca(2
T154 1472-1476 P24258 denotes Ca(2
T155 1472-1476 PR:P42737 denotes Ca(2
T156 1472-1476 PR:P27139 denotes Ca(2
T157 1472-1476 PR:000004918 denotes Ca(2
T158 1472-1476 PR:P00918 denotes Ca(2
T160 1472-1476 PR:P07630 denotes Ca(2
T162 1472-1476 PR:P00920 denotes Ca(2
T164 1472-1476 PR:P00921 denotes Ca(2
T161 1472-1476 CVCL_B845 denotes Ca(2
T165 1472-1476 UBERON:0003882 denotes Ca(2
T166 1480-1489 GO:0015297 denotes exchanger
T167 1500-1513 GO:0005622 denotes intracellular
T168 1514-1521 1895 denotes calcium
T169 1514-1521 CHEBI:29320 denotes calcium
T170 1514-1521 CHEBI:22984 denotes calcium
T171 1538-1560 GO:0016529 denotes sarcoplasmic reticulum
T172 1551-1560 UBERON:0007361 denotes reticulum
T173 1561-1568 1895 denotes calcium
T174 1561-1568 CHEBI:29320 denotes calcium
T175 1561-1568 CHEBI:22984 denotes calcium
T176 1624-1629 P08424 denotes renin
T177 1624-1629 PR:000013883 denotes renin
T178 1624-1629 P00797 denotes renin
T179 1624-1629 Q6DLS0 denotes renin
T180 1624-1629 Q6DLW5 denotes renin
T181 1624-1629 Q9TSZ1 denotes renin
T182 1624-1629 P60016 denotes renin
T183 1624-1629 Q6DYE7 denotes renin
T184 1624-1629 P52115 denotes renin
T185 1624-1629 D012083 denotes renin
T187 1631-1639 52175 denotes losartan
T186 1631-1639 D019808 denotes losartan
T188 1631-1639 CHEBI:6541 denotes losartan
T189 1631-1639 D019808 denotes losartan
T199 1643-1657 PR:000036009 denotes angiotensin II
T201 1643-1657 1999003 denotes angiotensin II
T195 1643-1657 D000804 denotes angiotensin II
T196 1643-1657 CHEBI:2719 denotes angiotensin II
T197 1643-1657 D000804 denotes angiotensin II
T198 1643-1657 CHEBI:58506 denotes angiotensin II
T200 1643-1657 CHEBI:48432 denotes angiotensin II
T204 1686-1695 325646 denotes aliskiren
T202 1686-1695 C446481 denotes aliskiren
T203 1686-1695 C446481 denotes aliskiren
T205 1686-1695 CHEBI:601027 denotes aliskiren
T206 1711-1718 1895 denotes calcium
T207 1711-1718 CHEBI:29320 denotes calcium
T208 1711-1718 CHEBI:22984 denotes calcium
T211 1740-1749 325646 denotes aliskiren
T209 1740-1749 C446481 denotes aliskiren
T210 1740-1749 C446481 denotes aliskiren
T212 1740-1749 CHEBI:601027 denotes aliskiren
T213 1931-1944 D006333 denotes heart failure
T214 1931-1944 D006333 denotes heart failure
T217 1959-1968 325646 denotes aliskiren
T215 1959-1968 C446481 denotes aliskiren
T216 1959-1968 C446481 denotes aliskiren
T218 1959-1968 CHEBI:601027 denotes aliskiren

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 202-221 HP_0005110 denotes atrial fibrillation
T2 560-573 HP_0001371 denotes contractility
T3 1303-1316 HP_0001371 denotes contractility
T4 1931-1944 HP_0001635 denotes heart failure

Allie

Id Subject Object Predicate Lexical cue
SS1_21779913_1_0 202-221 expanded denotes atrial fibrillation
SS2_21779913_1_0 223-225 abbr denotes AF
SS1_21779913_2_0 232-246 expanded denotes pulmonary vein
SS2_21779913_2_0 248-250 abbr denotes PV
SS1_21779913_2_1 256-267 expanded denotes left atrium
SS2_21779913_2_1 269-271 abbr denotes LA
SS1_21779913_6_0 1119-1152 expanded denotes L-N(G)-Nitroarginine Methyl Ester
SS2_21779913_6_0 1154-1160 abbr denotes L-NAME
AE1_21779913_1_0 SS1_21779913_1_0 SS2_21779913_1_0 abbreviatedTo atrial fibrillation,AF
AE1_21779913_2_0 SS1_21779913_2_0 SS2_21779913_2_0 abbreviatedTo pulmonary vein,PV
AE1_21779913_2_1 SS1_21779913_2_1 SS2_21779913_2_1 abbreviatedTo left atrium,LA
AE1_21779913_6_0 SS1_21779913_6_0 SS2_21779913_6_0 abbreviatedTo L-N(G)-Nitroarginine Methyl Ester,L-NAME