PubMed:21497535 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":111},"obj":"Sentence"},{"id":"T2","span":{"begin":112,"end":123},"obj":"Sentence"},{"id":"T3","span":{"begin":124,"end":236},"obj":"Sentence"},{"id":"T4","span":{"begin":237,"end":328},"obj":"Sentence"},{"id":"T5","span":{"begin":329,"end":433},"obj":"Sentence"},{"id":"T6","span":{"begin":434,"end":442},"obj":"Sentence"},{"id":"T7","span":{"begin":443,"end":527},"obj":"Sentence"},{"id":"T8","span":{"begin":528,"end":691},"obj":"Sentence"},{"id":"T9","span":{"begin":692,"end":795},"obj":"Sentence"},{"id":"T10","span":{"begin":796,"end":809},"obj":"Sentence"},{"id":"T11","span":{"begin":810,"end":819},"obj":"Sentence"},{"id":"T12","span":{"begin":820,"end":827},"obj":"Sentence"},{"id":"T13","span":{"begin":828,"end":926},"obj":"Sentence"},{"id":"T14","span":{"begin":927,"end":939},"obj":"Sentence"},{"id":"T15","span":{"begin":940,"end":951},"obj":"Sentence"},{"id":"T16","span":{"begin":952,"end":958},"obj":"Sentence"},{"id":"T17","span":{"begin":959,"end":1121},"obj":"Sentence"},{"id":"T18","span":{"begin":1122,"end":1134},"obj":"Sentence"},{"id":"T19","span":{"begin":1135,"end":1144},"obj":"Sentence"},{"id":"T20","span":{"begin":1145,"end":1151},"obj":"Sentence"},{"id":"T21","span":{"begin":1152,"end":1279},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":111},"obj":"Sentence"},{"id":"T2","span":{"begin":112,"end":123},"obj":"Sentence"},{"id":"T3","span":{"begin":124,"end":236},"obj":"Sentence"},{"id":"T4","span":{"begin":237,"end":328},"obj":"Sentence"},{"id":"T5","span":{"begin":329,"end":433},"obj":"Sentence"},{"id":"T6","span":{"begin":434,"end":442},"obj":"Sentence"},{"id":"T7","span":{"begin":443,"end":527},"obj":"Sentence"},{"id":"T8","span":{"begin":528,"end":691},"obj":"Sentence"},{"id":"T9","span":{"begin":692,"end":795},"obj":"Sentence"},{"id":"T10","span":{"begin":796,"end":809},"obj":"Sentence"},{"id":"T11","span":{"begin":810,"end":819},"obj":"Sentence"},{"id":"T12","span":{"begin":820,"end":827},"obj":"Sentence"},{"id":"T13","span":{"begin":828,"end":926},"obj":"Sentence"},{"id":"T14","span":{"begin":927,"end":939},"obj":"Sentence"},{"id":"T15","span":{"begin":940,"end":951},"obj":"Sentence"},{"id":"T16","span":{"begin":952,"end":958},"obj":"Sentence"},{"id":"T17","span":{"begin":959,"end":1121},"obj":"Sentence"},{"id":"T18","span":{"begin":1122,"end":1134},"obj":"Sentence"},{"id":"T19","span":{"begin":1135,"end":1144},"obj":"Sentence"},{"id":"T20","span":{"begin":1145,"end":1151},"obj":"Sentence"},{"id":"T21","span":{"begin":1152,"end":1279},"obj":"Sentence"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":15,"end":37},"obj":"gene:3566"},{"id":"T1","span":{"begin":62,"end":82},"obj":"disease:C0003873"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":210,"end":230},"obj":"HP_0001370"},{"id":"T2","span":{"begin":221,"end":230},"obj":"HP_0001369"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"Allie","denotations":[{"id":"SS1_21497535_2_0","span":{"begin":210,"end":230},"obj":"expanded"},{"id":"SS2_21497535_2_0","span":{"begin":232,"end":234},"obj":"abbr"},{"id":"SS1_21497535_3_0","span":{"begin":249,"end":262},"obj":"expanded"},{"id":"SS2_21497535_3_0","span":{"begin":264,"end":268},"obj":"abbr"}],"relations":[{"id":"AE1_21497535_2_0","pred":"abbreviatedTo","subj":"SS1_21497535_2_0","obj":"SS2_21497535_2_0"},{"id":"AE1_21497535_3_0","pred":"abbreviatedTo","subj":"SS1_21497535_3_0","obj":"SS2_21497535_3_0"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"21497535-8#26#31#geners1801275","span":{"begin":985,"end":990},"obj":"geners1801275"},{"id":"21497535-8#26#31#geners774309663","span":{"begin":985,"end":990},"obj":"geners774309663"},{"id":"21497535-8#26#31#geners1801275","span":{"begin":985,"end":990},"obj":"geners1801275"},{"id":"21497535-8#26#31#geners774309663","span":{"begin":985,"end":990},"obj":"geners774309663"},{"id":"21497535-8#95#97#diseaseC0003873","span":{"begin":1054,"end":1056},"obj":"diseaseC0003873"},{"id":"21497535-8#135#137#diseaseC0003873","span":{"begin":1094,"end":1096},"obj":"diseaseC0003873"}],"relations":[{"id":"26#31#geners180127595#97#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners1801275","obj":"21497535-8#95#97#diseaseC0003873"},{"id":"26#31#geners1801275135#137#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners1801275","obj":"21497535-8#135#137#diseaseC0003873"},{"id":"26#31#geners77430966395#97#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners774309663","obj":"21497535-8#95#97#diseaseC0003873"},{"id":"26#31#geners774309663135#137#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners774309663","obj":"21497535-8#135#137#diseaseC0003873"},{"id":"26#31#geners180127595#97#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners1801275","obj":"21497535-8#95#97#diseaseC0003873"},{"id":"26#31#geners1801275135#137#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners1801275","obj":"21497535-8#135#137#diseaseC0003873"},{"id":"26#31#geners77430966395#97#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners774309663","obj":"21497535-8#95#97#diseaseC0003873"},{"id":"26#31#geners774309663135#137#diseaseC0003873","pred":"associated_with","subj":"21497535-8#26#31#geners774309663","obj":"21497535-8#135#137#diseaseC0003873"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"21497535-0#15#37#gene3566","span":{"begin":15,"end":37},"obj":"gene3566"},{"id":"21497535-0#62#82#diseaseC0003873","span":{"begin":62,"end":82},"obj":"diseaseC0003873"},{"id":"21497535-2#12#25#gene3565","span":{"begin":249,"end":262},"obj":"gene3565"},{"id":"21497535-2#27#31#gene3565","span":{"begin":264,"end":268},"obj":"gene3565"},{"id":"21497535-2#73#75#diseaseC0003873","span":{"begin":310,"end":312},"obj":"diseaseC0003873"},{"id":"21497535-7#14#20#gene3566","span":{"begin":842,"end":848},"obj":"gene3566"},{"id":"21497535-7#74#93#diseaseC1853829","span":{"begin":902,"end":921},"obj":"diseaseC1853829"}],"relations":[{"id":"15#37#gene356662#82#diseaseC0003873","pred":"associated_with","subj":"21497535-0#15#37#gene3566","obj":"21497535-0#62#82#diseaseC0003873"},{"id":"12#25#gene356573#75#diseaseC0003873","pred":"associated_with","subj":"21497535-2#12#25#gene3565","obj":"21497535-2#73#75#diseaseC0003873"},{"id":"27#31#gene356573#75#diseaseC0003873","pred":"associated_with","subj":"21497535-2#27#31#gene3565","obj":"21497535-2#73#75#diseaseC0003873"},{"id":"14#20#gene356674#93#diseaseC1853829","pred":"associated_with","subj":"21497535-7#14#20#gene3566","obj":"21497535-7#74#93#diseaseC1853829"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"PubTator4TogoVar","denotations":[{"id":"52","span":{"begin":555,"end":564},"obj":"SNP"},{"id":"55","span":{"begin":584,"end":593},"obj":"SNP"}],"attributes":[{"id":"A52","pred":"resolved_to","subj":"52","obj":"tmVar:rs1805010;VariantGroup:1;CorrespondingGene:3566;RS#:1805010;CorrespondingSpecies:9606"},{"id":"A55","pred":"resolved_to","subj":"55","obj":"tmVar:rs1801275;VariantGroup:0;CorrespondingGene:3566;RS#:1801275;CorrespondingSpecies:9606"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"52","span":{"begin":555,"end":564},"obj":"SNP"},{"id":"55","span":{"begin":584,"end":593},"obj":"SNP"},{"id":"T1","span":{"begin":555,"end":564},"obj":"SNP"},{"id":"T2","span":{"begin":584,"end":593},"obj":"SNP"}],"attributes":[{"id":"A52","pred":"resolved_to","subj":"52","obj":"tmVar:rs1805010;VariantGroup:1;CorrespondingGene:3566;RS#:1805010;CorrespondingSpecies:9606"},{"id":"A55","pred":"resolved_to","subj":"55","obj":"tmVar:rs1801275;VariantGroup:0;CorrespondingGene:3566;RS#:1801275;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs1805010;VariantGroup:1;CorrespondingGene:3566;RS#:1805010;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs1801275;VariantGroup:0;CorrespondingGene:3566;RS#:1801275;CorrespondingSpecies:9606"}],"text":"Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.\nOBJECTIVES: The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA). The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting. We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.\nMETHODS: One hundred and seventy-two RA patients and 172 controls were enrolled in the study. Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).\nRESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR: 1.97, 95% CI: 1-3.7, P: 0.035). Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR: 2.6, 95% CI: 1.1-6.1, P: 0.02). The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).\nCONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA."}