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PubMed:2163347 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 37-54 protein denotes proto-oncoprotein
T2 55-60 protein denotes ets-1
T3 71-105 DNA denotes transcriptional activator sequence
T4 117-137 DNA denotes long terminal repeat
T5 179-204 DNA denotes ets proto-oncogene family
T6 219-241 DNA denotes sequence-related genes
T7 299-316 protein denotes cellular proteins
T8 386-399 cell_type denotes T lymphocytes
T9 441-456 DNA denotes ets gene family
T10 467-504 protein denotes sequence-specific DNA-binding protein
T11 508-530 DNA denotes mouse ets-1 cDNA clone
T12 603-640 DNA denotes double-stranded oligonucleotide probe
T13 702-722 DNA denotes long terminal repeat
T14 724-727 DNA denotes LTR
T15 734-747 DNA denotes cDNA sequence
T16 755-780 DNA denotes 813-bp open reading frame
T17 782-785 DNA denotes ORF
T18 849-881 protein denotes 272 carboxy-terminal amino acids
T19 889-908 protein denotes human ets-1 protein
T20 914-917 DNA denotes ORF
T21 953-974 protein denotes 30-kD protein product
T22 1113-1123 DNA denotes mutant LTR
T23 1171-1189 DNA denotes ets-1 binding site
T24 1288-1304 DNA denotes MSV LTR promoter
T25 1331-1349 DNA denotes ets-1 binding site
T26 1384-1402 DNA denotes wild-type promoter
T27 1406-1425 cell_type denotes mouse T lymphocytes
T28 1486-1499 DNA denotes reporter gene
T29 1530-1535 protein denotes ets-1
T30 1629-1646 DNA denotes ets-related genes
T31 1673-1704 protein denotes eukaryotic DNA-binding proteins

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 682-689 HP_0100242 denotes sarcoma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-174 Sentence denotes Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.
S2 175-284 Sentence denotes The ets proto-oncogene family is a group of sequence-related genes whose normal cellular function is unknown.
S3 285-505 Sentence denotes In a study of cellular proteins involved in the transcriptional regulation of murine retroviruses in T lymphocytes, we have discovered that a member of the ets gene family encodes a sequence-specific DNA-binding protein.
S4 506-729 Sentence denotes A mouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus (MSV) long terminal repeat (LTR).
S5 730-909 Sentence denotes The cDNA sequence has an 813-bp open reading frame (ORF) whose predicted amino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein.
S6 910-1110 Sentence denotes The ORF was expressed in bacteria, and the 30-kD protein product was shown to bind DNA in a sequence-specific manner by mobility-shift assays, Southwestern blot analysis, and methylation interference.
S7 1111-1253 Sentence denotes A mutant LTR containing four base pair substitutions in the ets-1 binding site was constructed and was shown to have reduced binding in vitro.
S8 1254-1513 Sentence denotes Transcriptional efficiency of the MSV LTR promoter containing this disrupted ets-1 binding site was compared to the activity of a wild-type promoter in mouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed.
S9 1514-1705 Sentence denotes We propose that ets-1 functions as a transcriptional activator of mammalian type-C retroviruses and speculate that ets-related genes constitute a new group of eukaryotic DNA-binding proteins.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 113-173 NP denotes the long terminal repeat of the Moloney murine sarcoma virus
C2 208-241 NP denotes a group of sequence-related genes
C3 242-247 NP denotes whose
C4 663-728 NP denotes the Moloney murine sarcoma virus (MSV) long terminal repeat (LTR)
C5 752-786 NP denotes an 813-bp open reading frame (ORF)
C6 787-792 NP denotes whose
C7 910-917 NP denotes The ORF
R1 C3 C2 coref-relat whose,a group of sequence-related genes
R2 C4 C1 coref-ident the Moloney murine sarcoma virus (MSV) long terminal repeat (LTR),the long terminal repeat of the Moloney murine sarcoma virus
R3 C6 C5 coref-relat whose,an 813-bp open reading frame (ORF)
R4 C7 C5 coref-ident The ORF,an 813-bp open reading frame (ORF)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T42 1331-1336 protein_molecule denotes ets-1
T43 1384-1402 DNA_domain_or_region denotes wild-type promoter
T1 0-29 other_name denotes Sequence-specific DNA binding
T2 37-54 protein_family_or_group denotes proto-oncoprotein
T3 55-60 protein_molecule denotes ets-1
T4 71-105 DNA_domain_or_region denotes transcriptional activator sequence
T5 117-137 DNA_domain_or_region denotes long terminal repeat
T6 145-173 virus denotes Moloney murine sarcoma virus
T7 179-204 DNA_family_or_group denotes ets proto-oncogene family
T8 219-241 DNA_family_or_group denotes sequence-related genes
T9 255-272 other_name denotes cellular function
T10 299-316 protein_family_or_group denotes cellular proteins
T11 333-359 other_name denotes transcriptional regulation
T12 363-382 virus denotes murine retroviruses
T13 386-399 cell_type denotes T lymphocytes
T14 441-456 DNA_family_or_group denotes ets gene family
T15 467-504 protein_family_or_group denotes sequence-specific DNA-binding protein
T16 508-513 DNA_molecule denotes mouse
T17 514-519 protein_molecule denotes ets-1
T18 603-640 DNA_molecule denotes double-stranded oligonucleotide probe
T19 667-695 virus denotes Moloney murine sarcoma virus
T20 697-700 virus denotes MSV
T21 702-722 DNA_domain_or_region denotes long terminal repeat
T22 724-727 DNA_domain_or_region denotes LTR
T23 734-747 DNA_molecule denotes cDNA sequence
T24 755-780 DNA_domain_or_region denotes 813-bp open reading frame
T25 782-785 DNA_domain_or_region denotes ORF
T26 849-881 protein_domain_or_region denotes 272 carboxy-terminal amino acids
T27 889-894 protein_molecule denotes human
T28 895-900 protein_molecule denotes ets-1
T29 914-917 DNA_domain_or_region denotes ORF
T30 935-943 mono_cell denotes bacteria
T31 953-974 protein_molecule denotes 30-kD protein product
T32 1002-1026 other_name denotes sequence-specific manner
T33 1030-1051 other_name denotes mobility-shift assays
T34 1053-1079 other_name denotes Southwestern blot analysis
T35 1085-1109 other_name denotes methylation interference
T36 1113-1123 DNA_domain_or_region denotes mutant LTR
T37 1140-1163 other_name denotes base pair substitutions
T38 1171-1176 protein_molecule denotes ets-1
T39 1228-1243 other_name denotes reduced binding
T40 1254-1280 other_name denotes Transcriptional efficiency
T41 1288-1304 DNA_domain_or_region denotes MSV LTR promoter
T44 1406-1411 cell_type denotes mouse
T45 1412-1425 cell_type denotes T lymphocytes
T46 1486-1499 DNA_domain_or_region denotes reporter gene
T47 1530-1535 protein_molecule denotes ets-1
T48 1551-1576 other_name denotes transcriptional activator
T49 1580-1609 virus denotes mammalian type-C retroviruses
T50 1629-1646 DNA_family_or_group denotes ets-related genes
T51 1673-1704 protein_family_or_group denotes eukaryotic DNA-binding proteins