PubMed:21615796 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"21615796_0","span":{"begin":338,"end":379},"obj":"ProteinMutation"}],"attributes":[{"id":"21615796_0_ProteinMutation","pred":"proteinmutation","subj":"21615796_0","obj":"rs763780"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T2","span":{"begin":84,"end":194},"obj":"Sentence"},{"id":"T3","span":{"begin":195,"end":380},"obj":"Sentence"},{"id":"T4","span":{"begin":381,"end":402},"obj":"Sentence"},{"id":"T5","span":{"begin":403,"end":551},"obj":"Sentence"},{"id":"T6","span":{"begin":552,"end":673},"obj":"Sentence"},{"id":"T7","span":{"begin":674,"end":682},"obj":"Sentence"},{"id":"T8","span":{"begin":683,"end":830},"obj":"Sentence"},{"id":"T9","span":{"begin":831,"end":1008},"obj":"Sentence"},{"id":"T10","span":{"begin":1009,"end":1210},"obj":"Sentence"},{"id":"T11","span":{"begin":1211,"end":1222},"obj":"Sentence"},{"id":"T12","span":{"begin":1223,"end":1405},"obj":"Sentence"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-entities","denotations":[{"id":"8597","span":{"begin":0,"end":15},"obj":"GeneOrGeneProduct"},{"id":"8598","span":{"begin":37,"end":45},"obj":"OrganismTaxon"},{"id":"8599","span":{"begin":51,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8600","span":{"begin":98,"end":104},"obj":"GeneOrGeneProduct"},{"id":"8601","span":{"begin":116,"end":137},"obj":"GeneOrGeneProduct"},{"id":"8602","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8603","span":{"begin":235,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8604","span":{"begin":303,"end":311},"obj":"SequenceVariant"},{"id":"8605","span":{"begin":313,"end":320},"obj":"SequenceVariant"},{"id":"8606","span":{"begin":338,"end":379},"obj":"SequenceVariant"},{"id":"8607","span":{"begin":381,"end":389},"obj":"OrganismTaxon"},{"id":"8608","span":{"begin":419,"end":427},"obj":"OrganismTaxon"},{"id":"8609","span":{"begin":429,"end":432},"obj":"OrganismTaxon"},{"id":"8610","span":{"begin":433,"end":438},"obj":"OrganismTaxon"},{"id":"8611","span":{"begin":478,"end":489},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8612","span":{"begin":516,"end":519},"obj":"OrganismTaxon"},{"id":"8613","span":{"begin":520,"end":525},"obj":"OrganismTaxon"},{"id":"8614","span":{"begin":716,"end":724},"obj":"OrganismTaxon"},{"id":"8615","span":{"begin":730,"end":741},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8616","span":{"begin":785,"end":791},"obj":"GeneOrGeneProduct"},{"id":"8617","span":{"begin":792,"end":798},"obj":"SequenceVariant"},{"id":"8618","span":{"begin":845,"end":851},"obj":"GeneOrGeneProduct"},{"id":"8619","span":{"begin":852,"end":857},"obj":"SequenceVariant"},{"id":"8620","span":{"begin":876,"end":884},"obj":"OrganismTaxon"},{"id":"8621","span":{"begin":890,"end":901},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8622","span":{"begin":1022,"end":1030},"obj":"OrganismTaxon"},{"id":"8623","span":{"begin":1040,"end":1046},"obj":"GeneOrGeneProduct"},{"id":"8624","span":{"begin":1047,"end":1053},"obj":"SequenceVariant"},{"id":"8625","span":{"begin":1079,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8626","span":{"begin":1164,"end":1170},"obj":"GeneOrGeneProduct"},{"id":"8627","span":{"begin":1171,"end":1177},"obj":"SequenceVariant"},{"id":"8628","span":{"begin":1255,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"8629","span":{"begin":1262,"end":1268},"obj":"SequenceVariant"},{"id":"8630","span":{"begin":1328,"end":1339},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8631","span":{"begin":1363,"end":1369},"obj":"GeneOrGeneProduct"},{"id":"8632","span":{"begin":1393,"end":1404},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A28","pred":"db_id","subj":"8624","obj":"DBSNP:rs763780"},{"id":"A16","pred":"db_id","subj":"8612","obj":"NCBITaxon:9606"},{"id":"A21","pred":"db_id","subj":"8617","obj":"DBSNP:rs763780"},{"id":"A25","pred":"db_id","subj":"8621","obj":"MESH:D016553"},{"id":"A14","pred":"db_id","subj":"8610","obj":"NCBITaxon:9606"},{"id":"A10","pred":"db_id","subj":"8606","obj":"DBSNP:rs763780"},{"id":"A36","pred":"db_id","subj":"8632","obj":"MESH:D016553"},{"id":"A13","pred":"db_id","subj":"8609","obj":"NCBITaxon:9606"},{"id":"A11","pred":"db_id","subj":"8607","obj":"NCBITaxon:9606"},{"id":"A20","pred":"db_id","subj":"8616","obj":"NCBIGene:112744"},{"id":"A5","pred":"db_id","subj":"8601","obj":"NCBIGene:112744"},{"id":"A27","pred":"db_id","subj":"8623","obj":"NCBIGene:112744"},{"id":"A18","pred":"db_id","subj":"8614","obj":"NCBITaxon:9606"},{"id":"A19","pred":"db_id","subj":"8615","obj":"MESH:D016553"},{"id":"A1","pred":"db_id","subj":"8597","obj":"NCBIGene:112744"},{"id":"A35","pred":"db_id","subj":"8631","obj":"NCBIGene:112744"},{"id":"A30","pred":"db_id","subj":"8626","obj":"NCBIGene:112744"},{"id":"A4","pred":"db_id","subj":"8600","obj":"NCBIGene:112744"},{"id":"A23","pred":"db_id","subj":"8619","obj":"DBSNP:rs763780"},{"id":"A9","pred":"db_id","subj":"8605","obj":"DBSNP:rs763780"},{"id":"A12","pred":"db_id","subj":"8608","obj":"NCBITaxon:9606"},{"id":"A33","pred":"db_id","subj":"8629","obj":"DBSNP:rs763780"},{"id":"A15","pred":"db_id","subj":"8611","obj":"MESH:D016553"},{"id":"A24","pred":"db_id","subj":"8620","obj":"NCBITaxon:9606"},{"id":"A22","pred":"db_id","subj":"8618","obj":"NCBIGene:112744"},{"id":"A34","pred":"db_id","subj":"8630","obj":"MESH:D016553"},{"id":"A29","pred":"db_id","subj":"8625","obj":"MESH:D011696"},{"id":"A6","pred":"db_id","subj":"8602","obj":"MESH:D001327"},{"id":"A2","pred":"db_id","subj":"8598","obj":"NCBITaxon:9606"},{"id":"A3","pred":"db_id","subj":"8599","obj":"MESH:D016553"},{"id":"A26","pred":"db_id","subj":"8622","obj":"NCBITaxon:9606"},{"id":"A31","pred":"db_id","subj":"8627","obj":"DBSNP:rs763780"},{"id":"A8","pred":"db_id","subj":"8604","obj":"DBSNP:rs763780"},{"id":"A17","pred":"db_id","subj":"8613","obj":"NCBITaxon:9606"},{"id":"A32","pred":"db_id","subj":"8628","obj":"NCBIGene:112744"},{"id":"A7","pred":"db_id","subj":"8603","obj":"MESH:D016553"}],"namespaces":[{"prefix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gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":66,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0002049"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0007179"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":11,"end":15},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":100,"end":104},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":303,"end":311},"obj":"SequenceVariant"},{"id":"T4","span":{"begin":313,"end":318},"obj":"SequenceVariant"},{"id":"T5","span":{"begin":787,"end":791},"obj":"SequenceVariant"},{"id":"T6","span":{"begin":792,"end":798},"obj":"SequenceVariant"},{"id":"T7","span":{"begin":847,"end":851},"obj":"SequenceVariant"},{"id":"T8","span":{"begin":852,"end":857},"obj":"SequenceVariant"},{"id":"T9","span":{"begin":1042,"end":1046},"obj":"SequenceVariant"},{"id":"T10","span":{"begin":1047,"end":1053},"obj":"SequenceVariant"},{"id":"T11","span":{"begin":1166,"end":1170},"obj":"SequenceVariant"},{"id":"T12","span":{"begin":1171,"end":1177},"obj":"SequenceVariant"},{"id":"T13","span":{"begin":1257,"end":1261},"obj":"SequenceVariant"},{"id":"T14","span":{"begin":1365,"end":1369},"obj":"SequenceVariant"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":59,"end":65},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":98,"end":104},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":110,"end":115},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":255,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":345,"end":348},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":365,"end":375},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":390,"end":401},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":567,"end":577},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":585,"end":595},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":596,"end":601},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":657,"end":661},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":742,"end":747},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":768,"end":777},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":785,"end":791},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":845,"end":851},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1040,"end":1046},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1103,"end":1117},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1121,"end":1129},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1164,"end":1170},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1229,"end":1237},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1255,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1363,"end":1369},"obj":"GeneOrGeneProduct"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":98,"end":104},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":110,"end":115},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":255,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":365,"end":375},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":585,"end":595},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":596,"end":601},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":768,"end":777},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":785,"end":791},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":845,"end":851},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1040,"end":1046},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1103,"end":1117},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1164,"end":1170},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1255,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1363,"end":1369},"obj":"GeneOrGeneProduct"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":59,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":116,"end":128},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D016553"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D001327"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":98,"end":104},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":785,"end":791},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":845,"end":851},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":1040,"end":1046},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":1103,"end":1117},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1164,"end":1170},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1255,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1363,"end":1369},"obj":"GeneOrGeneProduct"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":59,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":243,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":429,"end":432},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":486,"end":489},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":516,"end":519},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":738,"end":741},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":898,"end":901},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1336,"end":1339},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1401,"end":1404},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0008558"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0008558"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0008558"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0007179"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0017169"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0008558"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0017169"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0008558"},{"id":"A2","pred":"mondo_id","subj":"T1","obj":"0002048"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0008558"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0008558"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":59,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":116,"end":128},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":235,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":478,"end":489},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":730,"end":741},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":890,"end":901},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1079,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1328,"end":1339},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1393,"end":1404},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"ID:","subj":"T4","obj":"DISEASE"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A9","pred":"ID:","subj":"T9","obj":"DISEASE"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D001327"},{"id":"A8","pred":"ID:","subj":"T8","obj":"DISEASE"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D016553"},{"id":"A7","pred":"ID:","subj":"T7","obj":"DISEASE"},{"id":"A10","pred":"ID:","subj":"T10","obj":"DISEASE"},{"id":"A5","pred":"ID:","subj":"T5","obj":"DISEASE"},{"id":"A2","pred":"ID:","subj":"T2","obj":"DISEASE"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":59,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":235,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":478,"end":489},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":730,"end":741},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":890,"end":901},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1079,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1328,"end":1339},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1393,"end":1404},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D016553"},{"id":"A7","pred":"#label","subj":"T7","obj":"DISEASE"},{"id":"A8","pred":"#label","subj":"T8","obj":"DISEASE"},{"id":"A9","pred":"#label","subj":"T9","obj":"DISEASE"},{"id":"A3","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A5","pred":"#label","subj":"T5","obj":"DISEASE"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A2","pred":"#label","subj":"T2","obj":"D001327"},{"id":"A4","pred":"#label","subj":"T4","obj":"DISEASE"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":37,"end":45},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":419,"end":427},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":429,"end":432},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":433,"end":438},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":516,"end":519},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":520,"end":525},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":716,"end":724},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":876,"end":884},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":1022,"end":1030},"obj":"OrganismTaxon"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":243,"end":246},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":345,"end":348},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":486,"end":489},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":738,"end":741},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":898,"end":901},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1336,"end":1339},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":1401,"end":1404},"obj":"ChemicalEntity"}],"attributes":[{"id":"A3","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_29952"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A11","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A9","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T13","span":{"begin":1401,"end":1404},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1336,"end":1339},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":898,"end":901},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":738,"end":741},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":486,"end":489},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":345,"end":348},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":243,"end":246},"obj":"ChemicalEntity"},{"id":"T38229","span":{"begin":1363,"end":1369},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1255,"end":1261},"obj":"GeneOrGeneProduct"},{"id":"T55765","span":{"begin":1164,"end":1170},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":1103,"end":1117},"obj":"GeneOrGeneProduct"},{"id":"T87147","span":{"begin":1040,"end":1046},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":845,"end":851},"obj":"GeneOrGeneProduct"},{"id":"T84845","span":{"begin":785,"end":791},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":98,"end":104},"obj":"GeneOrGeneProduct"},{"id":"T25295","span":{"begin":0,"end":15},"obj":"GeneOrGeneProduct"},{"id":"T91606","span":{"begin":1393,"end":1404},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7610","span":{"begin":1328,"end":1339},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T90356","span":{"begin":1079,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T36067","span":{"begin":890,"end":901},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8078","span":{"begin":730,"end":741},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T91020","span":{"begin":478,"end":489},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T25860","span":{"begin":235,"end":246},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21060","span":{"begin":174,"end":193},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T89062","span":{"begin":59,"end":82},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T93618","span":{"begin":1022,"end":1030},"obj":"OrganismTaxon"},{"id":"T3769","span":{"begin":876,"end":884},"obj":"OrganismTaxon"},{"id":"T35351","span":{"begin":716,"end":724},"obj":"OrganismTaxon"},{"id":"T47275","span":{"begin":520,"end":525},"obj":"OrganismTaxon"},{"id":"T6476","span":{"begin":516,"end":519},"obj":"OrganismTaxon"},{"id":"T90970","span":{"begin":433,"end":438},"obj":"OrganismTaxon"},{"id":"T44368","span":{"begin":429,"end":432},"obj":"OrganismTaxon"},{"id":"T63791","span":{"begin":419,"end":427},"obj":"OrganismTaxon"},{"id":"T16139","span":{"begin":37,"end":45},"obj":"OrganismTaxon"},{"id":"T14","span":{"begin":1365,"end":1369},"obj":"SequenceVariant"},{"id":"T60140","span":{"begin":1257,"end":1261},"obj":"SequenceVariant"},{"id":"T12","span":{"begin":1171,"end":1177},"obj":"SequenceVariant"},{"id":"T61663","span":{"begin":1166,"end":1170},"obj":"SequenceVariant"},{"id":"T10","span":{"begin":1047,"end":1053},"obj":"SequenceVariant"},{"id":"T40431","span":{"begin":1042,"end":1046},"obj":"SequenceVariant"},{"id":"T6673","span":{"begin":852,"end":857},"obj":"SequenceVariant"},{"id":"T35964","span":{"begin":847,"end":851},"obj":"SequenceVariant"},{"id":"T48153","span":{"begin":792,"end":798},"obj":"SequenceVariant"},{"id":"T61210","span":{"begin":787,"end":791},"obj":"SequenceVariant"},{"id":"T47547","span":{"begin":313,"end":318},"obj":"SequenceVariant"},{"id":"T12480","span":{"begin":303,"end":311},"obj":"SequenceVariant"},{"id":"T56900","span":{"begin":100,"end":104},"obj":"SequenceVariant"},{"id":"T52706","span":{"begin":11,"end":15},"obj":"SequenceVariant"}],"attributes":[{"id":"A62249","pred":"#label","subj":"T8078","obj":"DISEASE"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A9","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A11","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A29846","pred":"#label","subj":"T91020","obj":"DISEASE"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A93365","pred":"#label","subj":"T21060","obj":"D001327"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_16039"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_61402"},{"id":"A90583","pred":"#label","subj":"T7610","obj":"DISEASE"},{"id":"A36120","pred":"#label","subj":"T36067","obj":"DISEASE"},{"id":"A71059","pred":"#label","subj":"T25860","obj":"DISEASE"},{"id":"A52271","pred":"#label","subj":"T89062","obj":"D016553"},{"id":"A83938","pred":"#label","subj":"T91606","obj":"DISEASE"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A3","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_29952"},{"id":"A98881","pred":"#label","subj":"T90356","obj":"DISEASE"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":0,"end":15},"obj":"gene:112744"},{"id":"T1","span":{"begin":59,"end":82},"obj":"disease:C0398650"},{"id":"T2","span":{"begin":98,"end":104},"obj":"gene:112744"},{"id":"T3","span":{"begin":174,"end":193},"obj":"disease:C0004364"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":174,"end":184},"obj":"HP_0002960"},{"id":"T2","span":{"begin":174,"end":193},"obj":"HP_0002960"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"Allie","denotations":[{"id":"SS1_21615796_6_0","span":{"begin":585,"end":651},"obj":"expanded"},{"id":"SS2_21615796_6_0","span":{"begin":653,"end":661},"obj":"abbr"}],"relations":[{"id":"AE1_21615796_6_0","pred":"abbreviatedTo","subj":"SS1_21615796_6_0","obj":"SS2_21615796_6_0"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"21615796-0#0#15#gene112744","span":{"begin":0,"end":15},"obj":"gene112744"},{"id":"21615796-0#59#82#diseaseC0242584","span":{"begin":59,"end":82},"obj":"diseaseC0242584"},{"id":"21615796-0#59#82#diseaseC0272286","span":{"begin":59,"end":82},"obj":"diseaseC0272286"},{"id":"21615796-0#59#82#diseaseC0398650","span":{"begin":59,"end":82},"obj":"diseaseC0398650"},{"id":"21615796-1#0#6#gene112744","span":{"begin":98,"end":104},"obj":"gene112744"},{"id":"21615796-1#76#95#diseaseC0004364","span":{"begin":174,"end":193},"obj":"diseaseC0004364"}],"relations":[{"id":"0#15#gene11274459#82#diseaseC0242584","pred":"associated_with","subj":"21615796-0#0#15#gene112744","obj":"21615796-0#59#82#diseaseC0242584"},{"id":"0#15#gene11274459#82#diseaseC0272286","pred":"associated_with","subj":"21615796-0#0#15#gene112744","obj":"21615796-0#59#82#diseaseC0272286"},{"id":"0#15#gene11274459#82#diseaseC0398650","pred":"associated_with","subj":"21615796-0#0#15#gene112744","obj":"21615796-0#59#82#diseaseC0398650"},{"id":"0#6#gene11274476#95#diseaseC0004364","pred":"associated_with","subj":"21615796-1#0#6#gene112744","obj":"21615796-1#76#95#diseaseC0004364"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":303,"end":311},"obj":"SNP:rs763780"},{"id":"T2","span":{"begin":313,"end":320},"obj":"DNAMutation:g|SUB|T|7488|C"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"41","span":{"begin":303,"end":311},"obj":"SNP"},{"id":"T1","span":{"begin":303,"end":311},"obj":"SNP"}],"attributes":[{"id":"A41","pred":"resolved_to","subj":"41","obj":"tmVar:rs763780;VariantGroup:0;CorrespondingGene:112744;RS#:763780;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs763780;VariantGroup:0;CorrespondingGene:112744;RS#:763780;CorrespondingSpecies:9606"}],"text":"Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.\nINTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases. We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.\nPATIENTS AND METHODS: We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38). Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.\nRESULTS: Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P\u003c0.05). The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016). Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count\u003c10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).\nCONCLUSION: These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP."}