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PubMed:21497535 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.
T2 112-123 Sentence denotes OBJECTIVES:
T3 124-236 Sentence denotes The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA).
T4 237-328 Sentence denotes The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting.
T5 329-433 Sentence denotes We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.
T6 434-442 Sentence denotes METHODS:
T7 443-527 Sentence denotes One hundred and seventy-two RA patients and 172 controls were enrolled in the study.
T8 528-691 Sentence denotes Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).
T9 692-795 Sentence denotes RESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR:
T10 796-809 Sentence denotes 1.97, 95% CI:
T11 810-819 Sentence denotes 1-3.7, P:
T12 820-827 Sentence denotes 0.035).
T13 828-926 Sentence denotes Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR:
T14 927-939 Sentence denotes 2.6, 95% CI:
T15 940-951 Sentence denotes 1.1-6.1, P:
T16 952-958 Sentence denotes 0.02).
T17 959-1121 Sentence denotes The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR:
T18 1122-1134 Sentence denotes 2.7, 95% CI:
T19 1135-1144 Sentence denotes 1-7.7, P:
T20 1145-1151 Sentence denotes 0.04).
T21 1152-1279 Sentence denotes CONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA.
T1 0-111 Sentence denotes Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.
T2 112-123 Sentence denotes OBJECTIVES:
T3 124-236 Sentence denotes The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA).
T4 237-328 Sentence denotes The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting.
T5 329-433 Sentence denotes We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.
T6 434-442 Sentence denotes METHODS:
T7 443-527 Sentence denotes One hundred and seventy-two RA patients and 172 controls were enrolled in the study.
T8 528-691 Sentence denotes Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).
T9 692-795 Sentence denotes RESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR:
T10 796-809 Sentence denotes 1.97, 95% CI:
T11 810-819 Sentence denotes 1-3.7, P:
T12 820-827 Sentence denotes 0.035).
T13 828-926 Sentence denotes Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR:
T14 927-939 Sentence denotes 2.6, 95% CI:
T15 940-951 Sentence denotes 1.1-6.1, P:
T16 952-958 Sentence denotes 0.02).
T17 959-1121 Sentence denotes The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR:
T18 1122-1134 Sentence denotes 2.7, 95% CI:
T19 1135-1144 Sentence denotes 1-7.7, P:
T20 1145-1151 Sentence denotes 0.04).
T21 1152-1279 Sentence denotes CONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 15-37 gene:3566 denotes interleukin-4 receptor
T1 62-82 disease:C0003873 denotes rheumatoid arthritis
R1 T0 T1 associated_with interleukin-4 receptor,rheumatoid arthritis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 210-230 HP_0001370 denotes rheumatoid arthritis
T2 221-230 HP_0001369 denotes arthritis

Allie

Id Subject Object Predicate Lexical cue
SS1_21497535_2_0 210-230 expanded denotes rheumatoid arthritis
SS2_21497535_2_0 232-234 abbr denotes RA
SS1_21497535_3_0 249-262 expanded denotes interleukin-4
SS2_21497535_3_0 264-268 abbr denotes IL-4
AE1_21497535_2_0 SS1_21497535_2_0 SS2_21497535_2_0 abbreviatedTo rheumatoid arthritis,RA
AE1_21497535_3_0 SS1_21497535_3_0 SS2_21497535_3_0 abbreviatedTo interleukin-4,IL-4

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
21497535-8#26#31#geners1801275 985-990 geners1801275 denotes Q576R
21497535-8#26#31#geners774309663 985-990 geners774309663 denotes Q576R
21497535-8#26#31#geners1801275 985-990 geners1801275 denotes Q576R
21497535-8#26#31#geners774309663 985-990 geners774309663 denotes Q576R
21497535-8#95#97#diseaseC0003873 1054-1056 diseaseC0003873 denotes RA
21497535-8#135#137#diseaseC0003873 1094-1096 diseaseC0003873 denotes RA
26#31#geners180127595#97#diseaseC0003873 21497535-8#26#31#geners1801275 21497535-8#95#97#diseaseC0003873 associated_with Q576R,RA
26#31#geners1801275135#137#diseaseC0003873 21497535-8#26#31#geners1801275 21497535-8#135#137#diseaseC0003873 associated_with Q576R,RA
26#31#geners77430966395#97#diseaseC0003873 21497535-8#26#31#geners774309663 21497535-8#95#97#diseaseC0003873 associated_with Q576R,RA
26#31#geners774309663135#137#diseaseC0003873 21497535-8#26#31#geners774309663 21497535-8#135#137#diseaseC0003873 associated_with Q576R,RA
26#31#geners180127595#97#diseaseC0003873 21497535-8#26#31#geners1801275 21497535-8#95#97#diseaseC0003873 associated_with Q576R,RA
26#31#geners1801275135#137#diseaseC0003873 21497535-8#26#31#geners1801275 21497535-8#135#137#diseaseC0003873 associated_with Q576R,RA
26#31#geners77430966395#97#diseaseC0003873 21497535-8#26#31#geners774309663 21497535-8#95#97#diseaseC0003873 associated_with Q576R,RA
26#31#geners774309663135#137#diseaseC0003873 21497535-8#26#31#geners774309663 21497535-8#135#137#diseaseC0003873 associated_with Q576R,RA

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21497535-0#15#37#gene3566 15-37 gene3566 denotes interleukin-4 receptor
21497535-0#62#82#diseaseC0003873 62-82 diseaseC0003873 denotes rheumatoid arthritis
21497535-2#12#25#gene3565 249-262 gene3565 denotes interleukin-4
21497535-2#27#31#gene3565 264-268 gene3565 denotes IL-4
21497535-2#73#75#diseaseC0003873 310-312 diseaseC0003873 denotes RA
21497535-7#14#20#gene3566 842-848 gene3566 denotes IL-4Rα
21497535-7#74#93#diseaseC1853829 902-921 diseaseC1853829 denotes erosive arthropathy
15#37#gene356662#82#diseaseC0003873 21497535-0#15#37#gene3566 21497535-0#62#82#diseaseC0003873 associated_with interleukin-4 receptor,rheumatoid arthritis
12#25#gene356573#75#diseaseC0003873 21497535-2#12#25#gene3565 21497535-2#73#75#diseaseC0003873 associated_with interleukin-4,RA
27#31#gene356573#75#diseaseC0003873 21497535-2#27#31#gene3565 21497535-2#73#75#diseaseC0003873 associated_with IL-4,RA
14#20#gene356674#93#diseaseC1853829 21497535-7#14#20#gene3566 21497535-7#74#93#diseaseC1853829 associated_with IL-4Rα,erosive arthropathy

PubTator4TogoVar

Id Subject Object Predicate Lexical cue resolved_to
52 555-564 SNP denotes rs1805010 tmVar:rs1805010;VariantGroup:1;CorrespondingGene:3566;RS#:1805010;CorrespondingSpecies:9606
55 584-593 SNP denotes rs1801275 tmVar:rs1801275;VariantGroup:0;CorrespondingGene:3566;RS#:1801275;CorrespondingSpecies:9606

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
52 555-564 SNP denotes rs1805010 tmVar:rs1805010;VariantGroup:1;CorrespondingGene:3566;RS#:1805010;CorrespondingSpecies:9606
55 584-593 SNP denotes rs1801275 tmVar:rs1801275;VariantGroup:0;CorrespondingGene:3566;RS#:1801275;CorrespondingSpecies:9606
T1 555-564 SNP denotes rs1805010 tmVar:rs1805010;VariantGroup:1;CorrespondingGene:3566;RS#:1805010;CorrespondingSpecies:9606
T2 584-593 SNP denotes rs1801275 tmVar:rs1801275;VariantGroup:0;CorrespondingGene:3566;RS#:1801275;CorrespondingSpecies:9606