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PubMed:21364582 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
TextSentencer_T2 116-127 Sentence denotes BACKGROUND:
TextSentencer_T3 128-255 Sentence denotes Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component of desmosomes, is involved in carcinogenesis.
TextSentencer_T4 256-338 Sentence denotes However, the role of DSC3 in colorectal cancer (CRC) has not yet been established.
TextSentencer_T5 339-347 Sentence denotes METHODS:
TextSentencer_T6 348-435 Sentence denotes Desmocollin 3 expression in CRC cell lines was analysed by RT-PCR and western blotting.
TextSentencer_T7 436-557 Sentence denotes Methylation status of DSC3 was examined by demethylation tests, methylation-specific PCR, and bisulphite sequencing (BS).
TextSentencer_T8 558-618 Sentence denotes The regulatory role of p53 was investigated by transfection.
TextSentencer_T9 619-627 Sentence denotes RESULTS:
TextSentencer_T10 628-700 Sentence denotes Desmocollin 3 was downregulated in CRC cells at mRNA and protein levels.
TextSentencer_T11 701-816 Sentence denotes Desmocollin 3 expression was restored in five out of seven cell lines after 5-aza-2'-deoxycytidine (DAC) treatment.
TextSentencer_T12 817-910 Sentence denotes A heterogeneous methylation pattern was detected by BS in promoter region and exon 1 of DSC3.
TextSentencer_T13 911-1044 Sentence denotes Methylation of DSC3 genomic sequences was found in 41% (41 out of 99) of primary CRC, being associated with poor prognosis (P=0.002).
TextSentencer_T14 1045-1126 Sentence denotes Transfection of p53 alone or in combination of DAC increased the DSC3 expression.
TextSentencer_T15 1127-1234 Sentence denotes Similarly, treatment with p53 inducer adriamycin alone or in combination with DAC enhanced DSC3 expression.
TextSentencer_T16 1235-1320 Sentence denotes CONCLUSIONS: DNA methylation contributes to downregulation of DSC3 in CRC cell lines.
TextSentencer_T17 1321-1383 Sentence denotes Methylation status of DSC3 DNA is a prognostic marker for CRC.
TextSentencer_T18 1384-1452 Sentence denotes P53 appears to have an important role in regulating DSC3 expression.
T1 0-115 Sentence denotes DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
T2 116-127 Sentence denotes BACKGROUND:
T3 128-255 Sentence denotes Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component of desmosomes, is involved in carcinogenesis.
T4 256-338 Sentence denotes However, the role of DSC3 in colorectal cancer (CRC) has not yet been established.
T5 339-347 Sentence denotes METHODS:
T6 348-435 Sentence denotes Desmocollin 3 expression in CRC cell lines was analysed by RT-PCR and western blotting.
T7 436-557 Sentence denotes Methylation status of DSC3 was examined by demethylation tests, methylation-specific PCR, and bisulphite sequencing (BS).
T8 558-618 Sentence denotes The regulatory role of p53 was investigated by transfection.
T9 619-627 Sentence denotes RESULTS:
T10 628-700 Sentence denotes Desmocollin 3 was downregulated in CRC cells at mRNA and protein levels.
T11 701-816 Sentence denotes Desmocollin 3 expression was restored in five out of seven cell lines after 5-aza-2'-deoxycytidine (DAC) treatment.
T12 817-910 Sentence denotes A heterogeneous methylation pattern was detected by BS in promoter region and exon 1 of DSC3.
T13 911-1044 Sentence denotes Methylation of DSC3 genomic sequences was found in 41% (41 out of 99) of primary CRC, being associated with poor prognosis (P=0.002).
T14 1045-1126 Sentence denotes Transfection of p53 alone or in combination of DAC increased the DSC3 expression.
T15 1127-1234 Sentence denotes Similarly, treatment with p53 inducer adriamycin alone or in combination with DAC enhanced DSC3 expression.
T16 1235-1320 Sentence denotes CONCLUSIONS: DNA methylation contributes to downregulation of DSC3 in CRC cell lines.
T17 1321-1383 Sentence denotes Methylation status of DSC3 DNA is a prognostic marker for CRC.
T18 1384-1452 Sentence denotes P53 appears to have an important role in regulating DSC3 expression.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1297-1301 gene:1825 denotes DSC3
T1 1305-1308 disease:C0009402 denotes CRC
T2 1297-1301 gene:1825 denotes DSC3
T3 1305-1308 disease:C1527249 denotes CRC
T4 1297-1301 gene:1824 denotes DSC3
T5 1305-1308 disease:C0009402 denotes CRC
T6 1297-1301 gene:1824 denotes DSC3
T7 1305-1308 disease:C1527249 denotes CRC
T8 1343-1347 gene:1825 denotes DSC3
T9 1379-1382 disease:C0009402 denotes CRC
T10 1343-1347 gene:1825 denotes DSC3
T11 1379-1382 disease:C1527249 denotes CRC
T12 1343-1347 gene:1824 denotes DSC3
T13 1379-1382 disease:C0009402 denotes CRC
T14 1343-1347 gene:1824 denotes DSC3
T15 1379-1382 disease:C1527249 denotes CRC
R1 T0 T1 associated_with DSC3,CRC
R2 T2 T3 associated_with DSC3,CRC
R3 T4 T5 associated_with DSC3,CRC
R4 T6 T7 associated_with DSC3,CRC
R5 T8 T9 associated_with DSC3,CRC
R6 T10 T11 associated_with DSC3,CRC
R7 T12 T13 associated_with DSC3,CRC
R8 T14 T15 associated_with DSC3,CRC

Allie

Id Subject Object Predicate Lexical cue
SS1_21364582_2_0 128-141 expanded denotes Desmocollin 3
SS2_21364582_2_0 143-147 abbr denotes DSC3
SS1_21364582_3_0 285-302 expanded denotes colorectal cancer
SS2_21364582_3_0 304-307 abbr denotes CRC
SS1_21364582_6_0 530-551 expanded denotes bisulphite sequencing
SS2_21364582_6_0 553-555 abbr denotes BS
SS1_21364582_10_0 777-799 expanded denotes 5-aza-2'-deoxycytidine
SS2_21364582_10_0 801-804 abbr denotes DAC
AE1_21364582_2_0 SS1_21364582_2_0 SS2_21364582_2_0 abbreviatedTo Desmocollin 3,DSC3
AE1_21364582_3_0 SS1_21364582_3_0 SS2_21364582_3_0 abbreviatedTo colorectal cancer,CRC
AE1_21364582_6_0 SS1_21364582_6_0 SS2_21364582_6_0 abbreviatedTo bisulphite sequencing,BS
AE1_21364582_10_0 SS1_21364582_10_0 SS2_21364582_10_0 abbreviatedTo 5-aza-2'-deoxycytidine,DAC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 296-302 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21364582-0#0#4#gene1825 0-4 gene1825 denotes DSC3
21364582-0#56#60#gene1825 56-60 gene1825 denotes DSC3
21364582-0#97#114#diseaseC0009402 97-114 diseaseC0009402 denotes colorectal cancer
21364582-0#97#114#diseaseC1527249 97-114 diseaseC1527249 denotes colorectal cancer
21364582-0#97#114#diseaseC0009402 97-114 diseaseC0009402 denotes colorectal cancer
21364582-0#97#114#diseaseC1527249 97-114 diseaseC1527249 denotes colorectal cancer
21364582-1#0#13#gene1825 128-141 gene1825 denotes Desmocollin 3
21364582-1#0#13#gene1824 128-141 gene1824 denotes Desmocollin 3
21364582-1#15#19#gene1825 143-147 gene1825 denotes DSC3
21364582-1#112#126#diseaseC0596263 240-254 diseaseC0596263 denotes carcinogenesis
21364582-1#112#126#diseaseC0596263 240-254 diseaseC0596263 denotes carcinogenesis
21364582-6#35#38#diseaseC0009402 663-666 diseaseC0009402 denotes CRC
21364582-6#35#38#diseaseC1527249 663-666 diseaseC1527249 denotes CRC
0#4#gene182597#114#diseaseC0009402 21364582-0#0#4#gene1825 21364582-0#97#114#diseaseC0009402 associated_with DSC3,colorectal cancer
0#4#gene182597#114#diseaseC1527249 21364582-0#0#4#gene1825 21364582-0#97#114#diseaseC1527249 associated_with DSC3,colorectal cancer
0#4#gene182597#114#diseaseC0009402 21364582-0#0#4#gene1825 21364582-0#97#114#diseaseC0009402 associated_with DSC3,colorectal cancer
0#4#gene182597#114#diseaseC1527249 21364582-0#0#4#gene1825 21364582-0#97#114#diseaseC1527249 associated_with DSC3,colorectal cancer
56#60#gene182597#114#diseaseC0009402 21364582-0#56#60#gene1825 21364582-0#97#114#diseaseC0009402 associated_with DSC3,colorectal cancer
56#60#gene182597#114#diseaseC1527249 21364582-0#56#60#gene1825 21364582-0#97#114#diseaseC1527249 associated_with DSC3,colorectal cancer
56#60#gene182597#114#diseaseC0009402 21364582-0#56#60#gene1825 21364582-0#97#114#diseaseC0009402 associated_with DSC3,colorectal cancer
56#60#gene182597#114#diseaseC1527249 21364582-0#56#60#gene1825 21364582-0#97#114#diseaseC1527249 associated_with DSC3,colorectal cancer
0#13#gene1825112#126#diseaseC0596263 21364582-1#0#13#gene1825 21364582-1#112#126#diseaseC0596263 associated_with Desmocollin 3,carcinogenesis
0#13#gene1825112#126#diseaseC0596263 21364582-1#0#13#gene1825 21364582-1#112#126#diseaseC0596263 associated_with Desmocollin 3,carcinogenesis
0#13#gene1824112#126#diseaseC0596263 21364582-1#0#13#gene1824 21364582-1#112#126#diseaseC0596263 associated_with Desmocollin 3,carcinogenesis
0#13#gene1824112#126#diseaseC0596263 21364582-1#0#13#gene1824 21364582-1#112#126#diseaseC0596263 associated_with Desmocollin 3,carcinogenesis
15#19#gene1825112#126#diseaseC0596263 21364582-1#15#19#gene1825 21364582-1#112#126#diseaseC0596263 associated_with DSC3,carcinogenesis
15#19#gene1825112#126#diseaseC0596263 21364582-1#15#19#gene1825 21364582-1#112#126#diseaseC0596263 associated_with DSC3,carcinogenesis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1960 0-4 gene:1825 denotes DSC3
T1961 97-114 disease:C0009402 denotes colorectal cancer
T1962 56-60 gene:1825 denotes DSC3
T1963 128-141 gene:1825 denotes Desmocollin 3
T1964 240-254 disease:C0596263 denotes carcinogenesis
T1965 628-641 gene:1824 denotes Desmocollin 3
T1966 663-666 disease:C0009402 denotes CRC
R1 T1960 T1961 associated_with DSC3,colorectal cancer
R2 T1960 T1961 associated_with DSC3,colorectal cancer
R3 T1962 T1961 associated_with DSC3,colorectal cancer
R4 T1962 T1961 associated_with DSC3,colorectal cancer
R5 T1963 T1964 associated_with Desmocollin 3,carcinogenesis
R6 T1963 T1964 associated_with Desmocollin 3,carcinogenesis
R7 T1965 T1966 associated_with Desmocollin 3,CRC
R8 T1965 T1966 associated_with Desmocollin 3,CRC