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PubMed:21364021 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-91 Sentence denotes HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance.
TextSentencer_T2 92-100 Sentence denotes PURPOSE:
TextSentencer_T3 101-188 Sentence denotes Hypoxia-inducible factor 1 (HIF-1) promotes cancer cell survival and tumor progression.
TextSentencer_T4 189-331 Sentence denotes The specific role played by HIF-1 and tumor-stromal interactions toward determining tumor resistance to radiation treatment remains undefined.
TextSentencer_T5 332-501 Sentence denotes We applied a multimodality preclinical imaging platform to mechanistically characterize tumor response to radiation, with a focus on HIF-1-dependent resistance pathways.
TextSentencer_T6 502-659 Sentence denotes METHODS: C6 glioma and HN5 human squamous carcinoma cells were stably transfected with a dual HIF-1 signaling reporter construct (dxHRE-tk/eGFP-cmvRed2XPRT).
TextSentencer_T7 660-834 Sentence denotes Reporter cells were serially interrogated in vitro before and after irradiation as monolayer and multicellular spheroid cultures and as subcutaneous xenografts in nu/nu mice.
TextSentencer_T8 835-843 Sentence denotes RESULTS:
TextSentencer_T9 844-1016 Sentence denotes In vitro, single-dose irradiation of C6 and HN5 reporter cells modestly impacted HIF-1 signaling in normoxic monolayers and inhibited HIF-1 signaling in maturing spheroids.
TextSentencer_T10 1017-1232 Sentence denotes In contrast, irradiation of C6 or HN5 reporter xenografts with 8 Gy in vivo elicited marked upregulation of HIF-1 signaling and downstream proangiogenic signaling at 48 hours which preceded recovery of tumor growth.
TextSentencer_T11 1233-1386 Sentence denotes In situ ultrasound imaging and dynamic contrast-enhanced (DCE) MRI indicated that HIF-1 signaling followed acute disruption of stromal vascular function.
TextSentencer_T12 1387-1611 Sentence denotes High-resolution positron emission tomography and dual-contrast DCE-MRI of immobilized dorsal skin window tumors confirmed postradiotherapy HIF-1 signaling to spatiotemporally coincide with impaired stromal vascular function.
TextSentencer_T13 1612-1721 Sentence denotes Targeted disruption of HIF-1 signaling established this pathway to be a determinant of tumor radioresistance.
TextSentencer_T14 1722-1734 Sentence denotes CONCLUSIONS:
TextSentencer_T15 1735-2028 Sentence denotes Our results illustrate that tumor radioresistance is mediated by a capacity to compensate for stromal vascular disruption through HIF-1-dependent proangiogenic signaling and that clinically relevant vascular imaging techniques can spatially define mechanisms associated with tumor irradiation.
T1 0-91 Sentence denotes HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance.
T2 92-100 Sentence denotes PURPOSE:
T3 101-188 Sentence denotes Hypoxia-inducible factor 1 (HIF-1) promotes cancer cell survival and tumor progression.
T4 189-331 Sentence denotes The specific role played by HIF-1 and tumor-stromal interactions toward determining tumor resistance to radiation treatment remains undefined.
T5 332-501 Sentence denotes We applied a multimodality preclinical imaging platform to mechanistically characterize tumor response to radiation, with a focus on HIF-1-dependent resistance pathways.
T6 502-659 Sentence denotes METHODS: C6 glioma and HN5 human squamous carcinoma cells were stably transfected with a dual HIF-1 signaling reporter construct (dxHRE-tk/eGFP-cmvRed2XPRT).
T7 660-834 Sentence denotes Reporter cells were serially interrogated in vitro before and after irradiation as monolayer and multicellular spheroid cultures and as subcutaneous xenografts in nu/nu mice.
T8 835-843 Sentence denotes RESULTS:
T9 844-1016 Sentence denotes In vitro, single-dose irradiation of C6 and HN5 reporter cells modestly impacted HIF-1 signaling in normoxic monolayers and inhibited HIF-1 signaling in maturing spheroids.
T10 1017-1232 Sentence denotes In contrast, irradiation of C6 or HN5 reporter xenografts with 8 Gy in vivo elicited marked upregulation of HIF-1 signaling and downstream proangiogenic signaling at 48 hours which preceded recovery of tumor growth.
T11 1233-1386 Sentence denotes In situ ultrasound imaging and dynamic contrast-enhanced (DCE) MRI indicated that HIF-1 signaling followed acute disruption of stromal vascular function.
T12 1387-1611 Sentence denotes High-resolution positron emission tomography and dual-contrast DCE-MRI of immobilized dorsal skin window tumors confirmed postradiotherapy HIF-1 signaling to spatiotemporally coincide with impaired stromal vascular function.
T13 1612-1721 Sentence denotes Targeted disruption of HIF-1 signaling established this pathway to be a determinant of tumor radioresistance.
T14 1722-1734 Sentence denotes CONCLUSIONS:
T15 1735-2028 Sentence denotes Our results illustrate that tumor radioresistance is mediated by a capacity to compensate for stromal vascular disruption through HIF-1-dependent proangiogenic signaling and that clinically relevant vascular imaging techniques can spatially define mechanisms associated with tumor irradiation.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-5 gene:29072 denotes HIF-1
T1 38-46 disease:C0022116 denotes ischemia
T2 0-5 gene:3091 denotes HIF-1
T3 38-46 disease:C0022116 denotes ischemia
T4 129-134 gene:29072 denotes HIF-1
T5 170-187 disease:C0178874 denotes tumor progression
T6 129-134 gene:3091 denotes HIF-1
T7 170-187 disease:C0178874 denotes tumor progression
T8 129-134 gene:3091 denotes HIF-1
T9 145-151 disease:C0006826 denotes cancer
T10 129-134 gene:29072 denotes HIF-1
T11 145-151 disease:C1306459 denotes cancer
T12 129-134 gene:29072 denotes HIF-1
T13 145-151 disease:C0006826 denotes cancer
T14 129-134 gene:3091 denotes HIF-1
T15 145-151 disease:C1306459 denotes cancer
T16 217-222 gene:29072 denotes HIF-1
T17 227-240 disease:C0879615 denotes tumor-stromal
T18 217-222 gene:3091 denotes HIF-1
T19 227-240 disease:C0879615 denotes tumor-stromal
R1 T0 T1 associated_with HIF-1,ischemia
R2 T2 T3 associated_with HIF-1,ischemia
R3 T4 T5 associated_with HIF-1,tumor progression
R4 T6 T7 associated_with HIF-1,tumor progression
R5 T8 T9 associated_with HIF-1,cancer
R6 T10 T11 associated_with HIF-1,cancer
R7 T12 T13 associated_with HIF-1,cancer
R8 T14 T15 associated_with HIF-1,cancer
R9 T16 T17 associated_with HIF-1,tumor-stromal
R10 T18 T19 associated_with HIF-1,tumor-stromal

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 145-151 HP_0002664 denotes cancer
T2 170-175 HP_0002664 denotes tumor
T3 227-232 HP_0002664 denotes tumor
T4 273-278 HP_0002664 denotes tumor
T5 420-425 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21364021_2_0 101-127 expanded denotes Hypoxia-inducible factor 1
SS2_21364021_2_0 129-134 abbr denotes HIF-1
SS1_21364021_11_0 1264-1289 expanded denotes dynamic contrast-enhanced
SS2_21364021_11_0 1291-1294 abbr denotes DCE
AE1_21364021_2_0 SS1_21364021_2_0 SS2_21364021_2_0 abbreviatedTo Hypoxia-inducible factor 1,HIF-1
AE1_21364021_11_0 SS1_21364021_11_0 SS2_21364021_11_0 abbreviatedTo dynamic contrast-enhanced,DCE

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21364021-1#28#33#gene3091 129-134 gene3091 denotes HIF-1
21364021-1#28#33#gene29072 129-134 gene29072 denotes HIF-1
21364021-1#69#86#diseaseC0178874 170-187 diseaseC0178874 denotes tumor progression
21364021-2#28#33#gene3091 217-222 gene3091 denotes HIF-1
21364021-2#28#33#gene29072 217-222 gene29072 denotes HIF-1
21364021-2#38#51#diseaseC0879615 227-240 diseaseC0879615 denotes tumor-stromal
28#33#gene309169#86#diseaseC0178874 21364021-1#28#33#gene3091 21364021-1#69#86#diseaseC0178874 associated_with HIF-1,tumor progression
28#33#gene2907269#86#diseaseC0178874 21364021-1#28#33#gene29072 21364021-1#69#86#diseaseC0178874 associated_with HIF-1,tumor progression
28#33#gene309138#51#diseaseC0879615 21364021-2#28#33#gene3091 21364021-2#38#51#diseaseC0879615 associated_with HIF-1,tumor-stromal
28#33#gene2907238#51#diseaseC0879615 21364021-2#28#33#gene29072 21364021-2#38#51#diseaseC0879615 associated_with HIF-1,tumor-stromal

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1559 129-134 gene:3091 denotes HIF-1
T1560 170-187 disease:C0178874 denotes tumor progression
T1561 217-222 gene:3091 denotes HIF-1
T1562 227-240 disease:C0879615 denotes tumor-stromal
R1 T1559 T1560 associated_with HIF-1,tumor progression
R2 T1559 T1560 associated_with HIF-1,tumor progression
R3 T1561 T1562 associated_with HIF-1,tumor-stromal
R4 T1561 T1562 associated_with HIF-1,tumor-stromal