PubMed:2159545
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-44 | DNA | denotes | Epstein-Barr virus (EBV) ORI1yt enhancer |
| T2 | 112-145 | protein | denotes | EBV transcription factors R and Z |
| T3 | 151-181 | DNA | denotes | Epstein-Barr virus DR promoter |
| T4 | 209-221 | DNA | denotes | PstI repeats |
| T5 | 246-254 | DNA | denotes | TATA box |
| T6 | 271-286 | DNA | denotes | upstream region |
| T7 | 325-332 | protein | denotes | EB1 (Z) |
| T8 | 338-372 | protein | denotes | BZLF1-encoded transcription factor |
| T9 | 381-389 | DNA | denotes | enhancer |
| T10 | 436-437 | DNA | denotes | B |
| T11 | 439-447 | DNA | denotes | Domain B |
| T12 | 472-510 | DNA | denotes | B-cell-specific EB1-responsive element |
| T13 | 623-626 | protein | denotes | EB1 |
| T14 | 631-632 | protein | denotes | R |
| T15 | 637-654 | protein | denotes | EBV early product |
| T16 | 670-694 | DNA | denotes | open reading frame BRLF1 |
| T17 | 784-792 | DNA | denotes | domain B |
| T18 | 799-819 | DNA | denotes | R-responsive element |
| T19 | 823-833 | cell_line | denotes | HeLa cells |
| T20 | 858-896 | DNA | denotes | EB1-responsive B-cell-specific element |
| T21 | 919-935 | DNA | denotes | EB1-binding site |
| T22 | 937-942 | DNA | denotes | ZRE-B |
| T23 | 963-991 | DNA | denotes | R-responsive enhancer region |
| T24 | 993-998 | DNA | denotes | ZRE-B |
| T25 | 1120-1121 | protein | denotes | R |
| T26 | 1126-1129 | protein | denotes | EB1 |
| T27 | 1150-1158 | DNA | denotes | B domain |
| T28 | 1160-1165 | DNA | denotes | ZRE-B |
| T29 | 1175-1195 | DNA | denotes | R-responsive element |
| T30 | 1214-1222 | DNA | denotes | enhancer |
| T31 | 1224-1229 | DNA | denotes | ZRE-B |
| T32 | 1259-1279 | DNA | denotes | R-inducible enhancer |
| T33 | 1322-1333 | DNA | denotes | DR enhancer |
| T34 | 1334-1342 | DNA | denotes | B domain |
| T35 | 1438-1465 | DNA | denotes | rabbit beta-globin promoter |
| T36 | 1485-1505 | DNA | denotes | R-responsive element |
| T37 | 1526-1540 | DNA | denotes | protoenhancers |
| T38 | 1561-1569 | DNA | denotes | B domain |
| T39 | 1577-1591 | DNA | denotes | protoenhancers |
| T40 | 1630-1631 | protein | denotes | R |
| T41 | 1644-1658 | DNA | denotes | protoenhancers |
| T42 | 1672-1695 | DNA | denotes | overlapping palindromes |
| T43 | 1738-1748 | DNA | denotes | palindrome |
| T44 | 1785-1808 | DNA | denotes | overlapping palindromes |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1766-1776 | HP_0009609 | denotes | duplicated |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-146 | Sentence | denotes | The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z. |
| S2 | 147-438 | Sentence | denotes | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to the TATA box, it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor) and an enhancer with two functionally distinct domains, A and B. |
| S3 | 439-765 | Sentence | denotes | Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. M. Hardwick, and S. D. Hayward, J. Virol. 63:3040-3050, 1989) activated synergistically by EB1 and R, an EBV early product encoded by the open reading frame BRLF1 (M. A. Cox, J. Leahy, and J. M. Hardwick, J. Virol. 64:313-321, 1990). |
| S4 | 766-897 | Sentence | denotes | We show here that domain B is an R-responsive element in HeLa cells and is therefore not an EB1-responsive B-cell-specific element. |
| S5 | 898-992 | Sentence | denotes | However, there is an EB1-binding site (ZRE-B) located within the R-responsive enhancer region. |
| S6 | 993-1066 | Sentence | denotes | ZRE-B can be deleted without affecting the R-dependent enhancer activity. |
| S7 | 1067-1223 | Sentence | denotes | Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain (ZRE-B plus the R-responsive element) positioned as an enhancer. |
| S8 | 1224-1280 | Sentence | denotes | ZRE-B is therefore not part of the R-inducible enhancer. |
| S9 | 1281-1466 | Sentence | denotes | We have tested several subregions of the DR enhancer B domain, either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter. |
| S10 | 1467-1570 | Sentence | denotes | We found that the R-responsive element is composed of four protoenhancers that span the whole B domain. |
| S11 | 1571-1632 | Sentence | denotes | These protoenhancers alone are weakly or not responsive to R. |
| S12 | 1633-1724 | Sentence | denotes | One of the protoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3'. |
| S13 | 1725-1830 | Sentence | denotes | However, one palindrome, either alone or duplicated, or the overlapping palindromes did not respond to R. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 147-181 | NP | denotes | The Epstein-Barr virus DR promoter |
| C2 | 256-258 | NP | denotes | it |
| C3 | 325-373 | NP | denotes | EB1 (Z) (the BZLF1-encoded transcription factor) |
| C4 | 395-428 | NP | denotes | two functionally distinct domains |
| C5 | 430-437 | NP | denotes | A and B |
| C6 | 439-447 | NP | denotes | Domain B |
| C7 | 470-510 | NP | denotes | a B-cell-specific EB1-responsive element |
| C8 | 623-626 | NP | denotes | EB1 |
| C9 | 631-632 | NP | denotes | R |
| C10 | 634-694 | NP | denotes | an EBV early product encoded by the open reading frame BRLF1 |
| C11 | 784-792 | NP | denotes | domain B |
| C12 | 796-819 | NP | denotes | an R-responsive element |
| C13 | 855-896 | NP | denotes | an EB1-responsive B-cell-specific element |
| C14 | 916-943 | NP | denotes | an EB1-binding site (ZRE-B) |
| C15 | 993-998 | NP | denotes | ZRE-B |
| C16 | 1120-1121 | NP | denotes | R |
| C17 | 1146-1158 | NP | denotes | the B domain |
| C18 | 1160-1165 | NP | denotes | ZRE-B |
| C19 | 1171-1195 | NP | denotes | the R-responsive element |
| C20 | 1224-1229 | NP | denotes | ZRE-B |
| C22 | 1318-1342 | NP | denotes | the DR enhancer B domain |
| C21 | 1296-1342 | NP | denotes | several subregions of the DR enhancer B domain |
| C23 | 1380-1385 | NP | denotes | their |
| C24 | 1481-1505 | NP | denotes | the R-responsive element |
| C26 | 1521-1540 | NP | denotes | four protoenhancers |
| C27 | 1541-1545 | NP | denotes | that |
| C25 | 1521-1569 | NP | denotes | four protoenhancers that span the whole B domain |
| C28 | 1571-1591 | NP | denotes | These protoenhancers |
| C29 | 1630-1631 | NP | denotes | R |
| C30 | 1640-1658 | NP | denotes | the protoenhancers |
| C31 | 1668-1723 | NP | denotes | the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3' |
| C32 | 1781-1808 | NP | denotes | the overlapping palindromes |
| C33 | 1828-1829 | NP | denotes | R |
| R1 | C2 | C1 | coref-pron | it,The Epstein-Barr virus DR promoter |
| R2 | C5 | C4 | coref-appos | A and B,two functionally distinct domains |
| R3 | C8 | C3 | coref-ident | EB1,EB1 (Z) (the BZLF1-encoded transcription factor) |
| R4 | C10 | C9 | coref-appos | an EBV early product encoded by the open reading frame BRLF1,R |
| R5 | C11 | C6 | coref-ident | domain B,Domain B |
| R6 | C13 | C7 | coref-ident | an EB1-responsive B-cell-specific element,a B-cell-specific EB1-responsive element |
| R7 | C15 | C14 | coref-ident | ZRE-B,an EB1-binding site (ZRE-B) |
| R8 | C16 | C9 | coref-ident | R,R |
| R9 | C17 | C11 | coref-ident | the B domain,domain B |
| R10 | C18 | C14 | coref-ident | ZRE-B,an EB1-binding site (ZRE-B) |
| R11 | C19 | C12 | coref-ident | the R-responsive element,an R-responsive element |
| R12 | C20 | C15 | coref-ident | ZRE-B,ZRE-B |
| R13 | C22 | C17 | coref-ident | the DR enhancer B domain,the B domain |
| R14 | C23 | C21 | coref-pron | their,several subregions of the DR enhancer B domain |
| R15 | C24 | C19 | coref-ident | the R-responsive element,the R-responsive element |
| R16 | C27 | C26 | coref-relat | that,four protoenhancers |
| R17 | C28 | C25 | coref-ident | These protoenhancers,four protoenhancers that span the whole B domain |
| R18 | C29 | C16 | coref-ident | R,R |
| R19 | C30 | C28 | coref-ident | the protoenhancers,These protoenhancers |
| R20 | C32 | C31 | coref-ident | the overlapping palindromes,the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3' |
| R21 | C33 | C29 | coref-ident | R,R |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-22 | virus | denotes | Epstein-Barr virus |
| T2 | 24-27 | virus | denotes | EBV |
| T3 | 52-67 | other_name | denotes | B-cell specific |
| T4 | 151-181 | DNA_domain_or_region | denotes | Epstein-Barr virus DR promoter |
| T5 | 209-221 | DNA_domain_or_region | denotes | PstI repeats |
| T6 | 246-254 | DNA_domain_or_region | denotes | TATA box |
| T7 | 271-286 | DNA_domain_or_region | denotes | upstream region |
| T8 | 325-332 | protein_molecule | denotes | EB1 (Z) |
| T9 | 338-372 | protein_molecule | denotes | BZLF1-encoded transcription factor |
| T10 | 381-389 | DNA_domain_or_region | denotes | enhancer |
| T11 | 430-431 | DNA_substructure | denotes | A |
| T12 | 436-437 | DNA_domain_or_region | denotes | B |
| T13 | 439-447 | DNA_domain_or_region | denotes | Domain B |
| T14 | 472-487 | DNA_domain_or_region | denotes | B-cell-specific |
| T15 | 488-491 | protein_molecule | denotes | EB1 |
| T16 | 623-626 | protein_molecule | denotes | EB1 |
| T17 | 631-632 | protein_molecule | denotes | R |
| T18 | 637-654 | protein_family_or_group | denotes | EBV early product |
| T19 | 670-688 | DNA_domain_or_region | denotes | open reading frame |
| T20 | 689-694 | DNA_domain_or_region | denotes | BRLF1 |
| T21 | 784-792 | DNA_domain_or_region | denotes | domain B |
| T22 | 799-819 | DNA_family_or_group | denotes | R-responsive element |
| T23 | 823-833 | cell_line | denotes | HeLa cells |
| T24 | 858-861 | protein_molecule | denotes | EB1 |
| T25 | 919-922 | protein_molecule | denotes | EB1 |
| T26 | 937-942 | DNA_domain_or_region | denotes | ZRE-B |
| T27 | 963-991 | DNA_domain_or_region | denotes | R-responsive enhancer region |
| T28 | 993-998 | DNA_domain_or_region | denotes | ZRE-B |
| T29 | 1036-1065 | other_name | denotes | R-dependent enhancer activity |
| T30 | 1120-1121 | protein_molecule | denotes | R |
| T31 | 1126-1129 | protein_molecule | denotes | EB1 |
| T32 | 1150-1158 | DNA_domain_or_region | denotes | B domain |
| T33 | 1160-1165 | DNA_domain_or_region | denotes | ZRE-B |
| T34 | 1175-1195 | DNA_family_or_group | denotes | R-responsive element |
| T35 | 1214-1222 | DNA_domain_or_region | denotes | enhancer |
| T36 | 1224-1229 | DNA_domain_or_region | denotes | ZRE-B |
| T37 | 1259-1279 | DNA_domain_or_region | denotes | R-inducible enhancer |
| T38 | 1322-1333 | DNA_domain_or_region | denotes | DR enhancer |
| T39 | 1334-1342 | DNA_domain_or_region | denotes | B domain |
| T40 | 1411-1430 | other_name | denotes | R-activating signal |
| T41 | 1438-1465 | DNA_domain_or_region | denotes | rabbit beta-globin promoter |
| T42 | 1485-1505 | DNA_family_or_group | denotes | R-responsive element |
| T43 | 1526-1540 | DNA_family_or_group | denotes | protoenhancers |
| T44 | 1561-1569 | DNA_domain_or_region | denotes | B domain |
| T45 | 1577-1591 | DNA_family_or_group | denotes | protoenhancers |
| T46 | 1630-1631 | protein_molecule | denotes | R |
| T47 | 1644-1658 | DNA_family_or_group | denotes | protoenhancers |
| T48 | 1672-1695 | DNA_domain_or_region | denotes | overlapping palindromes |
| T49 | 1696-1723 | polynucleotide | denotes | 5'-TTGTCCcgtGGACAAaTGTCC-3' |
| T50 | 1738-1748 | DNA_domain_or_region | denotes | palindrome |
| T51 | 1785-1808 | DNA_domain_or_region | denotes | overlapping palindromes |