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PubMed:21706048 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-82 Sentence denotes MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.
TextSentencer_T2 83-260 Sentence denotes As invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen.
TextSentencer_T3 261-385 Sentence denotes To develop metastatic capabilities, invading tumor cells must acquire the capacity to negotiate this novel microenvironment.
TextSentencer_T4 386-457 Sentence denotes Collagen influences the fate of epithelial cells by inducing apoptosis.
TextSentencer_T5 458-568 Sentence denotes However, the mechanisms used by invading tumor cells to evade collagen-induced apoptosis remain to be defined.
TextSentencer_T6 569-786 Sentence denotes We demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14) confers breast cancer cells with the ability to escape apoptosis when embedded in a collagen gel and after orthotopic implantation in vivo.
TextSentencer_T7 787-979 Sentence denotes In the absence of MMP-14-dependent proteolysis, type I collagen triggers apoptosis by inducing the expression of the pro-apoptotic Bcl-2-interacting killer in luminal-like breast cancer cells.
TextSentencer_T8 980-1096 Sentence denotes These findings reveal a new mechanism whereby MMP-14 activity promotes tumor progression by circumventing apoptosis.
T1 0-82 Sentence denotes MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.
T2 83-260 Sentence denotes As invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen.
T3 261-385 Sentence denotes To develop metastatic capabilities, invading tumor cells must acquire the capacity to negotiate this novel microenvironment.
T4 386-457 Sentence denotes Collagen influences the fate of epithelial cells by inducing apoptosis.
T5 458-568 Sentence denotes However, the mechanisms used by invading tumor cells to evade collagen-induced apoptosis remain to be defined.
T6 569-786 Sentence denotes We demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14) confers breast cancer cells with the ability to escape apoptosis when embedded in a collagen gel and after orthotopic implantation in vivo.
T7 787-979 Sentence denotes In the absence of MMP-14-dependent proteolysis, type I collagen triggers apoptosis by inducing the expression of the pro-apoptotic Bcl-2-interacting killer in luminal-like breast cancer cells.
T8 980-1096 Sentence denotes These findings reveal a new mechanism whereby MMP-14 activity promotes tumor progression by circumventing apoptosis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-7 gene:4323 denotes MT1-MMP
T1 17-33 disease:C0678222 denotes breast carcinoma
T2 0-7 gene:4323 denotes MT1-MMP
T3 17-33 disease:C0006142 denotes breast carcinoma
T4 639-645 gene:4323 denotes MMP-14
T5 655-668 disease:C0678222 denotes breast cancer
T6 639-645 gene:4323 denotes MMP-14
T7 655-668 disease:C0006142 denotes breast cancer
T8 1026-1032 gene:4323 denotes MMP-14
T9 1051-1068 disease:C0178874 denotes tumor progression
R1 T0 T1 associated_with MT1-MMP,breast carcinoma
R2 T2 T3 associated_with MT1-MMP,breast carcinoma
R3 T4 T5 associated_with MMP-14,breast cancer
R4 T6 T7 associated_with MMP-14,breast cancer
R5 T8 T9 associated_with MMP-14,tumor progression

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 95-111 HP_0003002 denotes breast carcinoma
T2 191-196 HP_0011088 denotes dense
T3 306-311 HP_0002664 denotes tumor
T4 499-504 HP_0002664 denotes tumor
T5 655-668 HP_0003002 denotes breast cancer
T6 655-668 HP_0100013 denotes breast cancer
T7 662-668 HP_0002664 denotes cancer
T8 959-972 HP_0003002 denotes breast cancer
T9 959-972 HP_0100013 denotes breast cancer
T10 966-972 HP_0002664 denotes cancer
T11 1051-1056 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21706048-0#0#7#gene4323 0-7 gene4323 denotes MT1-MMP
21706048-0#17#33#diseaseC0678222 17-33 diseaseC0678222 denotes breast carcinoma
21706048-5#70#76#gene4323 639-645 gene4323 denotes MMP-14
21706048-5#86#99#diseaseC0006142 655-668 diseaseC0006142 denotes breast cancer
21706048-6#131#155#gene638 918-942 gene638 denotes Bcl-2-interacting killer
21706048-6#172#185#diseaseC0006142 959-972 diseaseC0006142 denotes breast cancer
21706048-6#172#185#diseaseC0678222 959-972 diseaseC0678222 denotes breast cancer
21706048-7#46#52#gene4323 1026-1032 gene4323 denotes MMP-14
21706048-7#71#88#diseaseC0178874 1051-1068 diseaseC0178874 denotes tumor progression
0#7#gene432317#33#diseaseC0678222 21706048-0#0#7#gene4323 21706048-0#17#33#diseaseC0678222 associated_with MT1-MMP,breast carcinoma
70#76#gene432386#99#diseaseC0006142 21706048-5#70#76#gene4323 21706048-5#86#99#diseaseC0006142 associated_with MMP-14,breast cancer
131#155#gene638172#185#diseaseC0006142 21706048-6#131#155#gene638 21706048-6#172#185#diseaseC0006142 associated_with Bcl-2-interacting killer,breast cancer
131#155#gene638172#185#diseaseC0678222 21706048-6#131#155#gene638 21706048-6#172#185#diseaseC0678222 associated_with Bcl-2-interacting killer,breast cancer
46#52#gene432371#88#diseaseC0178874 21706048-7#46#52#gene4323 21706048-7#71#88#diseaseC0178874 associated_with MMP-14,tumor progression

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T7 639-645 gene:4323 denotes MMP-14
T8 655-668 disease:C0006142 denotes breast cancer
T9 918-942 gene:638 denotes Bcl-2-interacting killer
T10 959-972 disease:C0006142 denotes breast cancer
R1 T7 T8 associated_with MMP-14,breast cancer
R2 T9 T10 associated_with Bcl-2-interacting killer,breast cancer
R3 T9 T10 associated_with Bcl-2-interacting killer,breast cancer

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 224-230 http://purl.obolibrary.org/obo/UBERON_0003891 denotes stroma
PD-UBERON-AE-B_T2 17-23 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 95-101 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 655-661 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 959-965 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 17-23 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 95-101 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 655-661 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 959-965 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 224-230 http://purl.obolibrary.org/obo/UBERON_0003891 denotes stroma