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PubMed:21421994 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 5-12 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 789-796 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 964-971 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 1273-1280 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T5 1333-1340 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 5-12 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 789-796 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T3 964-971 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T4 1273-1280 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T5 1333-1340 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 5-12 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 789-796 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 964-971 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 1273-1280 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T5 1333-1340 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 5-12 FMAID:82801 denotes mannose
_T2 5-12 FMAID:196796 denotes mannose
_T3 53-56 FMAID:167179 denotes IgG
_T4 57-67 FMAID:167180 denotes antibodies
_T5 77-82 FMAID:167330 denotes serum
_T6 171-185 FMAID:167177 denotes immunoglobulin
_T7 171-185 FMAID:62871 denotes immunoglobulin
_T8 171-187 FMAID:167178 denotes immunoglobulin G
_T9 171-187 FMAID:167181 denotes immunoglobulin G
_T10 171-187 FMAID:62873 denotes immunoglobulin G
_T11 171-187 FMAID:62874 denotes immunoglobulin G
_T12 171-187 FMAID:167183 denotes immunoglobulin G
_T13 171-187 FMAID:167187 denotes immunoglobulin G
_T14 171-187 FMAID:62876 denotes immunoglobulin G
_T15 171-187 FMAID:62875 denotes immunoglobulin G
_T16 171-187 FMAID:167185 denotes immunoglobulin G
_T17 171-187 FMAID:62872 denotes immunoglobulin G
_T18 189-192 FMAID:167179 denotes IgG
_T19 356-366 FMAID:167180 denotes antibodies
_T20 499-503 FMAID:167179 denotes IgGs
_T21 558-562 FMAID:167179 denotes IgGs
_T22 591-596 FMAID:167330 denotes serum
_T23 712-719 FMAID:90078 denotes mapping
_T24 789-796 FMAID:82801 denotes mannose
_T25 789-796 FMAID:196796 denotes mannose
_T26 940-944 FMAID:167179 denotes IgGs
_T27 964-971 FMAID:82801 denotes mannose
_T28 964-971 FMAID:196796 denotes mannose
_T29 1273-1280 FMAID:196796 denotes mannose
_T30 1273-1280 FMAID:82801 denotes mannose
_T31 1333-1340 FMAID:82801 denotes mannose
_T32 1333-1340 FMAID:196796 denotes mannose
_T33 1488-1498 FMAID:167180 denotes antibodies

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 345-355 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T2 1091-1095 http://purl.bioontology.org/ontology/NCBITAXON/293505 denotes area

GO-MF

Id Subject Object Predicate Lexical cue
T1 57-67 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2 356-366 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3 1488-1498 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4 171-185 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin

GO-CC

Id Subject Object Predicate Lexical cue
T1 53-67 http://purl.obolibrary.org/obo/GO_0071736 denotes IgG antibodies
T2 509-513 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG1
T3 524-529 http://purl.obolibrary.org/obo/GO_0071735 denotes IgG2s

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 77-82 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2 591-596 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

Allie

Id Subject Object Predicate Lexical cue
SS1_21421994_1_0 171-187 expanded denotes immunoglobulin G
SS2_21421994_1_0 189-192 abbr denotes IgG
SS1_21421994_2_0 345-366 expanded denotes monoclonal antibodies
SS2_21421994_2_0 368-372 abbr denotes Mabs
SS1_21421994_5_0 784-798 expanded denotes high-mannose 5
SS2_21421994_5_0 800-802 abbr denotes M5
AE1_21421994_1_0 SS1_21421994_1_0 SS2_21421994_1_0 abbreviatedTo immunoglobulin G,IgG
AE1_21421994_2_0 SS1_21421994_2_0 SS2_21421994_2_0 abbreviatedTo monoclonal antibodies,Mabs
AE1_21421994_5_0 SS1_21421994_5_0 SS2_21421994_5_0 abbreviatedTo high-mannose 5,M5

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
TextSentencer_T2 104-293 Sentence denotes Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear.
TextSentencer_T3 294-406 Sentence denotes Clearance is of obvious importance for therapeutic monoclonal antibodies (Mabs) as it directly impacts efficacy.
TextSentencer_T4 407-541 Sentence denotes Here, we study the impact of Fc glycan structure on the clearance of four therapeutic human IgGs (one IgG1 and three IgG2s) in humans.
TextSentencer_T5 542-764 Sentence denotes The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide mapping employing high-resolution mass spectrometry.
TextSentencer_T6 765-896 Sentence denotes Relative levels of high-mannose 5 (M5) glycan decreased as a function of circulation time, whereas other glycans remained constant.
TextSentencer_T7 897-1039 Sentence denotes These results demonstrate that therapeutic IgGs containing Fc high-mannose glycans are cleared more rapidly in humans than other glycan forms.
TextSentencer_T8 1040-1327 Sentence denotes The quantitative effect of this on pharmacokinetic area under the curve was calculated and shown to be relatively minor for three of the four molecules studied, but, depending on the dosing regimen and the relative level of the high-mannose glycan, this can also have significant impact.
TextSentencer_T9 1328-1499 Sentence denotes High-mannose content of therapeutic Mabs should be considered an important product quality attribute which may affect pharmacokinetic properties of therapeutic antibodies.
T1 0-103 Sentence denotes High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
T2 104-293 Sentence denotes Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear.
T3 294-406 Sentence denotes Clearance is of obvious importance for therapeutic monoclonal antibodies (Mabs) as it directly impacts efficacy.
T4 407-541 Sentence denotes Here, we study the impact of Fc glycan structure on the clearance of four therapeutic human IgGs (one IgG1 and three IgG2s) in humans.
T5 542-764 Sentence denotes The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide mapping employing high-resolution mass spectrometry.
T6 765-896 Sentence denotes Relative levels of high-mannose 5 (M5) glycan decreased as a function of circulation time, whereas other glycans remained constant.
T7 897-1039 Sentence denotes These results demonstrate that therapeutic IgGs containing Fc high-mannose glycans are cleared more rapidly in humans than other glycan forms.
T8 1040-1327 Sentence denotes The quantitative effect of this on pharmacokinetic area under the curve was calculated and shown to be relatively minor for three of the four molecules studied, but, depending on the dosing regimen and the relative level of the high-mannose glycan, this can also have significant impact.
T9 1328-1499 Sentence denotes High-mannose content of therapeutic Mabs should be considered an important product quality attribute which may affect pharmacokinetic properties of therapeutic antibodies.
T1 0-103 Sentence denotes High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
T2 104-293 Sentence denotes Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear.
T3 294-406 Sentence denotes Clearance is of obvious importance for therapeutic monoclonal antibodies (Mabs) as it directly impacts efficacy.
T4 407-541 Sentence denotes Here, we study the impact of Fc glycan structure on the clearance of four therapeutic human IgGs (one IgG1 and three IgG2s) in humans.
T5 542-764 Sentence denotes The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide mapping employing high-resolution mass spectrometry.
T6 765-896 Sentence denotes Relative levels of high-mannose 5 (M5) glycan decreased as a function of circulation time, whereas other glycans remained constant.
T7 897-1039 Sentence denotes These results demonstrate that therapeutic IgGs containing Fc high-mannose glycans are cleared more rapidly in humans than other glycan forms.
T8 1040-1327 Sentence denotes The quantitative effect of this on pharmacokinetic area under the curve was calculated and shown to be relatively minor for three of the four molecules studied, but, depending on the dosing regimen and the relative level of the high-mannose glycan, this can also have significant impact.
T9 1328-1499 Sentence denotes High-mannose content of therapeutic Mabs should be considered an important product quality attribute which may affect pharmacokinetic properties of therapeutic antibodies.

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 0-12 http://rdf.glycoinfo.org/glycan/G00028MO denotes High-mannose
T2 784-796 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose
T3 959-971 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose
T4 1268-1280 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 77-82 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 591-596 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 493-498 OrganismTaxon denotes human 9606
T2 610-615 OrganismTaxon denotes human 9606