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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling.
T2 141-213 Sentence denotes TGF-β1 is a pleiotropic cytokine with potent anti-inflammation property.
T3 214-310 Sentence denotes However, the mechanisms underlying TGF-β1 suppression of inflammation remain largely unexplored.
T4 311-454 Sentence denotes In this study, we demonstrated that TGF-β1 inhibited TNF-α- or IL-1-induced RANTES expression in human kidney tubular epithelial cells (HKC-8).
T5 455-618 Sentence denotes To delineate the mechanism by which TGF-β1 inhibits RANTES expression, we examined the potential signal pathway activated by TGF-β1 in suppressing NF-κB signaling.
T6 619-766 Sentence denotes TGF-β1 affected neither TNF-α-induced IκBα phosphorylation and subsequent degradation, nor p65 NF-κB phosphorylation and its nuclear translocation.
T7 767-938 Sentence denotes However, TGF-β1 could inhibit p65 and p50 binding to the κB site in human RANTES promoter as revealed by chromatin immunoprecipitation assay and protein-DNA binding assay.
T8 939-1074 Sentence denotes We found that TGF-β1 induced glycogen synthase kinase-3β (GSK-3β) phosphorylation on Ser-9 in HKC-8 cells, leading to its inactivation.
T9 1075-1260 Sentence denotes Knockdown of GSK-3β mimicked TGF-β1 and inhibited RANTES induction, whereas overexpression of GSK-3β abolished the inhibitory effect of TGF-β1 and completely restored RANTES expression.
T10 1261-1376 Sentence denotes Furthermore, TGF-β1 induced the dephosphorylation and activation of β-catenin, a major downstream target of GSK-3β.
T11 1377-1519 Sentence denotes Ectopic expression of constitutively active β-catenin mimicked the TGF-β1 effect and completely suppressed RANTES expression induced by TNF-α.
T12 1520-1739 Sentence denotes Interestingly, TGF-β1 induced a physical interaction between β-catenin and p65 NF-κB, which prevented p65 binding to the κB site, sequestered its trans-activating activity, and repressed p65-mediated gene transcription.
T13 1740-1875 Sentence denotes We conclude that TGF-β1 inhibition of proinflammatory RANTES expression is mediated by β-catenin-triggered blockade of NF-κB signaling.
T1 0-140 Sentence denotes Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling.
T2 141-213 Sentence denotes TGF-β1 is a pleiotropic cytokine with potent anti-inflammation property.
T3 214-310 Sentence denotes However, the mechanisms underlying TGF-β1 suppression of inflammation remain largely unexplored.
T4 311-454 Sentence denotes In this study, we demonstrated that TGF-β1 inhibited TNF-α- or IL-1-induced RANTES expression in human kidney tubular epithelial cells (HKC-8).
T5 455-618 Sentence denotes To delineate the mechanism by which TGF-β1 inhibits RANTES expression, we examined the potential signal pathway activated by TGF-β1 in suppressing NF-κB signaling.
T6 619-766 Sentence denotes TGF-β1 affected neither TNF-α-induced IκBα phosphorylation and subsequent degradation, nor p65 NF-κB phosphorylation and its nuclear translocation.
T7 767-938 Sentence denotes However, TGF-β1 could inhibit p65 and p50 binding to the κB site in human RANTES promoter as revealed by chromatin immunoprecipitation assay and protein-DNA binding assay.
T8 939-1074 Sentence denotes We found that TGF-β1 induced glycogen synthase kinase-3β (GSK-3β) phosphorylation on Ser-9 in HKC-8 cells, leading to its inactivation.
T9 1075-1260 Sentence denotes Knockdown of GSK-3β mimicked TGF-β1 and inhibited RANTES induction, whereas overexpression of GSK-3β abolished the inhibitory effect of TGF-β1 and completely restored RANTES expression.
T10 1261-1376 Sentence denotes Furthermore, TGF-β1 induced the dephosphorylation and activation of β-catenin, a major downstream target of GSK-3β.
T11 1377-1519 Sentence denotes Ectopic expression of constitutively active β-catenin mimicked the TGF-β1 effect and completely suppressed RANTES expression induced by TNF-α.
T12 1520-1739 Sentence denotes Interestingly, TGF-β1 induced a physical interaction between β-catenin and p65 NF-κB, which prevented p65 binding to the κB site, sequestered its trans-activating activity, and repressed p65-mediated gene transcription.
T13 1740-1875 Sentence denotes We conclude that TGF-β1 inhibition of proinflammatory RANTES expression is mediated by β-catenin-triggered blockade of NF-κB signaling.

sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling.
T2 141-213 Sentence denotes TGF-β1 is a pleiotropic cytokine with potent anti-inflammation property.
T3 214-310 Sentence denotes However, the mechanisms underlying TGF-β1 suppression of inflammation remain largely unexplored.
T4 311-454 Sentence denotes In this study, we demonstrated that TGF-β1 inhibited TNF-α- or IL-1-induced RANTES expression in human kidney tubular epithelial cells (HKC-8).
T5 455-618 Sentence denotes To delineate the mechanism by which TGF-β1 inhibits RANTES expression, we examined the potential signal pathway activated by TGF-β1 in suppressing NF-κB signaling.
T6 619-766 Sentence denotes TGF-β1 affected neither TNF-α-induced IκBα phosphorylation and subsequent degradation, nor p65 NF-κB phosphorylation and its nuclear translocation.
T7 767-938 Sentence denotes However, TGF-β1 could inhibit p65 and p50 binding to the κB site in human RANTES promoter as revealed by chromatin immunoprecipitation assay and protein-DNA binding assay.
T8 939-1074 Sentence denotes We found that TGF-β1 induced glycogen synthase kinase-3β (GSK-3β) phosphorylation on Ser-9 in HKC-8 cells, leading to its inactivation.
T9 1075-1260 Sentence denotes Knockdown of GSK-3β mimicked TGF-β1 and inhibited RANTES induction, whereas overexpression of GSK-3β abolished the inhibitory effect of TGF-β1 and completely restored RANTES expression.
T10 1261-1376 Sentence denotes Furthermore, TGF-β1 induced the dephosphorylation and activation of β-catenin, a major downstream target of GSK-3β.
T11 1377-1519 Sentence denotes Ectopic expression of constitutively active β-catenin mimicked the TGF-β1 effect and completely suppressed RANTES expression induced by TNF-α.
T12 1520-1739 Sentence denotes Interestingly, TGF-β1 induced a physical interaction between β-catenin and p65 NF-κB, which prevented p65 binding to the κB site, sequestered its trans-activating activity, and repressed p65-mediated gene transcription.
T13 1740-1875 Sentence denotes We conclude that TGF-β1 inhibition of proinflammatory RANTES expression is mediated by β-catenin-triggered blockade of NF-κB signaling.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 414-420 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 30-36 Gene_or_gene_product denotes RANTES
T2 51-60 Gene_or_gene_product denotes TGF-beta1
T3 76-106 Gene_or_gene_product denotes glycogen synthase kinase-3beta
T4 117-129 Gene_or_gene_product denotes beta-catenin
T5 141-147 Gene_or_gene_product denotes TGF-β1
T6 249-255 Gene_or_gene_product denotes TGF-β1
T7 347-353 Gene_or_gene_product denotes TGF-β1
T8 364-369 Gene_or_gene_product denotes TNF-α
T9 374-378 Gene_or_gene_product denotes IL-1
T10 387-393 Gene_or_gene_product denotes RANTES
T11 491-497 Gene_or_gene_product denotes TGF-β1
T12 507-513 Gene_or_gene_product denotes RANTES
T13 580-586 Gene_or_gene_product denotes TGF-β1
T14 602-607 Complex denotes NF-κB
T15 619-625 Gene_or_gene_product denotes TGF-β1
T16 643-648 Gene_or_gene_product denotes TNF-α
T17 657-661 Gene_or_gene_product denotes IκBα
T18 710-713 Gene_or_gene_product denotes p65
T19 714-719 Complex denotes NF-κB
T20 744-751 Cellular_component denotes nuclear
T21 776-782 Gene_or_gene_product denotes TGF-β1
T22 797-800 Gene_or_gene_product denotes p65
T23 805-808 Gene_or_gene_product denotes p50
T24 824-826 Complex denotes κB
T25 841-847 Gene_or_gene_product denotes RANTES
T26 872-881 Cellular_component denotes chromatin
T27 953-959 Gene_or_gene_product denotes TGF-β1
T28 968-995 Gene_or_gene_product denotes glycogen synthase kinase-3β
T29 997-1003 Gene_or_gene_product denotes GSK-3β
T30 1024-1029 Simple_chemical denotes Ser-9
T31 1088-1094 Gene_or_gene_product denotes GSK-3β
T32 1104-1110 Gene_or_gene_product denotes TGF-β1
T33 1125-1131 Gene_or_gene_product denotes RANTES
T34 1169-1175 Gene_or_gene_product denotes GSK-3β
T35 1211-1217 Gene_or_gene_product denotes TGF-β1
T36 1242-1248 Gene_or_gene_product denotes RANTES
T37 1274-1280 Gene_or_gene_product denotes TGF-β1
T38 1329-1338 Gene_or_gene_product denotes β-catenin
T39 1369-1375 Gene_or_gene_product denotes GSK-3β
T40 1421-1430 Gene_or_gene_product denotes β-catenin
T41 1444-1450 Gene_or_gene_product denotes TGF-β1
T42 1484-1490 Gene_or_gene_product denotes RANTES
T43 1513-1518 Gene_or_gene_product denotes TNF-α
T44 1535-1541 Gene_or_gene_product denotes TGF-β1
T45 1581-1590 Gene_or_gene_product denotes β-catenin
T46 1595-1598 Gene_or_gene_product denotes p65
T47 1599-1604 Complex denotes NF-κB
T48 1622-1625 Gene_or_gene_product denotes p65
T49 1641-1643 Complex denotes κB
T50 1707-1710 Gene_or_gene_product denotes p65
T51 1757-1763 Gene_or_gene_product denotes TGF-β1
T52 1794-1800 Gene_or_gene_product denotes RANTES
T53 1827-1836 Gene_or_gene_product denotes β-catenin
T54 1859-1864 Complex denotes NF-κB

Allie

Id Subject Object Predicate Lexical cue
SS1_21189258_7_0 968-995 expanded denotes glycogen synthase kinase-3β
SS2_21189258_7_0 997-1003 abbr denotes GSK-3β
AE1_21189258_7_0 SS1_21189258_7_0 SS2_21189258_7_0 abbreviatedTo glycogen synthase kinase-3β,GSK-3β

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 191-203 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 271-283 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 408-413 OrganismTaxon denotes human 9606
T2 835-840 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 414-420 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 429-445 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 414-420 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 429-445 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066