PubMed:20829364
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 31-39 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T3 | 460-468 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T5 | 591-599 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T7 | 806-814 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T9 | 967-975 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T11 | 1135-1143 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T13 | 1591-1599 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 31-39 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 460-468 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 591-599 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 806-814 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 967-975 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 1135-1143 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1591-1599 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-39 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T2 | 31-39 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T3 | 460-468 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T4 | 460-468 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T5 | 591-599 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T6 | 591-599 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T7 | 806-814 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T8 | 806-814 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T9 | 967-975 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T10 | 967-975 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T11 | 1135-1143 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T12 | 1135-1143 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T13 | 1591-1599 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T14 | 1591-1599 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-121 | Sentence | denotes | Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. |
| T2 | 122-337 | Sentence | denotes | Protein-protein interactions and/or signaling activities at focal adhesions, where integrin-mediated adhesion to extracellular matrix occurs, are critical for the regulation of adhesion-dependent cellular functions. |
| T3 | 338-559 | Sentence | denotes | Although the phosphorylation and activities of focal adhesion molecules have been intensively studied, the effects of the O-GlcNAc modification of their Ser/Thr residues on cellular functions have been largely unexplored. |
| T4 | 560-717 | Sentence | denotes | We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment. |
| T5 | 718-911 | Sentence | denotes | We found that paxillin, a key adaptor molecule in focal adhesions, could be modified by O-GlcNAc in INS-1 cells treated with GlcN and in pancreatic islets from mice treated with streptozotocin. |
| T6 | 912-1059 | Sentence | denotes | Ser-84/85 in human paxillin appeared to be modified by O-GlcNAc, which was inversely correlated to Ser-85 phosphorylation (Ser-83 in rat paxillin). |
| T7 | 1060-1169 | Sentence | denotes | Integrin-mediated adhesion signaling inhibited the GlcN treatment-enhanced O-GlcNAc modification of paxillin. |
| T8 | 1170-1326 | Sentence | denotes | Adherent INS-1 cells treated with GlcN showed restricted protrusions, whereas untreated cells showed active protrusions for multiple-elongated morphologies. |
| T9 | 1327-1447 | Sentence | denotes | Upon GlcN treatment, expression of a triple mutation (S83A/S84A/S85A) resulted in no further restriction of protrusions. |
| T10 | 1448-1689 | Sentence | denotes | Together these observations suggest that murine pancreatic β cells may have restricted actin organization upon GlcN treatment by virtue of the O-GlcNAc modification of paxillin, which can be antagonized by a persistent cell adhesion process. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 855-872 | http://purl.obolibrary.org/obo/MAT_0000076 | denotes | pancreatic islets |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 56-64 | gene:5829 | denotes | paxillin |
| T1 | 98-108 | disease:C0021670 | denotes | insulinoma |
| R1 | T0 | T1 | associated_with | paxillin,insulinoma |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 659-669 | HP_0012197 | denotes | insulinoma |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20829364_3_0 | 688-699 | expanded | denotes | glucosamine |
| SS2_20829364_3_0 | 701-705 | abbr | denotes | GlcN |
| AE1_20829364_3_0 | SS1_20829364_3_0 | SS2_20829364_3_0 | abbreviatedTo | glucosamine,GlcN |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 20829364-0#56#64#gene5829 | 56-64 | gene5829 | denotes | paxillin |
| 20829364-0#94#108#diseaseC4054121 | 94-108 | diseaseC4054121 | denotes | rat insulinoma |
| 20829364-9#168#176#gene5829 | 1616-1624 | gene5829 | denotes | paxillin |
| 20829364-9#208#218#diseaseC0332996 | 1656-1666 | diseaseC0332996 | denotes | persistent |
| 56#64#gene582994#108#diseaseC4054121 | 20829364-0#56#64#gene5829 | 20829364-0#94#108#diseaseC4054121 | associated_with | paxillin,rat insulinoma |
| 168#176#gene5829208#218#diseaseC0332996 | 20829364-9#168#176#gene5829 | 20829364-9#208#218#diseaseC0332996 | associated_with | paxillin,persistent |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 33-39 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 462-468 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 593-599 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T4 | 808-814 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 969-975 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T6 | 1137-1143 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T7 | 1593-1599 | chem:24139 | denotes | GlcNAc |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 855-872 | Body_part | denotes | pancreatic islets | http://purl.obolibrary.org/obo/MAT_0000076 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 98-108 | Disease | denotes | insulinoma | http://purl.obolibrary.org/obo/MONDO_0024677 |
| T2 | 659-669 | Disease | denotes | insulinoma | http://purl.obolibrary.org/obo/MONDO_0024677 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 31-39 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 460-468 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 591-599 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 806-814 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T5 | 967-975 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T6 | 1135-1143 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T7 | 1591-1599 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 31-39 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 460-468 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 591-599 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 806-814 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 967-975 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 1135-1143 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1591-1599 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 98-108 | Phenotype | denotes | insulinoma | HP:0012197 |
| T2 | 659-669 | Phenotype | denotes | insulinoma | HP:0012197 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 98-108 | Disease | denotes | insulinoma | http://purl.obolibrary.org/obo/MONDO_0024677 |
| T2 | 659-669 | Disease | denotes | insulinoma | http://purl.obolibrary.org/obo/MONDO_0024677 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 94-97 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 655-658 | OrganismTaxon | denotes | rat | 10114|10116 |
| T5 | 878-882 | OrganismTaxon | denotes | mice | 10088 |
| T6 | 925-930 | OrganismTaxon | denotes | human | 9606 |
| T7 | 1045-1048 | OrganismTaxon | denotes | rat | 10114|10116 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 235-255 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T2 | 855-872 | Body_part | denotes | pancreatic islets | http://purl.obolibrary.org/obo/UBERON_0000006 |
| T3 | 1227-1238 | Body_part | denotes | protrusions | http://purl.obolibrary.org/obo/UBERON_0004529 |
| T4 | 1278-1289 | Body_part | denotes | protrusions | http://purl.obolibrary.org/obo/UBERON_0004529 |
| T5 | 1435-1446 | Body_part | denotes | protrusions | http://purl.obolibrary.org/obo/UBERON_0004529 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 855-872 | Body_part | denotes | pancreatic islets | http://purl.obolibrary.org/obo/MAT_0000076 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-121 | Sentence | denotes | Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. |
| T2 | 122-337 | Sentence | denotes | Protein-protein interactions and/or signaling activities at focal adhesions, where integrin-mediated adhesion to extracellular matrix occurs, are critical for the regulation of adhesion-dependent cellular functions. |
| T3 | 338-559 | Sentence | denotes | Although the phosphorylation and activities of focal adhesion molecules have been intensively studied, the effects of the O-GlcNAc modification of their Ser/Thr residues on cellular functions have been largely unexplored. |
| T4 | 560-717 | Sentence | denotes | We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment. |
| T5 | 718-911 | Sentence | denotes | We found that paxillin, a key adaptor molecule in focal adhesions, could be modified by O-GlcNAc in INS-1 cells treated with GlcN and in pancreatic islets from mice treated with streptozotocin. |
| T6 | 912-1059 | Sentence | denotes | Ser-84/85 in human paxillin appeared to be modified by O-GlcNAc, which was inversely correlated to Ser-85 phosphorylation (Ser-83 in rat paxillin). |
| T7 | 1060-1169 | Sentence | denotes | Integrin-mediated adhesion signaling inhibited the GlcN treatment-enhanced O-GlcNAc modification of paxillin. |
| T8 | 1170-1326 | Sentence | denotes | Adherent INS-1 cells treated with GlcN showed restricted protrusions, whereas untreated cells showed active protrusions for multiple-elongated morphologies. |
| T9 | 1327-1447 | Sentence | denotes | Upon GlcN treatment, expression of a triple mutation (S83A/S84A/S85A) resulted in no further restriction of protrusions. |
| T10 | 1448-1689 | Sentence | denotes | Together these observations suggest that murine pancreatic β cells may have restricted actin organization upon GlcN treatment by virtue of the O-GlcNAc modification of paxillin, which can be antagonized by a persistent cell adhesion process. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-121 | Sentence | denotes | Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. |
| T2 | 122-337 | Sentence | denotes | Protein-protein interactions and/or signaling activities at focal adhesions, where integrin-mediated adhesion to extracellular matrix occurs, are critical for the regulation of adhesion-dependent cellular functions. |
| T3 | 338-559 | Sentence | denotes | Although the phosphorylation and activities of focal adhesion molecules have been intensively studied, the effects of the O-GlcNAc modification of their Ser/Thr residues on cellular functions have been largely unexplored. |
| T4 | 560-717 | Sentence | denotes | We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment. |
| T5 | 718-911 | Sentence | denotes | We found that paxillin, a key adaptor molecule in focal adhesions, could be modified by O-GlcNAc in INS-1 cells treated with GlcN and in pancreatic islets from mice treated with streptozotocin. |
| T6 | 912-1059 | Sentence | denotes | Ser-84/85 in human paxillin appeared to be modified by O-GlcNAc, which was inversely correlated to Ser-85 phosphorylation (Ser-83 in rat paxillin). |
| T7 | 1060-1169 | Sentence | denotes | Integrin-mediated adhesion signaling inhibited the GlcN treatment-enhanced O-GlcNAc modification of paxillin. |
| T8 | 1170-1326 | Sentence | denotes | Adherent INS-1 cells treated with GlcN showed restricted protrusions, whereas untreated cells showed active protrusions for multiple-elongated morphologies. |
| T9 | 1327-1447 | Sentence | denotes | Upon GlcN treatment, expression of a triple mutation (S83A/S84A/S85A) resulted in no further restriction of protrusions. |
| T10 | 1448-1689 | Sentence | denotes | Together these observations suggest that murine pancreatic β cells may have restricted actin organization upon GlcN treatment by virtue of the O-GlcNAc modification of paxillin, which can be antagonized by a persistent cell adhesion process. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 31-39 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 460-468 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 591-599 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 806-814 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T5 | 967-975 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T6 | 1135-1143 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T7 | 1591-1599 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 31-39 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 460-468 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 591-599 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 806-814 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 967-975 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 1135-1143 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1591-1599 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 94-97 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 655-658 | OrganismTaxon | denotes | rat | 10114|10116 |
| T5 | 878-882 | OrganismTaxon | denotes | mice | 10088 |
| T6 | 925-930 | OrganismTaxon | denotes | human | 9606 |
| T7 | 1045-1048 | OrganismTaxon | denotes | rat | 10114|10116 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 235-255 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T2 | 855-872 | Body_part | denotes | pancreatic islets | http://purl.obolibrary.org/obo/UBERON_0000006 |
| T3 | 1227-1238 | Body_part | denotes | protrusions | http://purl.obolibrary.org/obo/UBERON_0004529 |
| T4 | 1278-1289 | Body_part | denotes | protrusions | http://purl.obolibrary.org/obo/UBERON_0004529 |
| T5 | 1435-1446 | Body_part | denotes | protrusions | http://purl.obolibrary.org/obo/UBERON_0004529 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 98-108 | Phenotype | denotes | insulinoma | HP:0012197 |
| T2 | 659-669 | Phenotype | denotes | insulinoma | HP:0012197 |