PubMed:20978009
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-108 | Sentence | denotes | Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. |
| TextSentencer_T2 | 109-218 | Sentence | denotes | Sulfation represents an essential modification for various molecules and regulates many biological processes. |
| TextSentencer_T3 | 219-348 | Sentence | denotes | The sulfation of glycans requires a specific transporter for 3'-phosphoadenosine 5'-phosphosulfate (PAPS) on the Golgi apparatus. |
| TextSentencer_T4 | 349-539 | Sentence | denotes | This study investigated the expression of PAPS transporter genes in colorectal carcinomas and the significance of Golgi-specific sulfation in the proliferation of colorectal carcinoma cells. |
| TextSentencer_T5 | 540-658 | Sentence | denotes | The relative amount of PAPST1 transcripts was found to be higher than those of PAPST2 in colorectal cancerous tissues. |
| TextSentencer_T6 | 659-857 | Sentence | denotes | Immunohistochemically, the enhanced expression of PAPST1 was observed in fibroblasts in the vicinity of invasive cancer cells, whereas the expression of PAPST2 was decreased in the epithelial cells. |
| TextSentencer_T7 | 858-1041 | Sentence | denotes | RNA interference of either of the two PAPS transporter genes reduced the extent of sulfation of cellular proteins and cellular proliferation of DLD-1 human colorectal carcinoma cells. |
| TextSentencer_T8 | 1042-1137 | Sentence | denotes | Silencing the PAPS transporter genes reduced fibroblast growth factor signaling in DLD-1 cells. |
| TextSentencer_T9 | 1138-1363 | Sentence | denotes | These findings indicate that PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status. |
| T1 | 0-108 | Sentence | denotes | Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. |
| T2 | 109-218 | Sentence | denotes | Sulfation represents an essential modification for various molecules and regulates many biological processes. |
| T3 | 219-348 | Sentence | denotes | The sulfation of glycans requires a specific transporter for 3'-phosphoadenosine 5'-phosphosulfate (PAPS) on the Golgi apparatus. |
| T4 | 349-539 | Sentence | denotes | This study investigated the expression of PAPS transporter genes in colorectal carcinomas and the significance of Golgi-specific sulfation in the proliferation of colorectal carcinoma cells. |
| T5 | 540-658 | Sentence | denotes | The relative amount of PAPST1 transcripts was found to be higher than those of PAPST2 in colorectal cancerous tissues. |
| T6 | 659-857 | Sentence | denotes | Immunohistochemically, the enhanced expression of PAPST1 was observed in fibroblasts in the vicinity of invasive cancer cells, whereas the expression of PAPST2 was decreased in the epithelial cells. |
| T7 | 858-1041 | Sentence | denotes | RNA interference of either of the two PAPS transporter genes reduced the extent of sulfation of cellular proteins and cellular proliferation of DLD-1 human colorectal carcinoma cells. |
| T8 | 1042-1137 | Sentence | denotes | Silencing the PAPS transporter genes reduced fibroblast growth factor signaling in DLD-1 cells. |
| T9 | 1138-1363 | Sentence | denotes | These findings indicate that PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status. |
| T1 | 0-108 | Sentence | denotes | Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. |
| T2 | 109-218 | Sentence | denotes | Sulfation represents an essential modification for various molecules and regulates many biological processes. |
| T3 | 219-348 | Sentence | denotes | The sulfation of glycans requires a specific transporter for 3'-phosphoadenosine 5'-phosphosulfate (PAPS) on the Golgi apparatus. |
| T4 | 349-539 | Sentence | denotes | This study investigated the expression of PAPS transporter genes in colorectal carcinomas and the significance of Golgi-specific sulfation in the proliferation of colorectal carcinoma cells. |
| T5 | 540-658 | Sentence | denotes | The relative amount of PAPST1 transcripts was found to be higher than those of PAPST2 in colorectal cancerous tissues. |
| T6 | 659-857 | Sentence | denotes | Immunohistochemically, the enhanced expression of PAPST1 was observed in fibroblasts in the vicinity of invasive cancer cells, whereas the expression of PAPST2 was decreased in the epithelial cells. |
| T7 | 858-1041 | Sentence | denotes | RNA interference of either of the two PAPS transporter genes reduced the extent of sulfation of cellular proteins and cellular proliferation of DLD-1 human colorectal carcinoma cells. |
| T8 | 1042-1137 | Sentence | denotes | Silencing the PAPS transporter genes reduced fibroblast growth factor signaling in DLD-1 cells. |
| T9 | 1138-1363 | Sentence | denotes | These findings indicate that PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 709-715 | gene:347734 | denotes | PAPST1 |
| T1 | 763-778 | disease:C0677898 | denotes | invasive cancer |
| T2 | 1002-1005 | gene:60343 | denotes | DLD |
| T3 | 1014-1034 | disease:C0009402 | denotes | colorectal carcinoma |
| T4 | 1002-1005 | gene:197257 | denotes | DLD |
| T5 | 1014-1034 | disease:C0009402 | denotes | colorectal carcinoma |
| T6 | 1002-1005 | gene:1738 | denotes | DLD |
| T7 | 1014-1034 | disease:C0009402 | denotes | colorectal carcinoma |
| R1 | T0 | T1 | associated_with | PAPST1,invasive cancer |
| R2 | T2 | T3 | associated_with | DLD,colorectal carcinoma |
| R3 | T4 | T5 | associated_with | DLD,colorectal carcinoma |
| R4 | T6 | T7 | associated_with | DLD,colorectal carcinoma |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 640-649 | HP_0002664 | denotes | cancerous |
| T2 | 772-778 | HP_0002664 | denotes | cancer |
| T3 | 1311-1317 | HP_0002664 | denotes | cancer |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 332-347 | FMAID:162311 | denotes | Golgi apparatus |
| _T2 | 408-413 | FMAID:198663 | denotes | genes |
| _T3 | 533-538 | FMAID:68646 | denotes | cells |
| _T4 | 533-538 | FMAID:169002 | denotes | cells |
| _T5 | 650-657 | FMAID:256050 | denotes | tissues |
| _T6 | 732-743 | FMAID:63877 | denotes | fibroblasts |
| _T7 | 732-743 | FMAID:162340 | denotes | fibroblasts |
| _T8 | 779-784 | FMAID:169002 | denotes | cells |
| _T9 | 779-784 | FMAID:68646 | denotes | cells |
| _T10 | 840-856 | FMAID:69074 | denotes | epithelial cells |
| _T11 | 840-856 | FMAID:165528 | denotes | epithelial cells |
| _T12 | 840-856 | FMAID:165731 | denotes | epithelial cells |
| _T13 | 840-856 | FMAID:67559 | denotes | epithelial cells |
| _T14 | 840-856 | FMAID:169652 | denotes | epithelial cells |
| _T15 | 840-856 | FMAID:169653 | denotes | epithelial cells |
| _T16 | 840-856 | FMAID:69075 | denotes | epithelial cells |
| _T17 | 840-856 | FMAID:164922 | denotes | epithelial cells |
| _T18 | 840-856 | FMAID:67799 | denotes | epithelial cells |
| _T19 | 840-856 | FMAID:83514 | denotes | epithelial cells |
| _T20 | 840-856 | FMAID:197786 | denotes | epithelial cells |
| _T21 | 840-856 | FMAID:66768 | denotes | epithelial cells |
| _T22 | 851-856 | FMAID:68646 | denotes | cells |
| _T23 | 851-856 | FMAID:169002 | denotes | cells |
| _T24 | 913-918 | FMAID:198663 | denotes | genes |
| _T25 | 963-971 | FMAID:165447 | denotes | proteins |
| _T26 | 963-971 | FMAID:67257 | denotes | proteins |
| _T27 | 1035-1040 | FMAID:169002 | denotes | cells |
| _T28 | 1035-1040 | FMAID:68646 | denotes | cells |
| _T29 | 1073-1078 | FMAID:198663 | denotes | genes |
| _T30 | 1087-1097 | FMAID:162340 | denotes | fibroblast |
| _T31 | 1087-1097 | FMAID:63877 | denotes | fibroblast |
| _T32 | 1131-1136 | FMAID:68646 | denotes | cells |
| _T33 | 1131-1136 | FMAID:169002 | denotes | cells |
| _T34 | 1242-1247 | FMAID:68646 | denotes | cells |
| _T35 | 1242-1247 | FMAID:169002 | denotes | cells |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 563-569 | http://www.uniprot.org/uniprot/Q7Z2G3 | denotes | PAPST1 |
| T2 | 709-715 | http://www.uniprot.org/uniprot/Q7Z2G3 | denotes | PAPST1 |
| T3 | 619-625 | http://www.uniprot.org/uniprot/Q9H1N7 | denotes | PAPST2 |
| T4 | 812-818 | http://www.uniprot.org/uniprot/Q9H1N7 | denotes | PAPST2 |
| T5 | 1002-1005 | http://www.uniprot.org/uniprot/Q86WU2 | denotes | DLD |
| T6 | 1125-1128 | http://www.uniprot.org/uniprot/Q86WU2 | denotes | DLD |
| T7 | 1002-1005 | http://www.uniprot.org/uniprot/P09622 | denotes | DLD |
| T8 | 1125-1128 | http://www.uniprot.org/uniprot/P09622 | denotes | DLD |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1002-1005 | http://www.uniprot.org/uniprot/Q7TNG8 | denotes | DLD |
| T2 | 1125-1128 | http://www.uniprot.org/uniprot/Q7TNG8 | denotes | DLD |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 98-107 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T2 | 192-196 | http://purl.bioontology.org/ontology/NCBITAXON/9973 | denotes | many |
| T3 | 428-438 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
| T4 | 523-532 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T5 | 533-538 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T6 | 640-649 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancerous |
| T7 | 650-657 | http://purl.bioontology.org/ontology/STY/T024 | denotes | tissues |
| T8 | 772-778 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T9 | 779-784 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T10 | 851-856 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T11 | 1025-1034 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T12 | 1035-1040 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T13 | 1131-1136 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T14 | 1144-1152 | http://purl.bioontology.org/ontology/STY/T033 | denotes | findings |
| T15 | 1232-1241 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T16 | 1242-1247 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T17 | 1311-1317 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 65-77 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporters |
| T2 | 264-275 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
| T3 | 396-407 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
| T4 | 901-912 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
| T5 | 1061-1072 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
| T6 | 109-118 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | Sulfation |
| T7 | 223-232 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfation |
| T8 | 478-487 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfation |
| T9 | 941-950 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfation |
| T10 | 1346-1355 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfation |
| T11 | 182-191 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulates |
| T12 | 319-323 | http://purl.obolibrary.org/obo/GO_0043751 | denotes | PAPS |
| T13 | 391-395 | http://purl.obolibrary.org/obo/GO_0043751 | denotes | PAPS |
| T14 | 896-900 | http://purl.obolibrary.org/obo/GO_0043751 | denotes | PAPS |
| T15 | 1056-1060 | http://purl.obolibrary.org/obo/GO_0043751 | denotes | PAPS |
| T16 | 1167-1171 | http://purl.obolibrary.org/obo/GO_0043751 | denotes | PAPS |
| T17 | 391-407 | http://purl.obolibrary.org/obo/GO_0046963 | denotes | PAPS transporter |
| T18 | 896-912 | http://purl.obolibrary.org/obo/GO_0046963 | denotes | PAPS transporter |
| T19 | 1056-1072 | http://purl.obolibrary.org/obo/GO_0046963 | denotes | PAPS transporter |
| T20 | 1167-1184 | http://purl.obolibrary.org/obo/GO_0046963 | denotes | PAPS transporters |
| T21 | 570-581 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcripts |
| T22 | 858-874 | http://purl.obolibrary.org/obo/GO_0016246 | denotes | RNA interference |
| T23 | 954-962 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T24 | 976-984 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T25 | 1098-1104 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T26 | 1318-1324 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T27 | 1112-1121 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 332-337 | http://purl.obolibrary.org/obo/GO_0005794 | denotes | Golgi |
| T2 | 463-468 | http://purl.obolibrary.org/obo/GO_0005794 | denotes | Golgi |
| T3 | 332-347 | http://purl.obolibrary.org/obo/GO_0005794 | denotes | Golgi apparatus |
| T4 | 533-538 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T5 | 779-784 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T6 | 851-856 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 1035-1040 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 1131-1136 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T9 | 1242-1247 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 650-657 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20978009_2_0 | 280-317 | expanded | denotes | 3'-phosphoadenosine 5'-phosphosulfate |
| SS2_20978009_2_0 | 319-323 | abbr | denotes | PAPS |
| AE1_20978009_2_0 | SS1_20978009_2_0 | SS2_20978009_2_0 | abbreviatedTo | 3'-phosphoadenosine 5'-phosphosulfate,PAPS |
EDAM-topics
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 81-86 | http://edamontology.org/topic_2815 | denotes | human |
| T2 | 168-177 | http://edamontology.org/topic_2839 | denotes | molecules |
| T3 | 332-347 | http://edamontology.org/topic_0616 | denotes | Golgi apparatus |
| T4 | 354-359 | http://edamontology.org/topic_3678 | denotes | study |
| T5 | 570-581 | http://edamontology.org/topic_0110 | denotes | transcripts |
| T6 | 570-581 | http://edamontology.org/topic_0203 | denotes | transcripts |
| T7 | 570-581 | http://edamontology.org/topic_3308 | denotes | transcripts |
| T8 | 570-581 | http://edamontology.org/topic_3512 | denotes | transcripts |
| T9 | 640-649 | http://edamontology.org/topic_2640 | denotes | cancerous |
| T10 | 772-778 | http://edamontology.org/topic_2640 | denotes | cancer |
| T11 | 963-971 | http://edamontology.org/topic_0078 | denotes | proteins |
| T12 | 1008-1013 | http://edamontology.org/topic_2815 | denotes | human |
| T13 | 1311-1317 | http://edamontology.org/topic_2640 | denotes | cancer |
EDAM-DFO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 208-217 | http://edamontology.org/operation_2409 | denotes | processes |
| T2 | 208-217 | http://edamontology.org/operation_0004 | denotes | processes |
| T3 | 963-971 | http://edamontology.org/format_1208 | denotes | proteins |
| T4 | 963-971 | http://edamontology.org/data_1467 | denotes | proteins |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 20978009-5#50#56#gene347734 | 709-715 | gene347734 | denotes | PAPST1 |
| 20978009-5#153#159#gene51000 | 812-818 | gene51000 | denotes | PAPST2 |
| 20978009-5#104#119#diseaseC0677898 | 763-778 | diseaseC0677898 | denotes | invasive cancer |
| 20978009-6#144#147#gene1738 | 1002-1005 | gene1738 | denotes | DLD |
| 20978009-6#156#176#diseaseC0009402 | 1014-1034 | diseaseC0009402 | denotes | colorectal carcinoma |
| 50#56#gene347734104#119#diseaseC0677898 | 20978009-5#50#56#gene347734 | 20978009-5#104#119#diseaseC0677898 | associated_with | PAPST1,invasive cancer |
| 153#159#gene51000104#119#diseaseC0677898 | 20978009-5#153#159#gene51000 | 20978009-5#104#119#diseaseC0677898 | associated_with | PAPST2,invasive cancer |
| 144#147#gene1738156#176#diseaseC0009402 | 20978009-6#144#147#gene1738 | 20978009-6#156#176#diseaseC0009402 | associated_with | DLD,colorectal carcinoma |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 650-657 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 87-107 | Disease | denotes | colorectal carcinoma | http://purl.obolibrary.org/obo/MONDO_0024331 |
| T2 | 417-438 | Disease | denotes | colorectal carcinomas | http://purl.obolibrary.org/obo/MONDO_0024331 |
| T3 | 512-532 | Disease | denotes | colorectal carcinoma | http://purl.obolibrary.org/obo/MONDO_0024331 |
| T4 | 629-649 | Disease | denotes | colorectal cancerous | http://purl.obolibrary.org/obo/MONDO_0005575 |
| T5 | 772-778 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T6 | 1014-1034 | Disease | denotes | colorectal carcinoma | http://purl.obolibrary.org/obo/MONDO_0024331 |
| T7 | 1221-1241 | Disease | denotes | colorectal carcinoma | http://purl.obolibrary.org/obo/MONDO_0024331 |
| T8 | 1311-1317 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 81-86 | OrganismTaxon | denotes | human | 9606 |
| T2 | 1008-1013 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 332-347 | Body_part | denotes | Golgi apparatus | http://purl.obolibrary.org/obo/GO_0005794 |
| T2 | 463-468 | Body_part | denotes | Golgi | http://purl.obolibrary.org/obo/GO_0005794 |
| T3 | 732-743 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T4 | 840-856 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T5 | 1087-1097 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 98-107 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 428-438 | Phenotype | denotes | carcinomas | HP:0030731 |
| T3 | 523-532 | Phenotype | denotes | carcinoma | HP:0030731 |
| T4 | 629-649 | Phenotype | denotes | colorectal cancerous | HP:0003003 |
| T5 | 772-778 | Phenotype | denotes | cancer | HP:0002664 |
| T6 | 1025-1034 | Phenotype | denotes | carcinoma | HP:0030731 |
| T7 | 1232-1241 | Phenotype | denotes | carcinoma | HP:0030731 |
| T8 | 1311-1317 | Phenotype | denotes | cancer | HP:0002664 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 732-743 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T2 | 772-784 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 840-856 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T4 | 1087-1097 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |