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PubMed:21615796 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
21615796_0 338-379 ProteinMutation denotes His-to-Arg substitution at amino acid 161 rs763780

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.
T2 84-194 Sentence denotes INTRODUCTION: IL-17F is a novel inflammatory cytokine and plays an important role in some autoimmune diseases.
T3 195-380 Sentence denotes We investigated the association between chronic ITP and the frequency of the single-nucleotide polymorphism rs763780 (7488T/C), which causes a His-to-Arg substitution at amino acid 161.
T4 381-402 Sentence denotes PATIENTS AND METHODS:
T5 403-551 Sentence denotes We examined 102 patients (men/women, 40/62; median age, 42) diagnosed with chronic ITP and 188 healthy controls (men/women, 78/110; median age, 38).
T6 552-673 Sentence denotes Genotyping was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
T7 674-682 Sentence denotes RESULTS:
T8 683-830 Sentence denotes Compared with the control group, patients with chronic ITP had a significantly lower frequency of the IL-17F 7488CC genotype (0% vs. 4.8%, P<0.05).
T9 831-1008 Sentence denotes The number of IL-17F 7488C alleles among the patients with chronic ITP was also significantly lower than in the control group (8.7% vs. 15.2% OR=0.48, 95%CI=0.27-0.84, P=0.016).
T10 1009-1210 Sentence denotes Furthermore, patients with the IL-17F 7488TT genotype showed a severe thrombocytopenic state (platelet count<10×10(9) /L) at diagnosis than those with the IL-17F 7488TC genotype (20.9% vs. 0%, P=0.04).
T11 1211-1222 Sentence denotes CONCLUSION:
T12 1223-1405 Sentence denotes These findings suggest that the IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic ITP.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8597 0-15 GeneOrGeneProduct denotes Interleukin-17F NCBIGene:112744
8598 37-45 OrganismTaxon denotes patients NCBITaxon:9606
8599 51-82 DiseaseOrPhenotypicFeature denotes chronic immune thrombocytopenia MESH:D016553
8600 98-104 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8601 116-137 GeneOrGeneProduct denotes inflammatory cytokine NCBIGene:112744
8602 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases MESH:D001327
8603 235-246 DiseaseOrPhenotypicFeature denotes chronic ITP MESH:D016553
8604 303-311 SequenceVariant denotes rs763780 DBSNP:rs763780
8605 313-320 SequenceVariant denotes 7488T/C DBSNP:rs763780
8606 338-379 SequenceVariant denotes His-to-Arg substitution at amino acid 161 DBSNP:rs763780
8607 381-389 OrganismTaxon denotes PATIENTS NCBITaxon:9606
8608 419-427 OrganismTaxon denotes patients NCBITaxon:9606
8609 429-432 OrganismTaxon denotes men NCBITaxon:9606
8610 433-438 OrganismTaxon denotes women NCBITaxon:9606
8611 478-489 DiseaseOrPhenotypicFeature denotes chronic ITP MESH:D016553
8612 516-519 OrganismTaxon denotes men NCBITaxon:9606
8613 520-525 OrganismTaxon denotes women NCBITaxon:9606
8614 716-724 OrganismTaxon denotes patients NCBITaxon:9606
8615 730-741 DiseaseOrPhenotypicFeature denotes chronic ITP MESH:D016553
8616 785-791 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8617 792-798 SequenceVariant denotes 7488CC DBSNP:rs763780
8618 845-851 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8619 852-857 SequenceVariant denotes 7488C DBSNP:rs763780
8620 876-884 OrganismTaxon denotes patients NCBITaxon:9606
8621 890-901 DiseaseOrPhenotypicFeature denotes chronic ITP MESH:D016553
8622 1022-1030 OrganismTaxon denotes patients NCBITaxon:9606
8623 1040-1046 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8624 1047-1053 SequenceVariant denotes 7488TT DBSNP:rs763780
8625 1079-1095 DiseaseOrPhenotypicFeature denotes thrombocytopenic MESH:D011696
8626 1164-1170 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8627 1171-1177 SequenceVariant denotes 7488TC DBSNP:rs763780
8628 1255-1261 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8629 1262-1268 SequenceVariant denotes 7488 T DBSNP:rs763780
8630 1328-1339 DiseaseOrPhenotypicFeature denotes chronic ITP MESH:D016553
8631 1363-1369 GeneOrGeneProduct denotes IL-17F NCBIGene:112744
8632 1393-1404 DiseaseOrPhenotypicFeature denotes chronic ITP MESH:D016553

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 66-82 DiseaseOrPhenotypicFeature denotes thrombocytopenia 0002049
T2 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases 0007179

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 11-15 SequenceVariant denotes -17F
T2 100-104 SequenceVariant denotes -17F
T3 303-311 SequenceVariant denotes rs763780
T4 313-318 SequenceVariant denotes 7488T
T5 787-791 SequenceVariant denotes -17F
T6 792-798 SequenceVariant denotes 7488CC
T7 847-851 SequenceVariant denotes -17F
T8 852-857 SequenceVariant denotes 7488C
T9 1042-1046 SequenceVariant denotes -17F
T10 1047-1053 SequenceVariant denotes 7488TT
T11 1166-1170 SequenceVariant denotes -17F
T12 1171-1177 SequenceVariant denotes 7488TC
T13 1257-1261 SequenceVariant denotes -17F
T14 1365-1369 SequenceVariant denotes -17F

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-15 GeneOrGeneProduct denotes Interleukin-17F
T2 59-65 GeneOrGeneProduct denotes immune
T3 98-104 GeneOrGeneProduct denotes IL-17F
T4 110-115 GeneOrGeneProduct denotes novel
T5 255-264 GeneOrGeneProduct denotes frequency
T6 345-348 GeneOrGeneProduct denotes Arg
T7 365-375 GeneOrGeneProduct denotes amino acid
T8 390-401 GeneOrGeneProduct denotes AND METHODS
T9 567-577 GeneOrGeneProduct denotes determined
T10 585-595 GeneOrGeneProduct denotes polymerase
T11 596-601 GeneOrGeneProduct denotes chain
T12 657-661 GeneOrGeneProduct denotes RFLP
T13 742-747 GeneOrGeneProduct denotes had a
T14 768-777 GeneOrGeneProduct denotes frequency
T15 785-791 GeneOrGeneProduct denotes IL-17F
T16 845-851 GeneOrGeneProduct denotes IL-17F
T17 1040-1046 GeneOrGeneProduct denotes IL-17F
T18 1103-1117 GeneOrGeneProduct denotes platelet count
T19 1121-1129 GeneOrGeneProduct denotes 10(9) /L
T20 1164-1170 GeneOrGeneProduct denotes IL-17F
T21 1229-1237 GeneOrGeneProduct denotes findings
T22 1255-1261 GeneOrGeneProduct denotes IL-17F
T23 1363-1369 GeneOrGeneProduct denotes IL-17F

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-15 GeneOrGeneProduct denotes Interleukin-17F
T2 98-104 GeneOrGeneProduct denotes IL-17F
T3 110-115 GeneOrGeneProduct denotes novel
T4 255-264 GeneOrGeneProduct denotes frequency
T5 365-375 GeneOrGeneProduct denotes amino acid
T6 585-595 GeneOrGeneProduct denotes polymerase
T7 596-601 GeneOrGeneProduct denotes chain
T8 768-777 GeneOrGeneProduct denotes frequency
T9 785-791 GeneOrGeneProduct denotes IL-17F
T10 845-851 GeneOrGeneProduct denotes IL-17F
T11 1040-1046 GeneOrGeneProduct denotes IL-17F
T12 1103-1117 GeneOrGeneProduct denotes platelet count
T13 1164-1170 GeneOrGeneProduct denotes IL-17F
T14 1255-1261 GeneOrGeneProduct denotes IL-17F
T15 1363-1369 GeneOrGeneProduct denotes IL-17F

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 59-82 DiseaseOrPhenotypicFeature denotes immune thrombocytopenia D016553
T2 116-128 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T3 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases D001327

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-15 GeneOrGeneProduct denotes Interleukin-17F
T2 98-104 GeneOrGeneProduct denotes IL-17F
T3 785-791 GeneOrGeneProduct denotes IL-17F
T4 845-851 GeneOrGeneProduct denotes IL-17F
T5 1040-1046 GeneOrGeneProduct denotes IL-17F
T6 1103-1117 GeneOrGeneProduct denotes platelet count
T7 1164-1170 GeneOrGeneProduct denotes IL-17F
T8 1255-1261 GeneOrGeneProduct denotes IL-17F
T9 1363-1369 GeneOrGeneProduct denotes IL-17F

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 59-82 DiseaseOrPhenotypicFeature denotes immune thrombocytopenia 0008558|0002048
T3 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases 0007179
T4 243-246 DiseaseOrPhenotypicFeature denotes ITP 0008558
T5 429-432 DiseaseOrPhenotypicFeature denotes men 0017169
T6 486-489 DiseaseOrPhenotypicFeature denotes ITP 0008558
T7 516-519 DiseaseOrPhenotypicFeature denotes men 0017169
T8 738-741 DiseaseOrPhenotypicFeature denotes ITP 0008558
T9 898-901 DiseaseOrPhenotypicFeature denotes ITP 0008558
T10 1336-1339 DiseaseOrPhenotypicFeature denotes ITP 0008558
T11 1401-1404 DiseaseOrPhenotypicFeature denotes ITP 0008558

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 59-82 DiseaseOrPhenotypicFeature denotes immune thrombocytopenia D016553
T2 116-128 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T3 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases D001327
T4 235-246 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T5 478-489 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T6 730-741 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T7 890-901 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T8 1079-1095 DiseaseOrPhenotypicFeature denotes thrombocytopenic DISEASE
T9 1328-1339 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T10 1393-1404 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 59-82 DiseaseOrPhenotypicFeature denotes immune thrombocytopenia D016553
T2 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases D001327
T3 235-246 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T4 478-489 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T5 730-741 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T6 890-901 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T7 1079-1095 DiseaseOrPhenotypicFeature denotes thrombocytopenic DISEASE
T8 1328-1339 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T9 1393-1404 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 37-45 OrganismTaxon denotes patients
T2 419-427 OrganismTaxon denotes patients
T3 429-432 OrganismTaxon denotes men
T4 433-438 OrganismTaxon denotes women
T5 516-519 OrganismTaxon denotes men
T6 520-525 OrganismTaxon denotes women
T7 716-724 OrganismTaxon denotes patients
T8 876-884 OrganismTaxon denotes patients
T9 1022-1030 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 243-246 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_61402|http://purl.obolibrary.org/obo/CHEBI_16039
T3 345-348 ChemicalEntity denotes Arg http://purl.obolibrary.org/obo/CHEBI_29952|http://purl.obolibrary.org/obo/CHEBI_16467
T5 486-489 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_61402|http://purl.obolibrary.org/obo/CHEBI_16039
T7 738-741 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_61402|http://purl.obolibrary.org/obo/CHEBI_16039
T9 898-901 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_61402|http://purl.obolibrary.org/obo/CHEBI_16039
T11 1336-1339 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_61402|http://purl.obolibrary.org/obo/CHEBI_16039
T13 1401-1404 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_61402|http://purl.obolibrary.org/obo/CHEBI_16039

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T13 1401-1404 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_16039|http://purl.obolibrary.org/obo/CHEBI_61402
T11 1336-1339 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_16039|http://purl.obolibrary.org/obo/CHEBI_61402
T9 898-901 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_16039|http://purl.obolibrary.org/obo/CHEBI_61402
T7 738-741 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_16039|http://purl.obolibrary.org/obo/CHEBI_61402
T5 486-489 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_16039|http://purl.obolibrary.org/obo/CHEBI_61402
T3 345-348 ChemicalEntity denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T1 243-246 ChemicalEntity denotes ITP http://purl.obolibrary.org/obo/CHEBI_16039|http://purl.obolibrary.org/obo/CHEBI_61402
T38229 1363-1369 GeneOrGeneProduct denotes IL-17F
T8 1255-1261 GeneOrGeneProduct denotes IL-17F
T55765 1164-1170 GeneOrGeneProduct denotes IL-17F
T6 1103-1117 GeneOrGeneProduct denotes platelet count
T87147 1040-1046 GeneOrGeneProduct denotes IL-17F
T4 845-851 GeneOrGeneProduct denotes IL-17F
T84845 785-791 GeneOrGeneProduct denotes IL-17F
T2 98-104 GeneOrGeneProduct denotes IL-17F
T25295 0-15 GeneOrGeneProduct denotes Interleukin-17F
T91606 1393-1404 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T7610 1328-1339 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T90356 1079-1095 DiseaseOrPhenotypicFeature denotes thrombocytopenic DISEASE
T36067 890-901 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T8078 730-741 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T91020 478-489 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T25860 235-246 DiseaseOrPhenotypicFeature denotes chronic ITP DISEASE
T21060 174-193 DiseaseOrPhenotypicFeature denotes autoimmune diseases D001327
T89062 59-82 DiseaseOrPhenotypicFeature denotes immune thrombocytopenia D016553
T93618 1022-1030 OrganismTaxon denotes patients
T3769 876-884 OrganismTaxon denotes patients
T35351 716-724 OrganismTaxon denotes patients
T47275 520-525 OrganismTaxon denotes women
T6476 516-519 OrganismTaxon denotes men
T90970 433-438 OrganismTaxon denotes women
T44368 429-432 OrganismTaxon denotes men
T63791 419-427 OrganismTaxon denotes patients
T16139 37-45 OrganismTaxon denotes patients
T14 1365-1369 SequenceVariant denotes -17F
T60140 1257-1261 SequenceVariant denotes -17F
T12 1171-1177 SequenceVariant denotes 7488TC
T61663 1166-1170 SequenceVariant denotes -17F
T10 1047-1053 SequenceVariant denotes 7488TT
T40431 1042-1046 SequenceVariant denotes -17F
T6673 852-857 SequenceVariant denotes 7488C
T35964 847-851 SequenceVariant denotes -17F
T48153 792-798 SequenceVariant denotes 7488CC
T61210 787-791 SequenceVariant denotes -17F
T47547 313-318 SequenceVariant denotes 7488T
T12480 303-311 SequenceVariant denotes rs763780
T56900 100-104 SequenceVariant denotes -17F
T52706 11-15 SequenceVariant denotes -17F

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-15 gene:112744 denotes Interleukin-17F
T1 59-82 disease:C0398650 denotes immune thrombocytopenia
T2 98-104 gene:112744 denotes IL-17F
T3 174-193 disease:C0004364 denotes autoimmune diseases
R1 T0 T1 associated_with Interleukin-17F,immune thrombocytopenia
R2 T2 T3 associated_with IL-17F,autoimmune diseases

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 174-184 HP_0002960 denotes autoimmune
T2 174-193 HP_0002960 denotes autoimmune diseases

Allie

Id Subject Object Predicate Lexical cue
SS1_21615796_6_0 585-651 expanded denotes polymerase chain reaction-restriction fragment length polymorphism
SS2_21615796_6_0 653-661 abbr denotes PCR-RFLP
AE1_21615796_6_0 SS1_21615796_6_0 SS2_21615796_6_0 abbreviatedTo polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21615796-0#0#15#gene112744 0-15 gene112744 denotes Interleukin-17F
21615796-0#59#82#diseaseC0242584 59-82 diseaseC0242584 denotes immune thrombocytopenia
21615796-0#59#82#diseaseC0272286 59-82 diseaseC0272286 denotes immune thrombocytopenia
21615796-0#59#82#diseaseC0398650 59-82 diseaseC0398650 denotes immune thrombocytopenia
21615796-1#0#6#gene112744 98-104 gene112744 denotes IL-17F
21615796-1#76#95#diseaseC0004364 174-193 diseaseC0004364 denotes autoimmune diseases
0#15#gene11274459#82#diseaseC0242584 21615796-0#0#15#gene112744 21615796-0#59#82#diseaseC0242584 associated_with Interleukin-17F,immune thrombocytopenia
0#15#gene11274459#82#diseaseC0272286 21615796-0#0#15#gene112744 21615796-0#59#82#diseaseC0272286 associated_with Interleukin-17F,immune thrombocytopenia
0#15#gene11274459#82#diseaseC0398650 21615796-0#0#15#gene112744 21615796-0#59#82#diseaseC0398650 associated_with Interleukin-17F,immune thrombocytopenia
0#6#gene11274476#95#diseaseC0004364 21615796-1#0#6#gene112744 21615796-1#76#95#diseaseC0004364 associated_with IL-17F,autoimmune diseases

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 303-311 SNP:rs763780 denotes rs763780
T2 313-320 DNAMutation:g|SUB|T|7488|C denotes 7488T/C

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
41 303-311 SNP denotes rs763780 tmVar:rs763780;VariantGroup:0;CorrespondingGene:112744;RS#:763780;CorrespondingSpecies:9606
T1 303-311 SNP denotes rs763780 tmVar:rs763780;VariantGroup:0;CorrespondingGene:112744;RS#:763780;CorrespondingSpecies:9606