PubMed:2159545 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":4,"end":44},"obj":"DNA"},{"id":"T2","span":{"begin":112,"end":145},"obj":"protein"},{"id":"T3","span":{"begin":151,"end":181},"obj":"DNA"},{"id":"T4","span":{"begin":209,"end":221},"obj":"DNA"},{"id":"T5","span":{"begin":246,"end":254},"obj":"DNA"},{"id":"T6","span":{"begin":271,"end":286},"obj":"DNA"},{"id":"T7","span":{"begin":325,"end":332},"obj":"protein"},{"id":"T8","span":{"begin":338,"end":372},"obj":"protein"},{"id":"T9","span":{"begin":381,"end":389},"obj":"DNA"},{"id":"T10","span":{"begin":436,"end":437},"obj":"DNA"},{"id":"T11","span":{"begin":439,"end":447},"obj":"DNA"},{"id":"T12","span":{"begin":472,"end":510},"obj":"DNA"},{"id":"T13","span":{"begin":623,"end":626},"obj":"protein"},{"id":"T14","span":{"begin":631,"end":632},"obj":"protein"},{"id":"T15","span":{"begin":637,"end":654},"obj":"protein"},{"id":"T16","span":{"begin":670,"end":694},"obj":"DNA"},{"id":"T17","span":{"begin":784,"end":792},"obj":"DNA"},{"id":"T18","span":{"begin":799,"end":819},"obj":"DNA"},{"id":"T19","span":{"begin":823,"end":833},"obj":"cell_line"},{"id":"T20","span":{"begin":858,"end":896},"obj":"DNA"},{"id":"T21","span":{"begin":919,"end":935},"obj":"DNA"},{"id":"T22","span":{"begin":937,"end":942},"obj":"DNA"},{"id":"T23","span":{"begin":963,"end":991},"obj":"DNA"},{"id":"T24","span":{"begin":993,"end":998},"obj":"DNA"},{"id":"T25","span":{"begin":1120,"end":1121},"obj":"protein"},{"id":"T26","span":{"begin":1126,"end":1129},"obj":"protein"},{"id":"T27","span":{"begin":1150,"end":1158},"obj":"DNA"},{"id":"T28","span":{"begin":1160,"end":1165},"obj":"DNA"},{"id":"T29","span":{"begin":1175,"end":1195},"obj":"DNA"},{"id":"T30","span":{"begin":1214,"end":1222},"obj":"DNA"},{"id":"T31","span":{"begin":1224,"end":1229},"obj":"DNA"},{"id":"T32","span":{"begin":1259,"end":1279},"obj":"DNA"},{"id":"T33","span":{"begin":1322,"end":1333},"obj":"DNA"},{"id":"T34","span":{"begin":1334,"end":1342},"obj":"DNA"},{"id":"T35","span":{"begin":1438,"end":1465},"obj":"DNA"},{"id":"T36","span":{"begin":1485,"end":1505},"obj":"DNA"},{"id":"T37","span":{"begin":1526,"end":1540},"obj":"DNA"},{"id":"T38","span":{"begin":1561,"end":1569},"obj":"DNA"},{"id":"T39","span":{"begin":1577,"end":1591},"obj":"DNA"},{"id":"T40","span":{"begin":1630,"end":1631},"obj":"protein"},{"id":"T41","span":{"begin":1644,"end":1658},"obj":"DNA"},{"id":"T42","span":{"begin":1672,"end":1695},"obj":"DNA"},{"id":"T43","span":{"begin":1738,"end":1748},"obj":"DNA"},{"id":"T44","span":{"begin":1785,"end":1808},"obj":"DNA"}],"text":"The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.\nThe Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. ZRE-B can be deleted without affecting the R-dependent enhancer activity. Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. ZRE-B is therefore not part of the R-inducible enhancer. We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. These protoenhancers alone are weakly or not responsive to R. One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":1766,"end":1776},"obj":"HP_0009609"}],"text":"The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.\nThe Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. ZRE-B can be deleted without affecting the R-dependent enhancer activity. Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. ZRE-B is therefore not part of the R-inducible enhancer. We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. These protoenhancers alone are weakly or not responsive to R. One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":146},"obj":"Sentence"},{"id":"S2","span":{"begin":147,"end":438},"obj":"Sentence"},{"id":"S3","span":{"begin":439,"end":765},"obj":"Sentence"},{"id":"S4","span":{"begin":766,"end":897},"obj":"Sentence"},{"id":"S5","span":{"begin":898,"end":992},"obj":"Sentence"},{"id":"S6","span":{"begin":993,"end":1066},"obj":"Sentence"},{"id":"S7","span":{"begin":1067,"end":1223},"obj":"Sentence"},{"id":"S8","span":{"begin":1224,"end":1280},"obj":"Sentence"},{"id":"S9","span":{"begin":1281,"end":1466},"obj":"Sentence"},{"id":"S10","span":{"begin":1467,"end":1570},"obj":"Sentence"},{"id":"S11","span":{"begin":1571,"end":1632},"obj":"Sentence"},{"id":"S12","span":{"begin":1633,"end":1724},"obj":"Sentence"},{"id":"S13","span":{"begin":1725,"end":1830},"obj":"Sentence"}],"text":"The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.\nThe Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. ZRE-B can be deleted without affecting the R-dependent enhancer activity. Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. ZRE-B is therefore not part of the R-inducible enhancer. We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. These protoenhancers alone are weakly or not responsive to R. One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":147,"end":181},"obj":"NP"},{"id":"C2","span":{"begin":256,"end":258},"obj":"NP"},{"id":"C3","span":{"begin":325,"end":373},"obj":"NP"},{"id":"C4","span":{"begin":395,"end":428},"obj":"NP"},{"id":"C5","span":{"begin":430,"end":437},"obj":"NP"},{"id":"C6","span":{"begin":439,"end":447},"obj":"NP"},{"id":"C7","span":{"begin":470,"end":510},"obj":"NP"},{"id":"C8","span":{"begin":623,"end":626},"obj":"NP"},{"id":"C9","span":{"begin":631,"end":632},"obj":"NP"},{"id":"C10","span":{"begin":634,"end":694},"obj":"NP"},{"id":"C11","span":{"begin":784,"end":792},"obj":"NP"},{"id":"C12","span":{"begin":796,"end":819},"obj":"NP"},{"id":"C13","span":{"begin":855,"end":896},"obj":"NP"},{"id":"C14","span":{"begin":916,"end":943},"obj":"NP"},{"id":"C15","span":{"begin":993,"end":998},"obj":"NP"},{"id":"C16","span":{"begin":1120,"end":1121},"obj":"NP"},{"id":"C17","span":{"begin":1146,"end":1158},"obj":"NP"},{"id":"C18","span":{"begin":1160,"end":1165},"obj":"NP"},{"id":"C19","span":{"begin":1171,"end":1195},"obj":"NP"},{"id":"C20","span":{"begin":1224,"end":1229},"obj":"NP"},{"id":"C22","span":{"begin":1318,"end":1342},"obj":"NP"},{"id":"C21","span":{"begin":1296,"end":1342},"obj":"NP"},{"id":"C23","span":{"begin":1380,"end":1385},"obj":"NP"},{"id":"C24","span":{"begin":1481,"end":1505},"obj":"NP"},{"id":"C26","span":{"begin":1521,"end":1540},"obj":"NP"},{"id":"C27","span":{"begin":1541,"end":1545},"obj":"NP"},{"id":"C25","span":{"begin":1521,"end":1569},"obj":"NP"},{"id":"C28","span":{"begin":1571,"end":1591},"obj":"NP"},{"id":"C29","span":{"begin":1630,"end":1631},"obj":"NP"},{"id":"C30","span":{"begin":1640,"end":1658},"obj":"NP"},{"id":"C31","span":{"begin":1668,"end":1723},"obj":"NP"},{"id":"C32","span":{"begin":1781,"end":1808},"obj":"NP"},{"id":"C33","span":{"begin":1828,"end":1829},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-pron","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-appos","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C8","obj":"C3"},{"id":"R4","pred":"coref-appos","subj":"C10","obj":"C9"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C6"},{"id":"R6","pred":"coref-ident","subj":"C13","obj":"C7"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C9"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C11"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C14"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C12"},{"id":"R12","pred":"coref-ident","subj":"C20","obj":"C15"},{"id":"R13","pred":"coref-ident","subj":"C22","obj":"C17"},{"id":"R14","pred":"coref-pron","subj":"C23","obj":"C21"},{"id":"R15","pred":"coref-ident","subj":"C24","obj":"C19"},{"id":"R16","pred":"coref-relat","subj":"C27","obj":"C26"},{"id":"R17","pred":"coref-ident","subj":"C28","obj":"C25"},{"id":"R18","pred":"coref-ident","subj":"C29","obj":"C16"},{"id":"R19","pred":"coref-ident","subj":"C30","obj":"C28"},{"id":"R20","pred":"coref-ident","subj":"C32","obj":"C31"},{"id":"R21","pred":"coref-ident","subj":"C33","obj":"C29"}],"text":"The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.\nThe Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. ZRE-B can be deleted without affecting the R-dependent enhancer activity. Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. ZRE-B is therefore not part of the R-inducible enhancer. We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. These protoenhancers alone are weakly or not responsive to R. One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":4,"end":22},"obj":"virus"},{"id":"T2","span":{"begin":24,"end":27},"obj":"virus"},{"id":"T3","span":{"begin":52,"end":67},"obj":"other_name"},{"id":"T4","span":{"begin":151,"end":181},"obj":"DNA_domain_or_region"},{"id":"T5","span":{"begin":209,"end":221},"obj":"DNA_domain_or_region"},{"id":"T6","span":{"begin":246,"end":254},"obj":"DNA_domain_or_region"},{"id":"T7","span":{"begin":271,"end":286},"obj":"DNA_domain_or_region"},{"id":"T8","span":{"begin":325,"end":332},"obj":"protein_molecule"},{"id":"T9","span":{"begin":338,"end":372},"obj":"protein_molecule"},{"id":"T10","span":{"begin":381,"end":389},"obj":"DNA_domain_or_region"},{"id":"T11","span":{"begin":430,"end":431},"obj":"DNA_substructure"},{"id":"T12","span":{"begin":436,"end":437},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":439,"end":447},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":472,"end":487},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":488,"end":491},"obj":"protein_molecule"},{"id":"T16","span":{"begin":623,"end":626},"obj":"protein_molecule"},{"id":"T17","span":{"begin":631,"end":632},"obj":"protein_molecule"},{"id":"T18","span":{"begin":637,"end":654},"obj":"protein_family_or_group"},{"id":"T19","span":{"begin":670,"end":688},"obj":"DNA_domain_or_region"},{"id":"T20","span":{"begin":689,"end":694},"obj":"DNA_domain_or_region"},{"id":"T21","span":{"begin":784,"end":792},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":799,"end":819},"obj":"DNA_family_or_group"},{"id":"T23","span":{"begin":823,"end":833},"obj":"cell_line"},{"id":"T24","span":{"begin":858,"end":861},"obj":"protein_molecule"},{"id":"T25","span":{"begin":919,"end":922},"obj":"protein_molecule"},{"id":"T26","span":{"begin":937,"end":942},"obj":"DNA_domain_or_region"},{"id":"T27","span":{"begin":963,"end":991},"obj":"DNA_domain_or_region"},{"id":"T28","span":{"begin":993,"end":998},"obj":"DNA_domain_or_region"},{"id":"T29","span":{"begin":1036,"end":1065},"obj":"other_name"},{"id":"T30","span":{"begin":1120,"end":1121},"obj":"protein_molecule"},{"id":"T31","span":{"begin":1126,"end":1129},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1150,"end":1158},"obj":"DNA_domain_or_region"},{"id":"T33","span":{"begin":1160,"end":1165},"obj":"DNA_domain_or_region"},{"id":"T34","span":{"begin":1175,"end":1195},"obj":"DNA_family_or_group"},{"id":"T35","span":{"begin":1214,"end":1222},"obj":"DNA_domain_or_region"},{"id":"T36","span":{"begin":1224,"end":1229},"obj":"DNA_domain_or_region"},{"id":"T37","span":{"begin":1259,"end":1279},"obj":"DNA_domain_or_region"},{"id":"T38","span":{"begin":1322,"end":1333},"obj":"DNA_domain_or_region"},{"id":"T39","span":{"begin":1334,"end":1342},"obj":"DNA_domain_or_region"},{"id":"T40","span":{"begin":1411,"end":1430},"obj":"other_name"},{"id":"T41","span":{"begin":1438,"end":1465},"obj":"DNA_domain_or_region"},{"id":"T42","span":{"begin":1485,"end":1505},"obj":"DNA_family_or_group"},{"id":"T43","span":{"begin":1526,"end":1540},"obj":"DNA_family_or_group"},{"id":"T44","span":{"begin":1561,"end":1569},"obj":"DNA_domain_or_region"},{"id":"T45","span":{"begin":1577,"end":1591},"obj":"DNA_family_or_group"},{"id":"T46","span":{"begin":1630,"end":1631},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1644,"end":1658},"obj":"DNA_family_or_group"},{"id":"T48","span":{"begin":1672,"end":1695},"obj":"DNA_domain_or_region"},{"id":"T49","span":{"begin":1696,"end":1723},"obj":"polynucleotide"},{"id":"T50","span":{"begin":1738,"end":1748},"obj":"DNA_domain_or_region"},{"id":"T51","span":{"begin":1785,"end":1808},"obj":"DNA_domain_or_region"}],"text":"The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.\nThe Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. ZRE-B can be deleted without affecting the R-dependent enhancer activity. Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. ZRE-B is therefore not part of the R-inducible enhancer. We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. These protoenhancers alone are weakly or not responsive to R. One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R."}