PubMed:2116362 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":8,"end":52},"obj":"protein"},{"id":"T2","span":{"begin":118,"end":154},"obj":"protein"},{"id":"T3","span":{"begin":156,"end":160},"obj":"protein"},{"id":"T4","span":{"begin":182,"end":199},"obj":"protein"},{"id":"T5","span":{"begin":207,"end":225},"obj":"protein"},{"id":"T6","span":{"begin":226,"end":230},"obj":"protein"},{"id":"T7","span":{"begin":257,"end":266},"obj":"DNA"},{"id":"T8","span":{"begin":275,"end":325},"obj":"DNA"},{"id":"T9","span":{"begin":410,"end":427},"obj":"protein"},{"id":"T10","span":{"begin":428,"end":432},"obj":"protein"},{"id":"T11","span":{"begin":453,"end":477},"obj":"DNA"},{"id":"T12","span":{"begin":513,"end":517},"obj":"protein"},{"id":"T13","span":{"begin":573,"end":577},"obj":"protein"},{"id":"T14","span":{"begin":794,"end":832},"obj":"cell_type"},{"id":"T15","span":{"begin":844,"end":848},"obj":"protein"},{"id":"T16","span":{"begin":862,"end":898},"obj":"protein"},{"id":"T17","span":{"begin":905,"end":914},"obj":"DNA"},{"id":"T18","span":{"begin":925,"end":949},"obj":"DNA"},{"id":"T19","span":{"begin":986,"end":1005},"obj":"cell_line"},{"id":"T20","span":{"begin":1012,"end":1037},"obj":"DNA"},{"id":"T21","span":{"begin":1082,"end":1108},"obj":"DNA"},{"id":"T22","span":{"begin":1113,"end":1117},"obj":"protein"},{"id":"T23","span":{"begin":1127,"end":1145},"obj":"DNA"},{"id":"T24","span":{"begin":1149,"end":1213},"obj":"DNA"},{"id":"T25","span":{"begin":1231,"end":1235},"obj":"protein"},{"id":"T26","span":{"begin":1273,"end":1298},"obj":"DNA"}],"text":"A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.\nA novel B-cell-specific transcription factor, BSAP, was identified as a mammalian homolog of the sea urchin protein TSAP, which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes. As shown by mobility-shift, methylation interference, and mutational analyses, the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP; however, the two proteins differ in molecular weight. BSAP is exclusively restricted to the B-cell lineage of lymphoid differentiation. Its expression appears to be activated during pro-B-cell development, is abundant at the pre-B- and mature B-cell stages, but is absent in terminally differentiated plasma cells. Moreover, BSAP is clearly a B-cell-specific transcription factor, as a wild-type but not a mutant TSAP-binding site of the sea urchin functions only in transfected B cells as an upstream promoter element. Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes, suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"S2","span":{"begin":110,"end":326},"obj":"Sentence"},{"id":"S3","span":{"begin":327,"end":572},"obj":"Sentence"},{"id":"S4","span":{"begin":573,"end":654},"obj":"Sentence"},{"id":"S5","span":{"begin":655,"end":833},"obj":"Sentence"},{"id":"S6","span":{"begin":834,"end":1038},"obj":"Sentence"},{"id":"S7","span":{"begin":1039,"end":1299},"obj":"Sentence"}],"text":"A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.\nA novel B-cell-specific transcription factor, BSAP, was identified as a mammalian homolog of the sea urchin protein TSAP, which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes. As shown by mobility-shift, methylation interference, and mutational analyses, the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP; however, the two proteins differ in molecular weight. BSAP is exclusively restricted to the B-cell lineage of lymphoid differentiation. Its expression appears to be activated during pro-B-cell development, is abundant at the pre-B- and mature B-cell stages, but is absent in terminally differentiated plasma cells. Moreover, BSAP is clearly a B-cell-specific transcription factor, as a wild-type but not a mutant TSAP-binding site of the sea urchin functions only in transfected B cells as an upstream promoter element. Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes, suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":52},"obj":"NP"},{"id":"C2","span":{"begin":110,"end":154},"obj":"NP"},{"id":"C3","span":{"begin":156,"end":160},"obj":"NP"},{"id":"C4","span":{"begin":203,"end":230},"obj":"NP"},{"id":"C5","span":{"begin":232,"end":237},"obj":"NP"},{"id":"C6","span":{"begin":406,"end":432},"obj":"NP"},{"id":"C7","span":{"begin":513,"end":517},"obj":"NP"},{"id":"C8","span":{"begin":573,"end":577},"obj":"NP"},{"id":"C9","span":{"begin":655,"end":658},"obj":"NP"},{"id":"C10","span":{"begin":844,"end":848},"obj":"NP"},{"id":"C11","span":{"begin":1113,"end":1117},"obj":"NP"},{"id":"C12","span":{"begin":1231,"end":1235},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-appos","subj":"C3","obj":"C2"},{"id":"R3","pred":"coref-relat","subj":"C5","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C6","obj":"C2"},{"id":"R5","pred":"coref-ident","subj":"C7","obj":"C4"},{"id":"R6","pred":"coref-ident","subj":"C8","obj":"C6"},{"id":"R7","pred":"coref-pron","subj":"C9","obj":"C8"},{"id":"R8","pred":"coref-ident","subj":"C10","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R10","pred":"coref-ident","subj":"C12","obj":"C11"}],"text":"A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.\nA novel B-cell-specific transcription factor, BSAP, was identified as a mammalian homolog of the sea urchin protein TSAP, which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes. As shown by mobility-shift, methylation interference, and mutational analyses, the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP; however, the two proteins differ in molecular weight. BSAP is exclusively restricted to the B-cell lineage of lymphoid differentiation. Its expression appears to be activated during pro-B-cell development, is abundant at the pre-B- and mature B-cell stages, but is absent in terminally differentiated plasma cells. Moreover, BSAP is clearly a B-cell-specific transcription factor, as a wild-type but not a mutant TSAP-binding site of the sea urchin functions only in transfected B cells as an upstream promoter element. Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes, suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":8,"end":52},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":118,"end":154},"obj":"protein_family_or_group"},{"id":"T3","span":{"begin":156,"end":160},"obj":"protein_molecule"},{"id":"T4","span":{"begin":182,"end":199},"obj":"protein_family_or_group"},{"id":"T5","span":{"begin":207,"end":225},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":226,"end":230},"obj":"protein_molecule"},{"id":"T7","span":{"begin":257,"end":266},"obj":"DNA_domain_or_region"},{"id":"T8","span":{"begin":339,"end":353},"obj":"other_name"},{"id":"T9","span":{"begin":355,"end":379},"obj":"other_name"},{"id":"T10","span":{"begin":385,"end":404},"obj":"other_name"},{"id":"T11","span":{"begin":410,"end":427},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":428,"end":432},"obj":"protein_molecule"},{"id":"T13","span":{"begin":453,"end":477},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":513,"end":517},"obj":"protein_molecule"},{"id":"T15","span":{"begin":573,"end":577},"obj":"protein_molecule"},{"id":"T16","span":{"begin":629,"end":653},"obj":"other_name"},{"id":"T17","span":{"begin":659,"end":669},"obj":"other_name"},{"id":"T18","span":{"begin":701,"end":723},"obj":"other_name"},{"id":"T19","span":{"begin":794,"end":832},"obj":"cell_type"},{"id":"T20","span":{"begin":844,"end":848},"obj":"protein_molecule"},{"id":"T21","span":{"begin":862,"end":898},"obj":"protein_family_or_group"},{"id":"T22","span":{"begin":905,"end":914},"obj":"DNA_domain_or_region"},{"id":"T23","span":{"begin":925,"end":931},"obj":"DNA_domain_or_region"},{"id":"T24","span":{"begin":932,"end":936},"obj":"protein_molecule"},{"id":"T25","span":{"begin":957,"end":967},"obj":"multi_cell"},{"id":"T26","span":{"begin":986,"end":1005},"obj":"cell_line"},{"id":"T27","span":{"begin":1012,"end":1037},"obj":"DNA_domain_or_region"},{"id":"T28","span":{"begin":1082,"end":1108},"obj":"DNA_domain_or_region"},{"id":"T29","span":{"begin":1113,"end":1117},"obj":"protein_molecule"},{"id":"T30","span":{"begin":1127,"end":1145},"obj":"DNA_domain_or_region"},{"id":"T31","span":{"begin":1231,"end":1235},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1273,"end":1298},"obj":"DNA_domain_or_region"}],"text":"A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.\nA novel B-cell-specific transcription factor, BSAP, was identified as a mammalian homolog of the sea urchin protein TSAP, which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes. As shown by mobility-shift, methylation interference, and mutational analyses, the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP; however, the two proteins differ in molecular weight. BSAP is exclusively restricted to the B-cell lineage of lymphoid differentiation. Its expression appears to be activated during pro-B-cell development, is abundant at the pre-B- and mature B-cell stages, but is absent in terminally differentiated plasma cells. Moreover, BSAP is clearly a B-cell-specific transcription factor, as a wild-type but not a mutant TSAP-binding site of the sea urchin functions only in transfected B cells as an upstream promoter element. Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes, suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes."}